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  1. Article ; Online: Right atrial reservoir strain and right ventricular strain improves in patients recovered from hospitalisation for non-severe COVID-19.

    Sonsoz, Mehmet Rasih / Guven, Gulden / Yildiz, Ufuk / Koyuncu, Atilla / Altuntas Aydin, Ozlem / Kahveci, Gokhan

    Acta cardiologica

    2022  Volume 78, Issue 4, Page(s) 400–408

    Abstract: Purpose: Those hospitalised with coronavirus disease 2019 (COVID-19) have recently been shown to have impaired right ventricular (RV) strain, but data about the course of heart function after discharge are limited. Our aim was to compare right ... ...

    Abstract Purpose: Those hospitalised with coronavirus disease 2019 (COVID-19) have recently been shown to have impaired right ventricular (RV) strain, but data about the course of heart function after discharge are limited. Our aim was to compare right ventricular strain and right atrial reservoir strain (RASr) associated with COVID-19 between acute disease (during hospitalisation) and follow-up (after discharge).
    Methods: In this retrospective single-center study, we analysed the echocardiograms of 43 patients hospitalised for non-severe COVID-19 between December 2020 and March 2021, undergoing echocardiography both during and after hospitalisation. In addition to conventional echocardiographic parameters, we applied 2-dimensional speckle tracking to obtain RV global longitudinal strain (RV-GLS), RV free wall strain (RV-FWS), and RASr.
    Results: Mean (standard deviation) age of the study population was 50 (9) years, and 18 (42%) of the participants were women. Median duration between exams was 6 months (range, 5-7 months). Both mean RV-GLS and mean RV-FWS significantly increased at follow-up (-20.8 [3.8] vs. -23.5 [2.8],
    Conclusion: In patients hospitalised for non-severe COVID-19 pneumonia, RV-GLS, RV-FWS, and RASr improved significantly between acute disease and 6 months after discharge.
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; Acute Disease ; Retrospective Studies ; Atrial Fibrillation ; COVID-19 ; Hospitalization ; Ventricular Function, Right ; Ventricular Dysfunction, Right
    Language English
    Publishing date 2022-06-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 390197-x
    ISSN 1784-973X ; 0001-5385
    ISSN (online) 1784-973X
    ISSN 0001-5385
    DOI 10.1080/00015385.2022.2082734
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  2. Article ; Online: HIV/SARS-CoV-2 coinfected patients in Istanbul, Turkey.

    Altuntas Aydin, Ozlem / Kumbasar Karaosmanoglu, Hayat / Kart Yasar, Kadriye

    Journal of medical virology

    2020  Volume 92, Issue 11, Page(s) 2288–2290

    MeSH term(s) Adult ; CD4 Lymphocyte Count ; COVID-19/diagnostic imaging ; COVID-19/epidemiology ; Coinfection/epidemiology ; Coinfection/virology ; Comorbidity ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Male ; Tomography, X-Ray Computed ; Turkey/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-06-03
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25955
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  3. Article ; Online: Evaluation of Bone Mineral Density in Treatment-naive Patients with Human Immundeficiency Virus Infection

    Sevtap Şenoğlu / Özlem Altuntaş Aydın

    Türk Osteoporoz Dergisi, Vol 26, Iss 2, Pp 110-

    2020  Volume 114

    Abstract: Objective:Human Immundeficiency virus (HIV) infection is a risk factor for low bone mineral density (BMD). International HIV/AIDS guidelines do not recommend BMD screening for every patient. In this study, we aimed to compare the risk factors for the ... ...

    Abstract Objective:Human Immundeficiency virus (HIV) infection is a risk factor for low bone mineral density (BMD). International HIV/AIDS guidelines do not recommend BMD screening for every patient. In this study, we aimed to compare the risk factors for the development of osteoporosis/osteopenia between patients with treatment naive HIV infection, to whom routine BMD screening is not recommended and patients with osteoporosis/osteopenia risk factors like men over 50 years of age, postmenopausal women to whom routine BMD screening is recommended.Materials and Methods:A database was created in which the demographic, clinical and laboratory features of patients with HIV infection were recorded in the infectious diseases outpatient clinic between January 2015 and June 2019. A total of 284 HIV-infected patients with dual-energy X-ray absorptiometry (DXA) measurements at admission and before antiretroviral treatment were included in the study. The characteristics of those aged ≥50 years/postmenopausal and <50 years naive HIV-infected patients with osteoporosis/osteopenia were compared.Results:Overall, 131 (46%) of 284 treatment-naive HIV-infected individuals were diagnosed with osteoporosis/osteopenia by DXA. The osteoporosis/osteopenia rate was 42.9% (106/247) and 67% (25/37) in those aged <50 and ≥50 years, respectively (p= 0.007). Osteoporosis was detected in 26 patients and 16 (61.5%) were <50 years. Further, decrease in BMD was most commonly observed in the femoral region among the elderly and in the lumbar and femoral regions among the young individuals (p<0.001).Conclusion:This study reveals a high rate of decrease in BMD among our young patients who were not exposed to antiretroviral therapy. The early detection of the presence of osteoporosis/osteopenia is important to increase the quality of life and to decrease the drug load. Therefore, we recommend performing diagnostic tests at any age in naive patients for low BMD detection and early treatment, regardless of the treatment.
    Keywords hiv ; bone mineral density ; osteoporosis ; osteopenia ; Medicine ; R ; Other systems of medicine ; RZ201-999
    Subject code 610 ; 616
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
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  4. Article ; Online: Rapid initiation of antiretroviral therapy in Turkey: a modeling study.

    Yaylali, Emine / Erdogan, Zikriye Melisa / Calisir, Fethi / Pullukcu, Husnu / Yildirim, Figen / Inan, Asuman / Aydin, Ozlem Altuntas / Tekin, Suda / Sonmezer, Meliha Cagla / Sahin, Toros / Ozcagli, Tahsin Gokcem / Ozelgun, Berna

    Frontiers in public health

    2024  Volume 12, Page(s) 1224449

    Abstract: Background: To effectively control the HIV epidemic and meet global targets, policymakers recommend the rapid initiation of antiretroviral therapy (ART). Our study aims to investigate the effect of rapid ART programs on individuals diagnosed with HIV, ... ...

    Abstract Background: To effectively control the HIV epidemic and meet global targets, policymakers recommend the rapid initiation of antiretroviral therapy (ART). Our study aims to investigate the effect of rapid ART programs on individuals diagnosed with HIV, considering varying coverage and initiation days after diagnosis, and compare it to standard-of-care ART treatment in Turkey.
    Methods: We used a dynamic compartmental model to simulate the dynamics of HIV infection in Turkey. Rapid treatment, defined as initiation of ART within 7 days of diagnosis, was contrasted with standard-of-care treatment, which starts within 30 days of diagnosis. This study considered three coverage levels (10%, 50%, and 90%) and two rapid periods (7 and 14 days after diagnosis), comparing them to standard-of-care treatment in evaluating the number of HIV infections between 2020 and 2030.
    Results: Annual HIV incidence and prevalence for a 10-year period were obtained from model projections. In the absence of a rapid ART program, the model projected approximately 444,000 new HIV cases while the number of cases were reduced to 345,000 (22% reduction) with 90% of diagnosed cases included in the rapid ART program. Similarly, 10% and 50% rapid ART coverage has resulted in 3% and 13% reduction in HIV prevalence over a 10-year period.
    Conclusion: Rapid ART demonstrates the potential to mitigate the increasing HIV incidence in Turkey by reducing the number of infections. The benefit of the rapid ART program could be substantial when the coverage of the program reaches above a certain percentage of diagnosed population.
    MeSH term(s) Humans ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/diagnosis ; Turkey/epidemiology ; Incidence ; Prevalence ; Time Factors
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1224449
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  5. Article ; Online: Increasing modified CHA2DS2-VASc risk score is associated with acute cardiac injury in hospitalised COVID-19 patients.

    Sonsoz, Mehmet Rasih / Alp, Murat Erdem / Guven, Gulden / Guler, Ahmet / Unsel, Murat / Altuntas Aydin, Ozlem

    Acta cardiologica

    2021  Volume 77, Issue 5, Page(s) 435–441

    Abstract: Background: Prediction of hospital mortality in patients with COVID-19 by the CHA2DS2VASc (M-CHA2DS2VASc) has been recently shown. Because COVID-19 patients with acute cardiac injury have higher mortality compared to those without, we assumed that this ... ...

    Abstract Background: Prediction of hospital mortality in patients with COVID-19 by the CHA2DS2VASc (M-CHA2DS2VASc) has been recently shown. Because COVID-19 patients with acute cardiac injury have higher mortality compared to those without, we assumed that this risk score may also predict acute cardiac injury in these patients.
    Methods: In this retrospective, single centre cohort study, we included 352 hospitalised patients with laboratory-confirmed COVID-19 and divided into three groups according to M-CHA2DS2VASc risk score which was created by changing gender criteria of the CHA2DS2VASc from female to male (Group 1, score 0-1 (
    Results: As the M-CHA2DS2VASc risk score increased, acute cardiac injury was also significantly increased (Group 1, 11.3%; group 2, 48.6%; group 3, 76%;
    Conclusion: Admission M-CHA2DS2VASc risk score was associated with acute cardiac injury in hospitalised patients with COVID-19.
    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; Cohort Studies ; Female ; Heart Injuries/diagnosis ; Heart Injuries/epidemiology ; Heart Injuries/etiology ; Humans ; Male ; Predictive Value of Tests ; Retrospective Studies ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 2021-07-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 390197-x
    ISSN 1784-973X ; 0001-5385
    ISSN (online) 1784-973X
    ISSN 0001-5385
    DOI 10.1080/00015385.2021.1952000
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  7. Article ; Online: HIV/SARS‐CoV‐2 coinfected patients in Istanbul, Turkey

    Altuntas Aydin, Ozlem / Kumbasar Karaosmanoglu, Hayat / Kart Yasar, Kadriye

    Journal of Medical Virology

    2020  Volume 92, Issue 11, Page(s) 2288–2290

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25955
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  8. Article ; Online: The Impact of COVID-19 on Patients with Chronic Kidney Disease and Predictive Factors for Disease Mortality

    Arzu Özdemir / Sibel Yücel Koçak / Özlem Altuntaş Aydın / Mürvet Yılmaz

    Turkish Journal of Nephrology, Vol 31, Iss 1, Pp 49-

    2022  Volume 57

    Keywords Internal medicine ; RC31-1245 ; Pediatrics ; RJ1-570
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher AVES
    Document type Article ; Online
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  9. Article: Foodborne streptococcal tonsillopharyngitis outbreak in a hospital.

    Karabela, Şemsi Nur / Şenoğlu, Sevtap / Altuntaş Aydin, Özlem / Baydili, Kürşad Nuri / Aksu, Özlem / Kart Yaşar, Kadriye

    Central European journal of public health

    2023  Volume 30, Issue 4, Page(s) 225–229

    Abstract: Objective: Group A beta-haemolytic streptococci (GAS), which are responsible for most cases of acute bacterial tonsillopharyngitis, are transmitted from person to person and may rarely cause foodborne outbreaks. This study aims to report the epidemic ... ...

