LIVIVO - Search results -

Search results

Result 1 - 10 of total 288

Search options

Article ; Online: Howard A. Young's 4 Decades in Science: More Than Just Experiments.

Wahl, Sharon M

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

2022 Volume 42, Issue 12, Page(s) 611–617

Language	English
Publishing date	2022-08-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1226675-9
ISSN	1557-7465 ; 1079-9907
ISSN (online)	1557-7465
ISSN	1079-9907
DOI	10.1089/jir.2022.0093
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1748: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Memorial: Nancy McCartney-Francis, 1950-2014.

Wahl, Sharon M

Journal of leukocyte biology

2014 Volume 96, Issue 5, Page(s) 667–668

MeSH term(s)	Biology/history ; Famous Persons ; History, 20th Century ; History, 21st Century ; Leukocytes/immunology ; Leukocytes/metabolism
Language	English
Publishing date	2014-10-30
Publishing country	United States
Document type	Biography ; Historical Article ; Letter
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1189/jlb.4LT0614-301
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 603: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Harnessing imaging tools to guide immunotherapy trials: summary from the National Cancer Institute Cancer Imaging Steering Committee workshop.

The Lancet. Oncology

2023 Volume 24, Issue 3, Page(s) e133–e143

Abstract: As the immuno-oncology field continues the rapid growth witnessed over the past decade, optimising patient outcomes requires an evolution in the current response-assessment guidelines for phase 2 and 3 immunotherapy clinical trials and clinical care. ... ...

Abstract	As the immuno-oncology field continues the rapid growth witnessed over the past decade, optimising patient outcomes requires an evolution in the current response-assessment guidelines for phase 2 and 3 immunotherapy clinical trials and clinical care. Additionally, investigational tools-including image analysis of standard-of-care scans (such as CT, magnetic resonance, and PET) with analytics, such as radiomics, functional magnetic resonance agents, and novel molecular-imaging PET agents-offer promising advancements for assessment of immunotherapy. To document current challenges and opportunities and identify next steps in immunotherapy diagnostic imaging, the National Cancer Institute Clinical Imaging Steering Committee convened a meeting with diverse representation among imaging experts and oncologists to generate a comprehensive review of the state of the field.
MeSH term(s)	United States ; Humans ; National Cancer Institute (U.S.) ; Neoplasms ; Immunotherapy ; Image Processing, Computer-Assisted ; Medical Oncology
Language	English
Publishing date	2023-03-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(22)00742-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5696: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 460: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Transforming growth factor-beta: innately bipolar.

Wahl, Sharon M

Current opinion in immunology

2007 Volume 19, Issue 1, Page(s) 55–62

Abstract: Widely heralded for depressing ongoing immune responses, renewed interest in the proficiency by which transforming growth factor beta (TGF-beta) not only engages but also might drive an over-reactive innate response highlights its bipolar nature. ... ...

Abstract	Widely heralded for depressing ongoing immune responses, renewed interest in the proficiency by which transforming growth factor beta (TGF-beta) not only engages but also might drive an over-reactive innate response highlights its bipolar nature. Although coordination of the development and function of Treg, in addition to direct inhibition of cellular activation, are prominent pathways by which TGF-beta controls adaptive immunity, paradoxically TGF-beta appears instrumental in initiation of host responses to invasion through recruitment and activation of immune cells and persuasion of Th17 lineage commitment. Nevertheless, true to its manic-depressive behavior, new evidence links TGF-beta with depression of innate cells, including NK cells, and by way of a potential bridge between mast cells and Treg. Disruption of the tenuous balance between these opposing actions of TGF-beta underlies immunopathogenicity.
MeSH term(s)	Animals ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/immunology ; Cell Lineage/immunology ; Humans ; Immunity, Innate ; Inflammation/immunology ; Inflammation/prevention & control ; Transforming Growth Factor beta/physiology
Chemical Substances	Transforming Growth Factor beta
Language	English
Publishing date	2007-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Review
ZDB-ID	1035767-1
ISSN	1879-0372 ; 0952-7915
ISSN (online)	1879-0372
ISSN	0952-7915
DOI	10.1016/j.coi.2006.11.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2773: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 13: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Expression of APOBEC family members as regulators of endogenous retroelements and malignant transformation in systemic autoimmunity.

