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Article ; Online: Vitamin D levels in patients with seborrheic dermatitis.

Akbaş, Ayşe / Kılınç, Fadime / Şener, Sertaç / Hayran, Yıldız

Revista da Associacao Medica Brasileira (1992)

2023 Volume 69, Issue 7, Page(s) e20230022

Abstract: ... The aim of our study was to determine the serum level of 25-hydroxy vitamin D in patients ... vitamin D, calcium, phosphorus, and parathormone levels were measured in the patient and control groups ... vitamin D deficiency was more frequent among patients with seborrheic dermatitisSD compared to controls ...

Abstract	Objective: Seborrheic dermatitis is a common papulosquamous skin disease with unknown pathogenesis. The aim of our study was to determine the serum level of 25-hydroxy vitamin D in patients with seborrheic dermatitis SD. Methods: A total of 53 patients and 60 healthy controls were included in the study. Serum vitamin D, calcium, phosphorus, and parathormone levels were measured in the patient and control groups, and a comparison was made between the two groups regarding these parameters. Results: Severe vitamin D deficiency was more frequent among patients with seborrheic dermatitisSD compared to controls (52.8 vs. 25.8%, p=0.003). In patients with severe vitamin D deficiency, seborrheic dermatitis SD was detected more frequently at an early age (p=0048) and in women (p=0.015). No correlation was found between the seborrheic dermatitis skin involvement site and vitamin D level. Conclusion: The fact that vitamin D levels decreased in patients with seborrheic dermatitis SD and patients with severe vitamin D deficiency develop seborrheic dermatitis SD earlier suggests that the low levels of vitamin D are related to seborrheic dermatitis.
MeSH term(s)	Humans ; Female ; Dermatitis, Seborrheic/pathology ; Skin/pathology ; Vitamin D ; Vitamins ; Vitamin D Deficiency/complications
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2023-07-17
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.20230022
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Article ; Online: The prevalence of vitamin D deficiency and the factors affecting vitamin D levels in children admitted to the outpatient clinic of pediatric endocrinology in Bolu Province.

Baranoglu Kilinc, Yasemin / Bolu, Semih

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

2023 Volume 30, Issue 8, Page(s) 580–585

Abstract: Background: The present study aimed to determine the rate of vitamin D deficiency in children ... vitamin D levels.: Methods: Vitamin D levels of 1008 children and adolescents were retrospectively ... Results: The mean vitamin D level of the patients was 16.35±9.56 ng/mL and was lower in girls (14.90±9.56 ...

Abstract	Background: The present study aimed to determine the rate of vitamin D deficiency in children who presented to the pediatric endocrinology outpatient clinic in Bolu and to investigate the factors affecting vitamin D levels. Methods: Vitamin D levels of 1008 children and adolescents were retrospectively analyzed according to age group (0-1, 1-10, and 10-18 years), gender, season, month, obesity and other diseases, and deficiency category. Moreover, calcium, phosphorus, alkaline phosphatase, and parathyroid hormone levels were evaluated. Comparisons and correlation analyses between related groups were performed. Results: The mean vitamin D level of the patients was 16.35±9.56 ng/mL and was lower in girls (14.90±9.56 ng/mL) than in boys (18.68±9.63 ng/mL, p<0.001). Overall, 18.3% of the children and adolescents had vitamin D insufficiency, 52.3% had vitamin D deficiency, and 3.5% had severe vitamin D deficiency. Vitamin D levels were lower in 10-18-year age group than in the other age groups (p<0.001), and levels were higher in summer and autumn than in winter and spring (p<0.001). Vitamin D levels of participants with obesity (14.3 ± 8.3 ng/mL) were significantly lower than normal-weight participants with no health problems (15.9 ± 8.3 ng/mL, p = 0.004). There was a negative correlation between vitamin D, alkaline phosphatase, and parathyroid hormone levels in the 1-10-year age group, but a positive correlation between vitamin D, alkaline phosphatase, and calcium levels in the 10-18-year age group. Conclusion: The rate of vitamin D deficiency is high among children and adolescents who presented to the endocrine outpatient clinic in Bolu. The season appears to be an important factor affecting vitamin D levels as well as the relationship between vitamin D and parathyroid hormone. Obese children and adolescents living in this region may be advised to take vitamin D supplements in winter and spring.
MeSH term(s)	Male ; Female ; Adolescent ; Child ; Humans ; Infant, Newborn ; Vitamin D ; Calcium ; Retrospective Studies ; Prevalence ; Alkaline Phosphatase ; Pediatric Obesity/epidemiology ; Vitamin D Deficiency/epidemiology ; Parathyroid Hormone ; Vitamins ; Seasons
Chemical Substances	Vitamin D (1406-16-2) ; Calcium (SY7Q814VUP) ; Alkaline Phosphatase (EC 3.1.3.1) ; Parathyroid Hormone ; Vitamins
Language	English
Publishing date	2023-09-27
Publishing country	France
Document type	Journal Article
ZDB-ID	1181947-9
ISSN	1769-664X ; 0929-693X
ISSN (online)	1769-664X
ISSN	0929-693X
DOI	10.1016/j.arcped.2023.08.010
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Article ; Online: Relationship between Vitamin D Level and Index of Cardio Electrophysiological Balance in Children.

