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Article ; Online: WRIB Poster Awards winners 2023.

Getz, Jennifer / McGrath, Shannon / Hui, Gus

Bioanalysis

2024 Volume 16, Issue 4, Page(s) 185–189

MeSH term(s)	Mass Spectrometry ; Awards and Prizes
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	News
ISSN	1757-6199
ISSN (online)	1757-6199
DOI	10.4155/bio-2024-0012
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Article ; Online: Aspirin use and head and neck cancer survival and recurrence.

Zhang, Xinman / Ilyas, Omar S / Getz, Kayla R / Rozek, Laura S / Taylor, Jeremy M G / Chinn, Steven B / Wolf, Gregory T / Mondul, Alison M

Cancer causes & control : CCC

2023 Volume 35, Issue 4, Page(s) 605–609

Abstract: Background: Head and neck cancer (HNC) has low 5-year survival, and evidence-based recommendations for tertiary prevention are lacking. Aspirin improves outcomes for cancers at other sites, but its role in HNC tertiary prevention remains understudied.!## ...

Abstract	Background: Head and neck cancer (HNC) has low 5-year survival, and evidence-based recommendations for tertiary prevention are lacking. Aspirin improves outcomes for cancers at other sites, but its role in HNC tertiary prevention remains understudied. Methods: HNC patients were recruited in the University of Michigan Head and Neck Cancer Specialized Program of Research Excellence (SPORE) from 2003 to 2014. Aspirin data were collected through medical record review; outcomes (overall mortality, HNC-specific mortality, and recurrence) were collected through medical record review, Social Security Death Index, or LexisNexis. Cox proportional hazards models were used to evaluate the associations between aspirin use at diagnosis (yes/no) and HNC outcomes. Results: We observed no statistically significant associations between aspirin and cancer outcome in our HNC patient cohort (n = 1161) (HNC-specific mortality: HR = 0.91, 95% CI = 0.68-1.21; recurrence: HR = 0.94, 95% CI = 0.73-1.19). In analyses stratified by anatomic site, HPV status, and disease stage, we observed no association in any strata examined with the possible exception of a lower risk of recurrence in oropharynx patients (HR = 0.60, 95% CI 0.35-1.04). Conclusions: Our findings do not support a protective association between aspirin use and cancer-specific death or recurrence in HNC patients, with the possible exception of a lower risk of recurrence in oropharynx patients.
MeSH term(s)	Humans ; Aspirin/therapeutic use ; Head and Neck Neoplasms/drug therapy ; Proportional Hazards Models
Chemical Substances	Aspirin (R16CO5Y76E)
Language	English
Publishing date	2023-11-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1064022-8
ISSN	1573-7225 ; 0957-5243
ISSN (online)	1573-7225
ISSN	0957-5243
DOI	10.1007/s10552-023-01815-7
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Zs.A 3375: Show issues

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Article ; Online: The association between inflammatory biomarkers and statin use among patients with head and neck squamous cell carcinoma.

Getz, Kayla R / Bellile, Emily / Zarins, Katie R / Chinn, Steven B / Taylor, Jeremy M G / Rozek, Laura S / Wolf, Gregory T / Mondul, Alison M

Head & neck

2022 Volume 44, Issue 6, Page(s) 1393–1403

Abstract: Background: Tumor-infiltrating lymphocytes (TILs) and cytokines are associated with prognosis among patients with head and neck squamous cell carcinoma (HNSCC). Statins (cholesterol-lowering drugs) may improve HNSCC prognosis, particularly in human ... ...

