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  1. Article ; Online: Rebuttal from Nick J. Spencer, Tiong Cheng Sia, Simon J Brookes, Marcello Costa and Damien J. Keating.

    Spencer, Nick J / Sia, Tiong Cheng / Brookes, Simon J / Costa, Marcello / Keating, Damien J

    The Journal of physiology

    2015  Volume 593, Issue 15, Page(s) 3235

    MeSH term(s) Animals ; Humans ; Peristalsis ; Serotonin/metabolism
    Chemical Substances Serotonin (333DO1RDJY)
    Language English
    Publishing date 2015-08-01
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP270684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.65: Show issues Location:
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  2. Article ; Online: Letter 2: Randomized clinical trial of preoperative intravenous iron sucrose to reduce blood transfusion in anaemic patients after colorectal cancer surgery (Br J Surg 2009; 96: 1122-1128).

    Simpson, J A D / Tselepis, C / Iqbal, T / Acheson, A G / Brookes, M J

    The British journal of surgery

    2010  Volume 97, Issue 2, Page(s) 298–9; author reply 299

    MeSH term(s) Anemia, Iron-Deficiency/prevention & control ; Blood Transfusion ; Colorectal Neoplasms/surgery ; Ferric Compounds/administration & dosage ; Glucaric Acid ; Hematinics/administration & dosage ; Humans ; Infusions, Intravenous ; Postoperative Complications/prevention & control ; Preoperative Care/methods ; Randomized Controlled Trials as Topic
    Chemical Substances Ferric Compounds ; Hematinics ; ferric oxide, saccharated (FZ7NYF5N8L) ; Glucaric Acid (QLZ991V4A2)
    Language English
    Publishing date 2010-02
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.6981
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    Uk I Zs.66: Show issues Location:
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  3. Article ; Online: Evaluating the Classification Accuracy of Expression Quantitative Trait Loci Calculated Polygenic Risk Scores in Alzheimer's Disease.

    Brookes, Keeley J

    International journal of molecular sciences

    2023  Volume 24, Issue 16

    Abstract: Polygenic risk scores (PRS) hold promise for the early identification of those at risk from neurodegenerative disorders such as Alzheimer's Disease (AD), allowing for intervention to occur prior to neuronal damage. The current selection of informative ... ...

    Abstract Polygenic risk scores (PRS) hold promise for the early identification of those at risk from neurodegenerative disorders such as Alzheimer's Disease (AD), allowing for intervention to occur prior to neuronal damage. The current selection of informative single nucleotide polymorphisms (SNPs) to generate the risk scores is based on the modelling of large genome-wide association data using significance thresholds. However, the biological relevance of these SNPs is largely unknown. This study, in contrast, aims to identify SNPs with biological relevance to AD and then assess them for their ability to accurately classify cases and controls. Samples selected from the Brains for Dementia Research (BDR) were used to produce gene expression data to identify potential expression quantitative trait loci (eQTLs) relevant to AD. These SNPs were then incorporated into a PRS model to classify AD and controls in the full BDR cohort. Models derived from these eQTLs demonstrate modest classification potential with an accuracy between 61% and 67%. Although the model accuracy is not as high as some values in the literature based on significance thresholds from genome-wide association studies, these models may reflect a more biologically relevant model, which may provide novel targets for therapeutic intervention.
    MeSH term(s) Humans ; Alzheimer Disease/genetics ; Genome-Wide Association Study ; Quantitative Trait Loci ; Risk Factors ; Brain
    Language English
    Publishing date 2023-08-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241612799
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  4. Article: Re: arterial perforation (by balloon) during subintimal angioplasty by Dr Wright and colleagues from Leicester Royal Infirmary, Leicester, United Kingdom published in Eur J Vasc Endovasc Surg 28, 108-110 (2004).

    Brookes, J A S / Aly, S / Bishop, C C R

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2004  Volume 28, Issue 6, Page(s) 677–678

    MeSH term(s) Aged ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Angioplasty, Balloon/adverse effects ; Female ; Femoral Artery/injuries ; Femoral Artery/surgery ; Hematoma/etiology ; Humans ; Intraoperative Complications ; Ischemia/surgery ; Leg/blood supply ; Ligation ; Radiography ; Rupture ; Ultrasonography, Doppler, Duplex
    Language English
    Publishing date 2004-12
    Publishing country England
    Document type Case Reports ; Letter ; Comment
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2004.06.021
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2283: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 381: Show issues

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  5. Article ; Online: Risk-appropriate regulations for gene-editing technologies.

    Brookes, Graham / Smyth, Stuart J

    GM crops & food

    2024  Volume 15, Issue 1, Page(s) 1–14

    Abstract: This paper explores the scope for the newly emerging technologies, based on gene editing (GE) contributing to addressing the global challenges that we face. These challenges relate to food security, climate change and biodiversity depletion. In ... ...

