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  1. Article ; Online: Long noncoding RNA

    Du, Yong / Ding, Yi / Shi, Tianyun / He, Wei / Feng, Jingjing / Mei, Zhoufang / Chen, Xuru / Feng, Xintong / Zhang, Xiaohua / Jie, Zhijun

    Acta biochimica et biophysica Sinica

    2022  Volume 54, Issue 7, Page(s) 931–939

    Abstract: ... obstructive pulmonary disease (COPD), and long noncoding RNAs have been demonstrated to participate in COPD development and ... pathogenesis. Here, we investigate the role of long noncoding RNA ...

    Abstract Airway remodeling is a remarkable pathological characteristic of chronic obstructive pulmonary disease (COPD), and long noncoding RNAs have been demonstrated to participate in COPD development and pathogenesis. Here, we investigate the role of long noncoding RNA
    MeSH term(s) Airway Remodeling/genetics ; Animals ; Cigarette Smoking ; Cytokines ; Inflammation/complications ; Inflammation/genetics ; Mice ; MicroRNAs/genetics ; MicroRNAs/metabolism ; PTEN Phosphohydrolase/metabolism ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Disease, Chronic Obstructive/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
    Chemical Substances Cytokines ; MicroRNAs ; RNA, Long Noncoding ; long non-coding RNA GAS5, mouse ; PTEN Phosphohydrolase (EC 3.1.3.67) ; Pten protein, mouse (EC 3.1.3.67)
    Language English
    Publishing date 2022-06-06
    Publishing country China
    Document type Journal Article
    ZDB-ID 2175256-4
    ISSN 1745-7270 ; 0582-9879 ; 1672-9145
    ISSN (online) 1745-7270
    ISSN 0582-9879 ; 1672-9145
    DOI 10.3724/abbs.2022074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Long short-term memory with activation on gradient.

    Qin, Chuan / Chen, Liangming / Cai, Zangtai / Liu, Mei / Jin, Long

    Neural networks : the official journal of the International Neural Network Society

    2023  Volume 164, Page(s) 135–145

    Abstract: As the number of long short-term memory (LSTM) layers increases, vanishing/exploding gradient ...

    Abstract As the number of long short-term memory (LSTM) layers increases, vanishing/exploding gradient problems exacerbate and have a negative impact on the performance of the LSTM. In addition, the ill-conditioned problem occurs in the training process of LSTM and adversely affects its convergence. In this work, a simple and effective method of the gradient activation is applied to the LSTM, while empirical criteria for choosing gradient activation hyperparameters are found. Activating the gradient refers to modifying the gradient with a specific function named the gradient activation function. Moreover, different activation functions and different gradient operations are compared to prove that the gradient activation is effective on LSTM. Furthermore, comparative experiments are conducted, and their results show that the gradient activation alleviates the above problems and accelerates the convergence of the LSTM. The source code is publicly available at https://github.com/LongJin-lab/ACT-In-NLP.
    MeSH term(s) Neural Networks, Computer ; Memory, Short-Term ; Memory, Long-Term ; Software
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 740542-x
    ISSN 1879-2782 ; 0893-6080
    ISSN (online) 1879-2782
    ISSN 0893-6080
    DOI 10.1016/j.neunet.2023.04.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2365: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Short- and long-term results of open

    Quan, Ji-Chuan / Zhou, Xin-Jun / Mei, Shi-Wen / Liu, Jun-Guang / Qiu, Wen-Long / Zhang, Jin-Zhu / Li, Bo / Li, Yue-Gang / Wang, Xi-Shan / Chang, Hu / Tang, Jian-Qiang

    World journal of gastrointestinal surgery

    2023  Volume 15, Issue 9, Page(s) 1969–1977

    Abstract: ... term efficacy and long-term prognosis of OMRA as well as LMRA for SCRC located in separate segments ...

    Abstract Background: It remains unclear whether laparoscopic multisegmental resection and anastomosis (LMRA) is safe and advantageous over traditional open multisegmental resection and anastomosis (OMRA) for treating synchronous colorectal cancer (SCRC) located in separate segments.
    Aim: To compare the short-term efficacy and long-term prognosis of OMRA as well as LMRA for SCRC located in separate segments.
    Methods: Patients with SCRC who underwent surgery between January 2010 and December 2021 at the Cancer Hospital, Chinese Academy of Medical Sciences and the Peking University First Hospital were retrospectively recruited. In accordance with the inclusion and exclusion criteria, 109 patients who received right hemicolectomy together with anterior resection of the rectum or right hemicolectomy and sigmoid colectomy were finally included in the study. Patients were divided into the LMRA and OMRA groups (
    Results: LMRA patients showed markedly less intraoperative blood loss than OMRA patients (100
    Conclusion: LMRA is safe and feasible for patients with SCRC located in separate segments. Compared to OMRA, the LMRA approach has more advantages related to short-term efficacy.
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v15.i9.1969
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  4. Article ; Online: Long-range connectome of pyramidal neurons in the sensorimotor cortex.

