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  1. Article: Editorial: UN world AIDS day, a neuroscience perspective.

    Diaconu, Carmen C / Ellis, Ronald J / Hermann, Dirk M

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1288615

    Language English
    Publishing date 2023-10-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1288615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Time of Day Influences Concentrations of Total Protein and Albumin in Cerebrospinal Fluid in HIV.

    Kakarla, Visesha / Letendre, Scott L / Ellis, Ronald J

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: The accumulation of soluble proteins and metabolites during wakefulness and their clearance during sleep via the glymphatic system occurs in healthy adults and is disturbed in some neurological conditions. Such diurnal variations in the cerebrospinal ... ...

    Abstract The accumulation of soluble proteins and metabolites during wakefulness and their clearance during sleep via the glymphatic system occurs in healthy adults and is disturbed in some neurological conditions. Such diurnal variations in the cerebrospinal fluid (CSF) proteins produced outside the central nervous system and entering via the blood-brain barrier (BBB) have not been evaluated in people with HIV (PWH). CSF and blood were collected in 165 PWH at six US centers between 2003 and 2007. The time of collection was compared to CSF albumin, globulin, and total protein concentrations using bivariate and multivariate regression. Participants all took antiretroviral therapy (ART) and were mostly middle-aged (median age 44.0 years) men (78.8%), with AIDS (77.0%), plasma HIV RNA ≤ 200 copies/mL (75.8%), and immune recovery (median CD4+ T-cell count 414/µL). CSF was collected at median 1:10 p.m. (range 9:00 a.m. to 5:20 p.m.) and within a median of 15 min of blood collection. A later time of CSF collection was associated with higher total protein (
    MeSH term(s) Male ; Adult ; Middle Aged ; Humans ; HIV-1/metabolism ; HIV Infections/drug therapy ; HIV Infections/complications ; Central Nervous System/metabolism ; Blood-Brain Barrier/metabolism ; Albumins/metabolism ; RNA, Viral/metabolism ; Viral Load
    Chemical Substances Albumins ; RNA, Viral
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Time of Day Influences Concentrations of Total Protein and Albumin in Cerebrospinal Fluid in HIV

    Visesha Kakarla / Scott L. Letendre / Ronald J. Ellis

    International Journal of Molecular Sciences, Vol 24, Iss 2832, p

    2023  Volume 2832

    Abstract: The accumulation of soluble proteins and metabolites during wakefulness and their clearance during sleep via the glymphatic system occurs in healthy adults and is disturbed in some neurological conditions. Such diurnal variations in the cerebrospinal ... ...

    Abstract The accumulation of soluble proteins and metabolites during wakefulness and their clearance during sleep via the glymphatic system occurs in healthy adults and is disturbed in some neurological conditions. Such diurnal variations in the cerebrospinal fluid (CSF) proteins produced outside the central nervous system and entering via the blood–brain barrier (BBB) have not been evaluated in people with HIV (PWH). CSF and blood were collected in 165 PWH at six US centers between 2003 and 2007. The time of collection was compared to CSF albumin, globulin, and total protein concentrations using bivariate and multivariate regression. Participants all took antiretroviral therapy (ART) and were mostly middle-aged (median age 44.0 years) men (78.8%), with AIDS (77.0%), plasma HIV RNA ≤ 200 copies/mL (75.8%), and immune recovery (median CD4+ T-cell count 414/µL). CSF was collected at median 1:10 p.m. (range 9:00 a.m. to 5:20 p.m.) and within a median of 15 min of blood collection. A later time of CSF collection was associated with higher total protein ( p = 0.0077) and albumin ( p = 0.057) in CSF but not in serum, and was additionally associated with higher CSF globulin ( p = 0.013). The glymphatic clearance of albumin, globulin, and total protein is preserved in PWH. The analyses of soluble biomarkers in CSF should account for the time of collection.
    Keywords HIV ; cerebrospinal fluid ; glymphatic ; biomarker ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Publisher Correction: Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management.

    Ellis, Ronald J / Marquine, María J / Kaul, Marcus / Fields, Jerel Adam / Schlachetzki, Johannes C M

    Nature reviews. Neurology

    2023  Volume 19, Issue 12, Page(s) 787

    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-023-00895-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6257: Show issues Location:
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  5. Article ; Online: Latent Profile Analysis of Cognitive Performance and Depressive Symptoms Among People with HIV.

