LIVIVO - Search results -

Search results

Result 1 - 10 of total 10

Search options

Article ; Online: LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing.

Le Douce, Valentin / Colin, Laurence / Redel, Laetitia / Cherrier, Thomas / Herbein, Georges / Aunis, Dominique / Rohr, Olivier / Van Lint, Carine / Schwartz, Christian

Nucleic acids research

2011 Volume 40, Issue 5, Page(s) 1904–1915

Abstract: Microglial cells are the main HIV-1 targets in the central nervous system (CNS) and constitute an important reservoir of latently infected cells. Establishment and persistence of these reservoirs rely on the chromatin structure of the integrated ... ...

Abstract	Microglial cells are the main HIV-1 targets in the central nervous system (CNS) and constitute an important reservoir of latently infected cells. Establishment and persistence of these reservoirs rely on the chromatin structure of the integrated proviruses. We have previously demonstrated that the cellular cofactor CTIP2 forces heterochromatin formation and HIV-1 gene silencing by recruiting HDAC and HMT activities at the integrated viral promoter. In the present work, we report that the histone demethylase LSD1 represses HIV-1 transcription and viral expression in a synergistic manner with CTIP2. We show that recruitment of LSD1 at the HIV-1 proximal promoter is associated with both H3K4me3 and H3K9me3 epigenetic marks. Finally, our data suggest that LSD1-induced H3K4 trimethylation is linked to hSET1 recruitment at the integrated provirus.
MeSH term(s)	Cell Line ; Cell Nucleus/chemistry ; Cell Nucleus/virology ; Epigenesis, Genetic ; Gene Silencing ; HIV Long Terminal Repeat ; HIV-1/genetics ; HIV-1/physiology ; Histone Demethylases/analysis ; Histone Demethylases/metabolism ; Histone-Lysine N-Methyltransferase/metabolism ; Histones/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins ; Methylation ; Microglia/virology ; Promoter Regions, Genetic ; Repressor Proteins/analysis ; Repressor Proteins/metabolism ; Transcription, Genetic ; Tumor Suppressor Proteins/analysis ; Tumor Suppressor Proteins/metabolism ; Virus Replication ; tat Gene Products, Human Immunodeficiency Virus/analysis
Chemical Substances	BCL11B protein, human ; Histones ; Intracellular Signaling Peptides and Proteins ; Repressor Proteins ; Tumor Suppressor Proteins ; WDR5 protein, human ; tat Gene Products, Human Immunodeficiency Virus ; Histone Demethylases (EC 1.14.11.-) ; KDM1A protein, human (EC 1.5.-) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; Setd1A protein, human (EC 2.1.1.43)
Language	English
Publishing date	2011-11-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkr857
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1067: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Un virus tapi dans l'ombre : les bases moléculaires de la latence du VIH-1 - Partie II : la réactivation de la latence du VIH-1 et ses implications thérapeutiques.

Cherrier, Thomas / Le Douce, Valentin / Redel, Laetitia / Marban, Céline / Aunis, Dominique / Rohr, Olivier / Schwartz, Christian

Medecine sciences : M/S

2010 Volume 26, Issue 3, Page(s) 291–295

Abstract: The latent HIV-1 reservoirs established early during infection present a major obstacle for virus eradication. Complete eradication of the virus from infected patients may require a purge of the reservoirs. Since the development of a HIV-1 vaccine is not ...

Title translation	Molecular basis of HIV-1 latency - Part II: HIV-1 reactivation and therapeutic implications.
Abstract	The latent HIV-1 reservoirs established early during infection present a major obstacle for virus eradication. Complete eradication of the virus from infected patients may require a purge of the reservoirs. Since the development of a HIV-1 vaccine is not achieved, and therefore remains a major challenge for the immunologists, future direction towards an effective curative therapy for HIV-1 infection will rely on the development of original therapeutic strategies which take into account latency, chronic replication and accessibility to tissue-sanctuary.
MeSH term(s)	Disease Reservoirs ; HIV Infections/drug therapy ; HIV Infections/physiopathology ; HIV-1/genetics ; HIV-1/physiology ; Histone Deacetylase Inhibitors/therapeutic use ; Histone Deacetylases/metabolism ; Humans ; RNA, Messenger/genetics ; RNA, Viral/genetics ; Virus Latency ; Virus Replication
Chemical Substances	Histone Deacetylase Inhibitors ; RNA, Messenger ; RNA, Viral ; Histone Deacetylases (EC 3.5.1.98)
Language	French
Publishing date	2010-03
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/2010263291
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2872: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Un virus tapi dans l'ombre : les bases moléculaires de la latence du VIH-1 - Partie I : la physiologie de la latence du VIH-1.

