LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 152

Search options

  1. Article ; Online: [No title information]

    Maurin, Charlotte / Atkinson, Suzanne / Hamouche, Linda / Bussières, Jean-François

    The Canadian journal of hospital pharmacy

    2024  Volume 77, Issue 2, Page(s) e3497

    Abstract: Background: Since 2022, it has been mandatory in Québec to report all incidents and accidents (I&As) occurring in health-care facilities. Since 2011, a summary report of these I&As has been published each year. However, it is difficult to compare health ...

    Title translation Ratios d’incidents et d’accidents totaux et médicamenteux par 1000 jours-présence en établissement de santé au Québec: une étude exploratoire.
    Abstract Background: Since 2022, it has been mandatory in Québec to report all incidents and accidents (I&As) occurring in health-care facilities. Since 2011, a summary report of these I&As has been published each year. However, it is difficult to compare health facilities given that no denominator is specified and ratios are not calculated.
    Objective: The primary objective was to calculate the ratios of total I&As and medication-related I&As per 1000 inpatient-days per type of facility for all health-care facilities in Québec.
    Methods: This retrospective descriptive study was based on data from the period of April 1, 2016, to March 31, 2021. Data were extracted from the National Register of Incidents and Accidents Occurring during the Provision of Health Care and Social Services in Québec
    Results: A total of 85 health-care facilities had usable data, specifically 33 acute-care facilities, 45 long-term care facilities, and 7 rehabilitation facilities. The mean ratio for total I&As/1000 inpatient-days varied from 33 ± 19 to 38 ± 22 in acute-care facilities, from 14 ± 5 to 16 ± 7 in long-term care facilities, and from 99 ± 39 to 147 ± 55 in rehabilitation facilities. The mean ratio for medication-related I&As/1000 inpatient-days varied from 11 ± 7 to 12 ± 7 in acute care facilities, from 3 ± 2 to 4 ± 3 in long-term care facilities, and from 24 ± 10 to 40 ± 21 in rehabilitation facilities.
    Conclusions: This exploratory study demonstrated the feasibility of calculating I&A ratios from the National Register of Incidents and Accidents Occurring during the Provision of Health Care and Social Services in Québec. These ratios facilitate discussion of the reporting culture of I&As within the health-care system. It is hoped that these ratios will be added to future annual reports from the Québec I&A register.
    Language French
    Publishing date 2024-04-10
    Publishing country Canada
    Document type English Abstract ; Journal Article
    ZDB-ID 413450-3
    ISSN 1920-2903 ; 0008-4123
    ISSN (online) 1920-2903
    ISSN 0008-4123
    DOI 10.4212/cjhp.3497
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1844: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: [No title information]

    Maurin, Charlotte / Atkinson, Suzanne / Hamouche, Linda / Bussières, Jean-François

    The Canadian journal of hospital pharmacy

    2024  Volume 77, Issue 2, Page(s) e3528

    Abstract: Background: The safety of care provided is based on an analysis of medication incidents and accidents.: Objective: The primary objective was to describe medication-related incidents and accidents (I&A) within a university-affiliated hospital.: ... ...

    Title translation Incidents et accidents médicamenteux en établissement de santé : une analyse descriptive au sein d’un CHU mère-enfant de 2018 à 2022.
    Abstract Background: The safety of care provided is based on an analysis of medication incidents and accidents.
    Objective: The primary objective was to describe medication-related incidents and accidents (I&A) within a university-affiliated hospital.
    Methods: This retrospective descriptive study was based on data from a 500-bed mother-child university-affiliated hospital. All I&As declared between April 1, 2018, and March 31, 2022, were considered. The analysis included all medication-related I&As that occurred during an admission or in an outpatient setting. Some variables were recoded manually. Descriptive statistical analyses were performed.
    Results: A total of 23 284 I&As were considered, including 7578 medication-related I&As. Daily averages of 15.9 ± 14.0 I&As and 5.2 ± 0.3 medication-related I&As were reported. There were 22.4 medication-related I&As/1000 inpatient days. The majority of medication-related I&As occurred in surgery (20%, 1530/7578), oncology (19%, 1405/7578), and pediatrics (16%, 1200/7578). Most were associated with incorrect dosing (21%, 1575/7578); infiltration, extravasation, or removed lines (19%, 1405/7578); and omissions (16%, 1205/7578). Physical consequences were reported in 15% (1158/7578) of the medication-related I&As. Conversely, psychological consequences were reported in less than 1% (44/7578) of medication-related I&As.
    Conclusions: This study provides a comprehensive descriptive profile over a 4-year period. Most of the reported I&As did not lead to consequences for patients. The sharing of ratios promotes comparative analysis with other facilities and can contribute to discussions about risk reduction. A culture of reporting events is present within this health care facility.
    Language French
    Publishing date 2024-04-10
    Publishing country Canada
    Document type English Abstract ; Journal Article
    ZDB-ID 413450-3
    ISSN 1920-2903 ; 0008-4123
    ISSN (online) 1920-2903
    ISSN 0008-4123
    DOI 10.4212/cjhp.3528
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1844: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Diet After Ileostomy Study: an observational study describing dietary intake and stoma-related symptoms in people with an ileostomy.

