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Article ; Online: Do health assessments affect time to permanent residential aged care admission for older women with and without dementia?

Byles, Julie / Cavenagh, Dominic / Bryant, Jamie / Carey, Mariko / Mazza, Danielle / Sanson-Fisher, Rob

2023 Volume 23, Issue 8, Page(s) 595–602

Abstract: Aim: To investigate the effect of health assessments on permanent residential aged care admission for older Australian women with and without dementia.: Methods: A total of 1427 older Australian women who had a health assessment between March 2002 ... ...

Abstract	Aim: To investigate the effect of health assessments on permanent residential aged care admission for older Australian women with and without dementia. Methods: A total of 1427 older Australian women who had a health assessment between March 2002 and December 2013 were matched with 1427 women who did not have a health assessment in the same period. Linked administrative datasets were used to identify health assessment use, admission to permanent residential aged care, and dementia status. Outcome was time to residential aged care admission from the matched date of health assessment. Results: Women who had health assessments were less likely to be admitted to residential aged care in the short term (100 days), irrespective of dementia status (subdistribution hazard ratio [SDHR] = 0.35, 95% CI = [0.21, 0.59] for women with dementia; SDHR = 0.39, 95% CI = [0.25, 0.61] for women without dementia). However, there were no significant differences at 500- and 1000-days follow-up. At 2000-days follow-up, women who had a health assessment were more likely to be admitted to residential aged care, regardless of dementia status (SDHR = 1.41, 95% CI = [1.12, 1.79] for women with dementia; SDHR = 1.55, 95% CI = [1.32, 1.82] for women without dementia). Conclusions: Benefits from health assessments may depend on the recency of the assessment, with women less likely to be admitted to residential aged care in the short term after a health assessment. Our results add to a growing body of literature suggesting that health assessments may provide benefits to older people, including those with dementia. Geriatr Gerontol Int 2023; 23: 595-602.
MeSH term(s)	Aged ; Humans ; Female ; Nursing Homes ; Homes for the Aged ; Dementia/epidemiology ; Australia/epidemiology ; Hospitalization
Language	English
Publishing date	2023-06-29
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.14631
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Zs.A 5801: Show issues

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Article ; Online: NK cells CD56bright and CD56dim subset cytokine loss and exhaustion is associated with impaired survival in myeloma.

Seymour, Frances / Cavenagh, Jamie D / Mathews, Janet / Gribben, John G

Blood advances

2022 Volume 6, Issue 17, Page(s) 5152–5159

Abstract: Natural killer (NK) cells are the key cells of the innate immune system that share many characteristics with T lymphocytes; their activation, however, is based on the integration of a range of activatory and inhibitory signals via receptors recognizing ... ...

Abstract	Natural killer (NK) cells are the key cells of the innate immune system that share many characteristics with T lymphocytes; their activation, however, is based on the integration of a range of activatory and inhibitory signals via receptors recognizing recurrent pathogen-associated molecular patterns. Two important populations of NK cells with differing functions are recognized: CD56bright and CD56dim. NK cells have the potential to recognize and kill malignant plasma cells, which offers therapeutic opportunities. We used mass cytometry to examine the phenotype and function of NK cell subsets from patients with newly diagnosed multiple myeloma (NDMM). We show that NK cells in NDMM are shifted toward a CD56bright but dysfunctional cytotoxic phenotype, which exhibits selective loss of cytokine production. The CD56dim subset has features of exhaustion with impaired proliferation, upregulation of programmed cell death protein 1, and loss of T-cell immunoglobulin and mucin domain 3 expression. Poor expression of NK cell activation markers is seen and is associated with inferior long-term survival. These results suggest that NK cell exhaustion is already present by the time of myeloma diagnosis and likely contributes to the loss of immunologic control of malignant plasma cells. Restoring NK cell function via immune-directed therapies offers a route to restoring immunologic control in multiple myeloma.
MeSH term(s)	CD56 Antigen/metabolism ; Cytokines/metabolism ; Humans ; Killer Cells, Natural ; Lymphocyte Activation ; Multiple Myeloma/metabolism
Chemical Substances	CD56 Antigen ; Cytokines ; NCAM1 protein, human
Language	English
Publishing date	2022-07-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2022007905
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Article ; Online: Understanding the relationship between eye disease and driving in very old Australian women: a longitudinal thematic evaluation.

