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  1. Book: High content screening

    Johnston, Paul A. / Trask, Oscar J.

    a powerful approach to systems cell biology and phenotypic drug discovery

    (Methods in molecular biology ; 1683 ; Springer protocols ; Chemistry)

    2018  

    Author's details edited by Paul A. Johnston (Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA), Oscar J. Trask (Bahama Bio, LLC, Bahama, NC, USA; Perkin Elmer Inc., Waltham, MA, USA)
    Series title Methods in molecular biology ; 1683
    Springer protocols
    Chemistry
    Collection
    Keywords measure cells ; cell phenotypes ; HCS data ; data handling ; HCS/HCA/HCI
    Subject code 570
    Language English
    Size xiii, 397 Seiten, Illustrationen, 25.4 cm x 17.8 cm
    Edition Second edition
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT019509018
    ISBN 978-1-4939-7355-2 ; 1-4939-7355-X ; 9781493973576 ; 1493973576
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1683- verfügbar in Königswinter Königswinter

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  2. Article ; Online: UK Field Medical Care 2032: one Military Vision.

    Parker, Paul / Pynn, H / Haldane, A G / Ballard, M / König, T C / Johnston, A M

    BMJ military health

    2023  Volume 169, Issue 6, Page(s) 485–487

    MeSH term(s) Humans ; Military Personnel ; Military Medicine ; Emergency Medical Services ; United Kingdom
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Editorial
    ZDB-ID 3011686-7
    ISSN 2633-3775 ; 2633-3767
    ISSN (online) 2633-3775
    ISSN 2633-3767
    DOI 10.1136/bmjmilitary-2021-002056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Un I Zs.541: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: WITHDRAWN: Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines.

    Close, David A / Johnston, Paul A

    SLAS discovery : advancing life sciences R & D

    2023  Volume 29, Issue 1F, Page(s) 130

    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Retraction of Publication
    ZDB-ID 2885123-7
    ISSN 2472-5560 ; 2472-5552
    ISSN (online) 2472-5560
    ISSN 2472-5552
    DOI 10.1016/j.slasd.2023.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4911: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Chitin and Chitosan Binding to the α-Chitin Crystal: A Molecular Dynamics Study.

    Hudek, Magdalena / Kubiak-Ossowska, Karina / Johnston, Karen / Ferro, Valerie A / Mulheran, Paul A

    ACS omega

    2023  Volume 8, Issue 3, Page(s) 3470–3477

    Abstract: Understanding the binding of chitosan oligomers to the surface of a chitin nanocrystal is important for improving the enzymatic deacetylation of chitin and for the design of chitin/chitosan composite films. Here, we study the binding of several chito- ... ...

    Abstract Understanding the binding of chitosan oligomers to the surface of a chitin nanocrystal is important for improving the enzymatic deacetylation of chitin and for the design of chitin/chitosan composite films. Here, we study the binding of several chito-oligomers to the (100) surface of an α-chitin crystal using molecular dynamics (MD), steered MD, and umbrella sampling. The convergence of the free energy was carefully considered and yielded a binding energies of -12.5 and -2 kcal mol
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c07495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Organic enrichment reduces sediment bacterial and archaeal diversity, composition, and functional profile independent of bioturbator activity.

    Gonzalez, Sebastian Vadillo / Dafforn, Katherine A / Gribben, Paul E / O'Connor, Wayne A / Johnston, Emma L

    Marine pollution bulletin

    2023  Volume 196, Page(s) 115608

    Abstract: Eutrophication is a worldwide issue that can disrupt ecosystem processes in sediments. Studies have shown that macrofauna influences sediment processes by engineering environments that constrain microbial communities. Here, we explored the effect of ... ...

    Abstract Eutrophication is a worldwide issue that can disrupt ecosystem processes in sediments. Studies have shown that macrofauna influences sediment processes by engineering environments that constrain microbial communities. Here, we explored the effect of different sizes of the Sydney cockle (Anadara trapezia), on bacterial and archaeal communities in natural and experimentally enriched sediments. A mesocosm experiment was conducted with two enrichment conditions (natural or enriched) and 5 cockle treatments (small, medium, large, mixed sizes and a control). This study was unable to detect A. trapezia effects on microbial communities irrespective of body size. However, a substantial decrease of bacterial richness, diversity, and structural and functional shifts, were seen with organic enrichment of sediments. Archaea were similarly changed although the magnitude of effect was less than for bacteria. Overall, we found evidence to suggest that A. trapezia had limited capacity to affect sediment microbial communities and mitigate the effects of organic enrichment.
    MeSH term(s) Animals ; Archaea/genetics ; Geologic Sediments/chemistry ; Bacteria/genetics ; Microbiota ; Arcidae ; RNA, Ribosomal, 16S
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-10-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001296-2
    ISSN 1879-3363 ; 0025-326X
    ISSN (online) 1879-3363
    ISSN 0025-326X
    DOI 10.1016/j.marpolbul.2023.115608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Conference proceedings: Changing concepts for the efficient use of phosphorus in agriculture

