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Article ; Online: 1,25-Dihydroxycholecalciferol down-regulates 3-mercaptopyruvate sulfur transferase and caspase-3 in rat model of non-alcoholic fatty liver disease.

Ibrahim, Maher N / Khalifa, Abeer A / Hemead, Dalia A / Alsemeh, Amira Ebrahim / Habib, Marwa A

2023 Volume 54, Issue 2, Page(s) 119–134

Abstract: Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of liver morbidity and mortality and has multiple unclear pathogenic mechanisms. Vitamin D deficiency was associated with increased incidence and severity of NAFLD. Increased hepatic ... ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of liver morbidity and mortality and has multiple unclear pathogenic mechanisms. Vitamin D deficiency was associated with increased incidence and severity of NAFLD. Increased hepatic expression of 3-mercaptopyruvate sulfur transferase (MPST) and dysregulated hepatocyte apoptosis were involved in NAFLD pathogenesis. We aimed to explore the protective effect of 1,25-Dihydroxycholecalciferol (1,25-(OH)
MeSH term(s)	Rats ; Male ; Animals ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Calcitriol/pharmacology ; Calcitriol/metabolism ; Reactive Oxygen Species/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Caspase 3/metabolism ; Liver/metabolism ; Transferases/metabolism ; Transferases/pharmacology ; Glucose/metabolism ; Insulins/metabolism ; Insulins/pharmacology ; Sulfur/metabolism ; Sulfur/pharmacology ; Diet, High-Fat/adverse effects
Chemical Substances	Calcitriol (FXC9231JVH) ; Reactive Oxygen Species ; Tumor Necrosis Factor-alpha ; Caspase 3 (EC 3.4.22.-) ; 3-mercaptopyruvic acid (5Z1F5OW4YB) ; Transferases (EC 2.-) ; Glucose (IY9XDZ35W2) ; Insulins ; Sulfur (70FD1KFU70)
Language	English
Publishing date	2023-03-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2144021-9
ISSN	1567-2387 ; 1567-2379
ISSN (online)	1567-2387
ISSN	1567-2379
DOI	10.1007/s10735-023-10118-9
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Article: An electron microscopic and biochemical study of the potential protective effect of ginger against Cadmium-induced testicular pathology in rats.

Motawee, Moustafa E / Damanhory, Ahmed A / Sakr, Hany / Khalifa, Mohamed Mansour / Atia, Tarek / Elfiky, Mohamed M / Maher, Muhammad / Sakr, Hader I

Frontiers in physiology

2022 Volume 13, Page(s) 996020

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-10-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.996020
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Article ; Online: Evaluation of Global Dystonia Rating Scale as a predictor of unfavorable outcomes among acute antipsychotics poisoned patients.

Sharif, Asmaa Fady / Sobh, Zahraa Khalifa / Abdo, Sanaa Abd El-Fatah / Alahmadi, Osama M / Alharbi, Hatem A / Awaji, Mohannad Saif / Alabdullatif, Faris A / Baghlaf, Abdullah M / Alanazi, Ahmad F / Fayed, Manar Maher

Drug and chemical toxicology

2024 , Page(s) 1–18

Abstract: Worldwide, acute antipsychotic poisoning results in high morbidities and mortalities. Though extrapyramidal syndromes are commonly associated, the extent of extrapyramidal syndromes in relation to the severity of antipsychotic poisoning has not been ... ...

Abstract	Worldwide, acute antipsychotic poisoning results in high morbidities and mortalities. Though extrapyramidal syndromes are commonly associated, the extent of extrapyramidal syndromes in relation to the severity of antipsychotic poisoning has not been addressed yet. Thus, this study aimed to assess the Global Dystonia Rating Scale (GDRS) as an unfavorable outcomes predictive tool in acute antipsychotic poisoning. A cross-sectional study included 506 antipsychotic-poisoned patients admitted to Tanta University Poison Control Center, Egypt, over three years was conducted. The mean GDRS was 9.1 ± 16.7 in typical antipsychotic poisoning, which was significantly higher than that of atypical antipsychotics (4.2 ± 11.5) (
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	548368-2
ISSN	1525-6014 ; 0148-0545
ISSN (online)	1525-6014
ISSN	0148-0545
DOI	10.1080/01480545.2024.2313561
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Zs.A 1380: Show issues

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Article ; Online: Academic Entitlement Among Pharmacy Students in the Arab World: A Multi-National Exploratory Study.

Hammoudi Halat, Dalal / Al-Jumaili, Ali Azeez / Ahmed, Kawther Khalid / Rahal, Mohamad / Hamad, Anas / Darwish, Rula M / Alsous, Mervat M / Thomas, Dixon / Bukhatwa, Salma / Khdour, Maher / Alkhudair, Nora / Al Balushi, Abdullah Ali / Khalifa, Sherief / Alsharif, Naser Z

American journal of pharmaceutical education

2024 Volume 88, Issue 2, Page(s) 100640

Abstract: Objective: The study's aim was to explore academic entitlement among pharmacy students in different pharmacy colleges in the Arab World and assess associated factors.: Methods: This study design was a cross-sectional survey. Data were collected using ...

Abstract	Objective: The study's aim was to explore academic entitlement among pharmacy students in different pharmacy colleges in the Arab World and assess associated factors. Methods: This study design was a cross-sectional survey. Data were collected using a self-administered electronic questionnaire posted across pharmacy college networks in 10 Arab countries (Egypt, Iraq, Jordan, Lebanon, Libya, Oman, Palestine, Qatar, Saudi Arabia, and United Arab Emirates). The electronic survey was administered through Qualtrics Survey Software, and its link was open from January 23, 2022 to May 13, 2022. The multiple linear regression measured the association between different predictors and the academic entitlement. Results: A total of 2386 surveys were received from students studying in 10 different Arab countries. The majority of responding students were male and studying in a Bachelor of pharmacy program. Students reported an agreeable attitude in 4 areas: rewards for efforts, customer orientation, customer service expectation, and general academic entitlement. In accommodation, a neutral attitude was reported, while they reported a disagreeing attitude in the responsibility avoidance domain. In grade haggling, the 3 items of the domain had different attitudes. Only 3 factors had a significant negative association with student entitlement (professionalism, GPA, and year in the study program). Conclusion: The academic entitlement scores among pharmacy students in the Arab World were high and had a negative association with professionalism perceptions. This study finding is a call for pharmacy programs to consider the effect of academic entitlement on pharmacy education and to obtain in-depth evidence on its magnitude and associated factors.
MeSH term(s)	Humans ; Male ; Female ; Students, Pharmacy ; Cross-Sectional Studies ; Arab World ; Education, Pharmacy ; Middle East
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	603807-4
ISSN	1553-6467 ; 0002-9459
ISSN (online)	1553-6467
ISSN	0002-9459
DOI	10.1016/j.ajpe.2023.100640
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Zs.A 924: Show issues

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Article ; Online: Pharmacy faculty experiences with student academic entitlement: a multinational study from the Arab world.

Hammoudi Halat, Dalal / Alsous, Mervat M / Al-Jumaili, Ali Azeez / Malki, Ahmed / Ahmed, Kawther Khalid / Hamad, Anas / Darwish, Rula / Thomas, Dixon / Bukhatwa, Salma / Khdour, Maher / Alkhudair, Nora / Al Balushi, Abdullah Ali / Khalifa, Sherif / Alsharif, Naser Z / Rahal, Mohamad

BMC medical education

2024 Volume 24, Issue 1, Page(s) 470

Abstract: Academic Entitlement (AE) is the expectation by students to receive high grades or preferential treatment without significant effort. Exploring AE from faculty perspective has not been investigated in Arab colleges of pharmacy. The aim of this study was ... ...

Abstract	Academic Entitlement (AE) is the expectation by students to receive high grades or preferential treatment without significant effort. Exploring AE from faculty perspective has not been investigated in Arab colleges of pharmacy. The aim of this study was to explore experiences and perceptions towards student AE among pharmacy faculty in the Arab World. A cross-sectional, self-administered, anonymous, electronic survey was sent to pharmacy faculty across pharmacy colleges in Arab countries. The survey collected demographic data, an AE measure including 17 items reflecting seven AE components, and faculty perceptions and perceived reasons for AE. A total of 345 responses were collected. The AE level was moderate (46.05 ±7.29), and the highest scores among its components were for customer service expectation (62%) and responsibility avoidance (59%). In multiple linear regression, AE showed positive significant association with faculty in clinical pharmacy departments and those having fewer years of experience. Most common complaints heard by faculty from students were requests to turn in assignments late (90%), while the most common communication issues faculty faced with students were unprofessional verbal communication (58%) and unprofessional messages on social media (57%). Poor admission criteria (40%) and existence of multiple private colleges of pharmacy (37%) were the most common perceived reasons for AE by participating faculty. This study reveals moderate AE experienced by pharmacy faculty in the Arab World, as well as common complaints, communication issues, and AE reasons. In collaboration with other stakeholders, faculty play an important role in indicating expectations from students regarding AE, and research is warranted to check if such interventions reduce AE among pharmacy students.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Students, Pharmacy/psychology ; Male ; Female ; Faculty, Pharmacy ; Education, Pharmacy ; Arab World ; Adult ; Surveys and Questionnaires ; Schools, Pharmacy ; School Admission Criteria
Language	English
Publishing date	2024-04-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-024-05402-5
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Article ; Online: Evaluation of the Antimicrobial Effect of Thymoquinone against Different Dental Pathogens: An In Vitro Study.

Al-Khalifa, Khalifa S / AlSheikh, Rasha / Al-Hariri, Moahmmed T / El-Sayyad, Hosam / Alqurashi, Maher S / Ali, Saqib / Bugshan, Amr S

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 21

Abstract: This study aimed to evaluate the antimicrobial effect of Thymoquinone (TQ) on four different oral microorganisms. Minimum Bactericidal Concentration (MBC), Minimum Inhibition Concentration (MIC), Broth microdilution, and Well diffusion tests were used to ...

Abstract	This study aimed to evaluate the antimicrobial effect of Thymoquinone (TQ) on four different oral microorganisms. Minimum Bactericidal Concentration (MBC), Minimum Inhibition Concentration (MIC), Broth microdilution, and Well diffusion tests were used to determine the optimum antimicrobial concentrations of TQ against
MeSH term(s)	Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Benzoquinones/chemistry ; Benzoquinones/pharmacology ; Microbial Sensitivity Tests ; Staphylococcus aureus/drug effects ; Streptococcus mutans/drug effects ; Streptococcus oralis/drug effects ; Streptococcus salivarius/drug effects
Chemical Substances	Anti-Bacterial Agents ; Benzoquinones ; thymoquinone (O60IE26NUF)
Language	English
Publishing date	2021-10-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26216451
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Article ; Online: Modalities of Student Responses in Football Games According to Players’ Cognitive Structures

Makrem Zghibi / Hajer Sahli / Wissam Ben Khalifa / Hatem Ghouili / Maher Gharbi / Monoem Haddad

Sustainability, Vol 13, Iss 10193, p

2021 Volume 10193

Abstract: This work is part of a semio-constructivist conception of learning sport and physical education that emphasizes the primary role of language action in the co-construction of knowledge in/through action. The aim is to study the decision-making methods of ... ...

Abstract	This work is part of a semio-constructivist conception of learning sport and physical education that emphasizes the primary role of language action in the co-construction of knowledge in/through action. The aim is to study the decision-making methods of three groups of students in a verbal football cycle. A total of 48 pupils participates voluntarily in our study, in mixed teams, with/without a teacher (Time = 2 × 4 mn) before/after small sided games (2 × 10 mn). The language activity of students is dependent on the development of cognitive structures identified from the classes to which they belong.
Keywords	verbalization ; cognitive structures ; co-construction ; game ; football ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: The Outcome of Posterior-Stabilized, Rotating Platform Total Knee Arthroplasty at a Minimum Ten-Year Follow-Up, a Middle East Institution Experience.

Khalifa, Ahmed A / Fayez, Mostafa / Elkady, Hesham / Abdelaal, Ahmed M / Elassal, Maher A

The journal of knee surgery

2020 Volume 35, Issue 7, Page(s) 718–724

Abstract: Posterior-stabilized, rotating platform knee prosthesis design was aimed to decrease polyethylene wear for the sake of improving implant survivorship. The purpose of the present prospective study was to evaluate the long-term clinical and radiographic ... ...