White, Jennifer / Hambisa, Mitiku Teshome / Cavenagh, Dominic / Dolja-Gore, Xenia / Byles, Julie

BMC ophthalmology

2022 Volume 22, Issue 1, Page(s) 277

Abstract: Background: Over recent decades an increasing number of adults will retain their driver's licenses well into their later years. The aim of this study was to understand and explore the experience of driving and driving cessation in very old Australian ... ...

Abstract	Background: Over recent decades an increasing number of adults will retain their driver's licenses well into their later years. The aim of this study was to understand and explore the experience of driving and driving cessation in very old Australian women with self-reported eye disease. Methods: An interpretative qualitative study. Participants were from the Australian Longitudinal Study on Women's Health (cohort born in 1921-26), a sample broadly representative of similarly aged Australian women. Responses to open-ended questions were analysed using an inductive thematic approach, employing a process of constant comparison. Results: Qualitative data were from 216 older women with eye disease who made 2199 comments about driving, aged between 70 and 90 years depending on the timing of their comments. Themes included: (1) Access to treatment for eye disease promotes driving independence and quality of life; (2) Driving with restrictions for eye disease enables community engagement and (3) Driving cessation due to poor vision leads to significant lifestyle changes. Conclusions: Key findings highlighted driving cessation, or reduction, is often attributed to deterioration in vision. The consequence is dependence on others for transport, typically children and friends. Access to successful treatment for eye disease allowed older women to continue driving. We posit that occupational therapists can play an essential role in promote driving confidence and ability as women age. Trial registration: Not applicable.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Australia/epidemiology ; Automobile Driving ; Child ; Eye Diseases ; Female ; Humans ; Longitudinal Studies ; Quality of Life
Language	English
Publishing date	2022-06-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-022-02506-8
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Article ; Online: Data-driven lifestyle patterns and risk of dementia in older Australian women.

Dingle, Sara E / Bowe, Steven J / Bujtor, Melissa / Milte, Catherine M / Daly, Robin M / Byles, Julie / Cavenagh, Dominic / Torres, Susan J

Alzheimer's & dementia : the journal of the Alzheimer's Association

2023 Volume 20, Issue 2, Page(s) 798–808

Abstract: Introduction: Many lifestyle factors have been associated with dementia, but there is limited evidence of how these group together. The aim of this study was to examine the clustering of lifestyle behaviors and associations with dementia.: Methods: ... ...

Abstract	Introduction: Many lifestyle factors have been associated with dementia, but there is limited evidence of how these group together. The aim of this study was to examine the clustering of lifestyle behaviors and associations with dementia. Methods: This population-based study included 9947 older Australian women. Latent class analysis was employed to identify distinct lifestyle classes, and Cox proportional hazard regression compared these with incident dementia over 17 years. Results: Three classes were identified: (1) "highly social and non-smokers" (54.9%), (2) "highly social, smokers, and drinkers" (25.1%), and (3) "inactive and low socializers" (20.0%). Women in Class 3 exhibited a higher risk of dementia compared to both Class 1 (hazard ratio [HR] = 1.19, 95% confidence interval [CI]: 1.08 to 1.30) and Class 2 (HR = 1.12, 95% CI: 1.00 to 1.25). Discussion: A lifestyle pattern characterized by physical inactivity and low social engagement may be particularly detrimental for dementia risk in older women and should be prioritized in preventive strategies. Highlights: Latent class analysis was employed to identify distinct lifestyle clusters. Three lifestyle-related clusters were differentially associated with dementia risk. Inactive and low socializers exhibited the greatest risk of dementia. Targeting physical inactivity and low social engagement in prevention is vital.
MeSH term(s)	Humans ; Female ; Aged ; Australia/epidemiology ; Life Style ; Cluster Analysis ; Dementia/epidemiology ; Risk Factors
Language	English
Publishing date	2023-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13467
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Zs.A 6316: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The experience of delayed health care access during the COVID 19 pandemic in Australian women: A mixed methods exploration.

White, Jennifer / Cavenagh, Dominic / Byles, Julie / Mishra, Gita / Tooth, Leigh / Loxton, Deborah

Health & social care in the community

2021 Volume 30, Issue 4, Page(s) e1384–e1395

Abstract: Delayed health care access is a potential collateral effect of pandemic conditions, health rationing strategies and social distancing responses. We investigated experiences of delayed health care access in Australian women during COVID-19. A mixed ... ...