    Johnston, A. E. / Poulton, Paul R.

    paper presented to the International Fertiliser Society at a conference in Cambridge, UK, on 11th December 2014

    (Proceedings / International Fertiliser Society ; 757)

    2014  

    Author's details by A. E. Johnston and P. R. Poulton
    Series title Proceedings / International Fertiliser Society ; 757
    Proceedings / the International Fertiliser Society
    Collection Proceedings / the International Fertiliser Society
    Keywords Phosphatic fertilizers ; Fertilizers/Application ; Soils/Phosphorus content ; Phosphorus/Bioavailability ; Soil fertility
    Subject code 631.85
    Language English
    Size 40 S. : graph. Darst.
    Publishing place Colchester
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT018603251
    ISBN 978-0-85310-394-3 ; 0-85310-394-1
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    158/454 available for loan (reading room) Freihandmagazin (U1)

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  7. Article ; Online: Incorporating Measures of Sustainability Into Guideline Development.

    Ashley, Paul / Lyne, Alexandra / Johnston, Bridget / Duane, Brett

    International dental journal

    2023  Volume 73, Issue 6, Page(s) 800–803

    Language English
    Publishing date 2023-09-23
    Publishing country England
    Document type Editorial
    ZDB-ID 218262-2
    ISSN 1875-595X ; 0020-6539
    ISSN (online) 1875-595X
    ISSN 0020-6539
    DOI 10.1016/j.identj.2023.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 205: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines.

    Close, David A / Johnston, Paul A

    SLAS discovery : advancing life sciences R & D

    2021  Volume 27, Issue 1, Page(s) 39–54

    Abstract: In solid tumors like head and neck cancer (HNC), chronic and acute hypoxia have serious adverse clinical consequences including poorer overall patient prognosis, enhanced metastasis, increased genomic instability, and resistance to radiation-, chemo-, or ...

    Abstract In solid tumors like head and neck cancer (HNC), chronic and acute hypoxia have serious adverse clinical consequences including poorer overall patient prognosis, enhanced metastasis, increased genomic instability, and resistance to radiation-, chemo-, or immuno-therapies. However, cells in the two-dimensional monolayer cultures typically used for cancer drug discovery experience 20%-21% O
    MeSH term(s) Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/genetics ; Humans ; Hypoxia/drug therapy ; Spheroids, Cellular ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/genetics ; Tumor Microenvironment
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2021-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2885123-7
    ISSN 2472-5560 ; 2472-5552
    ISSN (online) 2472-5560
    ISSN 2472-5552
    DOI 10.1016/j.slasd.2021.10.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4911: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Battlefield REBOA: Aces High or Journey's End?

    Parker, Paul / Johnston, A M / Mountain, A / Pynn, H

    BMJ military health

    2023  Volume 169, Issue 6, Page(s) 482–484

    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Editorial
    ZDB-ID 3011686-7
    ISSN 2633-3775 ; 2633-3767
    ISSN (online) 2633-3775
    ISSN 2633-3767
    DOI 10.1136/bmjmilitary-2021-002054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Un I Zs.541: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Identification of differences in CD4

    Tutino, Mauro / Hankinson, Jenny / Murray, Clare / Lowe, Lesley / Kerry, Gina / Rattray, Magnus / Custovic, Adnan / Johnston, Sebastian L / Shi, Chenfu / Orozco, Gisela / Eyre, Stephen / Martin, Paul / Simpson, Angela / Curtin, John A

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 22796

    Abstract: Functional enrichment analysis of genome-wide association study (GWAS)-summary statistics has suggested that ... ...

    Abstract Functional enrichment analysis of genome-wide association study (GWAS)-summary statistics has suggested that CD4
    MeSH term(s) Humans ; Genome-Wide Association Study ; Asthma/metabolism ; Gene Expression Profiling ; Transcriptome ; CD4-Positive T-Lymphocytes ; Virus Diseases/metabolism ; Gene Regulatory Networks
    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-49135-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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