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Article ; Online: The neurobiology of pair bond formation, bond disruption, and social buffering.

Lieberwirth, Claudia / Wang, Zuoxin

2016 Volume 40, Page(s) 8–13

Abstract: Enduring social bonds play an essential role in human society. These bonds positively affect psychological, physiological, and behavioral functions. Here, we review the recent literature on the neurobiology, particularly the role of oxytocin and dopamine, ...

Abstract	Enduring social bonds play an essential role in human society. These bonds positively affect psychological, physiological, and behavioral functions. Here, we review the recent literature on the neurobiology, particularly the role of oxytocin and dopamine, of pair bond formation, bond disruption, and social buffering effects on stress responses, from studies utilizing the socially monogamous prairie vole (Microtus ochrogaster).
MeSH term(s)	Animals ; Arvicolinae/physiology ; Dopamine/physiology ; Humans ; Neurobiology/trends ; Oxytocin/physiology ; Pair Bond
Chemical Substances	Oxytocin (50-56-6) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2016-06-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1078046-4
ISSN	1873-6882 ; 0959-4388
ISSN (online)	1873-6882
ISSN	0959-4388
DOI	10.1016/j.conb.2016.05.006
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Zs.A 3260: Show issues

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Article: Social bonding: regulation by neuropeptides.

Lieberwirth, Claudia / Wang, Zuoxin

Frontiers in neuroscience

2014 Volume 8, Page(s) 171

Abstract: Affiliative social relationships (e.g., among spouses, family members, and friends) play an essential role in human society. These relationships affect psychological, physiological, and behavioral functions. As positive and enduring bonds are critical ... ...

Abstract	Affiliative social relationships (e.g., among spouses, family members, and friends) play an essential role in human society. These relationships affect psychological, physiological, and behavioral functions. As positive and enduring bonds are critical for the overall well-being of humans, it is not surprising that considerable effort has been made to study the neurobiological mechanisms that underlie social bonding behaviors. The present review details the involvement of the nonapeptides, oxytocin (OT), and arginine vasopressin (AVP), in the regulation of social bonding in mammals including humans. In particular, we will discuss the role of OT and AVP in the formation of social bonds between partners of a mating pair as well as between parents and their offspring. Furthermore, the role of OT and AVP in the formation of interpersonal bonding involving trust is also discussed.
Language	English
Publishing date	2014-06-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2014.00171
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The social environment and neurogenesis in the adult Mammalian brain.

Lieberwirth, Claudia / Wang, Zuoxin

Frontiers in human neuroscience

2012 Volume 6, Page(s) 118

Abstract: Adult neurogenesis - the formation of new neurons in adulthood - has been shown to be modulated by a variety of endogenous (e.g., trophic factors, neurotransmitters, and hormones) as well as exogenous (e.g., physical activity and environmental complexity) ...

Abstract	Adult neurogenesis - the formation of new neurons in adulthood - has been shown to be modulated by a variety of endogenous (e.g., trophic factors, neurotransmitters, and hormones) as well as exogenous (e.g., physical activity and environmental complexity) factors. Research on exogenous regulators of adult neurogenesis has focused primarily on the non-social environment. More recently, however, evidence has emerged suggesting that the social environment can also affect adult neurogenesis. The present review details the effects of adult-adult (e.g., mating and chemosensory interactions) and adult-offspring (e.g., gestation, parenthood, and exposure to offspring) interactions on adult neurogenesis. In addition, the effects of a stressful social environment (e.g., lack of social support and dominant-subordinate interactions) on adult neurogenesis are reviewed. The underlying hormonal mechanisms and potential functional significance of adult-generated neurons in mediating social behaviors are also discussed.
Language	English
Publishing date	2012-05-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2425477-0
ISSN	1662-5161 ; 1662-5161
ISSN (online)	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2012.00118
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Article ; Online: Hippocampal adult neurogenesis: Its regulation and potential role in spatial learning and memory.

Lieberwirth, Claudia / Pan, Yongliang / Liu, Yan / Zhang, Zhibin / Wang, Zuoxin

Brain research

2016 Volume 1644, Page(s) 127–140

Abstract: Adult neurogenesis, defined here as progenitor cell division generating functionally integrated neurons in the adult brain, occurs within the hippocampus of numerous mammalian species including humans. The present review details various endogenous (e.g., ...

Abstract	Adult neurogenesis, defined here as progenitor cell division generating functionally integrated neurons in the adult brain, occurs within the hippocampus of numerous mammalian species including humans. The present review details various endogenous (e.g., neurotransmitters) and environmental (e.g., physical exercise) factors that have been shown to influence hippocampal adult neurogenesis. In addition, the potential involvement of adult-generated neurons in naturally-occurring spatial learning behavior is discussed by summarizing the literature focusing on traditional animal models (e.g., rats and mice), non-traditional animal models (e.g., tree shrews), as well as natural populations (e.g., chickadees and Siberian chipmunk).
MeSH term(s)	Animals ; Female ; Hippocampus/physiology ; Humans ; Male ; Maze Learning ; Mice ; Neurogenesis ; Neurons/physiology ; Rats ; Spatial Learning/physiology ; Spatial Memory/physiology
Language	English
Publishing date	2016-05-10
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2016.05.015
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Article ; Online: Biodegradable Harmonophores for Targeted High-Resolution

Sonay, Ali Yasin / Kalyviotis, Konstantinos / Yaganoglu, Sine / Unsal, Aysen / Konantz, Martina / Teulon, Claire / Lieberwirth, Ingo / Sieber, Sandro / Jiang, Shuai / Behzadi, Shahed / Crespy, Daniel / Landfester, Katharina / Roke, Sylvie / Lengerke, Claudia / Pantazis, Periklis

ACS nano

2021 Volume 15, Issue 3, Page(s) 4144–4154

Abstract: Optical imaging probes have played a major role in detecting and monitoring a variety of diseases. In particular, nonlinear optical imaging probes, such as second harmonic generating (SHG) nanoprobes, hold great promise as clinical contrast agents, as ... ...

Abstract	Optical imaging probes have played a major role in detecting and monitoring a variety of diseases. In particular, nonlinear optical imaging probes, such as second harmonic generating (SHG) nanoprobes, hold great promise as clinical contrast agents, as they can be imaged with little background signal and unmatched long-term photostability. As their chemical composition often includes transition metals, the use of inorganic SHG nanoprobes can raise long-term health concerns. Ideally, contrast agents for biomedical applications should be degraded
MeSH term(s)	Animals ; Microscopy, Fluorescence ; Molecular Imaging ; Peptides ; Zebrafish
Chemical Substances	Peptides
Language	English
Publishing date	2021-02-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.0c10634
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Article ; Online: Behavioral and physiological responses of female prairie voles (Microtus ochrogaster) to various stressful conditions.

Smith, Adam S / Lieberwirth, Claudia / Wang, Zuoxin

Stress (Amsterdam, Netherlands)

2013 Volume 16, Issue 5, Page(s) 531–539

Abstract: Stressful life events elicit hypothalamic-pituitary-adrenal (HPA) axis activation, which may alter psychological states or behavioral routines. Therefore, the current study focused on the HPA axis response to better understand such manifestations in ... ...

Abstract	Stressful life events elicit hypothalamic-pituitary-adrenal (HPA) axis activation, which may alter psychological states or behavioral routines. Therefore, the current study focused on the HPA axis response to better understand such manifestations in female prairie voles (Microtus ochrogaster). In Experiment 1, females were stressed for 1 h via one of the four stressors: exposure to a novel environment, immobilization ("plastic mesh"), brief social defeat, or prolonged social defeat. Following a 30-min recovery, the females received a 5-min elevated plus maze (EPM) test and, subsequently, blood was collected to measure plasma corticosterone concentrations. Only immobilization stress induced an anxiety-like behavioral response in the EPM test and elevated plasma corticosterone levels compared to the control groups. Corticosterone concentrations were also significantly elevated following exposure to prolonged social defeat compared to the control conditions, but not after novel environment stress or short social defeat. In Experiment 2, females were exposed to immobilization stress over 1, 3, or 7 days in a daily (predictable; pIMO) or irregular (unpredictable; uIMO) schedule. The biobehavioral stress response in females exposed to pIMO for 3 or 7 days did not differ significantly from controls, suggesting these females habituated. By comparison, females exposed to uIMO over 3 or 7 days did not habituate behaviorally or physiologically, even producing augmented corticosterone levels. In both experiments, positive correlations were found between corticosterone levels and anxiety-like behaviors in the EPM test. Together, our data suggest that the stress response by female prairie voles is dependent on stress intensity, source, previous experience, and predictability. Furthermore, the HPA axis response, as evident by corticosterone levels, is associated with the impact that these factors have on behavioral routine.
MeSH term(s)	Animals ; Anxiety/physiopathology ; Arvicolinae ; Behavior, Animal ; Corticosterone/blood ; Female ; Habituation, Psychophysiologic ; Hypothalamo-Hypophyseal System/physiology ; Pituitary-Adrenal System/physiology ; Restraint, Physical/physiology ; Social Dominance ; Social Isolation ; Stress, Physiological ; Stress, Psychological
Chemical Substances	Corticosterone (W980KJ009P)
Language	English
Publishing date	2013-05-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1387706-9
ISSN	1607-8888 ; 1025-3890
ISSN (online)	1607-8888
ISSN	1025-3890
DOI	10.3109/10253890.2013.794449
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Zs.A 5673: Show issues

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Article ; Online: Social isolation impairs adult neurogenesis in the limbic system and alters behaviors in female prairie voles.

Lieberwirth, Claudia / Liu, Yan / Jia, Xixi / Wang, Zuoxin

Hormones and behavior

2012 Volume 62, Issue 4, Page(s) 357–366

Abstract: Disruptions in the social environment, such as social isolation, are distressing and can induce various behavioral and neural changes in the distressed animal. We conducted a series of experiments to test the hypothesis that long-term social isolation ... ...

Abstract	Disruptions in the social environment, such as social isolation, are distressing and can induce various behavioral and neural changes in the distressed animal. We conducted a series of experiments to test the hypothesis that long-term social isolation affects brain plasticity and alters behavior in the highly social prairie vole (Microtus ochrogaster). In Experiment 1, adult female prairie voles were injected with a cell division marker, 5-bromo-2'-deoxyuridine (BrdU), and then same-sex pair-housed (control) or single-housed (isolation) for 6 weeks. Social isolation reduced cell proliferation, survival, and neuronal differentiation and altered cell death in the dentate gyrus of the hippocampus and the amygdala. In addition, social isolation reduced cell proliferation in the medial preoptic area and cell survival in the ventromedial hypothalamus. These data suggest that long-term social isolation affects distinct stages of adult neurogenesis in specific limbic brain regions. In Experiment 2, isolated females displayed higher levels of anxiety-like behaviors in both the open field and elevated plus maze tests and higher levels of depression-like behavior in the forced swim test than controls. Further, isolated females showed a higher level of affiliative behavior than controls, but the two groups did not differ in social recognition memory. Together, our data suggest that social isolation not only impairs cell proliferation, survival, and neuronal differentiation in limbic brain areas, but also alters anxiety-like, depression-like, and affiliative behaviors in adult female prairie voles. These data warrant further investigation of a possible link between altered neurogenesis within the limbic system and behavioral changes.
MeSH term(s)	Adult Stem Cells/physiology ; Animals ; Arvicolinae/physiology ; Behavior, Animal/physiology ; Cell Death ; Cell Differentiation ; Cell Proliferation ; Corticosterone/blood ; Female ; Limbic System/cytology ; Limbic System/physiology ; Neural Stem Cells/physiology ; Neurogenesis/physiology ; Random Allocation ; Sex Factors ; Social Isolation/psychology
Chemical Substances	Corticosterone (W980KJ009P)
Language	English
Publishing date	2012-03-23
Publishing country	United States
Document type	Evaluation Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	214409-8
ISSN	1095-6867 ; 0018-506X
ISSN (online)	1095-6867
ISSN	0018-506X
DOI	10.1016/j.yhbeh.2012.03.005
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Article: On the pathway of cellular uptake: new insight into the interaction between the cell membrane and very small nanoparticles.

Messerschmidt, Claudia / Hofmann, Daniel / Kroeger, Anja / Landfester, Katharina / Mailänder, Volker / Lieberwirth, Ingo

Beilstein journal of nanotechnology

2016 Volume 7, Page(s) 1296–1311

Abstract: For any living cell the exchange with its environment is vital. Therefore, many different kinds of cargo are able to enter cells via energy-dependent or -independent routes. Nanoparticles are no exemption. It is known that small silica nanoparticles with ...