Abstract	Delayed health care access is a potential collateral effect of pandemic conditions, health rationing strategies and social distancing responses. We investigated experiences of delayed health care access in Australian women during COVID-19. A mixed methods study used quantitative and free-text data from the Australian Longitudinal Study on Women's Health COVID-19 survey 4 (health care access or delay). Logistic regression models were used to estimate factors associated with delaying access to general practitioners (GPs), specialists and allied health services. Free-text comments were analysed thematically, employing a process of constant comparison. COVID-19 survey 4 was completed by 8,200 women and 2,727 provided free-text comments. Of the women who needed the health service, 25% (1,268/5,071) delayed seeing their GP, 23.6% (570/1,695) delayed seeing a specialist and 45% (791/1,757) delayed use of an allied health service. Younger age was most significantly associated with delaying attendance. Women born 1989-95 were significantly more likely to delay compared to women born 1946-51 (OR (95% CI): GP = 0.28 (0.22, 0.35)); Specialist = 0.65 (0.45, 0.92; Allied Health = 0.59 (0.42, 0.82)). Women born 1973-78 were also likely to delay GP visits (0.69, (0.58, 0.83)). Four qualitative themes emerged including: (1) Challenges negotiating care during a pandemic; (2) Ongoing uncertainty towards accessing health care when a specialist delays an appointment; (3) Accessing health care (or not) using Telehealth and (4) Managing complex care needs. COVID-19 has had a significant effect on access to health care. Women delayed seeking help for cancer screening, mental health, and other health conditions involving chronic and complex needs for health and social care. While there is a need to rationalise and optimise health access during a pandemic, our outcomes suggest a need for public health campaigns that clarify how to access care, engage with telehealth and respond to missed appointments.
MeSH term(s)	Australia/epidemiology ; COVID-19/epidemiology ; Female ; Health Services Accessibility ; Humans ; Longitudinal Studies ; Pandemics
Language	English
Publishing date	2021-08-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1155902-0
ISSN	1365-2524 ; 0966-0410
ISSN (online)	1365-2524
ISSN	0966-0410
DOI	10.1111/hsc.13546
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Article ; Online: Resolution of dysglycaemia after treatment of monoclonal gammopathy of endocrine significance.

Grant, Bonnie / Ratnayake, Gowri / Williams, Claire L / Long, Anna / Halsall, David J / Semple, Robert K / Cavenagh, James D / Drake, William M / Church, David S

European journal of endocrinology

2023 Volume 189, Issue 6, Page(s) K25–K29

Abstract: In very rare cases of monoclonal gammopathy, insulin-binding paraprotein can cause disabling hypoglycaemia. We report a 67-year-old man re-evaluated for hyperinsulinaemic hypoglycaemia that persisted despite distal pancreatectomy. He had no medical ... ...

Abstract	In very rare cases of monoclonal gammopathy, insulin-binding paraprotein can cause disabling hypoglycaemia. We report a 67-year-old man re-evaluated for hyperinsulinaemic hypoglycaemia that persisted despite distal pancreatectomy. He had no medical history of diabetes mellitus or autoimmune disease but was being monitored for an IgG kappa monoclonal gammopathy of undetermined significance. On glucose tolerance testing, hyperglycaemia occurred at 60 min (glucose 216 mg/dL) and hypoglycaemia at 300 min (52 mg/dL) concurrent with an apparent plasma insulin concentration of 52 850 pmol/L on immunoassay. Laboratory investigation revealed an IgG2 kappa with very high binding capacity but low affinity (Kd 1.43 × 10-6 mol/L) for insulin. The monoclonal gammopathy was restaged as smouldering myeloma not warranting plasma cell-directed therapy from a haematological standpoint. Plasma exchange reduced paraprotein levels and improved fasting capillary glucose concentrations. Lenalidomide was used to treat disabling hypoglycaemia, successfully depleting paraprotein and leading to resolution of symptoms.
MeSH term(s)	Male ; Humans ; Aged ; Monoclonal Gammopathy of Undetermined Significance/complications ; Monoclonal Gammopathy of Undetermined Significance/therapy ; Paraproteinemias/complications ; Paraproteinemias/therapy ; Paraproteins ; Endocrine System Diseases/complications ; Insulin ; Hypoglycemia/drug therapy ; Hypoglycemia/complications ; Glucose ; Multiple Myeloma/complications ; Multiple Myeloma/diagnosis
Chemical Substances	Paraproteins ; Insulin ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-10-11
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1183856-5
ISSN	1479-683X ; 0804-4643
ISSN (online)	1479-683X
ISSN	0804-4643
DOI	10.1093/ejendo/lvad138
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Article ; Online: Fludarabine, Cytarabine, Granulocyte Colony-Stimulating Factor, and Idarubicin With Gemtuzumab Ozogamicin Improves Event-Free Survival in Younger Patients With Newly Diagnosed AML and Overall Survival in Patients With