Abstract	Background: Tumor-infiltrating lymphocytes (TILs) and cytokines are associated with prognosis among patients with head and neck squamous cell carcinoma (HNSCC). Statins (cholesterol-lowering drugs) may improve HNSCC prognosis, particularly in human papillomavirus (HPV)-positive cases, but the mechanism remains unclear. Methods: Statin use was collected from medical records for HNSCC cases (2008-2014). TILs were counted in tumor tissue, and a total weighted score (TILws) was created. Cytokines were measured in blood. The associations between statins and biomarkers were estimated using logistic (biomarker categories: <median, ≥median) and linear regression models (log-transformed continuous biomarkers) adjusted for age, smoking, and comorbidities.<br />Results: We observed a positive association between statins and TILs among HPV-positive patients (TILws odds ratio [OR] = 2.80; 95% CI = 1.03-7.61), but no association among HPV-negative patients. We observed no association between statins and cytokines. Conclusions: Statins may influence TILs in HPV-positive patients. This may be the mechanism through which they improve prognosis in HPV-positive HNSCC patients.
MeSH term(s)	Biomarkers, Tumor ; Cytokines ; Head and Neck Neoplasms/complications ; Head and Neck Neoplasms/drug therapy ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Papillomaviridae ; Papillomavirus Infections/complications ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/complications
Chemical Substances	Biomarkers, Tumor ; Cytokines ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2022-03-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27040
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Zs.A 1493: Show issues

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Article ; Online: Protective role of the placental efflux transporter BCRP/ABCG2 in the relationship between prenatal cadmium exposure, placenta weight, and size at birth.

Barrett, Emily S / Rivera-Núñez, Zorimar / Getz, Kylie / Ohman-Strickland, Pamela / Zhang, Ranran / Kozlosky, Danielle / Doherty, Cathleen L / Buckley, Brian T / Brunner, Jessica / Miller, Richard K / O'Connor, Thomas G / Aleksunes, Lauren M

Environmental research

2023 Volume 225, Page(s) 115597

Abstract: Background and aim: Placental efflux transporter proteins, such as BCRP, reduce the placental and fetal toxicity of environmental contaminants but have received little attention in perinatal environmental epidemiology. Here, we evaluate the potential ... ...

Abstract	Background and aim: Placental efflux transporter proteins, such as BCRP, reduce the placental and fetal toxicity of environmental contaminants but have received little attention in perinatal environmental epidemiology. Here, we evaluate the potential protective role of BCRP following prenatal exposure to cadmium, a metal that preferentially accumulates in the placenta and adversely impacts fetal growth. We hypothesized that individuals with a reduced function polymorphism in ABCG2, the gene encoding BCRP, would be most vulnerable to the adverse impacts of prenatal cadmium exposure, notably, smaller placental and fetal size. Methods: We measured cadmium in maternal urine samples at each trimester and in term placentas from UPSIDE-ECHO study participants (NY, USA; n = 269). We fit adjusted multivariable linear regression and generalized estimating equation models to examine log-transformed urinary and placental cadmium concentrations in relation to birthweight, birth length, placental weight, and fetoplacental weight ratio (FPR) and stratified models by ABCG2 Q141K (C421A) genotype. Results: Overall 17% of participants expressed the reduced-function ABCG2 C421A variant (AA or AC). Placental cadmium concentrations were inversely associated with placental weight (β = -19.55; 95%CI: -37.06, -2.04) and trended towards higher FPR (β = 0.25; 95%CI: -0.01, 0.52) with stronger associations in 421A variant infants. Notably, higher placental cadmium concentrations in 421A variant infants were associated with reduced placental weight (β = -49.42; 95%CI: 98.87, 0.03), and higher FPR (β = 0.85, 95%CI: 0.18, 1.52), while higher urinary cadmium concentration was associated with longer birth length (β = 0.98; 95%CI: 0.37, 1.59), lower ponderal index (β = -0.09; 95%CI: 0.15, -0.03), and higher FPR (β = 0.42; 95%CI: 0.14, 0.71). Conclusions: Infants with reduced function ABCG2 polymorphisms may be particularly vulnerable to the developmental toxicity of cadmium as well as other xenobiotics that are BCRP substrates. Additional work examining the influence of placental transporters in environmental epidemiology cohorts is warranted.
MeSH term(s)	Infant, Newborn ; Pregnancy ; Female ; Humans ; Placenta/metabolism ; Birth Weight ; Cadmium/toxicity ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism
Chemical Substances	Cadmium (00BH33GNGH) ; ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Neoplasm Proteins ; ABCG2 protein, human
Language	English
Publishing date	2023-03-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.115597
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Zs.A 726: Show issues

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Article ; Online: Discrete stochastic analogs of Erlang epidemic models.

