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  1. Article ; Online: When Dendritic Cells Go Viral: The Role of Siglec-1 in Host Defense and Dissemination of Enveloped Viruses.

    Perez-Zsolt, Daniel / Martinez-Picado, Javier / Izquierdo-Useros, Nuria

    Viruses

    2019  Volume 12, Issue 1

    Abstract: Dendritic cells (DCs) are among the first cells that recognize incoming viruses at the mucosal portals of entry. Initial interaction between DCs and viruses facilitates cell activation and migration to secondary lymphoid tissues, where these antigen ... ...

    Abstract Dendritic cells (DCs) are among the first cells that recognize incoming viruses at the mucosal portals of entry. Initial interaction between DCs and viruses facilitates cell activation and migration to secondary lymphoid tissues, where these antigen presenting cells (APCs) prime specific adaptive immune responses. Some viruses, however, have evolved strategies to subvert the migratory capacity of DCs as a way to disseminate infection systemically. Here we focus on the role of Siglec-1, a sialic acid-binding type I lectin receptor potently upregulated by type I interferons on DCs, that acts as a double edge sword, containing viral replication through the induction of antiviral immunity, but also favoring viral spread within tissues. Such is the case for distant enveloped viruses like human immunodeficiency virus (HIV)-1 or Ebola virus (EBOV), which incorporate sialic acid-containing gangliosides on their viral membrane and are effectively recognized by Siglec-1. Here we review how Siglec-1 is highly induced on the surface of human DCs upon viral infection, the way this impacts different antigen presentation pathways, and how enveloped viruses have evolved to exploit these APC functions as a potent dissemination strategy in different anatomical compartments.
    MeSH term(s) Animals ; Antigen Presentation/immunology ; Antigen-Presenting Cells/immunology ; Antigen-Presenting Cells/metabolism ; Biomarkers ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Dendritic Cells/virology ; Disease Resistance/genetics ; Disease Resistance/immunology ; Extracellular Vesicles/immunology ; Extracellular Vesicles/metabolism ; Gene Expression ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Sialic Acid Binding Ig-like Lectin 1/genetics ; Viral Load ; Virus Diseases/genetics ; Virus Diseases/immunology ; Virus Diseases/virology
    Chemical Substances Biomarkers ; SIGLEC1 protein, human ; Sialic Acid Binding Ig-like Lectin 1
    Keywords covid19
    Language English
    Publishing date 2019-12-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v12010008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: HIV-1

    Perez-Zsolt, Daniel / Raïch-Regué, Dàlia / Muñoz-Basagoiti, Jordana / Aguilar-Gurrieri, Carmen / Clotet, Bonaventura / Blanco, Julià / Izquierdo-Useros, Nuria

    Pathogens (Basel, Switzerland)

    2021  Volume 11, Issue 1

    Abstract: HIV-1 cell-to-cell transmission is key for an effective viral replication that evades immunity. This highly infectious mechanism is orchestrated by different cellular targets that utilize a wide variety of processes to efficiently transfer HIV-1 ... ...

    Abstract HIV-1 cell-to-cell transmission is key for an effective viral replication that evades immunity. This highly infectious mechanism is orchestrated by different cellular targets that utilize a wide variety of processes to efficiently transfer HIV-1 particles. Dendritic cells (DCs) are the most potent antigen presenting cells that initiate antiviral immune responses, but are also the cells with highest capacity to transfer HIV-1. This mechanism, known as
    Language English
    Publishing date 2021-12-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11010039
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  3. Article: SARS-CoV-2 Cellular Infection and Therapeutic Opportunities: Lessons Learned from Ebola Virus.

    Muñoz-Basagoiti, Jordana / Perez-Zsolt, Daniel / Carrillo, Jorge / Blanco, Julià / Clotet, Bonaventura / Izquierdo-Useros, Nuria

    Membranes

    2021  Volume 11, Issue 1

    Abstract: Viruses rely on the cellular machinery to replicate and propagate within newly infected individuals. Thus, viral entry into the host cell sets up the stage for productive infection and disease progression. Different viruses exploit distinct cellular ... ...