    Yao, Mei / Tudi, Ayizuohere / Jiang, Tao / An, Xu / Sun, Qingtao / Li, Anan / Huang, Z Josh / Gong, Hui / Li, Xiangning

    iScience

    2023  Volume 26, Issue 4, Page(s) 106316

    Abstract: ... IT) and pyramidal tract (PT) neurons at specific layers, we dissected the long-range connectome ...

    Abstract The neocortex mediates information processing through highly organized circuitry that contains various neuron types. Distinct populations of projection neurons in different cortical regions and layers make specific connections and participate in distinct physiological functions. Herein, with the fluorescence micro-optical sectioning tomography (fMOST) and transgenetic mice that targeted intratelencephalic (IT) and pyramidal tract (PT) neurons at specific layers, we dissected the long-range connectome of pyramidal neurons in six subregions of the sensorimtor cortex. The distribution of the input neurons indicated that IT and PT neurons in the same region received information from similar regions, while the neurons in different subregions received from the preferred neuron populations. Both the input and projection areas of these six subregions showed the transverse and longitudinal correspondence in the cortico-cortical, cortico-thalamic, and cortico-striatal circuits, which indicated that the connections were topologically organized. This study provides a comprehensive resource on the anatomical connections of cortical circuits.
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.106316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Long-Term Administration of Triterpenoids From

    Zeng, Miao / Qi, Longkai / Guo, Yinrui / Zhu, Xiangxiang / Tang, Xiaocui / Yong, Tianqiao / Xie, Yizhen / Wu, Qingping / Zhang, Mei / Chen, Diling

    Frontiers in aging neuroscience

    2021  Volume 13, Page(s) 628860

    Abstract: ... to improve longevity. In this study, long-term administration of triterpenoids of ...

    Abstract With the advent of the aging society, how to grow old healthily has become an important issue for the whole of society. Effective intervention strategies for healthy aging are most desired, due to the complexity and diversity of genetic information, it is a pressing concern to find a single drug or treatment to improve longevity. In this study, long-term administration of triterpenoids of
    Language English
    Publishing date 2021-05-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2021.628860
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  6. Article ; Online: Long-Term Follow-Up Cares and Check Initiative: A Program to Advance Long-Term Follow-Up in Newborns Identified with a Disease through Newborn Screening.

    Lietsch, Mei / Chan, Kee / Taylor, Jennifer / Lee, Bo Hoon / Ciafaloni, Emma / Kwon, Jennifer M / Waldrop, Megan A / Butterfield, Russell J / Rathore, Geetanjali / Veerapandiyan, Aravindhan / Kapil, Arya / Parsons, Julie A / Gibbons, Melissa / Brower, Amy

    International journal of neonatal screening

    2024  Volume 10, Issue 2

    Abstract: ... management and community support to achieve the best possible outcome. To advance the long-term follow-up ... of infants identified through newborn screening (NBS), the Long-Term Follow-up Cares and Check Initiative ...

    Abstract In the United States and around the world, newborns are screened on a population basis for conditions benefiting from pre-symptomatic diagnosis and treatment. The number of screened conditions continues to expand as novel technologies for screening, diagnosing, treating, and managing disease are discovered. While screening all newborns facilitates early diagnosis and treatment, most screened conditions are treatable but not curable. Patients identified by newborn screening often require lifelong medical management and community support to achieve the best possible outcome. To advance the long-term follow-up of infants identified through newborn screening (NBS), the Long-Term Follow-up Cares and Check Initiative (LTFU-Cares and Check) designed, implemented, and evaluated a system of longitudinal data collection and annual reporting engaging parents, clinical providers, and state NBS programs. The LTFU-Cares and Check focused on newborns identified with spinal muscular atrophy (SMA) through NBS and the longitudinal health information prioritized by parents and families. Pediatric neurologists who care for newborns with SMA entered annual data, and data tracking and visualization tools were delivered to state NBS programs with a participating clinical center. In this publication, we report on the development, use of, and preliminary results from the LTFU-Cares and Check Initiative, which was designed as a comprehensive model of LTFU. We also propose next steps for achieving the goal of a national system of LTFU for individuals with identified conditions by meaningfully engaging public health agencies, clinicians, parents, families, and communities.
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2409-515X
    ISSN (online) 2409-515X
    DOI 10.3390/ijns10020034
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  7. Article ; Online: Long-term cycling stability of NiCo

    Wu, Xiaoyu / Li, Songmei / Wang, Bo / Liu, Jianhua / Yu, Mei

    Chemical communications (Cambridge, England)

    2021  Volume 57, Issue 8, Page(s) 1002–1005

    Abstract: ... for long-term applications. ...