    England, Clare / Mitchell, Alexandra / Atkinson, Charlotte

    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

    2023  Volume 36, Issue 4, Page(s) 1600–1612

    Abstract: Background: People with ileostomy are frequently advised to avoid specific foods and food groups, making it plausible that they are at risk of a range of nutrition-related adverse health consequences. Despite this there has been no recent study in the ... ...

    Abstract Background: People with ileostomy are frequently advised to avoid specific foods and food groups, making it plausible that they are at risk of a range of nutrition-related adverse health consequences. Despite this there has been no recent study in the United Kingdom describing dietary intake, symptoms and food avoidance in people with ileostomy or post-reversal.
    Methods: A cross-sectional study was conducted at different time points in people with ileostomy and reversal. Participants were recruited at 6-10 weeks post-formation (n = 17) and ≥12 months with established ileostomy (n = 16) and with reversal (n = 20). In all participants, ileostomy/bowel-related symptoms in the previous week were assessed using a study-specific questionnaire. Dietary intake was assessed using three online diet recalls or 3-day dietary records. Food avoidance and reasons for food avoidance were assessed. Data were summarised using descriptive statistics.
    Results: Participants reported a few ileostomy/bowel-related symptoms in the previous week. However, over 85% of participants reported avoiding foods, particularly fruits and vegetables. At 6-10 weeks the most common reason was being advised to do so (71%), although 53% avoided foods due to gas. At ≥12 months the most common reasons were foods visible in the bag (60%) or advised to do so (60%). Reported intakes of most nutrients were comparable to population medians, apart from lower fibre in people with ileostomy. Intakes of free sugars and saturated fats were above recommended levels in all groups, due to high consumption of cakes and biscuits and sugar-sweetened drinks.
    Conclusion: After the initial healing period, foods should not be automatically excluded unless found to be problematic after reintroduction. There may be a need for healthy eating advice for people with established ileostomies and post-reversal, targeting discretionary high-fat, high-sugar foods.
    MeSH term(s) Humans ; Ileostomy/adverse effects ; Cross-Sectional Studies ; Diet ; Eating ; Vegetables ; Sugars ; Energy Intake
    Chemical Substances Sugars
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645183-4
    ISSN 1365-277X ; 0952-3871 ; 1465-8178
    ISSN (online) 1365-277X
    ISSN 0952-3871 ; 1465-8178
    DOI 10.1111/jhn.13168
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2551: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Healthcare professionals' perspectives on dietary advice provided to people with an ileostomy.

    Mitchell, Alexandra / Herbert, Georgia / England, Clare / Atkinson, Charlotte / Searle, Aidan

    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

    2023  Volume 36, Issue 3, Page(s) 716–728

    Abstract: Background: Diet is a common concern among people with an ileostomy as it can be associated with serious and burdensome complications, for example, dehydration and obstruction, and dietary advice is often unsatisfactory. In this study, we explored ... ...

