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  1. Article ; Online: Factors Contributing to Missing COVID-19 Cases During Contact Tracing.

    Rich, Shannan N / Richards, Veronica L / Klann, Emily M

    JAMA internal medicine

    2021  Volume 181, Issue 7, Page(s) 1014–1015

    Language English
    Publishing date 2021-03-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2021.0077
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.119: Show issues Location:
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  2. Article ; Online: Gut Microbiota and Coronavirus Disease 2019 (COVID-19): A Superfluous Diagnostic Biomarker or Therapeutic Target?

    Klann, Emily / Rich, Shannan / Mai, Volker

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 72, Issue 12, Page(s) 2247–2248

    MeSH term(s) Biomarkers ; COVID-19 ; Gastrointestinal Microbiome ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza, Human ; SARS-CoV-2
    Chemical Substances Biomarkers
    Keywords covid19
    Language English
    Publishing date 2020-11-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1191
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 480: Show issues

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  3. Article ; Online: The integrated stress response effector GADD34 is repurposed by neurons to promote stimulus-induced translation.

    Oliveira, Mauricio M / Mohamed, Muhaned / Elder, Megan K / Banegas-Morales, Keylin / Mamcarz, Maggie / Lu, Emily H / Golhan, Ela A N / Navrange, Nishika / Chatterjee, Snehajyoti / Abel, Ted / Klann, Eric

    Cell reports

    2024  Volume 43, Issue 2, Page(s) 113670

    Abstract: Neuronal protein synthesis is required for long-lasting plasticity and long-term memory consolidation. Dephosphorylation of eukaryotic initiation factor 2α is one of the key translational control events that is required to increase de novo protein ... ...

    Abstract Neuronal protein synthesis is required for long-lasting plasticity and long-term memory consolidation. Dephosphorylation of eukaryotic initiation factor 2α is one of the key translational control events that is required to increase de novo protein synthesis that underlies long-lasting plasticity and memory consolidation. Here, we interrogate the molecular pathways of translational control that are triggered by neuronal stimulation with brain-derived neurotrophic factor (BDNF), which results in eukaryotic initiation factor 2α (eIF2α) dephosphorylation and increases in de novo protein synthesis. Primary rodent neurons exposed to BDNF display elevated translation of GADD34, which facilitates eIF2α dephosphorylation and subsequent de novo protein synthesis. Furthermore, GADD34 requires G-actin generated by cofilin to dephosphorylate eIF2α and enhance protein synthesis. Finally, GADD34 is required for BDNF-induced translation of synaptic plasticity-related proteins. Overall, we provide evidence that neurons repurpose GADD34, an effector of the integrated stress response, as an orchestrator of rapid increases in eIF2-dependent translation in response to plasticity-inducing stimuli.
    MeSH term(s) Brain-Derived Neurotrophic Factor ; Actin Depolymerizing Factors ; Actins ; Eukaryotic Initiation Factor-2 ; Neurons
    Chemical Substances Brain-Derived Neurotrophic Factor ; Actin Depolymerizing Factors ; Actins ; Eukaryotic Initiation Factor-2
    Language English
    Publishing date 2024-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.113670
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  4. Article ; Online: Gut microbiota composition and diversity before, during, and two months after rifamycin-based tuberculosis preventive therapy.

    Séraphin, Marie Nancy / Bellot, Julia / Klann, Emily / Ukhanova, Maria / Saulsberry, Florence G / Peloquin, Charles A / Mai, Volker

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 18933

    Abstract: Tuberculosis (TB) preventive therapy (TPT) is an effective strategy to eliminate TB in low-incidence settings. Shorter TPT regimens incorporating the antimicrobial class of rifamycins are designed to improve adherence and completion rates but carry the ... ...

