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  1. Book: Guidelines for the validation and application of typing methods for use in bacterial epidemiology

    Belkum, A. van

    (Clinical microbiology and infection ; 13, Suppl. 3)

    2007  

    Author's details A. van Belkum
    Series title Clinical microbiology and infection ; 13, Suppl. 3
    Collection
    Language English
    Size 46 S. : Ill.
    Publisher Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015293001
    Database Catalogue ZB MED Medicine, Health

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    Zs A 4541 -13,Suppl.3- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: High frequency of carbapenemase in extensively drug-resistant Acinetobacter baumannii isolates in central Iran.

    Abbasi, Elnaz / van Belkum, Alex / Ghaznavi-Rad, Ehsanollah

    World journal of microbiology & biotechnology

    2023  Volume 39, Issue 11, Page(s) 321

    Abstract: Objectives: We assessed the frequency of occurrence for infections caused by wild-type A. baumannii, multidrug-resistant (MDR) or XDR A. baumannii, and CRAB. We detected different antibiotic resistance genes in the genomes of infectious A. baumannii ... ...

    Abstract Objectives: We assessed the frequency of occurrence for infections caused by wild-type A. baumannii, multidrug-resistant (MDR) or XDR A. baumannii, and CRAB. We detected different antibiotic resistance genes in the genomes of infectious A. baumannii strains from central Iran.
    Methods: This study investigated 546 clinical patient samples for the presence of A. baumannii by using conventional culture methods and PCR. Antibiotic resistance profiles, and the phenotypic and genotypic characteristics of various antibiotic genes were analyzed.
    Results: Out of 546 samples, 87 (15.9%) A. baumannii isolates were obtained using culture and all culture positive samples were also positive by PCR. The most effective antibiotics were polymyxin B (n = 84 strains) (96.6% susceptibility), colistin (n = 81) (93.1%), and ampicillin/sulbactam (n = 18) (20.7%). All clinical A. baumannii isolates were ESBL-positive. The number of CRAB was 84 (96.5%). All CRAB isolates were both MDR and XDR. Of all CRAB isolates, 78 out of 84 (92.4%) produced metallo-β-lactamase (MBL) by phenotypic diagnosis. The most abundant genes were bla
    Conclusion: High frequencies of XDR A. baumannii and CRAB (96.5%) were detected in central Iran. Quick and accurate diagnosis, appropriate isolation of patients colonized or infected by CRAB isolates, application of accurate and effective infection control policies and programs, and appropriate preventive measures are deemed helpful in preventing the further spread of these resistant and clinically highly relevant strains.
    MeSH term(s) Humans ; Acinetobacter baumannii/genetics ; Iran/epidemiology ; Bacterial Proteins/genetics ; beta-Lactamases/genetics ; Anti-Bacterial Agents/pharmacology
    Chemical Substances carbapenemase (EC 3.5.2.6) ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-09-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1499109-3
    ISSN 1573-0972 ; 0959-3993
    ISSN (online) 1573-0972
    ISSN 0959-3993
    DOI 10.1007/s11274-023-03778-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Common Etiological Agents in Adult Patients with Gastroenteritis from Central Iran.

    Abbasi, Elnaz / van Belkum, Alex / Ghaznavi-Rad, Ehsanollah

    Microbial drug resistance (Larchmont, N.Y.)

    2022  Volume 28, Issue 11, Page(s) 1043–1055

    Abstract: Aims: ...

    Abstract Aims:
    MeSH term(s) Humans ; Adult ; beta-Lactamases/genetics ; Microbial Sensitivity Tests ; Iran/epidemiology ; Anti-Bacterial Agents/pharmacology ; Shigella/genetics ; Gastroenteritis/drug therapy ; Gastroenteritis/epidemiology ; Escherichia coli Infections/microbiology
    Chemical Substances beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1290490-9
    ISSN 1931-8448 ; 1076-6294
    ISSN (online) 1931-8448
    ISSN 1076-6294
    DOI 10.1089/mdr.2021.0177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Performance of an innovative culture-based digital dipstick for detection of bacteriuria.

    Iseri, Emre / Nilsson, Sara / van Belkum, Alex / van der Wijngaart, Wouter / Özenci, Volkan

    Microbiology spectrum

    2023  Volume 12, Issue 1, Page(s) e0361323

    Abstract: Importance: In this study, we explore the transformative potential of UTI-lizer, an emerging technology not yet commercially available. Our manuscript shows that UTI-lizer is a promising alternative for detecting the five main pathogens that cause ... ...