Schwartz, Christian / Le Douce, Valentin / Cherrier, Thomas / Redel, Laetitia / Marban, Céline / Aunis, Dominique / Rohr, Olivier

Medecine sciences : M/S

2010 Volume 26, Issue 2, Page(s) 159–163

Abstract: The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1. Unfortunately, the optimism declined by revealing the existence of latent HIV-1 reservoirs in cells ... ...

Title translation	Molecular basis of HIV-1 latency - part I: physiology of HIV-1 latency.
Abstract	The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1. Unfortunately, the optimism declined by revealing the existence of latent HIV-1 reservoirs in cells targeted by the virus. The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1. Understanding the molecular mechanisms of virus latency is essential for efficient therapeutic intervention against the virus.
MeSH term(s)	DNA, Viral/genetics ; Epigenesis, Genetic ; Gene Expression Regulation, Viral ; HIV Infections/virology ; HIV-1/genetics ; HIV-1/physiology ; Host-Pathogen Interactions ; Humans ; Microglia/virology ; Proviruses/genetics ; Proviruses/physiology ; RNA, Viral/genetics ; Transcription, Genetic ; Virus Integration ; Virus Latency/genetics ; Virus Latency/physiology
Chemical Substances	DNA, Viral ; RNA, Viral
Language	French
Publishing date	2010-02
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	632733-3
ISSN	1958-5381 ; 0767-0974
ISSN (online)	1958-5381
ISSN	0767-0974
DOI	10.1051/medsci/2010262159
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2872: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: HIV-1 regulation of latency in the monocyte-macrophage lineage and in CD4+ T lymphocytes.

Redel, Laetitia / Le Douce, Valentin / Cherrier, Thomas / Marban, Céline / Janossy, Andrea / Aunis, Dominique / Van Lint, Carine / Rohr, Olivier / Schwartz, Christian

Journal of leukocyte biology

2010 Volume 87, Issue 4, Page(s) 575–588

Abstract: The introduction in 1996 of the HAART raised hopes for the eradication of HIV-1. Unfortunately, the discovery of latent HIV-1 reservoirs in CD4+ T cells and in the monocyte-macrophage lineage proved the optimism to be premature. The long-lived HIV-1 ... ...

Abstract	The introduction in 1996 of the HAART raised hopes for the eradication of HIV-1. Unfortunately, the discovery of latent HIV-1 reservoirs in CD4+ T cells and in the monocyte-macrophage lineage proved the optimism to be premature. The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1. In this review, we focus on the establishment and maintenance of HIV-1 latency in the two major targets for HIV-1: the CD4+ T cells and the monocyte-macrophage lineage. Understanding the cell-type molecular mechanisms of establishment, maintenance, and reactivation of HIV-1 latency in these reservoirs is crucial for efficient therapeutic intervention. A complete viral eradication, the holy graal for clinicians, might be achieved by strategic interventions targeting latently and productively infected cells. We suggest that new approaches, such as the combination of different kinds of proviral activators, may help to reduce dramatically the size of latent HIV-1 reservoirs in patients on HAART.
MeSH term(s)	Antiretroviral Therapy, Highly Active ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/virology ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV-1/physiology ; Humans ; Macrophages/immunology ; Macrophages/virology ; Monocytes/immunology ; Monocytes/virology ; Virus Activation/drug effects ; Virus Activation/immunology ; Virus Latency/drug effects ; Virus Latency/immunology
Language	English
Publishing date	2010-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1189/jlb.0409264
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 603: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: The cellular cofactor CTIP2 is a negative p-TEFb regulator. Contribution to HIV-1 post-integration latency

Rohr Olivier / Van Lint Carine / Dequiedt Franck / Aunis Dominique / Schwartz Christian / Marban Celine / Redel Laetitia / Goumon Yannick / Cherrier Thomas

Retrovirology, Vol 6, Iss Suppl 2, p O

2009 Volume 12

Keywords	Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2009-09-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing.