    Abstract Viruses rely on the cellular machinery to replicate and propagate within newly infected individuals. Thus, viral entry into the host cell sets up the stage for productive infection and disease progression. Different viruses exploit distinct cellular receptors for viral entry; however, numerous viral internalization mechanisms are shared by very diverse viral families. Such is the case of Ebola virus (EBOV), which belongs to the filoviridae family, and the recently emerged coronavirus SARS-CoV-2. These two highly pathogenic viruses can exploit very similar endocytic routes to productively infect target cells. This convergence has sped up the experimental assessment of clinical therapies against SARS-CoV-2 previously found to be effective for EBOV, and facilitated their expedited clinical testing. Here we review how the viral entry processes and subsequent replication and egress strategies of EBOV and SARS-CoV-2 can overlap, and how our previous knowledge on antivirals, antibodies, and vaccines against EBOV has boosted the search for effective countermeasures against the new coronavirus. As preparedness is key to contain forthcoming pandemics, lessons learned over the years by combating life-threatening viruses should help us to quickly deploy effective tools against novel emerging viruses.
    Language English
    Publishing date 2021-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes11010064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: When Dendritic Cells Go Viral: The Role of Siglec-1 in Host Defense and Dissemination of Enveloped Viruses

    Perez-Zsolt, Daniel / Martinez-Picado, Javier / Izquierdo-Useros, Nuria

    Viruses. 2019 Dec. 19, v. 12, no. 1

    2019  

    Abstract: Dendritic cells (DCs) are among the first cells that recognize incoming viruses at the mucosal portals of entry. Initial interaction between DCs and viruses facilitates cell activation and migration to secondary lymphoid tissues, where these antigen ... ...

    Abstract Dendritic cells (DCs) are among the first cells that recognize incoming viruses at the mucosal portals of entry. Initial interaction between DCs and viruses facilitates cell activation and migration to secondary lymphoid tissues, where these antigen presenting cells (APCs) prime specific adaptive immune responses. Some viruses, however, have evolved strategies to subvert the migratory capacity of DCs as a way to disseminate infection systemically. Here we focus on the role of Siglec-1, a sialic acid-binding type I lectin receptor potently upregulated by type I interferons on DCs, that acts as a double edge sword, containing viral replication through the induction of antiviral immunity, but also favoring viral spread within tissues. Such is the case for distant enveloped viruses like human immunodeficiency virus (HIV)-1 or Ebola virus (EBOV), which incorporate sialic acid-containing gangliosides on their viral membrane and are effectively recognized by Siglec-1. Here we review how Siglec-1 is highly induced on the surface of human DCs upon viral infection, the way this impacts different antigen presentation pathways, and how enveloped viruses have evolved to exploit these APC functions as a potent dissemination strategy in different anatomical compartments.
    Keywords Ebolavirus ; Human immunodeficiency virus ; antigen presentation ; dendritic cells ; gangliosides ; humans ; interferons ; lectins ; migratory behavior ; tissues ; virus replication ; viruses
    Language English
    Dates of publication 2019-1219
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v12010008
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination.

    Sisteré-Oró, Marta / Du, Juan / Wortmann, Diana D J / Filippi, Marina D / Cañas-Ruano, Esperanza / Arrieta-Aldea, Itziar / Marcos-Blanco, Agustín / Castells, Xavier / Grau, Santiago / García-Giralt, Natalia / Perez-Zsolt, Daniel / Boreika, Rytis / Izquierdo-Useros, Nuria / Güerri-Fernandez, Robert / Meyerhans, Andreas

    Journal of medical virology

    2023  Volume 96, Issue 1, Page(s) e29317

    Abstract: People living with human immunodeficiency virus (HIV) are the individuals most affected by the current Monkeypox virus outbreak that was first announced in May 2022. Here we report Pan-pox-specific T-cell responses in a cohort of HIV-1-infected ... ...