    Abstract Importance: In this study, we explore the transformative potential of UTI-lizer, an emerging technology not yet commercially available. Our manuscript shows that UTI-lizer is a promising alternative for detecting the five main pathogens that cause urinary tract infections (UTIs). The results also indicate that digital dipsticks have the potential to uniquely provide UTI diagnostic quality on par with that of gold-standard testing, with the added benefits of ease of testing, rapid test handling time, and simple test equipment. This technology can be helpful in quickly ruling out bacterial infections and reducing the unnecessary use of antibiotics, especially in primary care settings or at the point of care. Moreover, the UTI-lizer test can reduce the number of negative urine samples sent to central laboratories, thus easing the burden of UTI diagnostics on the healthcare system. We believe our study, as well as current and upcoming research based on this technology, is highly relevant for clinical microbiologists, microbiology scientists, general practitioners, and urologists.
    MeSH term(s) Humans ; Bacteriuria/diagnosis ; Bacteriuria/drug therapy ; Urinary Tract Infections/microbiology ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03613-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Change in brain activation after transcranial pulsed electromagnetic fields in treatment-resistant depression.

    van Belkum, Sjoerd M / Opmeer, Esther M / Geugies, Hanneke / de Boer, Marrit K / Schoevers, Robert A / Aleman, André

    European archives of psychiatry and clinical neuroscience

    2024  

    Abstract: Background: Preliminary evidence suggests antidepressant effects of transcranial pulsed electromagnetic fields (tPEMF). However, the precise mechanism of action in the brain is still unknown. The aim of this study was to investigate the influence of ... ...

    Abstract Background: Preliminary evidence suggests antidepressant effects of transcranial pulsed electromagnetic fields (tPEMF). However, the precise mechanism of action in the brain is still unknown. The aim of this study was to investigate the influence of tPEMF on brain activation in patients with treatment-resistant depression (TRD) by studying two processes that might be of particular interest in relation to the symptoms of depression: emotional processing and reward processing.
    Methods: Eligible participants (n = 50) with TRD in this sham-controlled double-blind multicenter trial [registered at the Dutch Trial Register ( http://www.trialregister.nl ), NTR3702] were randomly assigned to five weeks daily active or sham tPEMF. Pre- and post-treatment functional MR-scans were made during which participants performed a social-emotional task and a reward task.
    Results: Participants in the active treatment group showed a stronger decrease in activation post-treatment compared to sham during reward-outcome processing in the left inferior frontal gyrus and in a cluster comprising the right lingual gyrus and the posterior part of the middle temporal gyrus. No effect of tPEMF was found on activation during the social-emotional task. Neurostimulation with tPEMF did also not affect behavioral performance for both tasks.
    Conclusions: We found a decrease in reward-related activation as a result of tPEMF stimulation, while no effect of tPEMF on social-emotional processing was found. The treatment-related reduction in activation of regulatory regions may reflect normalization and may have implications for anhedonia. These findings suggest that there is an effect of tPEMF on brain activation of relevant circuits, albeit in the absence of a clinical antidepressant effect.
    Language English
    Publishing date 2024-04-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-024-01797-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Laboratory-Based and Point-of-Care Testing for MSSA/MRSA Detection in the Age of Whole Genome Sequencing.

    van Belkum, Alex / Rochas, Olivier

    Frontiers in microbiology

    2018  Volume 9, Page(s) 1437

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureus
    Language English
    Publishing date 2018-06-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2018.01437
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  7. Article: The effect of aging on the epidemiology of blood transfusions in North Khorasan province, Iran.

    Mortazavi, Hamed / Mohammadi, Akbar / Sharifian, Elham / Firouzeh, Nima / van Belkum, Alex / Ghasemzadeh-Moghaddam, Hamed

    American journal of blood research

    2023  Volume 13, Issue 1, Page(s) 44–52

    Abstract: Purpose: Additional knowledge on the epidemiology and recipients of blood transfusions will help health-care managers to estimate the future needs. The study was performed to define the blood transfusion rate based on gender, sex, and clinical features ... ...

    Abstract Purpose: Additional knowledge on the epidemiology and recipients of blood transfusions will help health-care managers to estimate the future needs. The study was performed to define the blood transfusion rate based on gender, sex, and clinical features of patients receiving blood products in all hospitals of the North Khorasan province of Iran.
    Methods: Data on blood transfusion implementation were extracted from blood bank documents. The data for all patients who received at least one blood product were collected from March 2018 to March 2019.
    Results: Among blood transfused patients, the highest transfusion rate was for packed red blood cells (PRBC) (47.7%). The two other most frequently used products were fresh frizzed plasma (FFP) (27.2%) and platelets (PLT) (21.9%). The patients in the age group of 51-80 years received the majority of PRBCs and FFPs. Patients aged 21-40 and 61-70 yrs had the highest transfusion rates for PLT. Elderly female patients (57.4%) received more blood products than their male counterparts. The highest blood transfusion rates were among patients with neoplasms, anemia, gastrointestinal bleeding, and gastric diseases.
    Conclusion: The primary Iranian blood recipients were elderly patients. Population aging is associated with an increase in the number of blood recipients and simultaneously declines the blood donors pool. It highlights the need for optimizing the use of blood in hospitals and having better strategies for overcoming the shortage of blood.
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2620435-6
    ISSN 2160-1992
    ISSN 2160-1992
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  8. Article ; Online: Global mapping of antibiotic resistance rates among clinical isolates of Stenotrophomonas maltophilia: a systematic review and meta-analysis.

    Bostanghadiri, Narjess / Sholeh, Mohammad / Navidifar, Tahereh / Dadgar-Zankbar, Leila / Elahi, Zahra / van Belkum, Alex / Darban-Sarokhalil, Davood

    Annals of clinical microbiology and antimicrobials

    2024  Volume 23, Issue 1, Page(s) 26

    Abstract: Introduction: Infections caused by Stenotrophomonas maltophilia are clinically important due to its intrinsic resistance to a broad range of antibiotics. Therefore, selecting the most appropriate antibiotic to treat S. maltophilia infection is a major ... ...

    Abstract Introduction: Infections caused by Stenotrophomonas maltophilia are clinically important due to its intrinsic resistance to a broad range of antibiotics. Therefore, selecting the most appropriate antibiotic to treat S. maltophilia infection is a major challenge.
    Aim: The current meta-analysis aimed to investigate the global prevalence of antibiotic resistance among S. maltophilia isolates to the develop more effective therapeutic strategies.
    Method: A systematic literature search was performed using the appropriate search syntax after searching Pubmed, Embase, Web of Science and Scopus databases (May 2023). Statistical analysis was performed using Pooled and the random effects model in R and the metafor package. A total of 11,438 articles were retrieved. After a thorough evaluation, 289 studies were finally eligible for inclusion in this systematic review and meta-analysis.
    Result: Present analysis indicated that the highest incidences of resistance were associated with doripenem (97%), cefoxitin (96%), imipenem and cefuroxime (95%), ampicillin (94%), ceftriaxone (92%), aztreonam (91%) and meropenem (90%) which resistance to Carbapenems is intrinsic. The lowest resistance rates were documented for minocycline (3%), cefiderocol (4%). The global resistance rate to TMP-SMX remained constant in two periods before and after 2010 (14.4% vs. 14.6%). A significant increase in resistance to tigecycline and ceftolozane/tazobactam was observed before and after 2010.
    Conclusions: Minocycline and cefiderocol can be considered the preferred treatment options due to low resistance rates, although regional differences in resistance rates to other antibiotics should be considered. The low global prevalence of resistance to TMP-SMX as a first-line treatment for S. maltophilia suggests that it remains an effective treatment option.
    MeSH term(s) Humans ; Trimethoprim, Sulfamethoxazole Drug Combination ; Minocycline/therapeutic use ; Stenotrophomonas maltophilia ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cefiderocol ; Drug Resistance, Microbial ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/epidemiology
    Chemical Substances Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2) ; Minocycline (FYY3R43WGO) ; Anti-Bacterial Agents ; Cefiderocol (SZ34OMG6E8)
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2097873-X
    ISSN 1476-0711 ; 1476-0711
    ISSN (online) 1476-0711
    ISSN 1476-0711
    DOI 10.1186/s12941-024-00685-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Does a learned journal require regular re-vamping?

    van Belkum, A

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2016  Volume 35, Issue 8, Page(s) 1217–1220

    MeSH term(s) Biomedical Research ; Humans ; Journal Impact Factor ; Periodicals as Topic/standards ; Periodicals as Topic/statistics & numerical data
    Language English
    Publishing date 2016-08
    Publishing country Germany
    Document type Editorial
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-016-2720-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: One System for All: Is Mass Spectrometry a Future Alternative for Conventional Antibiotic Susceptibility Testing?

    Welker, Martin / van Belkum, Alex

    Frontiers in microbiology

    2019  Volume 10, Page(s) 2711

    Abstract: The two main pillars of clinical microbiological diagnostics are the identification of potentially pathogenic microorganisms from patient samples and the testing for antibiotic susceptibility (AST) to allow efficient treatment with active antimicrobial ... ...

    Abstract The two main pillars of clinical microbiological diagnostics are the identification of potentially pathogenic microorganisms from patient samples and the testing for antibiotic susceptibility (AST) to allow efficient treatment with active antimicrobial agents. While routine microbial species identification is increasingly performed with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), routine AST still largely relies on conventional and molecular techniques such as broth microdilution or disk and gradient diffusion tests, PCR and automated variants thereof. However, shortly after the introduction of MALDI-TOF MS based routine identification, first attempts to perform AST on the same instruments were reported. Today, a number of different approaches to perform AST with MALDI-TOF MS and other MS techniques have been proposed, some restricted to particular microbial taxa and resistance mechanisms while others being more generic. Further, while some of the methods are in a stage of proof of principles, others are already commercialized. In this review we discuss the different principal approaches of mass spectrometry based AST and evaluate the advantages and disadvantages compared to conventional and molecular techniques. At present, the possibility that MS will soon become a routine tool for AST seems unlikely - still, the same was true for routine microbial identification a mere 15 years ago.
    Language English
    Publishing date 2019-11-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2019.02711
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