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  1. Article: Distinguishing Tics Secondary To Juvenile Huntington's Disease From A Primary Tic Disorder.

    Chan, Jason L / Sarna, Justyna R

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2023  , Page(s) 1–3

    Language English
    Publishing date 2023-05-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/cjn.2023.69
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1203: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: The Repeatability of Pharyngeal Opening Pressure Under Drug-Induced Sleep Endoscopy.

    Chan, Tyler G / Plageman, Jack / Yu, Jason L

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2024  

    Abstract: Objective: Pharyngeal opening pressure (PhOP) is a measure of upper airway collapsibility that can be obtained during drug-induced sleep endoscopy (DISE) using a continuous positive airway pressure (CPAP) titration. However, the stability of PhOP over ... ...

    Abstract Objective: Pharyngeal opening pressure (PhOP) is a measure of upper airway collapsibility that can be obtained during drug-induced sleep endoscopy (DISE) using a continuous positive airway pressure (CPAP) titration. However, the stability of PhOP over the course of sedation during DISE remains unclear. This study aims to compare repeat measures of PhOP over the course of DISE.
    Study design: Single arm prospective study.
    Setting: Single tertiary care institution.
    Methods: Patients had 2 CPAP titrations while undergoing DISE. Collected data included patient demographics, PhOP, patient sedation index (PSI), and duration of and between CPAP titrations. t Tests, test-retest coefficient analysis, and repeated measures correlation were performed.
    Results: Twenty-five patients completed the study between 2022 and 2023 with 22 patients having sedation depth (PSI) recording. Most were male (76%), obese (average body mass index: 30.24 kg/m
    Conclusion: The results showed repeatability of PhOP values over the course of DISE. When adjusted for sedation depth (PSI), deeper sedation was weakly associated with greater PHOP. However, the magnitude of this change was small and we conclude that PhOP remains relatively stable over the course of DISE (Effects of Lung Volume on Upper Airway Patency During DISE [DISE-Pulm], NCT05350332, clinicaltrials.gov).
    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1002/ohn.730
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  3. Article ; Online: Elastic Priming of Gait: An Effective Patient-Created Strategy for Freezing of Gait.

    Chan, Jason L / Amorelli, Gabriel / Sarna, Justyna R

    Movement disorders clinical practice

    2022  Volume 10, Issue 1, Page(s) 141–142

    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13594
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  4. Article ; Online: Systematic review on oral microbial dysbiosis and its clinical associations with head and neck squamous cell carcinoma.

    Ting, Haaron S L / Chen, Zigui / Chan, Jason Y K

    Head & neck

    2023  Volume 45, Issue 8, Page(s) 2120–2135

    Abstract: Objectives: The relationship between head and neck squamous cell carcinoma (HNSCC) and the oral microbiome has been drawn in various studies. Microbial diversities, microbiome profiles, metagenomic analysis, and host-pathogen interactions were collected ...

    Abstract Objectives: The relationship between head and neck squamous cell carcinoma (HNSCC) and the oral microbiome has been drawn in various studies. Microbial diversities, microbiome profiles, metagenomic analysis, and host-pathogen interactions were collected from these studies to highlight similarities and account for inconsistencies. We also evaluate the possible clinical applications of the microbiome regarding screening and diagnosis of HNSCC.
    Methods: Systematic analysis of studies regarding HNSCC and the microbiome was done according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guidelines. Articles were retrieved from four databases (PubMed, ScienceDirect, CUHK Full-Text Journals, and Cochrane database) and were screened using predefined criteria.
    Results: Twenty studies were chosen after screening for full-text review. α-diversity comparison was inconsistent whereas β-diversity between HNSCC and normal samples showed distinct clustering. Microbial dysbiosis characterized by change in the relative abundances of several bacterial species were also seen in HNSCC patients. At a phylum level, inconsistencies were seen between studies using HNSCC tumor tissue samples and saliva samples. At a genus level, Fusobacterium, Peptostreptococcus, Alloprevotella, Capnocytophaga, Catonella, and Prevotella were differentially enriched in HNSCC while Streptococcus, Actinomyces Veillonella, and Rothia were differentially depleted. Co-occurrence network analysis revealed a positive correlation of HNSCC with periodontal pathogens and a negative correlation with commensal bacteria. Metagenomic analysis of microbiota revealed a differential enrichment of pro-inflammatory genomic pathways which was consistent across various studies. Microbial dysbiosis was applied in clinical use as a tool for HNSCC screening. Random-forest analysis was adopted to differentiate between tumor and normal tissue, at 95.7% and 70.0% accuracies respectively in two studies. Microbial dysbiosis index was also used to predict prognosis.
    Conclusions: Oral microbial dysbiosis could be a promising tool for HNSCC screening and diagnosis. However, more research should be conducted pertaining to clinical applications to improve diagnostic accuracy and explore other clinical uses.
    MeSH term(s) Humans ; Bacteria ; Dysbiosis/diagnosis ; Dysbiosis/microbiology ; Head and Neck Neoplasms/diagnosis ; Microbiota/genetics ; Squamous Cell Carcinoma of Head and Neck
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27422
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    Zs.A 1493: Show issues Location:
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  5. Article ; Online: The impact of

    Arvin, Chelsey L / Sibila, Zachary / Lamendella, Regina / Chan, Jason / Staab, Trisha

    microPublication biology

    2023  Volume 2023

    Abstract: Ceramide glucosyltransferase (CGT) adds sugar moieties to ceramide, forming glucosylceramides that play roles in immune signaling, stress response, and host-bacterial interactions. Here, we examined whether mutations ... ...

    Abstract Ceramide glucosyltransferase (CGT) adds sugar moieties to ceramide, forming glucosylceramides that play roles in immune signaling, stress response, and host-bacterial interactions. Here, we examined whether mutations in
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.000758
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Current perspectives on tractography-guided deep brain stimulation for the treatment of mood disorders.

    Chan, Jason L / Carpentier, Ariane V / Middlebrooks, Erik H / Okun, Michael S / Wong, Joshua K

    Expert review of neurotherapeutics

    2024  Volume 24, Issue 1, Page(s) 11–24

    Abstract: Introduction: Deep brain stimulation (DBS) is an emerging therapy for mood disorders, particularly treatment-resistant depression (TRD). Different brain areas implicated in depression-related brain networks have been investigated as DBS targets and ... ...

    Abstract Introduction: Deep brain stimulation (DBS) is an emerging therapy for mood disorders, particularly treatment-resistant depression (TRD). Different brain areas implicated in depression-related brain networks have been investigated as DBS targets and variable clinical outcomes highlight the importance of target identification. Tractography has provided insight into how DBS modulates disorder-related brain networks and is being increasingly used to guide DBS for psychiatric disorders.
    Areas covered: In this perspective, an overview of the current state of DBS for TRD and the principles of tractography is provided. Next, a comprehensive review of DBS targets is presented with a focus on tractography. Finally, the challenges and future directions of tractography-guided DBS are discussed.
    Expert opinion: Tractography-guided DBS is a promising tool for improving DBS outcomes for mood disorders. Tractography is particularly useful for targeting patient-specific white matter tracts that are not visible using conventional structural MRI. Developments in tractography methods will help refine DBS targeting for TRD and may facilitate symptom-specific precision neuromodulation. Ultimately, the standardization of tractography methods will be essential to transforming DBS into an established therapy for mood disorders.
    MeSH term(s) Humans ; Mood Disorders/therapy ; Diffusion Tensor Imaging ; Deep Brain Stimulation ; Magnetic Resonance Imaging ; Brain/diagnostic imaging
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2112534-X
    ISSN 1744-8360 ; 1473-7175
    ISSN (online) 1744-8360
    ISSN 1473-7175
    DOI 10.1080/14737175.2023.2289573
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    Zs.A 6155: Show issues Location:
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  7. Article ; Online: Improving face identification of mask-wearing individuals.

    Manley, Krista D / Chan, Jason C K / Wells, Gary L

    Cognitive research: principles and implications

    2022  Volume 7, Issue 1, Page(s) 27

    Abstract: Research has consistently shown that concealing facial features can hinder subsequent identification. The widespread adoption of face masks due to the COVID-19 pandemic has highlighted the critical and urgent need to discover techniques to improve ... ...

