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  1. Article ; Online: Why We Should Be Willing to Pay for Hepatitis C Treatment.

    Chhatwal, Jagpreet / Chen, Qiushi / Kanwal, Fasiha

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2015  Volume 13, Issue 10, Page(s) 1711–1713

    MeSH term(s) Antiviral Agents/economics ; Antiviral Agents/therapeutic use ; Cost-Benefit Analysis ; Health Care Costs ; Health Services Accessibility ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/epidemiology ; Hepatitis C, Chronic/transmission ; Humans
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2015.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5836: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Retraction: Cancer-Associated PP2A Aα Subunits Induce Functional Haploinsufficiency and Tumorigenicity.

    Chen, Wen / Arroyo, Jason D / Timmons, Jamie C / Possemato, Richard / Hahn, William C

    Cancer research

    2024  Volume 84, Issue 6, Page(s) 935

    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Retraction of Publication
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-24-0434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Stem cell therapy for heart failure in the clinics: new perspectives in the era of precision medicine and artificial intelligence.

    Chowdhury, Mohammed A / Zhang, Jing J / Rizk, Rodrigue / Chen, William C W

    Frontiers in physiology

    2024  Volume 14, Page(s) 1344885

    Abstract: Stem/progenitor cells have been widely evaluated as a promising therapeutic option for heart failure (HF). Numerous clinical trials with stem/progenitor cell-based therapy (SCT) for HF have demonstrated encouraging results, but not without limitations or ...

    Abstract Stem/progenitor cells have been widely evaluated as a promising therapeutic option for heart failure (HF). Numerous clinical trials with stem/progenitor cell-based therapy (SCT) for HF have demonstrated encouraging results, but not without limitations or discrepancies. Recent technological advancements in multiomics, bioinformatics, precision medicine, artificial intelligence (AI), and machine learning (ML) provide new approaches and insights for stem cell research and therapeutic development. Integration of these new technologies into stem/progenitor cell therapy for HF may help address: 1) the technical challenges to obtain reliable and high-quality therapeutic precursor cells, 2) the discrepancies between preclinical and clinical studies, and 3) the personalized selection of optimal therapeutic cell types/populations for individual patients in the context of precision medicine. This review summarizes the current status of SCT for HF in clinics and provides new perspectives on the development of computation-aided SCT in the era of precision medicine and AI/ML.
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1344885
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  4. Article: Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age.

    Sarver, Dylan C / Saqib, Muzna / Chen, Fangluo / Wong, G William

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Organ function declines with age, and large-scale transcriptomic analyses have highlighted differential aging trajectories across tissues. The mechanisms underlying shared and organ-selective functional changes across the lifespan, however, still remains ...

    Abstract Organ function declines with age, and large-scale transcriptomic analyses have highlighted differential aging trajectories across tissues. The mechanisms underlying shared and organ-selective functional changes across the lifespan, however, still remains poorly understood. Given the central role of mitochondria in powering cellular processes needed to maintain tissue health, we therefore undertook a systematic assessment of respiratory activity across 33 different tissues in young (2.5 months) and old (20 months) mice of both sexes. Our high-resolution mitochondrial respiration atlas reveals: 1) within any group of mice, mitochondrial activity varies widely across tissues, with the highest values consistently seen in heart, brown fat, and kidney; 2) biological sex is a significant but minor contributor to mitochondrial respiration, and its contributions are tissue-specific, with major differences seen in the pancreas, stomach, and white adipose tissue; 3) age is a dominant factor affecting mitochondrial activity, especially across different fat depots and skeletal muscle groups, and most brain regions; 4) age-effects can be sex- and tissue-specific, with some of the largest effects seen in pancreas, heart, adipose tissue, and skeletal muscle; and 5) while aging alters the functional trajectories of mitochondria in a majority of tissues, some are remarkably resilient to age-induced changes. Altogether, our data provide the most comprehensive compendium of mitochondrial respiration and illuminate functional signatures of aging across diverse tissues and organ systems.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.26.586781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Protocol for immunofluorescence staining of murine helminth-infected intestinal and lung tissues.

    El-Naccache, Darine W / Chen, Fei / Gause, William C

    STAR protocols

    2023  Volume 4, Issue 2, Page(s) 102208

    Abstract: ... please refer to Chen et al. (2022) ...

    Abstract Preserving structurally intact tissue through proper tissue fixation and cryopreservation minimizes tissue autolysis, desiccation, and enzymatic degradation. In this protocol, we describe the use of an optimized fresh freezing technique that cryopreserves the tissue and favors the retention of the natural protein structure of antigens. We also detail the use of cold, low-concentration paraformaldehyde (PFA) fixation to enhance tissue morphology and detection of fluorescent proteins, such as GFP and TdTomato, in tissues of genetically engineered mice. For complete details on the use and execution of this protocol, please refer to Chen et al. (2022)
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Best Practices for Simulations and Calculations of Nanomaterials for Energy Applications: Avoiding "Garbage In, Garbage Out".

    Salanne, Mathieu / Buriak, Jillian M / Chen, Xiaodong / Chueh, William / Hersam, Mark C / Schaak, Raymond E

    ACS nano

    2023  Volume 17, Issue 7, Page(s) 6147–6149

    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Editorial
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c02368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Active Gαi/o mutants accelerate breast tumor metastasis via the c-Src pathway.

    Lyu, Cancan / Bhimani, Aarzoo K / Draus, William T / Weigel, Ronald / Chen, Songhai

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Constitutively active mutations in the ... ...

    Abstract Constitutively active mutations in the Gα
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.16.524334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Association of atopic dermatitis with schizophrenia and schizoaffective disorder.

    Fan, Ryan / Chen, Gloria / Leasure, Audrey C / Johnson, Matthew C / Damsky, William / Cohen, Jeffrey M

    Archives of dermatological research

    2023  Volume 315, Issue 9, Page(s) 2731–2733

    MeSH term(s) Humans ; Schizophrenia/epidemiology ; Dermatitis, Atopic/complications ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/epidemiology ; Psychotic Disorders/diagnosis ; Psychotic Disorders/psychology
    Language English
    Publishing date 2023-07-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 130131-7
    ISSN 1432-069X ; 0340-3696
    ISSN (online) 1432-069X
    ISSN 0340-3696
    DOI 10.1007/s00403-023-02674-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Asthma medication adherence during the coronavirus disease 2019 pandemic in children at high risk of exacerbation.

    Shannon, Colleen M / Flaherty, Carina / Quarshie, William O / Xiao, Rui / Kenyon, Chén C

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2023  Volume 131, Issue 1, Page(s) 118–119

    MeSH term(s) Humans ; Child ; Pandemics ; COVID-19 ; Asthma/drug therapy ; Asthma/epidemiology ; Anti-Asthmatic Agents/therapeutic use ; Medication Adherence
    Chemical Substances Anti-Asthmatic Agents
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2023.04.007
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  10. Article ; Online: Stem cell therapy for heart failure in the clinics

    Mohammed A. Chowdhury / Jing J. Zhang / Rodrigue Rizk / William C. W. Chen

    Frontiers in Physiology, Vol

    new perspectives in the era of precision medicine and artificial intelligence

    2024  Volume 14

    Abstract: Stem/progenitor cells have been widely evaluated as a promising therapeutic option for heart failure (HF). Numerous clinical trials with stem/progenitor cell-based therapy (SCT) for HF have demonstrated encouraging results, but not without limitations or ...

    Abstract Stem/progenitor cells have been widely evaluated as a promising therapeutic option for heart failure (HF). Numerous clinical trials with stem/progenitor cell-based therapy (SCT) for HF have demonstrated encouraging results, but not without limitations or discrepancies. Recent technological advancements in multiomics, bioinformatics, precision medicine, artificial intelligence (AI), and machine learning (ML) provide new approaches and insights for stem cell research and therapeutic development. Integration of these new technologies into stem/progenitor cell therapy for HF may help address: 1) the technical challenges to obtain reliable and high-quality therapeutic precursor cells, 2) the discrepancies between preclinical and clinical studies, and 3) the personalized selection of optimal therapeutic cell types/populations for individual patients in the context of precision medicine. This review summarizes the current status of SCT for HF in clinics and provides new perspectives on the development of computation-aided SCT in the era of precision medicine and AI/ML.
    Keywords stem cells ; heart failure ; cell therapy ; precision medicine ; artificial intelligence ; machine learning ; Physiology ; QP1-981
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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