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  1. Book ; Thesis: Determine quantifiable parameters in different mouse models for polyglutamine diseases

    Schmitz, Lisa Sophie

    2022  

    Author's details vorgelegt von Lisa Sophie Schmitz geb. Steiner
    Language English
    Size 75 Seiten, Illustrationen, Diagramme
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2022
    HBZ-ID HT021381487
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 D 468 order for loan Magazin

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  2. Article ; Online: Corrigendum to "A histochemical and morphological study of the mucus producing pedal gland system in Latia neritoides (Mollusca; Gastropoda; Hygrophila)" [Zoology 156 (2023) 126067].

    Greistorfer, Sophie / von Byern, Janek / Miller, Ingrid / Meyer-Rochow, Victor Benno / Farkas, Robert / Steiner, Gerhard

    Zoology (Jena, Germany)

    2023  Volume 159, Page(s) 126101

    Language English
    Publishing date 2023-06-06
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1191401-4
    ISSN 1873-2720 ; 0944-2006
    ISSN (online) 1873-2720
    ISSN 0944-2006
    DOI 10.1016/j.zool.2023.126101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Multiple faziale und orale Papeln bei einem 54-jährigen Mann.

    Wahl, Sophie / Steiner, Andreas / Feldmann, Robert

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete

    2020  Volume 71, Issue 8, Page(s) 647–649

    Title translation Multiple facial and oral mucosal papules in a 54-year-old man.
    MeSH term(s) Face ; Facial Dermatoses/pathology ; Humans ; Male ; Middle Aged ; Mouth Mucosa/pathology ; Skin Abnormalities
    Language German
    Publishing date 2020-05-11
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 2403-x
    ISSN 1432-1173 ; 0017-8470
    ISSN (online) 1432-1173
    ISSN 0017-8470
    DOI 10.1007/s00105-020-04568-5
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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Impaired B Cell Recall Memory and Reduced Antibody Avidity but Robust T Cell Response in CVID Patients After COVID-19 Vaccination.

    Steiner, Sophie / Schwarz, Tatjana / Corman, Victor M / Jeworowski, Lara M / Bauer, Sandra / Drosten, Christian / Scheibenbogen, Carmen / Hanitsch, Leif G

    Journal of clinical immunology

    2023  Volume 43, Issue 5, Page(s) 869–881

    Abstract: Purpose: Humoral and cellular immune responses were described after COVID-19 vaccination in patients with common variable immunodeficiency disorder (CVID). This study aimed to investigate SARS-CoV-2-specific antibody quality and memory function of B ... ...

    Abstract Purpose: Humoral and cellular immune responses were described after COVID-19 vaccination in patients with common variable immunodeficiency disorder (CVID). This study aimed to investigate SARS-CoV-2-specific antibody quality and memory function of B cell immunity as well as T cell responses after COVID-19 vaccination in seroresponding and non-responding CVID patients.
    Methods: We evaluated antibody avidity and applied a memory B cell ELSPOT assay for functional B cell recall memory response to SARS-CoV-2 after COVID-19 vaccination in CVID seroresponders. We comparatively analyzed SARS-CoV-2 spike reactive polyfunctional T cell response and reactive peripheral follicular T helper cells (pT
    Results: SARS-CoV-2 spike antibody avidity of seroresponding CVID patients was significantly lower than in healthy controls. Only 30% of seroresponding CVID patients showed a minimal memory B cell recall response in ELISPOT assay. One hundred percent of CVID seroresponders and 83% of non-seroresponders had a detectable polyfunctional T cell response. Induction of antigen-specific CD4
    Conclusion: Reduced avidity and significantly impaired recall memory formation after COVID-19 vaccination in seroresponding CVID patients stress the importance of a more differentiated analysis of humoral immune response in CVID patients. Our observations challenge the clinical implications that follow the binary categorization into seroresponder and non-seroresponder.
    MeSH term(s) Humans ; Memory B Cells ; COVID-19 Vaccines ; Antibody Affinity ; Common Variable Immunodeficiency/therapy ; COVID-19 ; SARS-CoV-2 ; Vaccination ; Antibodies, Viral
    Chemical Substances COVID-19 Vaccines ; Antibodies, Viral
    Language English
    Publishing date 2023-03-17
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-023-01468-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1640: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Portal hypertension in common variable immunodeficiency disorders - a single center analysis on clinical and immunological parameter in 196 patients.