    Kohli, Maulika / Ham, Lillian / Saloner, Rowan / Dung, Devin / Iudicello, Jennifer / Ellis, Ronald J / Moore, David J

    AIDS patient care and STDs

    2024  Volume 38, Issue 2, Page(s) 93–106

    Abstract: Depression and cognitive impairment are prevalent conditions among people with HIV (PWH), likely attributable to shared causes and common risk factors. Identifying subtypes of PWH with similar patterns of neurocognitive impairment (NCI) and depressive ... ...

    Abstract Depression and cognitive impairment are prevalent conditions among people with HIV (PWH), likely attributable to shared causes and common risk factors. Identifying subtypes of PWH with similar patterns of neurocognitive impairment (NCI) and depressive symptoms may inform development of patient-centered interventions that target-specific profiles. This study aimed to (1) classify PWH based on patterns of domain-specific NCI and depression; and (2) determine the relationship between latent class membership and pertinent clinical characteristics. PWH (
    MeSH term(s) Humans ; Male ; Female ; Depression/epidemiology ; Depression/diagnosis ; HIV Infections/complications ; Frailty ; Cognition ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/diagnosis
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1326868-5
    ISSN 1557-7449 ; 0893-5068 ; 1087-2914
    ISSN (online) 1557-7449
    ISSN 0893-5068 ; 1087-2914
    DOI 10.1089/apc.2023.0224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2328: Show issues Location:
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  6. Article ; Online: The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies.

    Ayoub, Samantha M / Holloway, Breanna M / Miranda, Alannah H / Roberts, Benjamin Z / Young, Jared W / Minassian, Arpi / Ellis, Ronald J

    Current HIV/AIDS reports

    2024  

    Abstract: Purpose of review: Cannabis may have beneficial anti-inflammatory effects in people with HIV (PWH); however, given this population's high burden of persisting neurocognitive impairment (NCI), clinicians are concerned they may be particularly vulnerable ... ...

    Abstract Purpose of review: Cannabis may have beneficial anti-inflammatory effects in people with HIV (PWH); however, given this population's high burden of persisting neurocognitive impairment (NCI), clinicians are concerned they may be particularly vulnerable to the deleterious effects of cannabis on cognition. Here, we present a systematic scoping review of clinical and preclinical studies evaluating the effects of cannabinoid exposure on cognition in HIV.
    Recent findings: Results revealed little evidence to support a harmful impact of cannabis use on cognition in HIV, with few eligible preclinical data existing. Furthermore, the beneficial/harmful effects of cannabis use observed on cognition were function-dependent and confounded by several factors (e.g., age, frequency of use). Results are discussed alongside potential mechanisms of cannabis effects on cognition in HIV (e.g., anti-inflammatory), and considerations are outlined for screening PWH that may benefit from cannabis interventions. We further highlight the value of accelerating research discoveries in this area by utilizing translatable cross-species tasks to facilitate comparisons across human and animal work.
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2151206-1
    ISSN 1548-3576 ; 1548-3568
    ISSN (online) 1548-3576
    ISSN 1548-3568
    DOI 10.1007/s11904-024-00698-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5920: Show issues Location:
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  7. Article ; Online: Neurocognition and its predictors in a linguistically and culturally diverse cohort of people with HIV.

    Breton, Jordana / Watson, Caitlin Wei-Ming / Kamalyan, Lily / Franklin, Donald / Fazeli, Pariya / Umlauf, Anya / Moore, Raeanne C / Ellis, Ronald / Grant, Igor / Heaton, Robert K / Cherner, Mariana / Moore, David J / Marquine, María J

    The Clinical neuropsychologist

    2024  , Page(s) 1–20

    Abstract: ... ...

    Abstract Objective
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 639080-8
    ISSN 1744-4144 ; 0920-1637 ; 1385-4046
    ISSN (online) 1744-4144
    ISSN 0920-1637 ; 1385-4046
    DOI 10.1080/13854046.2024.2319900
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3065: Show issues Location:
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  8. Article ; Online: Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management.

    Ellis, Ronald J / Marquine, María J / Kaul, Marcus / Fields, Jerel Adam / Schlachetzki, Johannes C M

    Nature reviews. Neurology

    2023  Volume 19, Issue 11, Page(s) 668–687

    Abstract: People living with HIV are affected by the chronic consequences of neurocognitive impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve health and extend life. Furthermore, viral suppression does not eliminate the ... ...