    Abstract This paper explores the scope for the newly emerging technologies, based on gene editing (GE) contributing to addressing the global challenges that we face. These challenges relate to food security, climate change and biodiversity depletion. In particular, it examines the science and evidence behind the most appropriate forms of agricultural production to meet these challenges, the targets set in the Global Biodiversity Framework (GBF) agreed to at the end of 2022 and the possible role of GE technologies in contributing to meeting these targets. It then examines the most risk-appropriate regulatory environment required to best facilitate the adoption of GE technology, drawing on the experiences of the impact of regulatory systems for other innovations used in agricultural and food production systems such as genetically modified organisms (GMOs).
    MeSH term(s) Gene Editing ; Plants, Genetically Modified/genetics ; Biotechnology ; Agriculture ; Biodiversity
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2706099-8
    ISSN 2164-5701 ; 2164-5701
    ISSN (online) 2164-5701
    ISSN 2164-5701
    DOI 10.1080/21645698.2023.2293510
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  6. Article ; Online: Is there evidence demonstrating venereal transmission of clitoral Pseudomonas aeruginosa in horses?

    Storme, Julie / Brookes, Victoria J / Gunn, Allan

    The Veterinary record

    2023  Volume 192, Issue 11, Page(s) 444–446

    MeSH term(s) Horses ; Animals ; Pseudomonas aeruginosa ; Pseudomonas Infections/veterinary ; Horse Diseases
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 390015-0
    ISSN 2042-7670 ; 0042-4900
    ISSN (online) 2042-7670
    ISSN 0042-4900
    DOI 10.1002/vetr.3140
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    Zs.B 645: Show issues Location:
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  7. Book ; Online: Applications of Novel Analytical Methods in Epidemiology

    VanderWaa, Kimberly / Brookes, Victoria J. / Alkhamis, Moh A.

    2018  

    Keywords Veterinary medicine ; Medicine (General)
    Size 1 electronic resource (109 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101957
    ISBN 9782889456581 ; 2889456587
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Twelve quick tips for deploying a Beacon.

    Fromont, Lauren A / Moldes, Mauricio / Baudis, Michael / Brookes, Anthony J / Navarro, Arcadi / Rambla, Jordi

    PLoS computational biology

    2024  Volume 20, Issue 3, Page(s) e1011817

    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1011817
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  9. Article ; Online: Dementia with Lewy Bodies: Genomics, Transcriptomics, and Its Future with Data Science.

    Goddard, Thomas R / Brookes, Keeley J / Sharma, Riddhi / Moemeni, Armaghan / Rajkumar, Anto P

    Cells

    2024  Volume 13, Issue 3

    Abstract: Dementia with Lewy bodies (DLB) is a significant public health issue. It is the second most common neurodegenerative dementia and presents with severe neuropsychiatric symptoms. Genomic and transcriptomic analyses have provided some insight into disease ... ...

    Abstract Dementia with Lewy bodies (DLB) is a significant public health issue. It is the second most common neurodegenerative dementia and presents with severe neuropsychiatric symptoms. Genomic and transcriptomic analyses have provided some insight into disease pathology. Variants within
    MeSH term(s) Humans ; Lewy Body Disease/genetics ; Data Science ; Genomics ; Gene Expression Profiling
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13030223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Using ImageJ (Fiji) to Analyze and Present X-Ray CT Images of Enamel.

    Brookes, Steven J

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1922, Page(s) 267–291

    Abstract: X-ray micro CT has become a popular methodology for the nondestructive analysis of dental tissues and has been used extensively in the amelogenesis field. The aim of this chapter is to introduce ImageJ/Fiji to researchers new to CT scanning and the ... ...

    Abstract X-ray micro CT has become a popular methodology for the nondestructive analysis of dental tissues and has been used extensively in the amelogenesis field. The aim of this chapter is to introduce ImageJ/Fiji to researchers new to CT scanning and the analysis of CT image data. The program can be applied to analyzing X-ray CT images of enamel but can be extrapolated to other tissues as well.
    MeSH term(s) Animals ; Bone Density ; Dental Enamel/chemistry ; Dental Enamel/ultrastructure ; Image Processing, Computer-Assisted/methods ; Machine Learning ; Mandible/chemistry ; Mandible/ultrastructure ; Mice ; Minerals/chemistry ; Molar/chemistry ; Molar/ultrastructure ; Software ; X-Ray Microtomography/methods
    Chemical Substances Minerals
    Language English
    Publishing date 2019-03-05
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9012-2_26
    Database MEDical Literature Analysis and Retrieval System OnLINE

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