Guzelcicek, Ahmet / Kilinc, Emrullah / Fedai, Halil / Dedeoglu, Necip Fazıl / Toprak, Kenan / Tascanov, Mustafa Begenc / Ocak, Metin / Gungorer, Bülent / Kose, Dogan

Combinatorial chemistry & high throughput screening

2023

Abstract: Background: Vitamin D deficiency has been found to be associated with various ... the relationship between vitamin D deficiency and iCEB and iCEBc values in children.: Methods: A total of 186 ... patients were included in this study. Group 1 included 114 patients with vitamin D levels below 20 ng/ml ...

Abstract	Background: Vitamin D deficiency has been found to be associated with various cardiovascular disorders, including hypertension, coronary artery disease, heart failure, peripheral vascular diseases, and sudden cardiac death. In the literature, it has been reported that many electrocardiographic parameters have been developed to predict ventricular arrhythmias. In recent studies, it is noteworthy that the index of cardio-electrophysiological balance (iCEB) and correct cardio-electrophysiological balance (iCEBc), which are electrocardiographic parameters, can be used as new, easy, cheap and non-invasive parameters to predict ventricular arrhythmias. Objective: This study aimed to investigate the relationship between vitamin D deficiency and iCEB and iCEBc values in children. Methods: A total of 186 patients were included in this study. Group 1 included 114 patients with vitamin D levels below 20 ng/ml; 50 patients with vitamin D levels of 21-29 ng/ml were included in Group 2; Group 3 consisted of 36 patients with a vitamin D level above 30 ng/ml. iCEB and iCEBc values were calculated by taking 12-lead ECG from all individuals and comparing them between groups. Results: A total of 186 children, 114 subjects in Group 1, 36 subjects in Group 2, and 36 subjects in Group 3, were included in the study. Demographic characteristics and height-weight values of the groups were similar. Significant differences were found between the groups in terms of QT, QTc, QT/QRS, and QTc/QRS levels (p: 0.003, 0.028, 0.001, and 0.001, respectively). In the correlation analysis, a negative correlation was found between QTc/QRS and vitamin D level (r=-0.320, p=<0.001) and between QT/QRS and vitamin D level (r=-0.268, p=<0.001). Moreover, vitamin D level (β=0.389, p<0.001) was determined as an independent predictor of QTc/QRS in multivariate logistic regression analysis. Conclusion: iCEB and iCEBc parameters increase significantly in children with low vitamin D levels. These parameters are also evaluated during the follow-up of children with vitamin D deficiency in terms of the risk of ventricular arrhythmia. iCEBc can be used as an easy, inexpensive, non-invasive, and reproducible parameter.
Language	English
Publishing date	2023-08-16
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/1386207326666230816094807
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Article ; Online: Glycyrrhizic acid Poly(D,L-lactide-co-glycolide) nanoparticles

Cigdem Cetin Aluc / Bahar Gok / Serda Kecel-Gunduz / Yasemin Budama-Kilinc

PeerJ, Vol 10, p e

anti-aging cosmeceutical formulation for topical applications

2022 Volume 14139

Abstract: ... In this context, GA-loaded Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) were prepared using ...