Russell, Nigel H / Wilhelm-Benartzi, Charlotte / Othman, Jad / Dillon, Richard / Knapper, Steven / Batten, Leona M / Canham, Joanna / Hinson, Emily L / Betteridge, Sophie / Overgaard, Ulrik Malthe / Gilkes, Amanda / Potter, Nicola / Mehta, Priyanka / Kottaridis, Panagiotis / Cavenagh, Jamie / Hemmaway, Claire / Arnold, Claire / Freeman, Sylvie D / Dennis, Mike

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2024 Volume 42, Issue 10, Page(s) 1158–1168

Abstract: Purpose: To determine the optimal induction chemotherapy regimen for younger adults with newly diagnosed AML without known adverse risk cytogenetics.: Patients and methods: One thousand thirty-three patients were randomly assigned to intensified ( ... ...

Abstract	Purpose: To determine the optimal induction chemotherapy regimen for younger adults with newly diagnosed AML without known adverse risk cytogenetics. Patients and methods: One thousand thirty-three patients were randomly assigned to intensified (fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin [FLAG-Ida]) or standard (daunorubicin and Ara-C [DA]) induction chemotherapy, with one or two doses of gemtuzumab ozogamicin (GO). The primary end point was overall survival (OS). Results: There was no difference in remission rate after two courses between FLAG-Ida + GO and DA + GO (complete remission [CR] + CR with incomplete hematologic recovery 93% Conclusion: Overall, FLAG-Ida + GO significantly reduced relapse without improving OS. However, exploratory analyses show that patients with
MeSH term(s)	Adult ; Humans ; Idarubicin ; Gemtuzumab/therapeutic use ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/diagnosis ; Progression-Free Survival ; Cytarabine/therapeutic use ; Neoplasm Recurrence, Local/drug therapy ; Vidarabine/therapeutic use ; Vidarabine/analogs & derivatives ; Nuclear Proteins/genetics ; Mutation ; Core Binding Factors ; Recurrence ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; fms-Like Tyrosine Kinase 3
Chemical Substances	Idarubicin (ZRP63D75JW) ; Gemtuzumab (93NS566KF7) ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Cytarabine (04079A1RDZ) ; fludarabine (P2K93U8740) ; Vidarabine (FA2DM6879K) ; Nuclear Proteins ; Core Binding Factors ; FLT3 protein, human (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1)
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.23.00943
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Addressing Dementia Through Analysis of Population Traits and Risk Factors (ADAPTOR) project: dementia incidence in an Australian cohort.

Nepal, Smriti / Dolja-Gore, Xenia / Cavenagh, Dominic / D'Este, Catherine / Anstey, Kaarin J / Brodaty, Henry / Welberry, Heidi J / Goh, Anita My / McNamara, Martin

Public health research & practice

2023 Volume 33, Issue 2

MeSH term(s)	Humans ; Incidence ; Australia/epidemiology ; Risk Factors ; Dementia/epidemiology ; Dementia/etiology
Language	English
Publishing date	2023-07-05
Publishing country	Australia
Document type	Journal Article
ISSN	2204-2091
ISSN (online)	2204-2091
DOI	10.17061/phrp3322317
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Article ; Online: Alcohol-related risk from pre-loading and heavy episodic drinking (HED) among a cohort of young Australian women: a cross-sectional analysis.

Anderson, Amy E / Cavenagh, Dominic / Forder, Peta / Loxton, Deborah / Byles, Julie

Australian and New Zealand journal of public health

2020 Volume 44, Issue 5, Page(s) 382–389

Abstract: Objective: To cross-sectionally examine heavy episodic drinking (HED) and pre-loading with alcohol among young Australian women in relation to the alcohol-induced adverse outcomes of memory loss, vomiting and injury.: Methods: A total of 7,800 ... ...