Getz, Wayne M / Dougherty, Eric R

Journal of biological dynamics

2017 Volume 12, Issue 1, Page(s) 16–38

Abstract: ... transition dynamics from susceptible (S) to exposed (E) to infectious (I) and removed (R) categories ... principle. Depending on which distributions are used (e.g. discretized Erlang, Gamma, Beta, or Uniform ...

Abstract	Erlang differential equation models of epidemic processes provide more realistic disease-class transition dynamics from susceptible (S) to exposed (E) to infectious (I) and removed (R) categories than the ubiquitous SEIR model. The latter is itself is at one end of the spectrum of Erlang SE[Formula: see text]I[Formula: see text]R models with [Formula: see text] concatenated E compartments and [Formula: see text] concatenated I compartments. Discrete-time models, however, are computationally much simpler to simulate and fit to epidemic outbreak data than continuous-time differential equations, and are also much more readily extended to include demographic and other types of stochasticity. Here we formulate discrete-time deterministic analogs of the Erlang models, and their stochastic extension, based on a time-to-go distributional principle. Depending on which distributions are used (e.g. discretized Erlang, Gamma, Beta, or Uniform distributions), we demonstrate that our formulation represents both a discretization of Erlang epidemic models and generalizations thereof. We consider the challenges of fitting SE[Formula: see text]I[Formula: see text]R models and our discrete-time analog to data (the recent outbreak of Ebola in Liberia). We demonstrate that the latter performs much better than the former; although confining fits to strict SEIR formulations reduces the numerical challenges, but sacrifices best-fit likelihood scores by at least 7%.
MeSH term(s)	Computer Simulation ; Epidemics ; Hemorrhagic Fever, Ebola/diagnosis ; Hemorrhagic Fever, Ebola/epidemiology ; Humans ; Incidence ; Models, Biological ; Monte Carlo Method ; Prevalence ; Probability ; Stochastic Processes
Keywords	covid19
Language	English
Publishing date	2017-11-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2274786-2
ISSN	1751-3766 ; 1751-3758
ISSN (online)	1751-3766
ISSN	1751-3758
DOI	10.1080/17513758.2017.1401677
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Article ; Online: Genomic Profiling to Contextualize the Results of Intervention for Smoldering Multiple Myeloma.

Kazandjian, Dickran / Diamond, Benjamin / Papadimitriou, Marios / Hill, Elizabeth / Sklavenitis-Pistofidis, Romanos / Ziccheddu, Bachisio / Blaney, Patrick / Chojnacka, Monika / Durante, Michael / Maclachlan, Kylee / Young, Ryan / Usmani, Saad / Davies, Faith / Getz, Gad / Ghobrial, Irene / Korde, Neha / Morgan, Gareth / Maura, Francesco / Landgren, Ola

Clinical cancer research : an official journal of the American Association for Cancer Research

2024

Abstract: Purpose: Early intervention for High-Risk Smoldering Multiple Myeloma (HR-SMM) achieves deep and prolonged responses. It is unclear if beneficial outcomes are due to treatment of less complex, susceptible disease or inaccuracy in clinical definition of ... ...

Abstract	Purpose: Early intervention for High-Risk Smoldering Multiple Myeloma (HR-SMM) achieves deep and prolonged responses. It is unclear if beneficial outcomes are due to treatment of less complex, susceptible disease or inaccuracy in clinical definition of cases entered. Experimental design: Here, we interrogated whole genome and whole exome sequencing for 54 patients across two HR-SMM interventional studies (NCT01572480, NCT02279394). Results: We reveal that the genomic landscape of treated HR-SMM is generally simple as compared to Newly Diagnosed (ND)MM counterparts with less inactivation of tumor suppressor genes, RAS pathway mutations, MYC disruption, and APOBEC contribution. The absence of these events parallels that of indolent precursor conditions, possibly explaining overall excellent outcomes. However, some patients harboring genomic complexity fail to sustain response and experience resistant, progressive disease. Overall, clinical risk scores do not effectively discriminate between genomically indolent and aggressive disease. Conclusions: Genomic profiling can contextualize the advantage of early intervention in SMM and guide personalization of therapy.
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-24-0210
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Zs.A 4223: Show issues

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Article ; Online: The impact of elective surgery restrictions during the COVID-19 (coronavirus disease 2019) pandemic on shoulder and elbow surgery: patient perceptions.