    Abstract People living with HIV are affected by the chronic consequences of neurocognitive impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve health and extend life. Furthermore, viral suppression does not eliminate the virus, and remaining infected cells may continue to produce viral proteins that trigger neurodegeneration. Comorbidities such as diabetes mellitus are likely to contribute substantially to CNS injury in people living with HIV, and some components of antiretroviral therapy exert undesirable side effects on the nervous system. No treatment for HIV-associated NCI has been approved by the European Medicines Agency or the US Food and Drug Administration. Historically, roadblocks to developing effective treatments have included a limited understanding of the pathophysiology of HIV-associated NCI and heterogeneity in its clinical manifestations. This heterogeneity might reflect multiple underlying causes that differ among individuals, rather than a single unifying neuropathogenesis. Despite these complexities, accelerating discoveries in HIV neuropathogenesis are yielding potentially druggable targets, including excessive immune activation, metabolic alterations culminating in mitochondrial dysfunction, dysregulation of metal ion homeostasis and lysosomal function, and microbiome alterations. In addition to drug treatments, we also highlight the importance of non-pharmacological interventions. By revisiting mechanisms implicated in NCI and potential interventions addressing these mechanisms, we hope to supply reasons for optimism in people living with HIV affected by NCI and their care providers.
    MeSH term(s) Humans ; HIV Infections/complications ; HIV Infections/drug therapy ; Central Nervous System Diseases ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/therapy
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-023-00879-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6257: Show issues Location:
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  9. Article ; Online: Cannabis and the Gut-Brain Axis Communication in HIV Infection.

    Wilson, Natalie L / Peterson, Scott N / Ellis, Ronald J

    Cannabis and cannabinoid research

    2021  Volume 6, Issue 2, Page(s) 92–104

    Abstract: People living with HIV infection (PWH) disclose that cannabis is an effective strategy for alleviating symptoms associated with HIV disease. However, some medical providers feel ill-informed to engage in evidence-based conversations. HIV leads to ... ...

    Abstract People living with HIV infection (PWH) disclose that cannabis is an effective strategy for alleviating symptoms associated with HIV disease. However, some medical providers feel ill-informed to engage in evidence-based conversations. HIV leads to alterations in the gut microbiome, gut-brain axis signaling, and chronic inflammation. The endocannabinoid system regulates homeostasis of multiple organ systems. When deficient, dysregulation of the gut-brain axis can result in chronic inflammation and neuroinflammation. Cannabis along with the naturally occurring endocannabinoids has antioxidant and anti-inflammatory properties that can support healing and restoration as an adjunctive therapy. The purpose of this literature review is to report the physiologic mechanisms that occur in the pathology of HIV and discuss potential benefits of cannabinoids in supporting health and reducing the negative effects of comorbidities in PWH.
    MeSH term(s) Brain-Gut Axis ; Cannabis ; HIV Infections/drug therapy ; Humans ; Neuroinflammatory Diseases
    Language English
    Publishing date 2021-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2867624-5
    ISSN 2378-8763 ; 2578-5125
    ISSN (online) 2378-8763
    ISSN 2578-5125
    DOI 10.1089/can.2020.0037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cannabis and Inflammation in HIV: A Review of Human and Animal Studies.

    Ellis, Ronald J / Wilson, Natalie / Peterson, Scott

    Viruses

    2021  Volume 13, Issue 8

    Abstract: Persistent inflammation occurs in people with HIV (PWH) and has many downstream adverse effects including myocardial infarction, neurocognitive impairment and death. Because the proportion of people with HIV who use cannabis is high and cannabis may be ... ...

    Abstract Persistent inflammation occurs in people with HIV (PWH) and has many downstream adverse effects including myocardial infarction, neurocognitive impairment and death. Because the proportion of people with HIV who use cannabis is high and cannabis may be anti-inflammatory, it is important to characterize the impact of cannabis use on inflammation specifically in PWH. We performed a selective, non-exhaustive review of the literature on the effects of cannabis on inflammation in PWH. Research in this area suggests that cannabinoids are anti-inflammatory in the setting of HIV. Anti-inflammatory actions are mediated in many cases through effects on the endocannabinoid system (ECS) in the gut, and through stabilization of gut-blood barrier integrity. Cannabidiol may be particularly important as an anti-inflammatory cannabinoid. Cannabis may provide a beneficial intervention to reduce morbidity related to inflammation in PWH.
    MeSH term(s) Animals ; Anti-Inflammatory Agents ; Cannabinoids ; Cannabis/immunology ; Disease Models, Animal ; Gastrointestinal Microbiome/drug effects ; HIV Infections/immunology ; HIV Infections/physiopathology ; Humans ; Inflammation/complications ; Inflammation/physiopathology ; Inflammation/virology
    Chemical Substances Anti-Inflammatory Agents ; Cannabinoids
    Language English
    Publishing date 2021-08-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13081521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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