    Abstract Background: Diet is a common concern among people with an ileostomy as it can be associated with serious and burdensome complications, for example, dehydration and obstruction, and dietary advice is often unsatisfactory. In this study, we explored healthcare professionals' (HCPs) perspectives on dietary advice for ileostomy management.
    Methods: Semi-structured interviews were conducted with HCPs, from multiple professions, who provide dietary advice to patients with an ileostomy. A framework approach to thematic analysis was used to understand and compare HCPs' experiences, beliefs and attitudes that influence how dietary advice is provided and the effectiveness of dietary management.
    Results: Findings from interviews with 21 HCPs, across 3 hospitals, related to 7 key themes: tailoring of dietary advice to the patient, patient autonomy and communication, HCP knowledge and understanding, patient pathway, mixed messages, access to formal and social support and patient understanding and relationship with dietary advice. Profession was a strong determinator of what and how dietary advice is provided; however, closer team working increased consistency in dietary advice. Lack of scientific research and consensus contributes to mixed messages and reduced confidence in dietary advice for people with an ileostomy. Due to individual differences between patients, experiential learning with diet is key to self-management and is encouraged in a controlled way by HCPs; however, a lack of 'one-size-fits-all' guidance can be difficult for some.
    Conclusion: The study findings should inform HCPs caring for patients with an ileostomy, and researchers designing and evaluating interventions, to improve how patients receive dietary advice for ileostomy management.
    MeSH term(s) Humans ; Ileostomy ; Health Personnel/education ; Diet ; Health Education ; Delivery of Health Care ; Qualitative Research
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645183-4
    ISSN 1365-277X ; 0952-3871 ; 1465-8178
    ISSN (online) 1365-277X
    ISSN 0952-3871 ; 1465-8178
    DOI 10.1111/jhn.13169
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2551: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Diet After Ileostomy Study: an observational study describing dietary intake and stoma‐related symptoms in people with an ileostomy

    England, Clare / Mitchell, Alexandra / Atkinson, Charlotte

    Journal of Human Nutrition and Dietetics. 2023 Aug., v. 36, no. 4 p.1600-1612

    2023  

    Abstract: BACKGROUND: People with ileostomy are frequently advised to avoid specific foods and food groups, making it plausible that they are at risk of a range of nutrition‐related adverse health consequences. Despite this there has been no recent study in the ... ...

    Abstract BACKGROUND: People with ileostomy are frequently advised to avoid specific foods and food groups, making it plausible that they are at risk of a range of nutrition‐related adverse health consequences. Despite this there has been no recent study in the United Kingdom describing dietary intake, symptoms and food avoidance in people with ileostomy or post‐reversal. METHODS: A cross‐sectional study was conducted at different time points in people with ileostomy and reversal. Participants were recruited at 6-10 weeks post‐formation (n = 17) and ≥12 months with established ileostomy (n = 16) and with reversal (n = 20). In all participants, ileostomy/bowel‐related symptoms in the previous week were assessed using a study‐specific questionnaire. Dietary intake was assessed using three online diet recalls or 3‐day dietary records. Food avoidance and reasons for food avoidance were assessed. Data were summarised using descriptive statistics. RESULTS: Participants reported a few ileostomy/bowel‐related symptoms in the previous week. However, over 85% of participants reported avoiding foods, particularly fruits and vegetables. At 6-10 weeks the most common reason was being advised to do so (71%), although 53% avoided foods due to gas. At ≥12 months the most common reasons were foods visible in the bag (60%) or advised to do so (60%). Reported intakes of most nutrients were comparable to population medians, apart from lower fibre in people with ileostomy. Intakes of free sugars and saturated fats were above recommended levels in all groups, due to high consumption of cakes and biscuits and sugar‐sweetened drinks. CONCLUSION: After the initial healing period, foods should not be automatically excluded unless found to be problematic after reintroduction. There may be a need for healthy eating advice for people with established ileostomies and post‐reversal, targeting discretionary high‐fat, high‐sugar foods.
    Keywords cross-sectional studies ; descriptive statistics ; dietetics ; food choices ; food intake ; ileostomy ; observational studies ; people ; questionnaires ; risk ; United Kingdom
    Language English
    Dates of publication 2023-08
    Size p. 1600-1612.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 645183-4
    ISSN 1365-277X ; 0952-3871 ; 1465-8178
    ISSN (online) 1365-277X
    ISSN 0952-3871 ; 1465-8178
    DOI 10.1111/jhn.13168
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 5100: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Two-year audit of compliance in the preparation and administration of medications by nursing staff in a mother-and-child university hospital center.

    Jacolin, Charlotte / Monnier, Amélie / Farcy, Élisabeth / Atkinson, Suzanne / Pelchat, Véronique / Duval, Stéphanie / Bussières, Jean-François

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

    2024  Volume 31, Issue 2, Page(s) 100–105

    Abstract: Objective: Audits are essential for reviewing and improving the medication-use process. Identifying areas for improvement can limit the risk of errors when preparing and administering drugs. Pediatric centers face specific challenges in ensuring the ... ...

    Abstract Objective: Audits are essential for reviewing and improving the medication-use process. Identifying areas for improvement can limit the risk of errors when preparing and administering drugs. Pediatric centers face specific challenges in ensuring the safety of the medication-use process. The objective of this study was to observe and compare compliance with criteria for the preparation and administration of medications by nurses in a mother-and-child university hospital center over two consecutive years.
    Methods: This observational cross-sectional study was conducted in a Canadian mother-and-child university hospital center. Audits were conducted over a 1-month period in 16 and 18 nursing care sectors in 2021 and 2022, respectively. The standardized audit evaluated compliance with prespecified criteria related to the preparation and administration of medication by nursing staff (77 criteria for 2021 and 82 criteria for 2022). The auditors comprised nurses and a pharmacist trained by the research team. Compliance was compared between years and assessed through a chi-square test.
    Results: The audit consisted of 522 observations in 2021 and 448 observations in 2022. Overall compliance was 76% in 2021 and 66% in 2022. The compliance rate by criterion ranged from 16% to 100%. In 2021 and 2022, 51 (84%) and 52 (87%) of the criteria, respectively, had compliance rates of more than 75%, and 12 (20%) and eight (13%), respectively, had 100% compliance. There were statistically significant decreases in compliance for nine of the 39 criteria for preparation of medications, notably prior hand hygiene (91%% vs. 84%, p = 0.002), and for six of the 17 criteria for administration of medications, including mentioning possible adverse effects to the patient (41% vs- 30%, p = 0.008).
    Conclusion: In this study, compliance was over 75% for most of the criteria. However, for a few criteria, we observed a decrease in compliance from 2021 to 2022. Various hypotheses are proposed to explain these decreases, such as the COVID-19 pandemic.
    MeSH term(s) Female ; Humans ; Mothers ; Pandemics ; Canada ; Pharmaceutical Preparations ; Nursing Staff ; Hospitals, University ; Nursing Staff, Hospital
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2024-01-22
    Publishing country France
    Document type Observational Study ; Journal Article
    ZDB-ID 1181947-9
    ISSN 1769-664X ; 0929-693X
    ISSN (online) 1769-664X
    ISSN 0929-693X
    DOI 10.1016/j.arcped.2023.09.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3942: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Prehabilitation provision and practice in the UK: a freedom of information survey.

    Pufulete, Maria / Coyle, Vicky / Provan, Debbie / Shaw, Clare / Kunzmann, Peter / Bowrey, David J / Barlow, Rachael / Grocott, Michael P W / Shah, Toral / Atkinson, Charlotte

    British journal of anaesthesia

    2024  Volume 132, Issue 4, Page(s) 815–819

    MeSH term(s) Humans ; Preoperative Exercise ; Surveys and Questionnaires ; Preoperative Care ; Freedom ; United Kingdom
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2024.01.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.80: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Healthcare professionals' perspectives on dietary advice provided to people with an ileostomy

    Mitchell, Alexandra / Herbert, Georgia / England, Clare / Atkinson, Charlotte / Searle, Aidan

    Journal of Human Nutrition and Dietetics. 2023 June, v. 36, no. 3 p.716-728

    2023  

    Abstract: BACKGROUND: Diet is a common concern among people with an ileostomy as it can be associated with serious and burdensome complications, for example, dehydration and obstruction, and dietary advice is often unsatisfactory. In this study, we explored ... ...