    Abstract Objective: Group A beta-haemolytic streptococci (GAS), which are responsible for most cases of acute bacterial tonsillopharyngitis, are transmitted from person to person and may rarely cause foodborne outbreaks. This study aims to report the epidemic caused by GAS in our hospital and to draw attention to the explosive outbreaks of the bacteria.
    Methods: Acute tonsillopharyngitis was seen in 201 of 450 hospital employees who ate in the hospital cafeteria on 4-5 June 2015.
    Results: GAS was detected in 106 (68%) of 157 cases and in 40 (63.5%) of 62 throat culture samples. The attack rate was 44.7%. The most suspected source of the outbreak was a food handler who had been showing signs of streptococcal tonsillopharyngitis for six days, and perhaps the food prepared by these staff.
    Conclusion: It should not be forgotten that GAS can cause explosive outbreaks by infecting food through hand lesions or mouth secretions of food service personnel.
    MeSH term(s) Humans ; Streptococcus pyogenes ; Streptococcal Infections/epidemiology ; Streptococcal Infections/diagnosis ; Streptococcal Infections/microbiology ; Pharyngitis/epidemiology ; Pharyngitis/diagnosis ; Pharyngitis/microbiology ; Disease Outbreaks ; Hospitals
    Language English
    Publishing date 2023-01-30
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 1176053-9
    ISSN 1803-1048 ; 1210-7778 ; 0022-1732
    ISSN (online) 1803-1048
    ISSN 1210-7778 ; 0022-1732
    DOI 10.21101/cejph.a6027
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  10. Article ; Online: Changing Characteristics of Patients Living with HIV/AIDS After the COVID-19 Pandemic in Turkey.

    Karaosmanoglu, Hayat Kumbasar / Mete, Birgul / Gunduz, Alper / Sevgi, Dilek Yildiz / Aydin, Ozlem Altuntas / Dokmetas, Ilyas / Tabak, Fehmi

    Current HIV research

    2022  Volume 20, Issue 3, Page(s) 236–241

    Abstract: Aims: The COVID-19 pandemic has substantially changed lives and presented several barriers to health services. HIV care continuum needs a high rate of diagnosis, effective treatment, and sustained suppression of viral replication. The COVID-19 pandemic ... ...

    Abstract Aims: The COVID-19 pandemic has substantially changed lives and presented several barriers to health services. HIV care continuum needs a high rate of diagnosis, effective treatment, and sustained suppression of viral replication. The COVID-19 pandemic has affected these three steps of HIV care. This study investigated the characteristics of newly diagnosed patients living with HIV/AIDS (PLWH) during the COVID pandemic and compared them with those before the pandemic.
    Methods: All newly diagnosed patients in three HIV healthcare centers, in Istanbul, Turkey, were included in the study. The pandemic period included April 1, 2020, to April 1, 2021, and the prepandemic period included March 1, 2019, to March 1, 2020.
    Results: 756 patients were diagnosed with HIV/AIDS. In the pandemic period, this figure was 58% less: 315. Patients in the pre-pandemic and pandemic period had comparable age and gender distributions. PLWH diagnosed in the pandemic period had higher rates of low CD4 cells: low CD4 (<350 cells /mm3) was measured in 243 (36.4%) patients in the pre-pandemic period, while it was done in 126 (47.9%) in the pandemic period (p<0.01). Also, the distribution of CD4 cells was significantly different between periods: In the pandemic period, CD4 cell distribution significantly skewed to lower CD4 categories. Symptomatic patient rates and AIDS-defining disorder rates among symptomatic patients were comparable. Viral loads were not significantly different in the two periods.
    Conclusion: A low number of newly diagnosed PLWH can be explained by less HIV testing, less admission to health care, or an actual decrease of HIV prevalence during the pandemic. Sexual behaviors may have changed during the COVID-19 pandemic, leading to HIV transmission restriction. Lower CD4 counts among the newly diagnosed PLWH suggest that admittance to health care is late and a significant portion of PLWH remain undiagnosed.
    MeSH term(s) Acquired Immunodeficiency Syndrome/epidemiology ; COVID-19/epidemiology ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; Humans ; Pandemics ; Turkey/epidemiology
    Language English
    Publishing date 2022-03-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2192348-6
    ISSN 1873-4251 ; 1570-162X
    ISSN (online) 1873-4251
    ISSN 1570-162X
    DOI 10.2174/1570162X20666220303103805
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