    Abstract Research has consistently shown that concealing facial features can hinder subsequent identification. The widespread adoption of face masks due to the COVID-19 pandemic has highlighted the critical and urgent need to discover techniques to improve identification of people wearing face coverings. Despite years of research on face recognition and eyewitness identifications, there are currently no evidence-based recommendations for lineup construction for cases involving masked individuals. The purpose of this study was to examine identification accuracy of a masked perpetrator as a function of lineup type (i.e., unmasked or masked lineups) and perpetrator presence (i.e., absent or present). In both experiments, discriminability was superior for masked lineups, a result that was due almost exclusively to higher hits rates in target-present conditions. These data suggest that presenting a masked lineup can enhance identification of masked faces, and they have important implications for both eyewitness identification and everyday face recognition of people with face coverings.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Facial Recognition ; Humans ; Pandemics/prevention & control ; Recognition, Psychology
    Language English
    Publishing date 2022-03-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2365-7464
    ISSN (online) 2365-7464
    DOI 10.1186/s41235-022-00369-7
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  8. Article: Sindbis virus is suppressed in the yellow fever mosquito

    Pujhari, Sujit / Heu, Chan C / Brustolin, Marco / Johnson, Rebecca M / Kim, Donghun / Rasgon, Jason L

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Autophagy is a critical modulator of pathogen invasion response in vertebrates and invertebrates. However, how it affects mosquito-borne viral pathogens that significantly burden public health remains underexplored. To address this gap, we use a genetic ... ...

    Abstract Autophagy is a critical modulator of pathogen invasion response in vertebrates and invertebrates. However, how it affects mosquito-borne viral pathogens that significantly burden public health remains underexplored. To address this gap, we use a genetic approach to activate macroautophagy/autophagy in the yellow fever mosquito (
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.02.526867
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  9. Article: Experimental and meta-analytic evidence that source variability of misinformation does not increase eyewitness suggestibility independently of repetition of misinformation.

    O'Donnell, Rachel / Chan, Jason C K / Foster, Jeffrey L / Garry, Maryanne

    Frontiers in psychology

    2023  Volume 14, Page(s) 1201674

    Abstract: Considerable evidence has shown that repeating the same misinformation increases its influence (i.e., repetition effects). However, very little research has examined whether having multiple witnesses present misinformation relative to one witness (i.e., ... ...

    Abstract Considerable evidence has shown that repeating the same misinformation increases its influence (i.e., repetition effects). However, very little research has examined whether having multiple witnesses present misinformation relative to one witness (i.e., source variability) increases the influence of misinformation. In two experiments, we orthogonally manipulated repetition and source variability. Experiment 1 used written interview transcripts to deliver misinformation and showed that repetition increased eyewitness suggestibility, but source variability did not. In Experiment 2, we increased source saliency by delivering the misinformation to participants via videos instead of written interviews, such that each witness was visibly and audibly distinct. Despite this stronger manipulation, there was no effect of source variability in Experiment 2. In addition, we reported a meta-analysis (
    Language English
    Publishing date 2023-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1201674
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  10. Article ; Online: Twice-Daily Proton Pump Inhibitor Induces Higher Remission Rate in Eosinophilic Esophagitis Than Once-Daily Regimen Regardless of Total Daily Dose.

    Muftah, Mayssan / Goldin, Alison H / Barshop, Kenneth / Hsu Blatman, Karen / Hamilton, Matthew J / Lo, Wai-Kit / Hornick, Jason L / Chan, Walter W

    The American journal of gastroenterology

    2024  

    Abstract: Introduction: The optimal proton pump inhibitor (PPI) regimen for eosinophilic esophagitis (EoE) is unclear. We compared histologic response rates of different dosing combinations.: Methods: A total of 305 patients with newly diagnosed EoE received ... ...

    Abstract Introduction: The optimal proton pump inhibitor (PPI) regimen for eosinophilic esophagitis (EoE) is unclear. We compared histologic response rates of different dosing combinations.
    Methods: A total of 305 patients with newly diagnosed EoE received standard (omeprazole 20 mg daily), once-daily moderate (40 mg daily), twice-daily moderate (20 mg twice daily), or high (40 mg twice daily) dose PPI for ≥8 weeks.
    Results: Approximately 42.3% achieved histologic response to PPI, with higher rates for twice-daily (moderate 52.8%/high 54.3%) than once-daily (standard 11.8%/moderate 10%) dosing ( P < 0.0001). On multivariable analysis, twice-daily moderate (adjusted odds ratio 6.75, confidence interval 2.53-18.0, P = 0.0008) and high (adjusted odds ratio 12.8, confidence interval 4.69-34.8, P < 0.0001) doses independently predicted histologic response.
    Discussion: Twice-daily PPI is associated with higher EoE histologic response rates than once-daily regimen.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002712
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