Mavragani, Clio P / Kirou, Kyriakos A / Nezos, Adrianos / Seshan, Surya / Wild, Teresa / Wahl, Sharon M / Moutsopoulos, Haralampos M / Crow, Mary K

Clinical immunology (Orlando, Fla.)

2020 Volume 223, Page(s) 108649

Abstract: Objective: To explore whether APOBEC family members are involved in the response to inappropriate expression of L1 retroelements in primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), as well as in SS related lymphomagenesis.: ... ...

Abstract	Objective: To explore whether APOBEC family members are involved in the response to inappropriate expression of L1 retroelements in primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), as well as in SS related lymphomagenesis. Methods: Minor salivary glands (MSG) and kidney biopsy (KB) specimens were obtained from 41 SS patients (10 with lymphoma) and 23 patients with SLE, respectively. PBMC and sera were also collected from 73 SLE patients. Full-length L1 transcripts, members of the APOBEC and IFN family were quantitated by real time PCR. Type I IFN activity was assessed in lupus plasma by a cell assay. Results: APOBEC3A was increased in SS MSG, SLE KB and PBMC and correlated with L1. AID and APOBEC3G were particularly overexpressed in MSG tissues derived from SS lymphoma patients. Conclusion: These data reveal a previously unappreciated role of APOBEC family proteins in the pathogenesis of systemic autoimmunity and SS related lymphomagenesis.
MeSH term(s)	Autoimmunity ; Cell Transformation, Neoplastic ; Cells, Cultured ; Cytidine Deaminase/genetics ; Cytidine Deaminase/metabolism ; Endogenous Retroviruses/genetics ; Gene Expression Regulation ; Humans ; Interferons/metabolism ; Kidney/physiology ; Leukocytes, Mononuclear/immunology ; Lupus Erythematosus, Systemic/immunology ; Lymphoma/immunology ; Proteins/genetics ; Proteins/metabolism ; Salivary Glands/physiology ; Sjogren's Syndrome/immunology
Chemical Substances	Proteins ; Interferons (9008-11-1) ; AICDA (activation-induced cytidine deaminase) (EC 3.5.4.-) ; APOBEC3A protein, human (EC 3.5.4.5) ; Cytidine Deaminase (EC 3.5.4.5)
Language	English
Publishing date	2020-12-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2020.108649
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 880: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The mouth: a gateway or a trap for HIV?

Malamud, Daniel / Wahl, Sharon M

AIDS (London, England)

2010 Volume 24, Issue 1, Page(s) 5–16

MeSH term(s)	Female ; HIV Infections/transmission ; HIV Infections/virology ; HIV-1 ; Humans ; Male ; Milk, Human/virology ; Mouth Mucosa/virology ; Pregnancy ; Saliva/virology
Language	English
Publishing date	2010-01-02
Publishing country	England
Document type	Editorial ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0b013e328333525f
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2228: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book: Host defense gone awry

Wahl, Sharon M

from inflammation to cancer

(The Anita B. Roberts lecture series)

2009

Abstract: CIT): The Anita B. Roberts Lecture Series This series highlights outstanding research achievements of women scientists at the NIH. The seminar is dedicated to Dr. Anita Roberts and honors her role as an exceptional mentor and scientist. Anita joined ... ...