Marban, Céline / Suzanne, Stella / Dequiedt, Franck / de Walque, Stéphane / Redel, Laetitia / Van Lint, Carine / Aunis, Dominique / Rohr, Olivier

The EMBO journal

2007 Volume 26, Issue 2, Page(s) 412–423

Abstract: Following entry and reverse transcription, the HIV-1 genome is integrated into the host genome. In contrast to productively infected cells, latently infected cells frequently harbor HIV-1 genomes integrated in heterochromatic structures, allowing ... ...

Abstract	Following entry and reverse transcription, the HIV-1 genome is integrated into the host genome. In contrast to productively infected cells, latently infected cells frequently harbor HIV-1 genomes integrated in heterochromatic structures, allowing persistence of transcriptionally silent proviruses. Microglial cells are the main HIV-1 target cells in the central nervous system and constitute an important reservoir for viral pathogenesis. In the present work, we show that, in microglial cells, the co-repressor COUP-TF interacting protein 2 (CTIP2) recruits a multienzymatic chromatin-modifying complex and establishes a heterochromatic environment at the HIV-1 promoter. We report that CTIP2 recruits histone deacetylase (HDAC)1 and HDAC2 to promote local histone H3 deacetylation at the HIV-1 promoter region. In addition, DNA-bound CTIP2 also associates with the histone methyltransferase SUV39H1, which increases local histone H3 lysine 9 methylation. This allows concomitant recruitment of HP1 proteins to the viral promoter and formation of local heterochromatin, leading to HIV-1 silencing. Altogether, our findings uncover new therapeutic opportunities for purging latent HIV-1 viruses from their cellular reservoirs.
MeSH term(s)	Cells, Cultured ; Chromatin/metabolism ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/physiology ; Gene Silencing ; HIV-1/genetics ; HIV-1/physiology ; Histone Deacetylase 1 ; Histone Deacetylase 2 ; Histone Deacetylases/metabolism ; Histone-Lysine N-Methyltransferase/metabolism ; Histones/metabolism ; Humans ; Methyltransferases/metabolism ; Models, Biological ; Promoter Regions, Genetic ; Protein Binding ; Protein Methyltransferases ; Repressor Proteins/metabolism ; Repressor Proteins/physiology ; Transcription, Genetic ; Tumor Suppressor Proteins/metabolism ; Tumor Suppressor Proteins/physiology ; Virus Replication
Chemical Substances	BCL11B protein, human ; Chromatin ; DNA-Binding Proteins ; Histones ; Repressor Proteins ; Tumor Suppressor Proteins ; SUV39H1 protein, human (EC 2.1.1.) ; Methyltransferases (EC 2.1.1.-) ; Protein Methyltransferases (EC 2.1.1.-) ; histone methyltransferase (EC 2.1.1.-) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; HDAC1 protein, human (EC 3.5.1.98) ; Histone Deacetylase 1 (EC 3.5.1.98) ; Histone Deacetylase 2 (EC 3.5.1.98) ; Histone Deacetylases (EC 3.5.1.98)
Language	English
Publishing date	2007-01-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.1038/sj.emboj.7601516
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1808: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 100: Show issues

Order via subito

Details ▾

Article ; Online: COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells.

Marban, Céline / Redel, Laetitia / Suzanne, Stella / Van Lint, Carine / Lecestre, Dominique / Chasserot-Golaz, Sylvette / Leid, Mark / Aunis, Dominique / Schaeffer, Evelyne / Rohr, Olivier

publication RETRACTED

Nucleic acids research

2005 Volume 33, Issue 7, Page(s) 2318–2331

Abstract: Human immunodeficiency virus type 1 (HIV-1) gene transcription is characterized by two temporally distinct phases. While the initial phase relies solely on cellular transcription factors, the subsequent phase is activated by the viral Tat transactivator. ...