Abstract	Posterior-stabilized, rotating platform knee prosthesis design was aimed to decrease polyethylene wear for the sake of improving implant survivorship. The purpose of the present prospective study was to evaluate the long-term clinical and radiographic results as well as the survival rate after using a rotating platform, posterior-stabilized knee prosthesis at a minimum of 10 years at a Middle East institution. We compared the results with reports in the literature on western populations. From January 2002 to June 2008, 96 patients (106 knees) underwent total knee arthroplasty (TKA) using a cemented rotating platform posterior-stabilized knee prosthesis. At a mean of 11.5 ± 1.3 years, 85 patients (95 TKAs) were available for clinical, radiographic, and implant survival analysis. At the final follow-up, 78.9% of the patients had excellent Knee Society Scoring system score, the average knee flexion was 110 ± 17 degrees, the average anatomical knee coronal alignment was 186 ± 2 degrees and 187 ± 3 degrees for varus and valgus knees, respectively. Five (5.2%) knees were revised of these: two for bearing dislocation, two for aseptic loosening, and one for infection. The Kaplan-Meier survival rate was 94.7% for all revisions and 97.8% when only revision for aseptic loosening considered as the end point. At a long-term follow-up, reasonable clinical and radiographic outcomes had been achieved after using a rotating platform, posterior-stabilized knee prosthesis in our population with acceptable survival rate reaching up to 95%, which is comparable to reports from the western population.
MeSH term(s)	Arthroplasty, Replacement, Knee/methods ; Follow-Up Studies ; Humans ; Knee Joint/surgery ; Knee Prosthesis ; Prospective Studies ; Prosthesis Design ; Prosthesis Failure ; Reoperation ; Treatment Outcome
Language	English
Publishing date	2020-10-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2075354-8
ISSN	1938-2480 ; 1538-8506 ; 0899-7403
ISSN (online)	1938-2480
ISSN	1538-8506 ; 0899-7403
DOI	10.1055/s-0040-1716850
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Zs.A 3867: Show issues

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Article ; Online: Electrochemistry and Radioactive Wastes

Maher Abed Elaziz / Mohamed Khalifa

Journal of the Turkish Chemical Society, Section A: Chemistry, Vol 3, Iss 1, Pp 47-

A Scientific Overview

2015 Volume 74

Abstract: Radioactive wastes are arising from nuclear applications such as nuclear medicine and nuclear power plants. Radioactive wastes should be managed in a safe manner to protect human beings and the environment now and in the future. The management strategy ... ...

Abstract	Radioactive wastes are arising from nuclear applications such as nuclear medicine and nuclear power plants. Radioactive wastes should be managed in a safe manner to protect human beings and the environment now and in the future. The management strategy depends on collection, segregation, treatment, immobilization, and disposal. The treatment process is a very important step in which the hazardous materials were converted to a more concentrated, less volume and less movable materials. Electrochemistry is the branch of chemistry in which the passage of electric current was producing a chemical change. Electrochemical treatment of radioactive wastes is widely used all over the world. It has a number of advantages and hence benefits. Electrochemistry can lead to remote, automatic control and increasing safety. The present work is focusing on the role of electrochemistry in the treatment of radioactive wastes worldwide. It contains the fundamentals of electrochemistry, the brief story of radioactive wastes, and the modern trends in the electrochemical treatment of radioactive wastes. An overview of electrochemical decomposition of organic wastes, electrochemical reduction of nitrates, electro- precipitation, electro- ion exchange, and electrochemical remediation of soil are outlined. The main operating factors, the mechanism of decontamination, energy consumption and examples of field trials are considered.
Keywords	- ; Chemistry ; QD1-999
Subject code	630
Language	English
Publishing date	2015-12-01T00:00:00Z
Publisher	Turkish Chemical Society
Document type	Article ; Online
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Article ; Online: Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis,

Taghour, Mohammed S / Mahdy, Hazem A / Gomaa, Maher H / Aglan, Ahmed / Eldeib, Mahmoud Gomaa / Elwan, Alaa / Dahab, Mohammed A / Elkaeed, Eslam B / Alsfouk, Aisha A / Khalifa, Mohamed M / Eissa, Ibrahim H / Elkady, Hazem

Journal of enzyme inhibition and medicinal chemistry

2022 Volume 37, Issue 1, Page(s) 2063–2077

Abstract: In this study, a set of novel benzoxazole derivatives were designed, synthesised, and biologically evaluated as potential VEGFR-2 inhibitors. Five compounds ( ...

Abstract	In this study, a set of novel benzoxazole derivatives were designed, synthesised, and biologically evaluated as potential VEGFR-2 inhibitors. Five compounds (
MeSH term(s)	Antineoplastic Agents/chemistry ; Apoptosis ; Benzoxazoles ; Dose-Response Relationship, Drug ; Drug Design ; Drug Screening Assays, Antitumor ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors ; Structure-Activity Relationship ; Vascular Endothelial Growth Factor Receptor-2
Chemical Substances	Antineoplastic Agents ; Benzoxazoles ; Protein Kinase Inhibitors ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1)
Language	English
Publishing date	2022-07-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2082578-X
ISSN	1475-6374 ; 1475-6366
ISSN (online)	1475-6374
ISSN	1475-6366
DOI	10.1080/14756366.2022.2103552
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