Sanko, Cassandra / Cox, Ryan / Hadley, Christopher / Gilmore, Griffin / Wood, Chelsey / Getz, Charles / Namdari, Surena / Davis, Daniel

Journal of shoulder and elbow surgery

2022 Volume 32, Issue 3, Page(s) 662–670

Abstract: Background: In late 2019 and early 2020, a novel coronavirus, COVID-19 (coronavirus disease 2019), spread across the world, creating a global pandemic. In the state of Pennsylvania, non-emergent, elective operations were temporarily delayed from ... ...

Abstract	Background: In late 2019 and early 2020, a novel coronavirus, COVID-19 (coronavirus disease 2019), spread across the world, creating a global pandemic. In the state of Pennsylvania, non-emergent, elective operations were temporarily delayed from proceeding with the normal standard of care. The primary purpose of this study was to determine the proportion of patients who required prescription pain medication during the surgical delay. Secondarily, we sought to determine the proportion of patients who perceived their surgical procedure as non-elective and to evaluate how symptoms were managed during the delay. Materials and methods: A single institutional database was used to retrospectively identify all shoulder and elbow surgical procedures scheduled between March 13 and May 6, 2020. Charts were manually reviewed. Patients who underwent non-shoulder and elbow-related procedures and patients treated by surgeons outside of Pennsylvania were excluded. Patients whose surgical procedures were postponed or canceled were administered a survey evaluating how symptoms were managed and perceptions regarding the delay. Preoperative functional scores were collected. Statistical analysis was performed to determine associations between procedure status, preoperative functional scores, perception of surgery, and requirement for prescription pain medication. Results: A total of 338 patients were scheduled to undergo shoulder and elbow surgery in our practice in Pennsylvania. Surgery was performed as initially scheduled in 89 of these patients (26.3%), whereas surgery was postponed in 179 (71.9%) and canceled in 70 (28.1%). The average delay in surgery was 86.7 days (range, 13-299 days). Responses to the survey were received from 176 patients (70.7%) in whom surgery was postponed or canceled. During the delay, 39 patients (22.2%) required prescription pain medication. The surgical procedure was considered elective in nature by 73 patients (41%). One hundred thirty-seven patients (78%) would have moved forward with surgery if performed safely under appropriate medical guidelines. Lower preoperative American Shoulder and Elbow Surgeons scores (r = -0.36, P < .001) and Single Assessment Numeric Evaluation scores (r = -0.26, P = .016) and higher preoperative visual analog scale scores (r = 0.28, P = .009) were correlated with requiring prescription pain medication. Higher preoperative American Shoulder and Elbow Surgeons scores were positively correlated with perception of surgery as elective (r = 0.4, P < .001). Conclusion: Patients undergoing elective shoulder and elbow surgical procedures during the COVID-19 (coronavirus disease 2019) pandemic experienced a delay of nearly 3 months on average. Fewer than half of patients perceived their surgical procedures as elective procedures. Nearly one-quarter of patients surveyed required extra prescription pain medicine during the delay. This study elucidates the fact that although orthopedic shoulder and elbow surgery is generally considered "elective," it is more important to a majority of patients. These findings may also be applicable to future potential mandated surgical care delays by other third-party organizations.
MeSH term(s)	Humans ; COVID-19 ; Elbow/surgery ; Retrospective Studies ; Pandemics ; Pain
Language	English
Publishing date	2022-11-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1170782-3
ISSN	1532-6500 ; 1058-2746
ISSN (online)	1532-6500
ISSN	1058-2746
DOI	10.1016/j.jse.2022.10.023
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Zs.A 3973: Show issues

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Article ; Online: Preclinical and translational pharmacology of afucosylated anti-CCR8 antibody for depletion of tumour-infiltrating regulatory T cells.

Gampa, Gautham / Spinosa, Phillip / Getz, Jennifer / Zhong, Yu / Halpern, Wendy / Esen, Emel / Davies, John / Chou, Cassie / Kwong, Mandy / Wang, Yingyun / Arenzana, Teresita L / Shivva, Vittal / Huseni, Mahrukh / Hsieh, Robert / Schartner, Jill / Koerber, James T / Rutz, Sascha / Hosseini, Iraj

British journal of pharmacology

2024

Abstract: Background and purpose: RO7502175 is an afucosylated antibody designed to eliminate C-C motif chemokine receptor 8 (CCR8): Experimental approach: We report findings from preclinical studies characterizing pharmacology, pharmacokinetics (PK)/ ... ...

Abstract	Background and purpose: RO7502175 is an afucosylated antibody designed to eliminate C-C motif chemokine receptor 8 (CCR8) Experimental approach: We report findings from preclinical studies characterizing pharmacology, pharmacokinetics (PK)/pharmacodynamics (PD) and safety profile of RO7502175 and discuss the translational PK/PD approach used to inform first-in-human (FiH) dosing strategy and clinical development in solid tumour indications. Key results: RO7502175 demonstrated selective ADCC against human CCR8 Conclusion and implications: This work demonstrates a translational research strategy for collecting and utilizing relevant nonclinical data, developing a mechanistic PK/PD model and using a comprehensive approach to inform clinical study design for RO7502175.
Language	English
Publishing date	2024-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.16326
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Article ; Online: Clonal origin of KMT2A wild-type lineage-switch leukemia following CAR-T cell and blinatumomab therapy.

Coorens, Tim H H / Collord, Grace / Treger, Taryn D / Adams, Stuart / Mitchell, Emily / Newman, Barbara / Getz, Gad / Godfrey, Anna L / Bartram, Jack / Behjati, Sam

Nature cancer

2023 Volume 4, Issue 8, Page(s) 1095–1101

Abstract: Children with acute lymphoblastic leukemia (ALL) undergoing anti-CD19 therapy occasionally develop acute myeloid leukemia (AML). The clonal origin of such lineage-switch ... ...

Abstract	Children with acute lymphoblastic leukemia (ALL) undergoing anti-CD19 therapy occasionally develop acute myeloid leukemia (AML). The clonal origin of such lineage-switch leukemias
MeSH term(s)	Child ; Female ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Antibodies, Bispecific/therapeutic use ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; T-Lymphocytes
Chemical Substances	blinatumomab (4FR53SIF3A) ; Antibodies, Bispecific
Language	English
Publishing date	2023-07-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2662-1347
ISSN (online)	2662-1347
DOI	10.1038/s43018-023-00604-0
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Article ; Online: Invariant Natural Killer T-Cells and Total CD1d Restricted Cells Differentially Influence Lipid Metabolism and Atherosclerosis in Low Density Receptor Deficient Mice.

VanderLaan, Paul A / Reardon, Catherine A / Cabana, Veneracion G / Wang, Chyung-Ru / Getz, Godfrey S

International journal of molecular sciences

2019 Volume 20, Issue 18

Abstract: Natural killer T (NKT) cells are a distinct subset of lymphocytes that bridge the innate and adaptive immune response and can be divided into type I invariant NKT cells (iNKT) and type II NKT cells. The objective of this study is to examine the effects ... ...

Abstract	Natural killer T (NKT) cells are a distinct subset of lymphocytes that bridge the innate and adaptive immune response and can be divided into type I invariant NKT cells (iNKT) and type II NKT cells. The objective of this study is to examine the effects of NKT cell on lipid metabolism and the initiation and progression of atherosclerosis in LDL receptor deficient (LDLR
MeSH term(s)	Adaptive Immunity ; Animals ; Antigens, CD1d/genetics ; Antigens, CD1d/immunology ; Antigens, CD1d/metabolism ; Aorta/pathology ; Atherosclerosis/immunology ; Atherosclerosis/pathology ; Cholesterol/blood ; Cholesterol/immunology ; Female ; Lipid Metabolism/immunology ; Lipoproteins/blood ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Natural Killer T-Cells/immunology ; Natural Killer T-Cells/metabolism ; Receptors, LDL/genetics
Chemical Substances	Antigens, CD1d ; CD1D protein, human ; Lipoproteins ; Receptors, LDL ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2019-09-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20184566
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