Abstract	For any living cell the exchange with its environment is vital. Therefore, many different kinds of cargo are able to enter cells via energy-dependent or -independent routes. Nanoparticles are no exemption. It is known that small silica nanoparticles with a diameter below 50 nm are taken up by cells and that their uptake exerts pronounced toxic effects beyond a certain concentration threshold. However, neither the exact uptake mechanism of these particles nor the actual reason for their toxicity has yet been elucidated. In this study we examined the uptake of silica nanoparticles with a diameter of 7, 12 and 22 nm by means of transmission electron microscopy, accompanied by toxicological assays. We show that for every particle diameter tested a different membrane morphology during uptake can be observed and that the amount of particles entering in one event is different for the three sizes. Silica particles with a diameter of 22 nm show single-particle internalization with a membrane wrapped around the particles in the cytosol, whereas 12 nm particles display row-like multi-particle uptake into elongated membrane structures and those with a diameter of 7 nm or less end up in tubular endocytic structures containing many particles. These membrane morphologies proved to be highly reproducible as we found them in five different cell lines. Additionally, we performed ATP and LDH assays to determine particle toxicity. Exceeding a certain concentration threshold the nanoparticles showed a high toxic potential both in the biochemical assay measurements and from morphological findings. We could not find any hint at the induction of apoptosis, neither morphologically nor biochemically. In this regard we discuss membrane damage and consumption as one possible mechanism of toxicity, linking morphological observations to toxicological findings to bridge the gap in understanding the mechanism of toxicity of small nanoparticles.
Language	English
Publishing date	2016-09-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2583584-1
ISSN	2190-4286
ISSN	2190-4286
DOI	10.3762/bjnano.7.121
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Article ; Online: SOCIAL BONDING

ClaudiaLieberwirth / ZuoxinWang

Frontiers in Neuroscience, Vol

REGULATION BY NEUROPEPTIDES

2014 Volume 8

Abstract	Affiliative social relationships (e.g., among spouses, family members, and friends) play an essential role in human society. These relationships affect psychological, physiological, and behavioral functions. As positive and enduring bonds are critical for the overall well-being of humans, it is not surprising that considerable effort has been made to study the neurobiological mechanisms that underlie social bonding behaviors. The present review details the involvement of the nonapeptides, oxytocin (OT) and arginine vasopressin (AVP), in the regulation of social bonding in mammals including humans. In particular, we will discuss the role of OT and AVP in the formation of social bonds between partners of a mating pair as well as between parents and their offspring. Furthermore, the role of OT and AVP in the formation of interpersonal bonding involving trust is also discussed.
Keywords	Oxytocin ; vasopressin ; affiliation ; pair bond ; social recognition ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R
Subject code	300
Language	English
Publishing date	2014-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fatherhood reduces the survival of adult-generated cells and affects various types of behavior in the prairie vole (Microtus ochrogaster ).

Lieberwirth, Claudia / Wang, Yue / Jia, Xixi / Liu, Yan / Wang, Zuoxin

The European journal of neuroscience

2013 Volume 38, Issue 9, Page(s) 3345–3355

Abstract: Motherhood has profound effects on physiology, neuronal plasticity, and behavior. We conducted a series of experiments to test the hypothesis that fatherhood, similarly to motherhood, affects brain plasticity (such as cell proliferation and survival) and ...

Abstract	Motherhood has profound effects on physiology, neuronal plasticity, and behavior. We conducted a series of experiments to test the hypothesis that fatherhood, similarly to motherhood, affects brain plasticity (such as cell proliferation and survival) and various behaviors in the highly social prairie vole (Microtus ochrogaster). In Experiment 1, adult males were housed with their same-sex cage mate (control), single-housed (isolation), or housed with a receptive female to mate and produce offspring (father) for 6 weeks. Fatherhood significantly reduced cell survival (assessed by bromodeoxyuridine labeling), but not cell proliferation (assessed by Ki67-labeling), in the amygdala, dentate gyrus of the hippocampus, and ventromedial hypothalamus, suggesting that fatherhood affects brain plasticity. In Experiment 2, neither acute (20 min) nor chronic (20 min daily for 10 consecutive days) pup exposure altered cell proliferation or survival in the brain, but chronic pup exposure increased circulating corticosterone levels. These data suggest that reduced cell survival in the brain of prairie vole fathers was unlikely to be due to the level of pup exposure and display of paternal behavior, and may not be mediated by circulating corticosterone. The effects of fatherhood on various behaviors (including anxiety-like, depression-like, and social behaviors) were examined in Experiment 3. The data indicated that fatherhood increased anxiety- and depression-like behaviors as well as altered aggression and social recognition memory in male prairie voles. These results warrant further investigation of a possible link between brain plasticity and behavioral changes observed due to fatherhood.
MeSH term(s)	Amygdala/cytology ; Amygdala/physiology ; Animals ; Arvicolinae ; Behavior, Animal ; Cell Proliferation ; Cell Survival ; Corticosterone/blood ; Female ; Hippocampus/cytology ; Hippocampus/physiology ; Male ; Neurons/physiology ; Paternal Behavior ; Sex Factors
Chemical Substances	Corticosterone (W980KJ009P)
Language	English
Publishing date	2013-07-31
Publishing country	France
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.12323
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