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  1. Book ; Online: Classification of Lymphomas and Hematological Neoplasia in the Era of Genomic Research

    Nicolae, Alina / Carbone, Antonino

    A Themed Issue in Honor of Dr. Elaine S. Jaffe

    2022  

    Keywords Medicine ; lymphomas in PLWH ; KSHV/HHV8 ; EBV ; lymphoma classification ; management ; cART ; HLX ; HOXB9 ; NFIB ; PBX1 ; STAT3 ; TLX2 ; autoimmune hemolytic anemia ; cold agglutinin ; B-cell lymphoproliferative disorder ; lymphomagenesis ; methylation ; histone modification ; indolent ; T-cell ; NK-cell ; lymphoproliferative disorder ; gastrointestinal tract ; genetics ; cell of origin ; T follicular helper cells ; TFH lymphoma ; angioimmunoblastic T-cell lymphoma ; follicular T-cell lymphoma ; peripheral T-cell lymphoma of T-follicular helper immunophenotype ; peripheral T-cell lymphoma ; primary cutaneous B-cell lymphoma ; primary cutaneous marginal zone B-cell lymphoma ; primary cutaneous follicle centre lymphoma ; primary cutaneous diffuse large B-cell lymphoma, leg-type ; primary cutaneous diffuse large B-cell lymphoma, not otherwise specified ; intravascular B-cell lymphoma ; EBV+ mucocutaneous ulcer ; Burkitt lymphoma ; epidemiology ; Plasmodium falciparum ; Epstein Barr virus ; registry studies ; multimodal cancer ; non-Hodgkin lymphoma ; HIV/AIDS ; follicular lymphoma ; in situ follicular neoplasia ; FL transformation ; FL in young patients ; diffuse large B-cell lymphoma NOS ; high grade B-cell lymphoma ; lymphoma ; gene expression profiling ; tumor microenvironment ; diagnostics ; centrocytic lymphoma ; intermediate lymphocytic lymphoma ; Jaffe ; mantle cell lymphoma ; mantle zone lymphoma ; cyclin D1 ; lymphomas ; people living with HIV ; tumor prevention in people living with HIV ; KSHV ; BCL2 rearrangement ; genetic alterations ; histological transformation ; targeted therapies ; transformed follicular lymphoma ; lymphoproliferative neoplasms of uncertain biological significance ; monoclonal B-cell lymphocytosis ; "in situ" follicular neoplasia ; "in situ" mantle cell neoplasia ; atypical germinal centers ; large B-cell lymphoma with IRF4 rearrangement ; "in situ" high-grade B lymphomas ; Hodgkin lymphoma
    Language English
    Size 1 electronic resource (252 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030378688
    ISBN 9783036557441 ; 303655744X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Cancer Classification at the Crossroads.

    Carbone, Antonino

    Cancers

    2020  Volume 12, Issue 4

    Abstract: Internationally accepted classifications of malignant tumors, developed by the World Health Organization (WHO) and the Union for International Cancer Control (UICC), are based on the histotype, site of origin, morphologic grade, and spread of cancer ... ...

    Abstract Internationally accepted classifications of malignant tumors, developed by the World Health Organization (WHO) and the Union for International Cancer Control (UICC), are based on the histotype, site of origin, morphologic grade, and spread of cancer throughout the body. The WHO classifications are the foundation of cancer diagnosis and the starting point for cancer management. Starting in 2000, the WHO classifications began to include biologic and molecular-genetic features. These developments are having a strong impact on cancer diagnosis and treatment, and this impact is amplifying, given the advances in cancer genomics. Molecular-genetic profiling can be used to refine existing classifications of tumors and, for a small but increasing number of cancers, even determine the treatment irrespective of histotype. Here I discuss how cancer classifications may change in the era of cancer genomics.
    Language English
    Publishing date 2020-04-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12040980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: La ricerca traslazionale e il ricercatore biomedico nell'IRCCS oncologico

    Carbone, Antonino

    Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, 23 gennaio 2004

    (I supplementi di tumori ; 3,6)

    2004  

    Institution Centro di Riferimento Oncologico
    Author's details guest ed. Antonino Carbone
    Series title I supplementi di tumori ; 3,6
    I supplementi di Tumori
    Collection I supplementi di Tumori
    Language Italian
    Size S33 S. : Ill.
    Publishing place Roma
    Publishing country Italy
    Document type Book
    HBZ-ID HT014801423
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 43 -Suppl.3,6- verfügbar in Königswinter Königswinter

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  4. Article ; Online: Immune deficiency/dysregulation -associated lymphoproliferative disorders. Revised classification and management.