    Abstract A bio-based N-doped carbon 3D network is designed to fabricate a composite anode for LIBs. Benefiting from the highly active substrate and the supported NiCo2S4 hollow nanowires, the composites exhibit an ultrahigh reversible capacity of 1198 mA h g-1 after 500 cycles, holding great potential for long-term applications.
    Language English
    Publishing date 2021-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d0cc06916g
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  8. Article ; Online: Compromised long-lived memory CD8

    Zhou, Ming-Ju / Huang, Hui-Huang / Song, Jin-Wen / Tu, Bo / Fan, Xing / Li, Jing / Jin, Jie-Hua / Cao, Wen-Jing / Hu, Wei / Yang, Tao / Zhou, Chun-Bao / Yuan, Jin-Hong / Fan, Jin / Zhang, Ji-Yuan / Jiao, Yan-Mei / Xu, Ruo-Nan / Zhen, Cheng / Shi, Ming / Zhang, Chao /
    Wang, Fu-Sheng

    European journal of immunology

    2021  Volume 51, Issue 8, Page(s) 2027–2039

    Abstract: ... in people living with HIV (PLWH). Long-lived memory CD8 ...

    Abstract Immune deficiency is one of the hallmarks of HIV infection and a major cause of adverse outcomes in people living with HIV (PLWH). Long-lived memory CD8
    MeSH term(s) Adult ; CD8-Positive T-Lymphocytes/immunology ; Female ; HIV Infections/immunology ; Humans ; Immunologic Memory/immunology ; Interleukin-7/immunology ; Male ; Middle Aged
    Chemical Substances IL7 protein, human ; Interleukin-7
    Language English
    Publishing date 2021-05-29
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202149203
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 85: Show issues

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  9. Article ; Online: Long non-coding RNAs in oncourology.

    Gareev, Ilgiz / Gileva, Yulia / Dzidzaria, Aleksandr / Beylerli, Ozal / Pavlov, Valentin / Agaverdiev, Murad / Mazorov, Bakhodur / Biganyakov, Ilfat / Vardikyan, Andranik / Jin, Mei / Ahmad, Aamir

    Non-coding RNA research

    2021  Volume 6, Issue 3, Page(s) 139–145

    Abstract: ... ncRNAs) play a key regulatory role in health and disease. Long noncoding RNAs (lncRNAs) are a group ...

    Abstract For several decades, research in tumor biology has focused on the involvement of genes encoding a protein. Only recently has it been discovered that a whole class of molecules called non-coding RNAs (ncRNAs) play a key regulatory role in health and disease. Long noncoding RNAs (lncRNAs) are a group of noncoding RNAs longer than 200 nucleotides. It has been found that lncRNAs play a fundamental role in the biology of many types of tumors, including tumors of the genitourinary system. As a result, hundreds of clinical trials dedicated to oncourology have begun, using lncRNA as new biomarkers or treatments. Identifying new specific biomarkers, in the form of lncRNAs, will increase the ability to differentiate the tumor and other processes, determine the localization and extent of the tumor, and the ability to predict the course of the disease, and plan treatment. Therapy of tumors, especially malignant ones, is also a difficult task. When surgery and chemotherapy fail, radiation therapy becomes the treatment choice. Therefore, the possibility that lncRNAs could represent innovative therapeutic agents or targets is an exciting idea. However, the possibility of their use in modern clinical practice is limited, and this is associated with several problems at the pre-, analytical and post-analytical stages. Another problem in the study of lncRNAs is the large number and variety of their functions in tumors. Therefore, solving technological problems in lncRNAs study in oncourology may open up new possibilities for lncRNAs use in modern clinical practice.
    Language English
    Publishing date 2021-08-26
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2468-0540
    ISSN (online) 2468-0540
    DOI 10.1016/j.ncrna.2021.08.001
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  10. Article: Genome-wide analysis of long non-coding RNAs (lncRNAs) in tea plants (

    Hu, Shunkai / Hu, Yimeng / Mei, Huiling / Li, Jianjie / Xuan, Wei / Jeyaraj, Anburaj / Zhao, Zhen / Zhao, Yuxin / Han, Rui / Chen, Xuan / Li, Xinghui

    Frontiers in plant science

    2023  Volume 14, Page(s) 1080427

    Abstract: Tea ( ...

    Abstract Tea (
    Language English
    Publishing date 2023-02-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1080427
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