Institution	National Institutes of Health (U.S.)
Author's details	Sharon Wahl
Series title	The Anita B. Roberts lecture series
Abstract	(CIT): The Anita B. Roberts Lecture Series This series highlights outstanding research achievements of women scientists at the NIH. The seminar is dedicated to Dr. Anita Roberts and honors her role as an exceptional mentor and scientist. Anita joined the NIH in 1976 and spent 30 years at NCI, rising to Chief of the Laboratory of Cell Regulation and Carcinogenesis. She died of gastric cancer in May 2006, leaving a legacy that touched both the professional and personal lives of all who knew her. Her work focused primarily on TGF-beta and its role in the growth of epithelial and lymphoid cells. In 2003, Thomas Scientific's Science Watch listed her among the 50 most-cited scientists during 1982 to 2002, a feature called "Twenty Years of Citation Superstars." Anita was a superstar to many for her mentoring talent and her ability to balance family and work life. Her successful lab was well known for meeting family needs and for providing an environment both intellectually and emotionally enriching. The lecture series in her name serves to highlight the fact that the NIH recognizes the value and necessity of a supportive workplace. For more information, visit http://www1.od.nih.gov/oir/sourcebook/comm-adv/wsa.htm.
MeSH term(s)	Neoplasms/etiology ; Secretory Leukocyte Peptidase Inhibitor/metabolism ; Cell Transformation, Neoplastic ; Inflammation
Language	English
Publisher	National Institutes of Health
Publishing place	Bethesda, Md
Document type	Book
Note	Open-captioned. ; Title from title screen. ; Streaming video (53 min. : sd., col.).
Database	Catalogue of the US National Library of Medicine (NLM)

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Book: IFN-[alpha], villain or hero?

Wahl, Sharon M

2008

Abstract: CIT): Dr. Wahl's laboratory studies pathways in innate and regulatory immunity and their role in pathogenesis of inflammatory disease, infection and autoimmunity. In addition to her longstanding interests regarding the pro and anti-inflammatory ... ...

Title variant	Interferon alpha, villain or hero? :
Institution	National Institutes of Health (U.S.). / Immunology Interest Group
Author's details	Sharon Wahl ; Immunology Interest Group
Abstract	(CIT): Dr. Wahl's laboratory studies pathways in innate and regulatory immunity and their role in pathogenesis of inflammatory disease, infection and autoimmunity. In addition to her longstanding interests regarding the pro and anti-inflammatory properties of TGF-β, another focus includes host-pathogen interactions and how phagocytic cells can become unwitting hosts to clever pathogens. In its bid for supremacy over its cellular targets, HIV takes host cell molecules as accomplices in enabling binding, entry, and completion of its life cycle. Although the macrophage is an enabler, it also possesses innate antiviral mechanisms, including APOBEC3 family DNA-editing enzymes. Differential expression of these enzymes, which are largely neutralized by HIV, is associated with viral susceptibility, but IFNx regulates APOBEC to render CD4+ targets tougher combatants to HIV in vitro and in AIDS patients. Although pivotal in host defense, too much IFNx can be detrimental, promoting autoimmune disease. How to harness the good and avoid the bad remains the key question.
MeSH term(s)	HIV/immunology ; Host-Pathogen Interactions ; Immunity, Innate ; Interferon-alpha/immunology ; Macrophages/immunology
Language	English
Publisher	National Institutes of Health
Publishing place	Bethesda, Md
Document type	Book
Note	Open-captioned. ; Title from title screen (viewed Apr. 9, 2009). ; Streaming video (1 hr., 39 sec. : sd., col.).
Database	Catalogue of the US National Library of Medicine (NLM)

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: TGF-beta can leave you breathless.

Qian, Bi-Feng / Wahl, Sharon M

Current opinion in pharmacology

2009 Volume 9, Issue 4, Page(s) 454–461

Abstract: Transforming growth factor-beta (TGF-beta), a ubiquitous and multifunctional cytokine, is central to the evolution and modulation of host defense. Early on, TGF-beta was recognized for its chemotactic and pro-inflammatory properties, but then ... ...