    Abstract BACKGROUND: Diet is a common concern among people with an ileostomy as it can be associated with serious and burdensome complications, for example, dehydration and obstruction, and dietary advice is often unsatisfactory. In this study, we explored healthcare professionals' (HCPs) perspectives on dietary advice for ileostomy management. METHODS: Semi‐structured interviews were conducted with HCPs, from multiple professions, who provide dietary advice to patients with an ileostomy. A framework approach to thematic analysis was used to understand and compare HCPs' experiences, beliefs and attitudes that influence how dietary advice is provided and the effectiveness of dietary management. RESULTS: Findings from interviews with 21 HCPs, across 3 hospitals, related to 7 key themes: tailoring of dietary advice to the patient, patient autonomy and communication, HCP knowledge and understanding, patient pathway, mixed messages, access to formal and social support and patient understanding and relationship with dietary advice. Profession was a strong determinator of what and how dietary advice is provided; however, closer team working increased consistency in dietary advice. Lack of scientific research and consensus contributes to mixed messages and reduced confidence in dietary advice for people with an ileostomy. Due to individual differences between patients, experiential learning with diet is key to self‐management and is encouraged in a controlled way by HCPs; however, a lack of ‘one‐size‐fits‐all’ guidance can be difficult for some. CONCLUSION: The study findings should inform HCPs caring for patients with an ileostomy, and researchers designing and evaluating interventions, to improve how patients receive dietary advice for ileostomy management.
    Keywords diet ; dietetics ; health services ; ileostomy ; occupations ; patients ; people ; social support
    Language English
    Dates of publication 2023-06
    Size p. 716-728.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 645183-4
    ISSN 1365-277X ; 0952-3871 ; 1465-8178
    ISSN (online) 1365-277X
    ISSN 0952-3871 ; 1465-8178
    DOI 10.1111/jhn.13169
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 5100: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Long-Distance Avian Migrants Fail to Bring 2.3.4.4b HPAI H5N1 Into Australia for a Second Year in a Row.

    Wille, Michelle / Atkinson, Robyn / Barr, Ian G / Burgoyne, Charlotte / Bond, Alexander L / Boyle, David / Christie, Maureen / Dewar, Meagan / Douglas, Tegan / Fitzwater, Teagan / Hassell, Chris / Jessop, Roz / Klaassen, Hiske / Lavers, Jennifer L / Leung, Katherine K-S / Ringma, Jeremy / Sutherland, Duncan R / Klaassen, Marcel

    Influenza and other respiratory viruses

    2024  Volume 18, Issue 4, Page(s) e13281

    MeSH term(s) Animals ; Humans ; Influenza A Virus, H5N1 Subtype/genetics ; Birds ; Influenza in Birds/epidemiology ; Australia/epidemiology
    Language English
    Publishing date 2024-03-30
    Publishing country England
    Document type Letter
    ZDB-ID 2274538-5
    ISSN 1750-2659 ; 1750-2640
    ISSN (online) 1750-2659
    ISSN 1750-2640
    DOI 10.1111/irv.13281
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6568: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Persistent low-level variants in a subset of viral genes are highly predictive of poor outcome in immunocompromised patients with cytomegalovirus infection.

    Venturini, Cristina / Colston, Julia M / Charles, Oscar / Lankina, Anastasia / Best, Timothy / Atkinson, Claire / Forrest, Calum / Williams, Charlotte A / Rao, Kanchan / Worth, Austen / Thorburn, Doug / Harber, Mark / Griffiths, Paul / Breuer, Judith

    The Journal of infectious diseases

    2024  

    Abstract: Background: Human cytomegalovirus is the most common and serious opportunistic infection after solid organ and haematopoietic stem cell transplantation. In this study, we used whole-genome cytomegalovirus data to investigate viral factors associated ... ...

    Abstract Background: Human cytomegalovirus is the most common and serious opportunistic infection after solid organ and haematopoietic stem cell transplantation. In this study, we used whole-genome cytomegalovirus data to investigate viral factors associated with the clinical outcome.
    Methods: We sequenced cytomegalovirus samples from 16 immunocompromised paediatric patients with persistent viraemia. 8/16 patients died of complications due to cytomegalovirus infection. We also sequenced samples from 35 infected solid organ adult recipients of whom one died with cytomegalovirus infection.
    Results: We showed that samples from both groups have fixed variants at resistance sites and mixed infections. NGS sequencing also revealed non-fixed variants at resistance sites in most of the patients who died (6/9). A machine learning approach identified 10 genes with non-fixed variants in these patients. These genes formed a viral signature which discriminated patients with cytomegalovirus infection who died from those that survived with high accuracy (AUC=0.96). Lymphocyte numbers for a subset of patients showed no recovery post-transplant in the patients who died.
    Conclusions: We hypothesise that the viral signature identified in this study may be a useful biomarker for poor response to antiviral drug treatment and indirectly for poor T cell function, potentially identifying early, those patients requiring non-pharmacological interventions.
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiae001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.50: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 445: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top