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  1. Book ; Online ; E-Book: Immune Checkpoint Biology in Health and Disease

    Galluzzi, Lorenzo / Garg, Abhishek

    2024  

    Author's details Lorenzo Galluzzi and Abhishek Garg
    Keywords Immunity
    Subject code 616.079
    Language English
    Size 1 online resource (310 pages)
    Edition First edition.
    Publisher Zoe Kruze
    Publishing place Cambridge, MA
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-443-13573-8 ; 0-443-13574-6 ; 978-0-443-13573-6 ; 978-0-443-13574-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: A synthetic thiol molecule releasing N-acetyl-l-cysteine and cysteamine drives early up-regulation of immunoproteasome subunits in the lymph nodes of mice infected with LP-BM5 leukemia retrovirus.

    Crinelli, Rita / Monittola, Francesca / Masini, Sofia / Diotallevi, Aurora / Bartoccini, Francesca / Smietana, Michaël / Galluzzi, Luca / Magnani, Mauro / Fraternale, Alessandra

    Biochimica et biophysica acta. Molecular basis of disease

    2023  Volume 1870, Issue 1, Page(s) 166918

    Abstract: ... that I-152, a thiol molecule metabolized to release N-acetyl-l-cysteine and cysteamine and acting as a pro ...

    Abstract Thiol molecules have been recently re-considered as drug candidates in viral infections because of their ability to induce redox changes which interfere with virus life cycle and modulate the host immune response. Little is known about the molecular mechanisms of their immunomodulatory properties. Here we show that I-152, a thiol molecule metabolized to release N-acetyl-l-cysteine and cysteamine and acting as a pro-glutathione agent, causes early up-regulation of immunoproteasome subunits in the lymph nodes of murine leukemia virus infected mice. This evidence suggests that the immunoproteasome may be modulated by thiol-based compounds with important implications in understanding redox-controlled immunoregulation.
    MeSH term(s) Mice ; Animals ; Acetylcysteine/pharmacology ; Acetylcysteine/metabolism ; Murine Acquired Immunodeficiency Syndrome/pathology ; Cysteamine/pharmacology ; Sulfhydryl Compounds ; Up-Regulation ; Retroviridae/metabolism ; Lymph Nodes/pathology ; Leukemia
    Chemical Substances Acetylcysteine (WYQ7N0BPYC) ; Cysteamine (5UX2SD1KE2) ; Sulfhydryl Compounds
    Language English
    Publishing date 2023-10-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2023.166918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Book ; Online ; E-Book: Cilia

    Galluzzi, Lorenzo / Bravo-San Pedro, Jose Manuel

    from mechanisms to disease. Part A

    (Issn Series)

    2023  

    Author's details Lorenzo Galluzzi ; edited by Jose Manuel Bravo-San Pedro
    Series title Issn Series
    Keywords Cilia and ciliary motion
    Subject code 571.67
    Language English
    Size 1 online resource (270 pages)
    Publisher Elsevier Inc
    Publishing place Cambridge, MA
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 9780443185878 ; 0443185875
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online ; E-Book: Animal Models of Disease Part A

    Galluzzi, Lorenzo / Aranda Vega, Fernando / Martinez, Aitziber Buque / Bravo-San Pedro, Jose Manuel

    2024  

    Subject code 616.027
    Language English
    Size 1 online resource (250 pages)
    Edition 1st ed.
    Publisher Elsevier Science & Technology
    Publishing place San Diego
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 9780443222399 ; 0443222398
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: The use of kDNA minicircle subclass relative abundance to differentiate between Leishmania (L.) infantum and Leishmania (L.) amazonensis.