    Carbone, Antonino / Chadburn, Amy / Gloghini, Annunziata / Vaccher, Emanuela / Bower, Mark

    Blood reviews

    2024  Volume 64, Page(s) 101167

    Abstract: Significant advances in the field of lymphoma have resulted in two recent classification proposals, the International Consensus Classification (ICC) and the 5th edition WHO. A few entities are categorized differently in the ICC compared to the WHO. ... ...

    Abstract Significant advances in the field of lymphoma have resulted in two recent classification proposals, the International Consensus Classification (ICC) and the 5th edition WHO. A few entities are categorized differently in the ICC compared to the WHO. Nowhere is this more apparent than the immunodeficiency lymphoproliferative disorders. The three previous versions of the WHO classification (3rd, 4th and revised 4th editions) and the ICC focused on four clinical settings in which these lesions arise for primary categorization. In contrast the 2023 WHO 5th edition includes pathologic characteristics including morphology and viral status, in addition to clinical setting, as important information for lesion classification. In addition, the 2023 WHO recognizes a broader number of clinical scenarios in which these lesions arise, including not only traditional types of immune deficiency but also immune dysregulation. With this classification it is hoped that new treatment strategies will be developed leading to better patient outcomes.
    MeSH term(s) Humans ; Lymphoproliferative Disorders/diagnosis ; Lymphoproliferative Disorders/etiology ; Lymphoproliferative Disorders/therapy ; Lymphoma/pathology
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2023.101167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Tumor microenvironment contribution to checkpoint blockade therapy: lessons learned from Hodgkin lymphoma.

    Carbone, Antonino / Gloghini, Annunziata / Carlo-Stella, Carmelo

    Blood

    2023  Volume 141, Issue 18, Page(s) 2187–2193

    Abstract: Classic Hodgkin lymphoma (cHL) is characterized by a tumor microenvironment (TME) containing inflammatory/immune cells. Follicular lymphoma, mediastinal gray zone lymphoma, and diffuse large B-cell lymphomas may show a TME containing inflammatory/immune ... ...

    Abstract Classic Hodgkin lymphoma (cHL) is characterized by a tumor microenvironment (TME) containing inflammatory/immune cells. Follicular lymphoma, mediastinal gray zone lymphoma, and diffuse large B-cell lymphomas may show a TME containing inflammatory/immune cells, but the TMEs are quite different. In B-cell lymphomas and cHL, programmed cell death 1 (PD-1)-PD ligand 1 pathway blockade drugs differ in their effectiveness among patients with refractory/relapsed disease. Further research should explore innovative assays that could reveal which molecules influence sensitivity or resistance to therapy in an individual patient.
    MeSH term(s) Humans ; Hodgkin Disease/pathology ; Tumor Microenvironment ; Lymphoma, Large B-Cell, Diffuse/pathology ; Lymphoma, Follicular ; Mediastinal Neoplasms/pathology
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022016590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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  6. Article ; Online: Simultaneous occurrence of KSHV-associated malignancies in a patient affected by HIV.

    Vaccher, Emanuela / Carbone, Antonino

    Blood

    2021  Volume 137, Issue 22, Page(s) 3149

    MeSH term(s) Adult ; Castleman Disease/metabolism ; Castleman Disease/pathology ; Castleman Disease/virology ; HIV Infections/metabolism ; HIV Infections/pathology ; HIV Infections/virology ; HIV-1/metabolism ; Herpesvirus 8, Human/metabolism ; Humans ; Male ; Sarcoma, Kaposi/metabolism ; Sarcoma, Kaposi/pathology ; Sarcoma, Kaposi/virology
    Language English
    Publishing date 2021-06-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021011649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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  7. Article ; Online: Lymphomas included in the AIDS case definition: an update 30 years later.

    Vaccher, Emanuela / Chadburn, Amy / Gloghini, Annunziata / Antinori, Andrea / Bower, Mark / Carbone, Antonino

    The lancet. HIV

    2023  Volume 10, Issue 10, Page(s) e635

    Language English
    Publishing date 2023-09-06
    Publishing country Netherlands
    Document type Letter
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(23)00199-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Classification of B-Cell Lymphomas and Immunodeficiency-Related Lymphoproliferations

    Amy Chadburn / Annunziata Gloghini / Antonino Carbone

    Hemato, Vol 4, Iss 3, Pp 26-

    What’s New?

    2023  Volume 41

    Abstract: New insights from genomic studies have had an impact on the definition and the diagnosis of several lymphoid tumors including follicular B-cell lymphomas, aggressive diffuse large B-cell lymphomas, and lymphoproliferations associated with acquired and ... ...

    Abstract New insights from genomic studies have had an impact on the definition and the diagnosis of several lymphoid tumors including follicular B-cell lymphomas, aggressive diffuse large B-cell lymphomas, and lymphoproliferations associated with acquired and posttransplant immunodeficiencies. Follicular lymphoma (FL) includes tumors whose behavior varies widely from indolent/early lesions to aggressive/transformed lymphomas. Although some large B-cell lymphomas can be subclassified as specific entities, the majority lack the characteristics necessary for subclassification and, thus, are termed diffuse large B-cell lymphoma, NOS. There have been, however, some changes in the classification of specific subtypes of large B-cell lymphoma as well as the addition of new entities, a few of which are highlighted in this article. The immunodeficiency-related lymphoproliferative disorders are currently divided into four major categories based on the clinical setting in which they arose: primary immune deficiency, post-transplant, HIV infection, and iatrogenic immunosuppression. In the two upcoming classifications systems for hematolymphoid neoplasms, International Consensus Classification (ICC) and WHO-HAEM-5, there is a divergence in the approach to categorize these lesions. Furthermore, whereas the WHO-HAEM-5 confirms the ability to classify a spectrum of EBV+ lesions as EBV+ DLBCL, NOS, the ICC has separated out lesions that are composed of a heterogenous cellular infiltrate into a new separate category, “EBV-positive polymorphic B cell lymphoproliferative disorder, NOS”. Both WHO-HAEM-5 and ICC recognize a number of KSHV/HHV8-associated lymphoid lesions and acknowledge that there is significant overlap among the different lesions. In the future, translation of these innovations in general practice requires further validation.
    Keywords WHO classification ; B-cell lymphomas ; follicular lymphomas ; diffuse large B-cell lymphomas ; immunodeficiency-related lymphoproliferations ; viral-associated lymphoproliferations ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: HIV-related lymphomas.

    Vaccher, Emanuela / Gloghini, Annunziata / Carbone, Antonino

    Current opinion in oncology

    2022  Volume 34, Issue 5, Page(s) 439–445

    Abstract: Purpose of review: To summarize the recent evidence on the pathology, current standard of care and recent advances in the treatment of HIV-related lymphomas.: Recent findings: Lymphomas remain a major cause of morbidity and mortality in people living ...

    Abstract Purpose of review: To summarize the recent evidence on the pathology, current standard of care and recent advances in the treatment of HIV-related lymphomas.
    Recent findings: Lymphomas remain a major cause of morbidity and mortality in people living with HIV, even in the era of combination antiretroviral therapy (cART). However, treatment outcomes for these malignancies have improved in recent decades, due to full-dose chemotherapy, effective cART and supportive care. Recent advances include the identification of novel driving signaling pathways as promising molecular targets to improve lymphoma outcomes.
    Summary: Patients with HIV-related lymphomas who receive effective cART should be treated like the general population.
    MeSH term(s) Antiretroviral Therapy, Highly Active ; HIV Infections/drug therapy ; Humans ; Lymphoma, AIDS-Related/drug therapy ; Neoplasms/drug therapy ; Treatment Outcome
    Language English
    Publishing date 2022-07-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1049384-0
    ISSN 1531-703X ; 1040-8746
    ISSN (online) 1531-703X
    ISSN 1040-8746
    DOI 10.1097/CCO.0000000000000890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3046: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: KSHV/HHV8-Associated Lymphoproliferative Disorders

    Mark Bower / Antonino Carbone

    Hemato, Vol 2, Iss 47, Pp 703-

    Lessons Learnt from People Living with HIV

    2021  Volume 712

    Abstract: In 1992, Kaposi sarcoma herpesvirus (KSHV/HHV8) was discovered and identified as the causative agent for Kaposi sarcoma. Subsequently, the presence of this virus has been detected in a number of lymphoproliferative disorders in people living with HIV ( ... ...

    Abstract In 1992, Kaposi sarcoma herpesvirus (KSHV/HHV8) was discovered and identified as the causative agent for Kaposi sarcoma. Subsequently, the presence of this virus has been detected in a number of lymphoproliferative disorders in people living with HIV (PLWH), including: KSHV-associated multicentric Castleman disease, primary effusion lymphoma, KSHV-positive diffuse large B-cell lymphoma, and germinotropic lymphoproliferative disorder. Each of these rare entities has subsequently been diagnosed in HIV-negative individuals. The recognition of some of these KSHV/HHV8-associated lymphoproliferative disorders has led to their inclusion in the WHO classification of lymphomas in 2008 and the revision of 2016; however, further revision is under way to update the classification. The relatively recent recognition of these lymphoproliferative disorders and their low incidence, particularly in the HIV-negative population, means that there is little published evidence and consensus on their clinical features and management. The publication of a new WHO classification of lymphomas should yield diagnostic clarity, providing an impetus for retrospective case series and prospective clinical trials in these KSHV/HHV8-associated lymphoproliferative disorders.
    Keywords lymphomas in PLWH ; KSHV/HHV8 ; EBV ; lymphoma classification ; management ; cART ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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