    Hanitsch, Leif G / Steiner, Sophie / Schumann, Michael / Wittke, Kirsten / Kedor, Claudia / Scheibenbogen, Carmen / Fischer, Andreas

    Frontiers in immunology

    2023  Volume 14, Page(s) 1268207

    Abstract: Background: Liver manifestations and in particular portal hypertension (PH) contribute significantly to morbidity and mortality of patients with common variable immunodeficiency disorders (CVID). Screening strategies and early detection are limited due ... ...

    Abstract Background: Liver manifestations and in particular portal hypertension (PH) contribute significantly to morbidity and mortality of patients with common variable immunodeficiency disorders (CVID). Screening strategies and early detection are limited due to the lack of specific diagnostic tools.
    Methods: We evaluated clinical, immunological, histological, and imaging parameters in CVID patients with clinical manifestation of portal hypertension (CVID+PH).
    Results: Portal hypertension was present in 5.6% of CVID patients and was associated with high clinical burden and increased mortality (18%). Longitudinal data on clinical and immunological parameters in patients before and during clinically manifest portal hypertension revealed a growing splenomegaly and increasing gamma-glutamyl transferase (GGT) and soluble interleukin 2 receptor (SIL-2R) levels with decreasing platelets over time. While ultrasound of the liver failed to detect signs of portal hypertension in most affected patients, transient elastography was elevated in all patients. All CVID+PH patients had reduced naïve CD45RA+CD4+ T-cells (mean of 6,2%). The frequency of severe B-lymphocytopenia (Euroclass B-) was higher in CVID+PH patients. The main histological findings included lymphocytic infiltration, nodular regenerative hyperplasia-like changes (NRH-LC), and porto(-septal) fibrosis.
    Conclusion: CVID patients with lower naïve CD45RA+CD4+ T-cells or severely reduced B-cells might be at higher risk for portal hypertension. The combination of biochemical (increasing sIL-2R, GGT, and decreasing platelets) and imaging parameters (increasing splenomegaly) should raise suspicion of the beginning of portal hypertension.
    MeSH term(s) Humans ; Common Variable Immunodeficiency/complications ; Splenomegaly/etiology ; Hypertension, Portal/diagnosis ; Hypertension, Portal/etiology ; Affect ; Leukocyte Common Antigens
    Chemical Substances Leukocyte Common Antigens (EC 3.1.3.48)
    Language English
    Publishing date 2023-12-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1268207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Ex Vivo High-Resolution Magic Angle Spinning (HRMAS)

    Steiner, Annabel / Schmidt, Stefan Andreas / Fellmann, Cara Sophie / Nowak, Johannes / Wu, Chin-Lee / Feldman, Adam Scott / Beer, Meinrad / Cheng, Leo L

    Cancers

    2022  Volume 14, Issue 9

    Abstract: The aim of our study was to assess ex vivo HRMAS (high-resolution magic angle spinning) ...

    Abstract The aim of our study was to assess ex vivo HRMAS (high-resolution magic angle spinning)
    Language English
    Publishing date 2022-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14092162
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  7. Article ; Online: The Adipose-Derived Stem Cell and Endothelial Cell Coculture System-Role of Growth Factors?

    Steiner, Dominik / Mutschall, Hilkea / Winkler, Sophie / Horch, Raymund E / Arkudas, Andreas

    Cells

    2021  Volume 10, Issue 8

    Abstract: Adequate vascularization is a fundamental prerequisite for bone regeneration, formation and tissue engineering applications. Endothelialization of scaffold materials is a promising strategy to support neovascularization and bone tissue formation. Besides ...