    Ceccarelli, Marcello / Galluzzi, Luca / Diotallevi, Aurora / Andreoni, Francesca / Fowler, Hailie / Petersen, Christine / Vitale, Fabrizio / Magnani, Mauro

    Parasites & vectors

    2017  Volume 10, Issue 1, Page(s) 239

    Abstract: ... demonstrated discrimination between L. (Leishmania) and L. (Viannia) by SYBR green-based qPCR assays designed ... fully distinguish L. (L.) infantum from L. (L.) amazonensis, which can coexist in the same geographical ... area.: Methods: DNA from 18 strains/isolates of L. (L.) infantum, L. (L.) amazonensis, L. (V ...

    Abstract Background: Leishmaniasis is a neglected disease caused by many Leishmania species, belonging to subgenera Leishmania (Leishmania) and Leishmania (Viannia). Several qPCR-based molecular diagnostic approaches have been reported for detection and quantification of Leishmania species. Many of these approaches use the kinetoplast DNA (kDNA) minicircles as the target sequence. These assays had potential cross-species amplification, due to sequence similarity between Leishmania species. Previous works demonstrated discrimination between L. (Leishmania) and L. (Viannia) by SYBR green-based qPCR assays designed on kDNA, followed by melting or high-resolution melt (HRM) analysis. Importantly, these approaches cannot fully distinguish L. (L.) infantum from L. (L.) amazonensis, which can coexist in the same geographical area.
    Methods: DNA from 18 strains/isolates of L. (L.) infantum, L. (L.) amazonensis, L. (V.) braziliensis, L. (V.) panamensis, L. (V.) guyanensis, and 62 clinical samples from L. (L.) infantum-infected dogs were amplified by a previously developed qPCR (qPCR-ML) and subjected to HRM analysis; selected PCR products were sequenced using an ABI PRISM 310 Genetic Analyzer. Based on the obtained sequences, a new SYBR-green qPCR assay (qPCR-ama) intended to amplify a minicircle subclass more abundant in L. (L.) amazonensis was designed.
    Results: The qPCR-ML followed by HRM analysis did not allow discrimination between L. (L.) amazonensis and L. (L.) infantum in 53.4% of cases. Hence, the novel SYBR green-based qPCR (qPCR-ama) has been tested. This assay achieved a detection limit of 0.1 pg of parasite DNA in samples spiked with host DNA and did not show cross amplification with Trypanosoma cruzi or host DNA. Although the qPCR-ama also amplified L. (L.) infantum strains, the C
    Conclusions: A new and affordable SYBR-green qPCR-based approach to distinguish between L. (L.) infantum and L. (L.) amazonensis was developed exploiting the major abundance of a minicircle sequence rather than targeting a hypothetical species-specific sequence. The fast and accurate discrimination between these species can be useful to provide adequate prognosis and treatment.
    Language English
    Publishing date 2017-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2409480-8
    ISSN 1756-3305 ; 1756-3305
    ISSN (online) 1756-3305
    ISSN 1756-3305
    DOI 10.1186/s13071-017-2181-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Differentiation of Leishmania(L.)infantum, Leishmania(L.)amazonensis and Leishmania(L.)mexicana Using Sequential qPCR Assays and High-Resolution Melt Analysis

    Ceccarelli, Marcello / Diotallevi, Aurora / Buffi, Gloria / De Santi, Mauro / Fernández-Figueroa, Edith A. / Rangel-Escareño, Claudia / Muñoz-Montero, Said A. / Becker, Ingeborg / Magnani, Mauro / Galluzzi, Luca

    Microorganisms. 2020 May 29, v. 8, no. 6

    2020  

    Abstract: ... In this attempt, many qPCR-based assays have been developed. Recently, we have shown that L. (L.) infantum and L ... L.) amazonensis can be distinguished through the comparison of the Cq values from two qPCR assays ... qPCR-ML and qPCR-ama), designed to amplify kDNA minicircle subclasses more represented in L. (L ...

    Abstract Leishmania protozoa are the etiological agents of visceral, cutaneous and mucocutaneous leishmaniasis. In specific geographical regions, such as Latin America, several Leishmania species are endemic and simultaneously present; therefore, a diagnostic method for species discrimination is warranted. In this attempt, many qPCR-based assays have been developed. Recently, we have shown that L. (L.) infantum and L. (L.) amazonensis can be distinguished through the comparison of the Cq values from two qPCR assays (qPCR-ML and qPCR-ama), designed to amplify kDNA minicircle subclasses more represented in L. (L.) infantum and L. (L.) amazonensis, respectively. This paper describes the application of this approach to L. (L.) mexicana and introduces a new qPCR-ITS1 assay followed by high-resolution melt (HRM) analysis to differentiate this species from L. (L.) amazonensis. We show that L. (L.) mexicana can be distinguished from L. (L.) infantum using the same approach we had previously validated for L. (L.) amazonensis. Moreover, it was also possible to reliably discriminate L. (L.) mexicana from L. (L.) amazonensis by using qPCR-ITS1 followed by an HRM analysis. Therefore, a diagnostic algorithm based on sequential qPCR assays coupled with HRM analysis was established to identify/differentiate L. (L.) infantum, L. (L.) amazonensis, L. (L.) mexicana and Viannia subgenus. These findings update and extend previous data published by our research group, providing an additional diagnostic tool in endemic areas with co-existing species.
    Keywords algorithms ; diagnostic techniques ; kinetoplast DNA ; leishmaniasis ; Latin America
    Language English
    Dates of publication 2020-0529
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8060818
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Differentiation of Leishmania ( L .) infantum , Leishmania ( L .) amazonensis and Leishmania ( L .) mexicana Using Sequential qPCR Assays and High-Resolution Melt Analysis

    Marcello Ceccarelli / Aurora Diotallevi / Gloria Buffi / Mauro De Santi / Edith A. Fernández-Figueroa / Claudia Rangel-Escareño / Said A. Muñoz-Montero / Ingeborg Becker / Mauro Magnani / Luca Galluzzi

    Microorganisms, Vol 8, Iss 818, p

    2020  Volume 818

    Abstract: ... In this attempt, many qPCR-based assays have been developed. Recently, we have shown that L. (L.) infantum and L ... L.) amazonensis can be distinguished through the comparison of the Cq values from two qPCR assays ... qPCR-ML and qPCR-ama), designed to amplify kDNA minicircle subclasses more represented in L. (L ...

    Abstract Leishmania protozoa are the etiological agents of visceral, cutaneous and mucocutaneous leishmaniasis. In specific geographical regions, such as Latin America, several Leishmania species are endemic and simultaneously present; therefore, a diagnostic method for species discrimination is warranted. In this attempt, many qPCR-based assays have been developed. Recently, we have shown that L. (L.) infantum and L. (L.) amazonensis can be distinguished through the comparison of the Cq values from two qPCR assays (qPCR-ML and qPCR-ama), designed to amplify kDNA minicircle subclasses more represented in L. (L.) infantum and L. (L.) amazonensis , respectively. This paper describes the application of this approach to L. (L.) mexicana and introduces a new qPCR-ITS1 assay followed by high-resolution melt (HRM) analysis to differentiate this species from L. (L.) amazonensis . We show that L. (L.) mexicana can be distinguished from L. (L.) infantum using the same approach we had previously validated for L. (L.) amazonensis . Moreover, it was also possible to reliably discriminate L. (L.) mexicana from L. (L .) amazonensis by using qPCR-ITS1 followed by an HRM analysis. Therefore, a diagnostic algorithm based on sequential qPCR assays coupled with HRM analysis was established to identify/differentiate L. (L.) infantum , L. (L.) amazonensis , L. (L.) mexicana and Viannia subgenus. These findings update and extend previous data published by our research group, providing an additional diagnostic tool in endemic areas with co-existing species.
    Keywords leishmania infantum ; leishmania amazonensis ; leishmania mexicana ; qPCR ; high resolution melting ; kDNA ; Biology (General) ; QH301-705.5
    Subject code 630
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Functions of BCL-X L at the Interface between Cell Death and Metabolism.