Abstract	Glycyrrhizic acid (GA) is one of the components of licorice roots (Glycyrrhiza glabra L.). GA is a triterpenoid saponin can be used as a medicinal plant with its antiallergic, antiviral, anti-inflammatory, anti-ulcer, hepatoprotective, anticancer, anti-oxidation activities and several other therapeutic properties. The aim of this study is to develop an anti-aging formulation for topical application containing GA. In this context, GA-loaded Poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) were prepared using the double emulsion method, and were characterized by various spectroscopic methods. The efficacy of GA-PLGA NPs was evaluated with in vitro and in silico methods. The encapsulation efficiency and loading capacity were calculated. The in vitro release study was conducted, and the GA release profile was determined. The genotoxic activity of GA and GA-PLGA NPs was evaluated by the Ames test using TA98 and TA100 mutant strains of Salmonella typhimurium. The cytotoxic potential of GA-PLGA NPs was evaluated on the HaCaT cell line using the MTT assay. According to the genotoxicity and cytotoxicity results, it was found that the GA-PLGA NP formulation did not exhibit genotoxic and cytotoxic effects. Moreover, the efficacy of GA in preventing UVB-induced photo-aging in HaCaT cells and the clarification of the molecular mechanism of GA binding to MMPs were revealed by molecular docking analysis. In addition, through molecular dynamics (MD) analysis, the binding interaction of GA with MMPs in a dynamic system, and protein-ligand stability were predicted as a result of 50 ns MD simulation studies considering various analysis parameters. Finally, it was evaluated that GA-PLGA nanoformulation might be used as an alternative anti-aging skin care product candidate via topical application.
Keywords	Glycyrrhizic acid ; Nanoparticles ; PLGA ; Genotoxicity ; Cytotoxicity ; Molecular docking ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	500
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
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Article ; Online: The association between preoperative 25-OH vitamin D levels and postoperative complications in patients undergoing colorectal cancer surgery.

Balci, B / Kilinc, G / Calik, B / Aydin, C

BMC surgery

2021 Volume 21, Issue 1, Page(s) 369

Abstract: ... prospectively included in this single-center observational study. Preoperative serum 25-OH vitamin D levels were ... measured and analyzed for infectious and postoperative complications.: Results: Serum 25-OH vitamin D ... the mean serum 25-OH vitamin D level was 15.95 (± 9.08) ng/ml. In patients with surgical site infection and ...

Abstract	Background: Determining the modifiable risk factors for postoperative complications is particularly significant in patients undergoing colorectal surgery since those are associated with worse long-term outcomes. Methods: Consecutive newly diagnosed 104 colorectal cancer patients were prospectively included in this single-center observational study. Preoperative serum 25-OH vitamin D levels were measured and analyzed for infectious and postoperative complications. Results: Serum 25-OH vitamin D levels were found to be < 20 ng/ml in 74 patients (71.2%) and ≥ 20 ng/ml in 30 patients (28.8%); and the mean serum 25-OH vitamin D level was 15.95 (± 9.08) ng/ml. In patients with surgical site infection and infectious complications, 25-OH vitamin D levels were significantly lower than patients without complications (p = 0.036 and p = 0.026). However, no significant difference was demonstrated in 25-OH vitamin D levels according to overall postoperative complications. Conclusions: Our results suggest that vitamin D levels might be a potential risk factor for infectious complications in patients undergoing colorectal cancer surgery.
MeSH term(s)	Colorectal Neoplasms/surgery ; Digestive System Surgical Procedures ; Humans ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Risk Factors ; Vitamin D ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2021-10-19
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/s12893-021-01369-y
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Article ; Online: Vitamin D status and premature adrenarche.

Akın, Onur / Bideci, Aysun / Döğer, Esra / Demet Akbaş, Emine / Kilinç Uğurlu, Aylin / Yavuz, Süleyman Tolga / Elbeğ, Şehri / Çamurdan, Orhun / Cinaz, Peyami

Pediatrics international : official journal of the Japan Pediatric Society

2018 Volume 60, Issue 10, Page(s) 938–942

Abstract: Background: Vitamin D, an important factor in calcium-phosphate homeostasis, has recently been ... such as hyperandrogenism. The aim of this study was to investigate the relationship between vitamin D status and premature ... anthropometric measures including height, weight, and body mass index (BMI) were obtained. 25-Hydroxyvitamin D ...

Abstract	Background: Vitamin D, an important factor in calcium-phosphate homeostasis, has recently been suggested to play an important role in the pathogenesis of numerous chronic conditions such as hyperandrogenism. The aim of this study was to investigate the relationship between vitamin D status and premature adrenarche (PA). Methods: A total of 71 girls with PA and 52 healthy girls, as the control group, were recruited. Axillary and/or pubic hair development before the age of 8 years was defined as PA. Bone age and anthropometric measures including height, weight, and body mass index (BMI) were obtained. 25-Hydroxyvitamin D (25(OH)D), fasting plasma glucose and insulin were measured. Vitamin D insufficiency was defined as <20 ng/mL. Results: The PA patients had older bone age, higher BMI standard deviation score, homeostasis model of assessment-insulin resistance (HOMA-IR), and androgen but lower 25(OH)D than the control group. HOMA-IR and dehydroepiandrosterone sulfate were also higher in PA patients with vitamin D insufficiency compared with those with normal vitamin D. There was a negative correlation between 25(OH)D and HOMA-IR. Conclusion: Low vitamin D is associated with PA; and insulin resistance may be a factor in this association.
MeSH term(s)	Adrenarche ; Case-Control Studies ; Child ; Cross-Sectional Studies ; Female ; Humans ; Hyperandrogenism/diagnosis ; Hyperandrogenism/etiology ; Insulin Resistance ; Logistic Models ; Puberty, Precocious/etiology ; Risk Factors ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/physiopathology
Language	English
Publishing date	2018-10-08
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.13682
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Article: Serum Levels of Vitamin D in Children with or without Isolated Distal Radius Fractures: A Prospective Clinical Study.

Talmac, Mehmet Ali / Gorgel, Mehmer Akif / Varol, Ali / Ak, Semih / Kilinc, Bekir Eray / Ozdemir, Hacı Mustafa

Revista brasileira de ortopedia

2021 Volume 56, Issue 3, Page(s) 351–355

Abstract: ... ...

Abstract	Objective
Language	English
Publishing date	2021-03-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2411301-3
ISSN	1982-4378 ; 0102-3616
ISSN (online)	1982-4378
ISSN	0102-3616
DOI	10.1055/s-0040-1721362
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Article ; Online: The effects of vitamin D supplementation during pregnancy and maternal vitamin D levels on neonatal vitamin D levels and birth parameters.

Kılıcaslan, Ayse Özlem / Kutlu, Ruhusen / Kilinc, Ibrahim / Ozberk, Derya Isıklar

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2017 Volume 31, Issue 13, Page(s) 1727–1734

Abstract: Objective: The current study aimed to measure the levels of vitamin 25(OH)D in pregnant women and ... in the umbilical cord blood of newborns and to evaluate the association of vitamin D levels with birth parameters.: Methods ... to these mothers. Plasma vitamin D level was measured and birth parameters of the babies were recorded.: Results ...

Abstract	Objective: The current study aimed to measure the levels of vitamin 25(OH)D in pregnant women and in the umbilical cord blood of newborns and to evaluate the association of vitamin D levels with birth parameters. Methods: This cross-sectional analytic investigation was performed in 100 pregnant women at term and in 100 newborns born to these mothers. Plasma vitamin D level was measured and birth parameters of the babies were recorded. Results: Mean vitamin D levels in pregnant women and cord blood were 11.39 ± 6.24 ng/ml and 8.00 ± 4.95 ng/ml, respectively. Vitamin D levels were found to be higher in the women who had received vitamin D support during pregnancy (p < .001). Height (p = .004), head circumference (p = .003), and chest circumference (p = .005) of newborns born to mothers who had received vitamin D support were higher compared to non-receivers. Maternal vitamin D deficiency (<10 ng/ml) and insufficiency (10-30 ng/ml) was detected in 53.0% and 47.0% of the cases, respectively. None of the women had sufficient levels of vitamin D. Conclusions: This study established that vitamin D levels were low in maternal and cord blood in spite of the administration program of Ministry of Health in pregnant women. The importance of vitamin D supplementation should be explained to the pregnant women in each visit.
MeSH term(s)	25-Hydroxyvitamin D3 1-alpha-Hydroxylase/blood ; Adolescent ; Adult ; Apgar Score ; Birth Weight ; Cross-Sectional Studies ; Dietary Supplements ; Female ; Fetal Blood ; Humans ; Infant, Newborn ; Linear Models ; Pregnancy ; Prenatal Nutritional Physiological Phenomena ; Vitamin D/blood ; Vitamin D/therapeutic use ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/epidemiology ; Vitamin D Deficiency/prevention & control ; Vitamins/therapeutic use ; Young Adult
Chemical Substances	Vitamins ; Vitamin D (1406-16-2) ; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (EC 1.14.13.13)
Language	English
Publishing date	2017-05-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2017.1326897
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Article ; Online: Ossifying Fibroma Involving Three Quadrants of the Jaws in a Patient With Vitamin D Deficiency.

Kilinç, Adnan / Tepecik, Tahsin / Dayi, Ertunç / Gündoğdu, Betül

The Journal of craniofacial surgery

2017 Volume 28, Issue 1, Page(s) 296–297

Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000003256
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Article: Serum Vitamins A, D, and Zinc Levels in Children with Coronavirus Disease 2019 and Multisystem Inflammatory Syndrome in Children

Yilmaz, Aslı İmran / Ünal, Gökçen / Keleş, Sevgi / Pekcan, Sevgi / Kiliç, Ahmet Osman / Akcan, Özge Metin / Erdoğan, Kubra Nur / Özdemir, Hüseyin Safa / Kilinç, Ibrahim / Özdemir, Mehmet

Journal of Pediatric Infectious Diseases

2022 Volume 17, Issue 06, Page(s) 275–281

Abstract: Objective: Vitamin D, due to its immunomodulating effect, zinc, and vitamin A, which affect ... COVID-19) infection. The present study evaluates the association between vitamin A, D, and zinc ... of vitamin A, D, and zinc at the time of diagnosis of 123 pediatric patients who presented to our hospital ...

Abstract	Objective: Vitamin D, due to its immunomodulating effect, zinc, and vitamin A, which affect cellular and humoral immunity, are thought to affect the clinical severity of coronavirus disease 2019 (COVID-19) infection. The present study evaluates the association between vitamin A, D, and zinc deficiencies and disease severity in pediatric patients with COVID-19 infections. Methods: The levels of vitamin A, D, and zinc at the time of diagnosis of 123 pediatric patients who presented to our hospital and were diagnosed as having hospitalized, nonhospitalized COVID-19 infection group, and multisystem inflammatory syndrome in children (MIS-C) were evaluated. The correlations of the measured levels with the disease severity and the need for intensive care or hospitalization were analyzed. Results: Among the 123 patients, 21.1% ( n = 26), 42.2% ( n = 52), and 36.7% ( n = 45) had a diagnosis of MIS-C, belonged to the hospitalized COVID-19 infection group, or belonged to the nonhospitalized COVID-19 infection group, respectively. Zinc levels were significantly lower in the MIS-C group than in the nonhospitalized group ( p < 0.05). Vitamin A levels were found to be significantly lower in the MIS-C group than in the nonhospitalized group ( p < 0.01) and significantly lower in the hospitalized group when compared with the nonhospitalized group ( p < 0.001). Deficiencies in vitamin A, vitamin D, and zinc levels were found to be most common in the MIS-C group (42.3%) and in hospitalized COVID-19 group (15.3%). In the nonhospitalized COVID-19 group, it was found to be the lowest at 6.6%. Conclusion: Based on the results of the present study and a literature review, it can be said that vitamin A, D, and zinc deficiencies may associate with the severity of COVID-19, although more studies are required to clarify this subject further.
Keywords	COVID-19 ; pandemic ; vitamin D ; vitamin A ; zinc
Language	English
Publishing date	2022-09-16
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2236947-8
ISSN	1305-7693 ; 1305-7707 ; 1871-0336
ISSN (online)	1305-7693
ISSN	1305-7707 ; 1871-0336
DOI	10.1055/s-0042-1756442
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