Abstract	Objective: To cross-sectionally examine heavy episodic drinking (HED) and pre-loading with alcohol among young Australian women in relation to the alcohol-induced adverse outcomes of memory loss, vomiting and injury. Methods: A total of 7,800 participants, aged 20-25 years, from the 1989-95 cohort of the Australian Longitudinal Study on Women's Health answered all questions on alcohol use, reported drinking alcohol in the previous year and were not pregnant at the third survey in 2015. Log-binomial models were used to estimate prevalence ratios for adverse outcomes associated with increased frequency of HED and pre-loading. Results: The majority of participants reported HED (83.4%) and/or pre-loading (65.6%), which had a moderate correlation (r=0.646). Just over half (55.2%) of participants experienced at least one adverse event, with vomiting being most common. As the frequency of HED or pre-loading increased, so did the risk of an adverse outcome. Conclusions: Both HED and pre-loading pose a risk to young Australian women, and that risk rises with increased frequency. Implications for public health: Although HED has been a target of public health policy and interventions, pre-loading has received limited attention. In addition to addressing HED, there is a need to consider the risk posed by pre-loading, a related, yet unique risky drinking behaviour.
MeSH term(s)	Adult ; Alcohol Drinking/epidemiology ; Australia/epidemiology ; Cohort Studies ; Cross-Sectional Studies ; Female ; Health Behavior ; Humans ; Memory Disorders/epidemiology ; Prevalence ; Risk Factors ; Vomiting/epidemiology ; Women's Health ; Wounds and Injuries/epidemiology ; Young Adult
Language	English
Publishing date	2020-08-10
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1323548-5
ISSN	1753-6405 ; 1326-0200
ISSN (online)	1753-6405
ISSN	1326-0200
DOI	10.1111/1753-6405.13018
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Article ; Online: Common combinations of medications used among oldest-old women: a population-based study over 15 years.

Thiruchelvam, Kaeshaelya / Byles, Julie / Hasan, Syed Shahzad / Egan, Nicholas / Cavenagh, Dominic / Kairuz, Therese

Aging clinical and experimental research

2020 Volume 33, Issue 7, Page(s) 1919–1928

Abstract: Background: Older people use many medications, but combinations of medications used among the oldest old (≥ 80 years) are not commonly reported.: Aims: This study aimed to determine common combinations of medications used among women aged 77-96 years ...

Abstract	Background: Older people use many medications, but combinations of medications used among the oldest old (≥ 80 years) are not commonly reported. Aims: This study aimed to determine common combinations of medications used among women aged 77-96 years and to describe characteristics associated with these combinations. Methods: A cohort study of older women enroled in the Australian Longitudinal Study on Women's Health over a 15-year period was used to determine combinations of medications using latent class analysis. Multinomial logistic regression was used to determine characteristics associated with these combinations. Results: The highest medication users during the study were for the cardiovascular (2003: 80.28%; 2017: 85.63%) and nervous (2003: 66.03%; 2017: 75.41%) systems. A 3-class latent model described medication use combinations: class 1: 'Cardiovascular & neurology anatomical group' (27.25%) included participants using medications of the cardiovascular and nervous systems in their later years; class 2: 'Multiple anatomical group' (16.49%) and class 3: 'Antiinfectives & multiple anatomical group' (56.27%). When compared to the reference class (class 1), the risk of participants being in class 3 was slightly higher than being in class 2 if they had > 4 general practitioner visits (RRR 2.37; 95% CI 2.08, 2.71), Department of Veterans Affairs' coverage (RRR 1.59; 95% CI 1.36, 1.86), ≥ 4 chronic diseases (RRR 3.16; 95% CI 2.56, 3.90) and were frail (RRR 1.47; 95% CI 1.27, 1.69). Conclusion: Identification of combinations of medication use may provide opportunities to develop multimorbidity guidelines and target medication reviews, and may help reduce medication load for older individuals.
MeSH term(s)	Aged ; Aged, 80 and over ; Australia ; Chronic Disease ; Cohort Studies ; Female ; Humans ; Longitudinal Studies ; Multimorbidity
Language	English
Publishing date	2020-09-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-020-01693-y
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