    Abstract Adequate vascularization is a fundamental prerequisite for bone regeneration, formation and tissue engineering applications. Endothelialization of scaffold materials is a promising strategy to support neovascularization and bone tissue formation. Besides oxygen and nutrition supply, the endothelial network plays an important role concerning osteogenic differentiation of osteoprogenitor cells and consecutive bone formation. In this study we aimed to enhance the growth stimulating, proangiogenic and osteogenic features of the ADSC and HUVEC coculture system by means of VEGFA165 and BMP2 application. We were able to show that sprouting phenomena and osteogenic differentiation were enhanced in the ADSC/HUVEC coculture. Furthermore, apoptosis was unidirectionally decreased in HUVECs, but these effects were not further enhanced upon VEGFA165 or BMP2 application. In summary, the ADSC/HUVEC coculture system per se is a powerful tool for bone tissue engineering applications.
    MeSH term(s) Adipose Tissue/cytology ; Adipose Tissue/metabolism ; Alkaline Phosphatase/metabolism ; Apoptosis/drug effects ; Bone Morphogenetic Protein 2/pharmacology ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Coculture Techniques ; Human Umbilical Vein Endothelial Cells ; Humans ; Osteogenesis/drug effects ; Recombinant Proteins/pharmacology ; Stem Cells/cytology ; Stem Cells/metabolism ; Tissue Engineering ; Transforming Growth Factor beta/pharmacology ; Vascular Endothelial Growth Factor A/pharmacology
    Chemical Substances Bone Morphogenetic Protein 2 ; Recombinant Proteins ; Transforming Growth Factor beta ; Vascular Endothelial Growth Factor A ; recombinant human bone morphogenetic protein-2 ; Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 2021-08-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10082074
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  8. Article ; Online: Adherence to the Mediterranean Diet and Incidence of Pre-Frailty and Frailty in Community-Dwelling Adults 70+: The 3-Year DO-HEALTH Study.

    Gängler, Stephanie / Steiner, Hanna / Gagesch, Michael / Guyonnet, Sophie / Orav, E John / von Eckardstein, Arnold / Willett, Walter C / Bischoff-Ferrari, Heike A

    Nutrients

    2022  Volume 14, Issue 19

    Abstract: The Mediterranean diet has been associated with many health benefits. Therefore, we investigated whether the degree of adherence to the Mediterranean diet at baseline, or changes in adherence over time, were associated with the incidence of pre-frailty ... ...

    Abstract The Mediterranean diet has been associated with many health benefits. Therefore, we investigated whether the degree of adherence to the Mediterranean diet at baseline, or changes in adherence over time, were associated with the incidence of pre-frailty or frailty in generally healthy older adults. This study used the DO-HEALTH trial data. We evaluated Mediterranean diet adherence with Panagiotakos' MedDietScore at baseline and at 3-year follow-up; frailty was assessed annually with the Fried frailty phenotype. We used minimally and fully adjusted mixed logistic regression models to estimate the exposure-disease relationship. We included 1811 participants without frailty at baseline (mean age 74.7 years; 59.4% women). Baseline adherence, as reflected by the MedDietScore, was not associated with becoming pre-frail [OR(95%CI) = 0.93 (0.83-1.03) for five-point greater adherence] or frail [OR(95%CI) = 0.90 (0.73-1.12) for five points]. However, a five-point increase in the MedDietScore over three years was associated with lower odds of becoming pre-frail [OR(95%CI) = 0.77 (0.68-0.88)] and frail [OR(95%CI) = 0.77 (0.64-0.92)]. In generally healthy and active older adults, baseline adherence to the Mediterranean diet was not associated with the incidence of pre-frailty or frailty over a 3-year follow-up. However, improved adherence to the Mediterranean diet over time was associated with significantly lower odds of becoming pre-frail or frail.
    MeSH term(s) Aged ; Diet, Mediterranean ; Female ; Frail Elderly ; Frailty/epidemiology ; Frailty/prevention & control ; Humans ; Incidence ; Independent Living ; Male
    Language English
    Publishing date 2022-10-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14194145
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  9. Article ; Online: A histochemical and morphological study of the mucus producing pedal gland system in Latia neritoides (Mollusca; Gastropoda; Hygrophila).

    Greistorfer, Sophie / von Byern, Janek / Miller, Ingrid / Meyer-Rochow, Victor Benno / Farkas, Robert / Steiner, Gerhard

    Zoology (Jena, Germany)

    2022  Volume 156, Page(s) 126067

    Abstract: The freshwater gastropod Latia neritoides is endemic to the streams of New Zealand's North Island. This species has evolved a unique defence system: it exudes a luminescent mucus thought to deter predators. While the bioluminescence itself has been ... ...

    Abstract The freshwater gastropod Latia neritoides is endemic to the streams of New Zealand's North Island. This species has evolved a unique defence system: it exudes a luminescent mucus thought to deter predators. While the bioluminescence itself has been investigated before, the underlying gland system has remained unstudied and relevant information to understand the defence system has been missing till now. For the release of the glowing mucus of L. neritoides two places of origin were assumed: the lateral foot area or the mantel cavity. In this study the focus was on the first suggestion. To gain insight into the defence system, morphological as well as histochemical analyses were performed involving all secretory gland types in the sub-epithelial foot layer. The results were compared with the foot gland system of Neritina sp., a snail living in a comparable habitat, but using a different survival strategy. The gland types of the two gastropods were compared and their mucus types were investigated. Seven subepithelial gland cell types can be distinguished in the foot region of L. neritoides. Neritina sp., in contrast, has six gland cell types of which three laterally located ones are epithelial. Both species show a pedal gland in the anterior foot region. A striking difference between the species are two prominent subepithelial gland cell types (L1l/L2l) in the lateral foot area of L. neritoides, which are missing in Neritina sp. These gland cells are distributed throughout the entire lateral foot area of L. neritoides and make up about 85% of the mucus gland cells in this area. Defence mucus and trail mucus of L. neritoides show different specificities in lectin staining, but are not equally represented in the gland cell types. Yet, based on the huge size and high density of L1l and L2L, we envision a role for these gland types in the defence system.
    MeSH term(s) Animals ; Gastropoda ; Acanthaceae ; Snails ; Foot ; Mucus/metabolism
    Language English
    Publishing date 2022-12-22
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1191401-4
    ISSN 1873-2720 ; 0944-2006
    ISSN (online) 1873-2720
    ISSN 0944-2006
    DOI 10.1016/j.zool.2022.126067
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    In stock of ZB MED Bonn / Germany

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  10. Article ; Online: The Adipose-Derived Stem Cell and Endothelial Cell Coculture System—Role of Growth Factors?

    Dominik Steiner / Hilkea Mutschall / Sophie Winkler / Raymund E. Horch / Andreas Arkudas

    Cells, Vol 10, Iss 2074, p

    2021  Volume 2074

    Abstract: Adequate vascularization is a fundamental prerequisite for bone regeneration, formation and tissue engineering applications. Endothelialization of scaffold materials is a promising strategy to support neovascularization and bone tissue formation. Besides ...

    Abstract Adequate vascularization is a fundamental prerequisite for bone regeneration, formation and tissue engineering applications. Endothelialization of scaffold materials is a promising strategy to support neovascularization and bone tissue formation. Besides oxygen and nutrition supply, the endothelial network plays an important role concerning osteogenic differentiation of osteoprogenitor cells and consecutive bone formation. In this study we aimed to enhance the growth stimulating, proangiogenic and osteogenic features of the ADSC and HUVEC coculture system by means of VEGFA165 and BMP2 application. We were able to show that sprouting phenomena and osteogenic differentiation were enhanced in the ADSC/HUVEC coculture. Furthermore, apoptosis was unidirectionally decreased in HUVECs, but these effects were not further enhanced upon VEGFA165 or BMP2 application. In summary, the ADSC/HUVEC coculture system per se is a powerful tool for bone tissue engineering applications.
    Keywords bone tissue engineering ; ADSC ; HUVEC ; VEGFA165 ; BMP2 ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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