    Abstract Tuberculosis (TB) preventive therapy (TPT) is an effective strategy to eliminate TB in low-incidence settings. Shorter TPT regimens incorporating the antimicrobial class of rifamycins are designed to improve adherence and completion rates but carry the risk of modifications to the gut microbiota. We enrolled six subjects diagnosed with latent TB infection (LTBI) who accepted to initiate TPT. We also enrolled six healthy volunteers unexposed to the rifamycins. We profiled the gut microbiota using 16S rRNA amplicon sequencing (V1-V2 region) to document the immediate effect of rifamycin-based TPT on the gut microbiota composition and tracked recovery to baseline two months after TPT. Overall, TPT accounted for 17% of the variance in gut microbial community dissimilarity. This rifamycin-based TPT induced dysbiosis was characterized by a depletion of butyrate-producing taxa (Clostridium-XIVa and Roseburia) and expansion of potentially pathogenic taxa within the Firmicutes and Proteobacteria phyla. Recovery of the gut microbial composition was incomplete two months after TPT. Robust clinical studies are necessary to comprehensively catalogue TPT-induced gut microbiota dysbiosis to inform strategies to mitigate potential long-term sequelae of this important TB control intervention.
    MeSH term(s) Humans ; Gastrointestinal Microbiome/genetics ; Dysbiosis ; RNA, Ribosomal, 16S/genetics ; Rifamycins/pharmacology ; Rifamycins/therapeutic use ; Latent Tuberculosis/drug therapy
    Chemical Substances RNA, Ribosomal, 16S ; Rifamycins
    Language English
    Publishing date 2023-11-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-44854-5
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  5. Article: Therapies for Parkinson's disease and the gut microbiome: evidence for bidirectional connection.

    Hey, Grace / Nair, Navya / Klann, Emily / Gurrala, Anjela / Safarpour, Delaram / Mai, Volker / Ramirez-Zamora, Adolfo / Vedam-Mai, Vinata

    Frontiers in aging neuroscience

    2023  Volume 15, Page(s) 1151850

    Abstract: The gut brain axis (GBA), a bidirectional communication pathway has often been linked to health and disease, and gut microbiota (GM), a key component of this pathway shown to be altered in Parkinson's disease (PD), are suggested to contribute to the ... ...

    Abstract The gut brain axis (GBA), a bidirectional communication pathway has often been linked to health and disease, and gut microbiota (GM), a key component of this pathway shown to be altered in Parkinson's disease (PD), are suggested to contribute to the pathogenesis of PD. There are few studies that report the impact of oral medication therapy on GM, however, there are even fewer studies that discuss the impact of other treatments such as device assisted therapies (DAT) including deep brain stimulation (DBS), levodopa-carbidopa intestinal gel infusion (LCIG) and photobiomodulation (PBM) and how these might impact GM. Here, we review the literature and summarize findings of the potential contributions of GM to the heterogenous clinical response to pharmaceutical therapies among individuals with PD. We also discuss the potential interactions between the GM and DATs such as DBS and LCIG and present evidence for alterations in GM in response to DATs. Given the complexity and highly individual nature of the GM of patients with PD and the potential influence that other external factors such as diet, lifestyle, medications, stage of the disease and other comorbidities, further investigations into the response of GM to therapies are worthy of future study in prospective, controlled trials as well as medication naïve individuals. Such detailed studies will help us further comprehend the relationship between GM in PD patients, and will help investigate the potential of targeting GM associated changes as a treatment avenue for PD.
    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2023.1151850
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  6. Article ; Online: Evaluating differences in tuberculosis and nontuberculous mycobacterial lung disease in Florida.

    Klann, Emily / Beal, Stacy G / Tremblay, Elizabeth E

    American journal of infection control

    2019  Volume 47, Issue 11, Page(s) 1324–1328

    Abstract: Background: Currently, very little data exists that compare the features of pulmonary nontuberculous mycobacteria (NTM) and Mycobacterium tuberculosis (TB). Both have similar symptomology and analogous preliminary laboratory results, as both present ... ...

    Abstract Background: Currently, very little data exists that compare the features of pulmonary nontuberculous mycobacteria (NTM) and Mycobacterium tuberculosis (TB). Both have similar symptomology and analogous preliminary laboratory results, as both present with positive acid-fast bacilli stains. The objective of this study was to provide data that would help guide clinicians in their decision making regarding isolation precautions for patients, with a preliminary positive result for mycobacteria, prior to species identification.
    Methods: We conducted queries for patients who had positive respiratory cultures for mycobacteria via our electronic medical record system, between January 1, 2011, and December 31, 2017. Additionally, we collected demographic and medical history, clinical presentation, and radiographic findings. The 2-sample unpaired Student t test, the Χ
    Results: Through logistic regression, 8 variables were significantly associated with patients who grew either TB or NTM. History of incarceration, born outside of the United States, cavitation, and lymphadenopathy were associated with TB; tobacco smoke exposure, pre-existing lung disease, immunosuppression, and bronchiectasis were associated with NTM. Incidence of HIV and hemoptysis was not significantly different between the 2 groups.
    Conclusions: Through the use of our study findings, improper use of airborne isolation precautions may be reduced or avoided.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bronchiectasis ; Emigration and Immigration ; Female ; Florida/epidemiology ; Humans ; Immunocompromised Host ; Male ; Middle Aged ; Mycobacterium Infections, Nontuberculous/epidemiology ; Preexisting Condition Coverage ; Prisons ; Risk Factors ; Tobacco Smoke Pollution ; Tuberculosis, Pulmonary/epidemiology ; Young Adult
    Chemical Substances Tobacco Smoke Pollution
    Language English
    Publishing date 2019-06-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2019.04.171
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1773: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Evaluation of screen, test, & protect: A public health program to control and prevent COVID-19 at a large academic university.

    Rich, Shannan N / Klann, Emily M / Gurka, Kelly K / Froman, Meghan / Walser, Matthew / Prins, Cindy / Myers, Paul / Lauzardo, Michael / Shapiro, Jerne

    Journal of American college health : J of ACH

    2022  , Page(s) 1–4

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604907-2
    ISSN 1940-3208 ; 0744-8481
    ISSN (online) 1940-3208
    ISSN 0744-8481
    DOI 10.1080/07448481.2022.2080506
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 427: Show issues Location:
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  8. Article: The Gut-Brain Axis and Its Relation to Parkinson's Disease: A Review.

    Klann, Emily M / Dissanayake, Upuli / Gurrala, Anjela / Farrer, Matthew / Shukla, Aparna Wagle / Ramirez-Zamora, Adolfo / Mai, Volker / Vedam-Mai, Vinata

    Frontiers in aging neuroscience

    2022  Volume 13, Page(s) 782082

    Abstract: Parkinson's disease is a chronic neurodegenerative disease characterized by the accumulation of misfolded alpha-synuclein protein (Lewy bodies) in dopaminergic neurons of ... ...

    Abstract Parkinson's disease is a chronic neurodegenerative disease characterized by the accumulation of misfolded alpha-synuclein protein (Lewy bodies) in dopaminergic neurons of the
    Language English
    Publishing date 2022-01-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2021.782082
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  9. Article ; Online: The integrated stress response effector GADD34 is repurposed by neurons to promote stimulus-induced translation

    Mauricio M. Oliveira / Muhaned Mohamed / Megan K. Elder / Keylin Banegas-Morales / Maggie Mamcarz / Emily H. Lu / Ela A.N. Golhan / Nishika Navrange / Snehajyoti Chatterjee / Ted Abel / Eric Klann

    Cell Reports, Vol 43, Iss 2, Pp 113670- (2024)

    2024  

    Abstract: Summary: Neuronal protein synthesis is required for long-lasting plasticity and long-term memory consolidation. Dephosphorylation of eukaryotic initiation factor 2α is one of the key translational control events that is required to increase de novo ... ...

    Abstract Summary: Neuronal protein synthesis is required for long-lasting plasticity and long-term memory consolidation. Dephosphorylation of eukaryotic initiation factor 2α is one of the key translational control events that is required to increase de novo protein synthesis that underlies long-lasting plasticity and memory consolidation. Here, we interrogate the molecular pathways of translational control that are triggered by neuronal stimulation with brain-derived neurotrophic factor (BDNF), which results in eukaryotic initiation factor 2α (eIF2α) dephosphorylation and increases in de novo protein synthesis. Primary rodent neurons exposed to BDNF display elevated translation of GADD34, which facilitates eIF2α dephosphorylation and subsequent de novo protein synthesis. Furthermore, GADD34 requires G-actin generated by cofilin to dephosphorylate eIF2α and enhance protein synthesis. Finally, GADD34 is required for BDNF-induced translation of synaptic plasticity-related proteins. Overall, we provide evidence that neurons repurpose GADD34, an effector of the integrated stress response, as an orchestrator of rapid increases in eIF2-dependent translation in response to plasticity-inducing stimuli.
    Keywords CP: Neuroscience ; CP: Molecular biology ; Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2024-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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