    Michels, Judith / Kepp, Oliver / Senovilla, Laura / Lissa, Delphine / Castedo, Maria / Kroemer, Guido / Galluzzi, Lorenzo

    International journal of cell biology

    2013  Volume 2013, Page(s) 705294

    Abstract: The BCL-2 homolog BCL-XL, one of the two protein products of BCL2L1, has originally been characterized for its prominent prosurvival functions. Similar to BCL-2, BCL-XL binds to its multidomain proapoptotic counterparts BAX and BAK, hence preventing the ... ...

    Abstract The BCL-2 homolog BCL-XL, one of the two protein products of BCL2L1, has originally been characterized for its prominent prosurvival functions. Similar to BCL-2, BCL-XL binds to its multidomain proapoptotic counterparts BAX and BAK, hence preventing the formation of lethal pores in the mitochondrial outer membrane, as well as to multiple BH3-only proteins, thus interrupting apical proapoptotic signals. In addition, BCL-XL has been suggested to exert cytoprotective functions by sequestering a cytosolic pool of the pro-apoptotic transcription factor p53 and by binding to the voltage-dependent anion channel 1 (VDAC1), thereby inhibiting the so-called mitochondrial permeability transition (MPT). Thus, BCL-XL appears to play a prominent role in the regulation of multiple distinct types of cell death, including apoptosis and regulated necrosis. More recently, great attention has been given to the cell death-unrelated functions of BCL-2-like proteins. In particular, BCL-XL has been shown to modulate a number of pathophysiological processes, including-but not limited to-mitochondrial ATP synthesis, protein acetylation, autophagy and mitosis. In this short review article, we will discuss the functions of BCL-XL at the interface between cell death and metabolism.
    Language English
    Publishing date 2013-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2536742-0
    ISSN 1687-8884 ; 1687-8876
    ISSN (online) 1687-8884
    ISSN 1687-8876
    DOI 10.1155/2013/705294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: MiRNAs in aging and cancer

    Galluzzi, Lorenzo

    (International review of cell and molecular biology ; volume 334)

    2017  

    Author's details edited by Lorenzo Galluzzi, Ilio Vitale
    Series title International review of cell and molecular biology ; volume 334
    Collection
    Language English
    Size x, 343 Seiten, Illustrationen
    Edition First edition
    Publisher Elsevier Academic Press
    Publishing place Cambridge, MA
    Publishing country United States
    Document type Book
    Note Includes index
    HBZ-ID HT019469459
    ISBN 978-0-12-811868-9 ; 0-12-811868-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uc I Zs 317 -334- verfügbar in Königswinter Königswinter

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  10. Book: Tumors of the prostate gland, seminal vesicles, penis, and scrotum

    Epstein, Jonathan I. / Magi-Galluzzi, Cristina / Zhou, Ming / Cubilla, Antonio L.

    (AFIP atlas of tumor and non-tumor pathology. Fifth series / editor Elizabeth A. Montgomery ; fasc. 2)

    2020  

    Author's details by Jonathan I. Epstein, Cristina Magi-Galluzzi, Ming Zhou, Antonio L. Cubilla
    Series title AFIP atlas of tumor and non-tumor pathology. Fifth series / editor Elizabeth A. Montgomery ; fasc. 2
    AFIP atlas of tumor pathology
    Collection AFIP atlas of tumor pathology
    Keywords Prostate -- Tumors -- Atlases ; Seminal vesicles -- Tumors -- Atlases ; Penis -- Tumors -- Atlases ; Scrotum -- Tumors -- Atlases
    Subject code 616.99463070222
    Language English
    Size xix, 757 Seiten, Illustrationen, 29 cm
    Publisher American Registry of Pathology
    Publishing place Arlington
    Publishing country United States
    Document type Book
    HBZ-ID HT020807288
    ISBN 978-1-933477-90-9 ; 1-933477-90-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 A 677 available for loan (reading room) Lesesaal EG

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