Abstract	Transforming growth factor-beta (TGF-beta), a ubiquitous and multifunctional cytokine, is central to the evolution and modulation of host defense. Early on, TGF-beta was recognized for its chemotactic and pro-inflammatory properties, but then identification of its powerful suppressive activities focused attention on dissecting its mechanisms of immune inhibition. Just as quickly as TGF-beta-mediated regulation of a population of CD4(+)CD25(+)Foxp3(+) regulatory T cells became the rage, a surprising finding that TGF-beta was the impetus behind a subset of pro-inflammatory T helper (Th)17 cells brought back a re-emphasis on its broader ability to dictate inflammatory events. Emerging evidence indicates that much remains to be discovered regarding the complex and intertwined roles of TGF-beta in inflammation, T cell lineage commitment, antibody generation, immune suppression, and tolerance. While it may appear that TGF-beta has multiple, ill-defined, contradictory and overlapping modes of activity that are impossible to unravel, the current excitement for dissecting how TGF-beta controls immunity defines a challenge worthy of pursuit. The lung is particularly vulnerable to the influences of TGF-beta, which is produced by its immune and non-immune cell populations. In its absence, lung pathology becomes lethal, whereas TGF-beta overproduction also has untoward consequences, potentially leaving one breathless, and underscoring the paradoxical, but essential contribution of TGF-beta to tissue and immune homeostasis.
MeSH term(s)	Animals ; Antibody Formation/immunology ; Cell Differentiation/immunology ; Humans ; Immune Tolerance/immunology ; Inflammation Mediators/adverse effects ; Inflammation Mediators/physiology ; Respiration/immunology ; Respiration Disorders/immunology ; Respiration Disorders/metabolism ; Respiration Disorders/pathology ; T-Lymphocyte Subsets/cytology ; T-Lymphocyte Subsets/immunology ; Transforming Growth Factor beta/physiology
Chemical Substances	Inflammation Mediators ; Transforming Growth Factor beta
Language	English
Publishing date	2009-05-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2037057-X
ISSN	1471-4973 ; 1471-4892
ISSN (online)	1471-4973
ISSN	1471-4892
DOI	10.1016/j.coph.2009.04.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5608: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseases.

Wahl, Sharon M / Chen, Wanjun

Arthritis research & therapy

2005 Volume 7, Issue 2, Page(s) 62–68

Abstract: Naturally occurring CD4+CD25+ regulatory T cells mediate immune suppression to limit immunopathogenesis associated with chronic inflammation, persistent infections and autoimmune diseases. Their mode of suppression is contact-dependent, antigen- ... ...

Abstract	Naturally occurring CD4+CD25+ regulatory T cells mediate immune suppression to limit immunopathogenesis associated with chronic inflammation, persistent infections and autoimmune diseases. Their mode of suppression is contact-dependent, antigen-nonspecific and involves a nonredundant contribution from the cytokine transforming growth factor (TGF)-beta. Not only can TGF-beta mediate cell-cell suppression between the regulatory T cells and CD4+CD25- or CD8+ T cells, but new evidence also reveals its role in the conversion of CD4+CD25- T cells, together with TCR antigen stimulation, into the regulatory phenotype. Elemental to this conversion process is induction of expression of the forkhead transcription factor, Foxp3. This context-dependent coercion of naive CD4+ T cells into a powerful subset of regulatory cells provides a window into potential manipulation of these cells to orchestrate therapeutic intervention in diseases characterized by inadequate suppression, as well as a promising means of controlling pathologic situations in which excessive suppression dominates.
MeSH term(s)	Animals ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/therapy ; Asthma/therapy ; Autoimmune Diseases/immunology ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Clonal Anergy ; Disease Models, Animal ; Forkhead Transcription Factors/biosynthesis ; Forkhead Transcription Factors/genetics ; Gene Expression Regulation ; Humans ; Immune Tolerance/immunology ; Immunotherapy, Adoptive ; Inflammation/immunology ; Lupus Erythematosus, Systemic/immunology ; Mice ; Mice, Knockout ; Receptors, Interleukin-2/analysis ; Signal Transduction/physiology ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/transplantation ; Transforming Growth Factor beta/physiology
Chemical Substances	FOXP3 protein, human ; Forkhead Transcription Factors ; Receptors, Interleukin-2 ; Transforming Growth Factor beta
Language	English
Publishing date	2005-01-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/ar1504
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5490: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito