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  1. Article: INTEREST 2022: new perspectives in HIV treatment, pathogenesis and prevention in Africa.

    Baluku, Joseph Baruch / Torpey, Kwasi

    Therapeutic advances in infectious disease

    2023  Volume 10, Page(s) 20499361231177856

    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Editorial
    ZDB-ID 2728410-4
    ISSN 2049-937X ; 2049-9361
    ISSN (online) 2049-937X
    ISSN 2049-9361
    DOI 10.1177/20499361231177856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: INTEREST 2021 conference: is Africa still hoping against hope in the fight against HIV?

    Baluku, Joseph Baruch

    Therapeutic advances in infectious disease

    2021  Volume 8, Page(s) 20499361211061293

    Language English
    Publishing date 2021-12-02
    Publishing country England
    Document type Editorial
    ZDB-ID 2728410-4
    ISSN 2049-937X ; 2049-9361
    ISSN (online) 2049-937X
    ISSN 2049-9361
    DOI 10.1177/20499361211061293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Commentary: Factors Associated With Mortality Among the COVID-19 Patients Treated at Gulu Regional Referral Hospital.

    Olum, Ronald / Baluku, Joseph Baruch

    Frontiers in public health

    2022  Volume 10, Page(s) 931309

    MeSH term(s) COVID-19 ; Hospitals ; Humans ; Referral and Consultation ; Retrospective Studies ; Uganda
    Language English
    Publishing date 2022-07-05
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.931309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Commentary

    Ronald Olum / Joseph Baruch Baluku

    Frontiers in Public Health, Vol

    Factors Associated With Mortality Among the COVID-19 Patients Treated at Gulu Regional Referral Hospital

    2022  Volume 10

    Keywords COVID ; mortality ; Uganda ; outcome ; commentary ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Roles and challenges of nurses in tuberculosis care in Africa: A narrative review.

    Baruch Baluku, Joseph / Katusabe, Shamim / Mutesi, Caroline / Bongomin, Felix

    Journal of clinical tuberculosis and other mycobacterial diseases

    2023  Volume 31, Page(s) 100366

    Abstract: Nurses form the bulk of the health care workforce in Africa although their roles and challenges in tuberculosis (TB) care are not well documented. In this article we discuss roles and challenges of nurses in TB care in Africa. Nurses in Africa are key in ...

    Abstract Nurses form the bulk of the health care workforce in Africa although their roles and challenges in tuberculosis (TB) care are not well documented. In this article we discuss roles and challenges of nurses in TB care in Africa. Nurses in Africa are key in TB prevention, diagnosis, treatment initiation, treatment monitoring, and evaluation and documentation of TB treatment outcomes. However, there is little involvement of nurses in TB-related research and policy. Challenges faced by nurses in TB care mostly relate to poor working conditions that compromise their occupational safety and mental health. There is need to expand nursing school curricula on TB to equip nurses with broad skills required for the wide repertoire of roles. Nurses should be equipped with research skills and funding opportunities for nurse-led TB research projects should be easily accessible. Occupational safety of nurses through infrastructural modification of TB units, provision of personal protective equipment and ensuring access to compensation in case a nurse develops active TB is important. Nurses also need psychosocial support given the complexity of caring for people with TB.
    Language English
    Publishing date 2023-04-01
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2405-5794
    ISSN (online) 2405-5794
    DOI 10.1016/j.jctube.2023.100366
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  6. Article ; Online: Definition of recurrence of chronic pulmonary aspergillosis; a hard nut to crack.

    Bongomin, Felix / Baluku, Joseph Baruch

    The Journal of infection

    2021  Volume 83, Issue 4, Page(s) e11

    MeSH term(s) Causality ; Humans ; Neoplasms ; Nuts ; Pulmonary Aspergillosis/diagnosis ; Pulmonary Aspergillosis/drug therapy ; Recurrence
    Language English
    Publishing date 2021-08-06
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2021.08.007
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Clinical features, resistance patterns and treatment outcomes of drug-resistant extra-pulmonary tuberculosis: A scoping review.

    Miiro, Emmanuel / Olum, Ronald / Baluku, Joseph Baruch

    Journal of clinical tuberculosis and other mycobacterial diseases

    2023  Volume 33, Page(s) 100390

    Abstract: Background: Drug-resistant tuberculosis (DR-TB) is a threat to tuberculosis (TB) control. Extra-pulmonary forms of DR-TB (DR-epTB) are not well characterized. This review summarizes the clinical features, resistance patterns and treatment outcomes of DR- ...

    Abstract Background: Drug-resistant tuberculosis (DR-TB) is a threat to tuberculosis (TB) control. Extra-pulmonary forms of DR-TB (DR-epTB) are not well characterized. This review summarizes the clinical features, resistance patterns and treatment outcomes of DR-epTB.
    Methods: We searched EMBASE to identify studies that reported drug-resistance among extra-pulmonary TB sites. All age groups were included in this review. Studies which did not describe drug-resistance patterns at extra-pulmonary TB sites were excluded. We summarized the proportion of resistance to individual anti-TB drugs as well as multi-drug resistant (MDR), pre-extensively drug resistant (pre-XDR) and extensively drug-resistant (XDR) TB.
    Results: Eighteen studies with a total of 10,222 patients with extra-pulmonary TB of whom 1,236 (12.0%) had DR-epTB, were included in this review. DR-epTB was mostly reported in young people aged 28 to 46 years. While TB meningitis is the most commonly studied form, adenitis is the commonest form of DR-epTB reported in 21% to 47%. Central nervous system TB (3.8% to 51.6%), pleural TB (11.3% to 25.9%), skeletal TB (9.4% to 18.1%), abdominal TB (4.3% to 6.5%), and disseminated TB (3.8%) are also encountered. The HIV co-infection rate is reported to be 5.0% to 81.3% while 2.6% to 25.4 % have diabetes mellitus. Clinical symptoms of DR-epTB are consistent with morbidity in the affected body system. Among patients with DR-epTB, the proportion of MDR TB was 5% to 53% while that for pre-XDR TB and XDR TB was 3% to 40% and 4% to 33%, respectively. Treatment success is achieved in 26% to 83% of patients with DR-epTB while death, treatment loss-to-follow up, and treatment failure occur in 2% to 76%, 7% to 15%, and 0% to 4% respectively. Patients with DR-epTB were reported to have poorer outcomes than those with pulmonary DR-TB and extra-pulmonary drug-susceptible TB.
    Conclusion: Clinical features of DR-epTB are similar to those observed among people with drug-susceptible EPTB but patients with DR-epTB post worse treatment outcomes.
    Language English
    Publishing date 2023-08-04
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2405-5794
    ISSN (online) 2405-5794
    DOI 10.1016/j.jctube.2023.100390
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  8. Article: Respiratory morbidity in

    Baluku, Joseph Baruch / Olum, Ronald / Sanya, Richard E / Ocama, Ponsiano

    Therapeutic advances in infectious disease

    2023  Volume 10, Page(s) 20499361231220152

    Abstract: Background: Schistosomiasis contributes to 2.5 million disability-adjusted life years globally. Acute and chronic respiratory morbidity of : Methods: We carried out a comprehensive literature search in Embase and MEDLINE from the inception of the ... ...

    Abstract Background: Schistosomiasis contributes to 2.5 million disability-adjusted life years globally. Acute and chronic respiratory morbidity of
    Methods: We carried out a comprehensive literature search in Embase and MEDLINE from the inception of the databases to 13th March 2023.
    Results: A total of 2243 patients with
    Conclusion: There is a high prevalence of respiratory morbidity among patients with
    Language English
    Publishing date 2023-12-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2728410-4
    ISSN 2049-937X ; 2049-9361
    ISSN (online) 2049-937X
    ISSN 2049-9361
    DOI 10.1177/20499361231220152
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  9. Article ; Online: Treatment outcomes of pregnant women with drug-resistant tuberculosis in Uganda: A retrospective review of 18 cases.

    Baluku, Joseph Baruch / Bongomin, Felix

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2021  Volume 105, Page(s) 230–233

    Abstract: Background: There is a dearth of reports on drug-resistant tuberculosis (DRTB) treatment outcomes among pregnant women in tuberculosis (TB)/HIV high-burdened countries. We report treatment outcomes of 18 pregnant women with DRTB in Uganda.: Methods: ... ...

    Abstract Background: There is a dearth of reports on drug-resistant tuberculosis (DRTB) treatment outcomes among pregnant women in tuberculosis (TB)/HIV high-burdened countries. We report treatment outcomes of 18 pregnant women with DRTB in Uganda.
    Methods: We reviewed charts of individuals who received DRTB treatment in Uganda across 16 DRTB treatment sites. We included all women who were pregnant during DRTB treatment and had a treatment outcome documented between 2013 and 2019.
    Results: There were 18 pregnant women with a mean age (standard deviation (SD)) of 27.5 (5.2) years, of whom 8 (44.4%) were HIV co-infected. Among these women, 12 (66.7%) had primary DRTB and 8 (44.4%) had multidrug-resistant TB. Levofloxacin (Lfx), Pyrazinamide, Cycloserine and Kanamycin (Kn) were the most (>78%) used drugs in the treatment regimen and the mean (SD) treatment duration was 17.6 (7.5) months. Elevated liver enzymes (81.8%, n = 11) and hearing loss (33.3%, n = 15) were the most frequently encountered drug adverse events. Treatment success was observed among 15 (83.3%) patients, 2 (11.1%) patients were lost to follow up and 1 (5.6%) patient died.
    Conclusion: The treatment success among pregnant women with DRTB in Uganda was high despite a high prevalence of HIV co-infection.
    MeSH term(s) Adolescent ; Adult ; Antitubercular Agents/therapeutic use ; Coinfection/drug therapy ; Female ; HIV Infections/drug therapy ; Humans ; Male ; Middle Aged ; Pregnancy ; Retrospective Studies ; Treatment Outcome ; Tuberculosis, Multidrug-Resistant/drug therapy ; Uganda ; Young Adult
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2021-02-18
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2021.02.032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Diagnostic accuracy of clinical diagnostic scoring systems for childhood tuberculosis: a systematic review and meta-analysis protocol.

    Kakinda, Michael / Olum, Ronald / Baluku, Joseph Baruch / Bongomin, Felix

    BMJ open

    2023  Volume 13, Issue 4, Page(s) e069448

    Abstract: Introduction: Diagnosis of childhood tuberculosis (TB) poses several challenges. Therefore, clinical signs and symptoms, radiological studies, laboratory examinations, point-based scoring systems or diagnostic algorithms have been developed to improve ... ...

    Abstract Introduction: Diagnosis of childhood tuberculosis (TB) poses several challenges. Therefore, clinical signs and symptoms, radiological studies, laboratory examinations, point-based scoring systems or diagnostic algorithms have been developed to improve diagnostic yields in this population. However, there are limited data on the diagnostic test accuracy of paediatric TB scoring systems. Therefore, this systematic review and meta-analysis aims to synthesise the available evidence on the diagnostic accuracy of childhood TB diagnostic scoring systems.
    Methods and analysis: This protocol describes a systematic review, developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses of Diagnostic Test Accuracy. We will conduct a comprehensive literature search for relevant articles in the following databases: PubMed, CINAHL, Embase, Scopus and Cochrane Databases. The eligibility criteria for studies will be formulated based on the Participants (Population), Index Test, Comparator Test and Target Condition criteria for the review question. The index test will be defined as any attempt to diagnose childhood TB using either a scoring system or a diagnostic algorithm, whereas a composite reference standard will be used as a reference standard. This will include any attempt to confirm diagnosis of TB. Where bacteriological confirmation is not obtained and there are at least two of the following features: chest radiograph consistent with TB, immunological evidence of
    Ethics and dissemination: This research is exempt from ethics approval given that this is a protocol for a systematic review, which uses published data. The findings from this review will be disseminated through peer-reviewed publications and scientific conferences.
    Prospero registration number: CRD42022367049.
    MeSH term(s) Humans ; Child ; Sensitivity and Specificity ; Tuberculosis/diagnosis ; Reference Standards ; Research Design ; Meta-Analysis as Topic ; Systematic Reviews as Topic
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-069448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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