    Abstract People living with human immunodeficiency virus (HIV) are the individuals most affected by the current Monkeypox virus outbreak that was first announced in May 2022. Here we report Pan-pox-specific T-cell responses in a cohort of HIV-1-infected individuals after receiving the nonreplicative, attenuated smallpox vaccine JYNNEOS from Bavarian Nordic. Intradermal (i.d.) and subcutaneous (s.c.) vaccination was safe without major side effects. Dose-sparing i.d. vaccination was superior to s.c. vaccination and promoted T-cell polyfunctionality, and the expression of the gut-homing marker α4β7 integrin on lymphocytes. HIV-1-infected individuals with CD4 T-cell counts ≤500/mm
    MeSH term(s) Humans ; HIV-1 ; HIV Infections ; CD4-Positive T-Lymphocytes ; Vaccination
    Language English
    Publishing date 2023-12-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: HIV-1 trans-Infection Mediated by DCs: The Tip of the Iceberg of Cell-to-Cell Viral Transmission

    Perez-Zsolt, Daniel / Raïch-Regué, Dàlia / Muñoz-Basagoiti, Jordana / Aguilar-Gurrieri, Carmen / Clotet, Bonaventura / Blanco, Julià / Izquierdo-Useros, Nuria

    Pathogens. 2021 Dec. 31, v. 11, no. 1

    2021  

    Abstract: HIV-1 cell-to-cell transmission is key for an effective viral replication that evades immunity. This highly infectious mechanism is orchestrated by different cellular targets that utilize a wide variety of processes to efficiently transfer HIV-1 ... ...

    Abstract HIV-1 cell-to-cell transmission is key for an effective viral replication that evades immunity. This highly infectious mechanism is orchestrated by different cellular targets that utilize a wide variety of processes to efficiently transfer HIV-1 particles. Dendritic cells (DCs) are the most potent antigen presenting cells that initiate antiviral immune responses, but are also the cells with highest capacity to transfer HIV-1. This mechanism, known as trans-infection, relies on the capacity of DCs to capture HIV-1 particles via lectin receptors such as the sialic acid-binding I-type lectin Siglec-1/CD169. The discovery of the molecular interaction of Siglec-1 with sialylated lipids exposed on HIV-1 membranes has enlightened how this receptor can bind to several enveloped viruses. The outcome of these interactions can either mount effective immune responses, boost the productive infection of DCs and favour innate sensing, or fuel viral transmission via trans-infection. Here we review these scenarios focusing on HIV-1 and other enveloped viruses such as Ebola virus or SARS-CoV-2.
    Keywords Ebolavirus ; Severe acute respiratory syndrome coronavirus 2 ; antigens ; lectins ; virus replication ; virus transmission
    Language English
    Dates of publication 2021-1231
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11010039
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: HIV-1 trans -Infection Mediated by DCs

    Daniel Perez-Zsolt / Dàlia Raïch-Regué / Jordana Muñoz-Basagoiti / Carmen Aguilar-Gurrieri / Bonaventura Clotet / Julià Blanco / Nuria Izquierdo-Useros

    Pathogens, Vol 11, Iss 39, p

    The Tip of the Iceberg of Cell-to-Cell Viral Transmission

    2022  Volume 39

    Abstract: HIV-1 cell-to-cell transmission is key for an effective viral replication that evades immunity. This highly infectious mechanism is orchestrated by different cellular targets that utilize a wide variety of processes to efficiently transfer HIV-1 ... ...

    Abstract HIV-1 cell-to-cell transmission is key for an effective viral replication that evades immunity. This highly infectious mechanism is orchestrated by different cellular targets that utilize a wide variety of processes to efficiently transfer HIV-1 particles. Dendritic cells (DCs) are the most potent antigen presenting cells that initiate antiviral immune responses, but are also the cells with highest capacity to transfer HIV-1. This mechanism, known as trans -infection, relies on the capacity of DCs to capture HIV-1 particles via lectin receptors such as the sialic acid-binding I-type lectin Siglec-1/CD169. The discovery of the molecular interaction of Siglec-1 with sialylated lipids exposed on HIV-1 membranes has enlightened how this receptor can bind to several enveloped viruses. The outcome of these interactions can either mount effective immune responses, boost the productive infection of DCs and favour innate sensing, or fuel viral transmission via trans -infection. Here we review these scenarios focusing on HIV-1 and other enveloped viruses such as Ebola virus or SARS-CoV-2.
    Keywords DC ; trans -infection ; HIV-1 ; Ebola virus ; SARS-CoV-2 ; Medicine ; R
    Subject code 570
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Role of Siglecs in viral infections: A double-edged sword interaction.

    Raïch-Regué, Dàlia / Resa-Infante, Patricia / Gallemí, Marçal / Laguia, Fernando / Muñiz-Trabudua, Xabier / Muñoz-Basagoiti, Jordana / Perez-Zsolt, Daniel / Chojnacki, Jakub / Benet, Susana / Clotet, Bonaventura / Martinez-Picado, Javier / Izquierdo-Useros, Nuria

    Molecular aspects of medicine

    2022  Volume 90, Page(s) 101113

    Abstract: Sialic-acid-binding immunoglobulin-like lectins are cell surface immune receptors known as Siglecs that play a paramount role as modulators of immunity. In recent years, research has underscored how the underlaying biology of this family of receptors ... ...

    Abstract Sialic-acid-binding immunoglobulin-like lectins are cell surface immune receptors known as Siglecs that play a paramount role as modulators of immunity. In recent years, research has underscored how the underlaying biology of this family of receptors influences the outcome of viral infections. While Siglecs are needed to promote effective antiviral immune responses, they can also pave the way to viral dissemination within tissues. Here, we review how recent preclinical findings focusing on the interplay between Siglecs and viruses may translate into promising broad-spectrum therapeutic interventions or key biomarkers to monitor the course of viral infections.
    MeSH term(s) Humans ; Sialic Acid Binding Immunoglobulin-like Lectins/genetics ; Sialic Acid Binding Immunoglobulin-like Lectins/metabolism ; Virus Diseases/genetics
    Chemical Substances Sialic Acid Binding Immunoglobulin-like Lectins
    Language English
    Publishing date 2022-08-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2022.101113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1189: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Physicochemical characterization of the recombinant lectin scytovirin and microbicidal activity of the SD1 domain produced in rice against HIV-1.

    Armario-Najera, Victoria / Blanco-Perera, Amaya / Shenoy, Shilpa R / Sun, Yi / Marfil, Silvia / Muñoz-Basagoiti, Jordana / Perez-Zsolt, Daniel / Blanco, Julià / Izquierdo-Useros, Nuria / Capell, Teresa / O'Keefe, Barry R / Christou, Paul

    Plant cell reports

    2022  Volume 41, Issue 4, Page(s) 1013–1023

    Abstract: Key message: Rice-produced SD1 retains its physicochemical properties and provides efficient pre-exposure HIV-1 prophylaxis against infection in vitro. Scytovirin (SVN) is an HIV-neutralizing lectin that features two structural domains (SD1 and SD2) ... ...

    Abstract Key message: Rice-produced SD1 retains its physicochemical properties and provides efficient pre-exposure HIV-1 prophylaxis against infection in vitro. Scytovirin (SVN) is an HIV-neutralizing lectin that features two structural domains (SD1 and SD2) that bind to HIV-1 envelope glycoproteins. We expressed SD1 in rice seeds as a potential large-scale production platform and confirmed that rice-derived SD1 binds the HIV-1 envelope glycoprotein gp120 in vitro. We analyzed the thermodynamic properties of SD1 compared to full-size SVN (produced in E. coli) by isothermal titration and differential scanning calorimetry to characterize the specific interactions between SVN/SD1 and gp120 as well as to high-mannose oligosaccharides. SVN bound with moderate affinity (K
    MeSH term(s) Bacterial Proteins/metabolism ; Carrier Proteins/metabolism ; Escherichia coli/genetics ; Escherichia coli/metabolism ; HIV Envelope Protein gp120/genetics ; HIV Envelope Protein gp120/metabolism ; HIV-1 ; Lectins/chemistry ; Lectins/metabolism ; Membrane Proteins/metabolism ; Oryza/genetics ; Oryza/metabolism ; Syndactyly
    Chemical Substances Bacterial Proteins ; Carrier Proteins ; HIV Envelope Protein gp120 ; Lectins ; Membrane Proteins
    Language English
    Publishing date 2022-02-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8397-5
    ISSN 1432-203X ; 0721-085X ; 0721-7714
    ISSN (online) 1432-203X
    ISSN 0721-085X ; 0721-7714
    DOI 10.1007/s00299-022-02834-5
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    In stock of ZB MED Bonn / Germany

    Z 85/705: Show issues

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  10. Article ; Online: Plitidepsin as an Immunomodulator against Respiratory Viral Infections.

    Losada, Alejandro / Izquierdo-Useros, Nuria / Aviles, Pablo / Vergara-Alert, Júlia / Latino, Irene / Segalés, Joaquim / Gonzalez, Santiago F / Cuevas, Carmen / Raïch-Regué, Dàlia / Muñoz-Alonso, María J / Perez-Zsolt, Daniel / Muñoz-Basagoiti, Jordana / Rodon, Jordi / Chang, Lauren A / Warang, Prajakta / Singh, Gagandeep / Brustolin, Marco / Cantero, Guillermo / Roca, Núria /
    Pérez, Mònica / Bustos-Morán, Eugenio / White, Kris / Schotsaert, Michael / García-Sastre, Adolfo

    Journal of immunology (Baltimore, Md. : 1950)

    2024  Volume 212, Issue 8, Page(s) 1307–1318

    Abstract: Plitidepsin is a host-targeted compound known for inducing a strong anti-SARS-CoV-2 activity, as well as for having the capacity of reducing lung inflammation. Because IL-6 is one of the main cytokines involved in acute respiratory distress syndrome, the ...

    Abstract Plitidepsin is a host-targeted compound known for inducing a strong anti-SARS-CoV-2 activity, as well as for having the capacity of reducing lung inflammation. Because IL-6 is one of the main cytokines involved in acute respiratory distress syndrome, the effect of plitidepsin in IL-6 secretion in different in vitro and in vivo experimental models was studied. A strong plitidepsin-mediated reduction of IL-6 was found in human monocyte-derived macrophages exposed to nonproductive SARS-CoV-2. In resiquimod (a ligand of TLR7/8)-stimulated THP1 human monocytes, plitidepsin-mediated reductions of IL-6 mRNA and IL-6 levels were also noticed. Additionally, although resiquimod-induced binding to DNA of NF-κB family members was unaffected by plitidepsin, a decrease in the regulated transcription by NF-κB (a key transcription factor involved in the inflammatory cascade) was observed. Furthermore, the phosphorylation of p65 that is required for full transcriptional NF-κB activity was significantly reduced by plitidepsin. Moreover, decreases of IL-6 levels and other proinflammatory cytokines were also seen in either SARS-CoV-2 or H1N1 influenza virus-infected mice, which were treated at low enough plitidepsin doses to not induce antiviral effects. In summary, plitidepsin is a promising therapeutic agent for the treatment of viral infections, not only because of its host-targeted antiviral effect, but also for its immunomodulatory effect, both of which were evidenced in vitro and in vivo by the decrease of proinflammatory cytokines.
    MeSH term(s) Humans ; Animals ; Mice ; NF-kappa B/metabolism ; Influenza A Virus, H1N1 Subtype ; Interleukin-6/pharmacology ; Antiviral Agents/pharmacology ; Immunologic Factors/pharmacology ; Cytokines/metabolism ; SARS-CoV-2/metabolism ; Depsipeptides
    Chemical Substances NF-kappa B ; plitidepsin (Y76ID234HW) ; Interleukin-6 ; Antiviral Agents ; Immunologic Factors ; Cytokines ; Depsipeptides
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2300426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.37: Show issues Location:
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