Abstract	Human immunodeficiency virus type 1 (HIV-1) gene transcription is characterized by two temporally distinct phases. While the initial phase relies solely on cellular transcription factors, the subsequent phase is activated by the viral Tat transactivator. We have previously reported that the subsequent phase of viral gene transcription can be repressed by the chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (CTIP2) in human microglial cells [O. Rohr, D. Lecestre, S. Chasserot-Golaz, C. Marban, D. Avram, D. Aunis, M. Leid and E. Schaeffer (2003), J. Virol., 77, 5415-5427]. Here, we demonstrate that CTIP proteins also repress the initial phase of HIV-1 gene transcription, mainly supported by the cellular transcription factors Sp1 and COUP-TF in microglial cells. We report that CTIP2 represses Sp1- and COUP-TF-mediated activation of HIV-1 gene transcription and viral replication as a result of physical interactions with COUP-TF and Sp1 in microglial nuclei. Using laser confocal microscopy CTIP2 was found to colocalize with Sp1, COUP-TF and the heterochromatin-associated protein Hp1alpha, which is mainly detected in transcriptionally repressed heterochromatic region. Moreover, we describe that CTIP2 can be recruited to the HIV-1 promoter via its association with Sp1 bound to the GC-box sequences of the long terminal repeat (LTR). Since our findings demonstrate that CTIP2 interacts with the HIV-1 proximal promoter, it is likely that CTIP2 promotes HIV-1 gene silencing by forcing transcriptionally repressed heterochromatic environment to the viral LTR region.
MeSH term(s)	COUP Transcription Factors ; Carrier Proteins/physiology ; Cell Line ; Cell Nucleus Structures/chemistry ; Chromobox Protein Homolog 5 ; Chromosomal Proteins, Non-Histone/analysis ; DNA-Binding Proteins/analysis ; DNA-Binding Proteins/antagonists & inhibitors ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/physiology ; Gene Expression Regulation, Viral ; HIV Long Terminal Repeat ; HIV-1/genetics ; HIV-1/physiology ; Humans ; Microglia/metabolism ; Microglia/virology ; Nuclear Proteins/physiology ; Protein Structure, Tertiary ; Receptors, Steroid/analysis ; Receptors, Steroid/antagonists & inhibitors ; Receptors, Steroid/chemistry ; Repressor Proteins/analysis ; Repressor Proteins/physiology ; Sp1 Transcription Factor/analysis ; Sp1 Transcription Factor/antagonists & inhibitors ; Sp1 Transcription Factor/chemistry ; Transcription Factors/analysis ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/chemistry ; Transcription, Genetic ; Tumor Suppressor Proteins ; Virus Replication
Chemical Substances	BCL11A protein, human ; BCL11B protein, human ; CBX5 protein, human ; COUP Transcription Factors ; Carrier Proteins ; Chromosomal Proteins, Non-Histone ; DNA-Binding Proteins ; Nuclear Proteins ; Receptors, Steroid ; Repressor Proteins ; Sp1 Transcription Factor ; Transcription Factors ; Tumor Suppressor Proteins ; Chromobox Protein Homolog 5 (107283-02-3)
Language	English
Publishing date	2005-04-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Retracted Publication
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gki529
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1067: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Medecine Sciences : M/S

Schwartz, Christian / Le Douce, Valentin / Cherrier, Thomas / Redel, Laetitia / Marban, Celine / Aunis, Dominique / Rohr, Olivier

Language	fra
Document type	Article
ISSN	0767-0974
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Medecine Sciences : M/S

Cherrier, Thomas / Le Douce, Valentin / Redel, Laetitia / Marban, Celine / Aunis, Dominique / Rohr, Olivier / Schwartz, Christian

Language	fra
Document type	Article
ISSN	0767-0974
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Journal of Leukocyte Biology

Redel, Laetitia / Le Douce, Valentin / Cherrier, Thomas / Marban, Celine / Janossy, Andrea / Aunis, Dominique / Van Lint, Carine / Rohr, Olivier / Schwartz, Christian

Language	English
Document type	Article
ISSN	0741-5400
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED