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  1. Article ; Online: Acute tubular injury in a patient with acetaminophen toxicity.

    Duan, Zhe Ran S / Dalal, Umesh / D'Agati, Vivette / Kudose, Satoru

    Kidney international

    2023  Volume 104, Issue 3, Page(s) 623

    MeSH term(s) Humans ; Acetaminophen/adverse effects
    Chemical Substances Acetaminophen (362O9ITL9D)
    Language English
    Publishing date 2023-08-20
    Publishing country United States
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Immunofluorescence Staining for IgG Subclass: Cause for Discrepancy in the Detection of IgG1.

    Kudose, Satoru / Sekulic, Miroslav / Walavalkar, Vighnesh / Batal, Ibrahim / Stokes, M Barry / Markowitz, Glen S / D'Agati, Vivette D / Santoriello, Dominick

    Kidney international reports

    2023  Volume 8, Issue 11, Page(s) 2416–2420

    Abstract: Introduction: Immunofluorescence (IF) staining for IgG subclasses plays an important role in the classification of kidney disease. However, widely used IgG subclass-specific antibodies are now commercially unavailable. Thus, we compared alternative ... ...

    Abstract Introduction: Immunofluorescence (IF) staining for IgG subclasses plays an important role in the classification of kidney disease. However, widely used IgG subclass-specific antibodies are now commercially unavailable. Thus, we compared alternative antibodies for performing IgG subclass staining.
    Methods: A total of 21 cases were stained by 3 different methods: direct IF using fluorescein isothiocyanate (FITC)-conjugated polyclonal antibodies against IgG1-4 (commercially unavailable method), direct IF using FITC-conjugated monoclonal antibodies (clones HP-6091, 6014, 6050, and 6025), indirect IF using monoclonal antibodies (clones HP-6069, 6002, 6050, and 6025), and FITC-conjugated polyclonal secondary antibody. For cases with discrepancy in IgG1 staining, additional direct IF using FITC-conjugated monoclonal antibody (clone 4E3) was performed.
    Results: Of 21 cases, 11 (52%) had no staining for IgG1 by direct IF using the clone HP-6091 despite ≥1+ staining by the direct IF using polyclonal antibodies. Similarly, direct IF for IgG1 using the clone 4E3 had negative result in all 10 cases with available tissue. However, indirect IF for IgG1 using the clone HP-6069 had similar staining intensity (within 1 order of magnitude) as direct IF using the polyclonal antibodies (10 of 10). Results of IF for IgG2, IgG3, and IgG4 were similar in most cases.
    Conclusion: The choice of antibodies influences the result of IgG subclass staining, especially for anti-IgG1 antibodies, in which 2 monoclonal antibodies (HP6091 and 4E3) appear less sensitive. Although this may be due to unaccounted variables and requires confirmation, our results may partially explain the difference in IgG1 staining in the literature and underscore the need for careful validation.
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.08.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Non-neoplastic kidney diseases

    D'Agati, Vivette / Jennette, J. Charles / Silva, Fred G.

    (Atlas of nontumor pathology ; Ser. 1, fasc. 4)

    2005  

    Author's details Vivette D. D'Agati ; J. Charles Jennette ; Fred G. Silva
    Series title Atlas of nontumor pathology ; Ser. 1, fasc. 4
    Collection
    Keywords Kidney Diseases / pathology ; Kidney / abnormalities ; Kidney / pathology
    Language English
    Size XVII, 721 S. : zahlr. Ill.
    Publisher American Registry of Pathology u.a.
    Publishing place Washington, DC
    Publishing country United States
    Document type Book
    HBZ-ID HT014933397
    ISBN 1-881041-96-4 ; 978-1-881041-96-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 4392 order for loan Magazin

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  4. Article ; Online: Outcomes of Sentinel Lymph Node Biopsy for Patients With Node-positive Breast Cancer Treated With Neoadjuvant Chemotherapy.

    Cipolla, Calogero / Vieni, Salvatore / D'Agati, Eleonora / Grassi, Nello / Genova, Pietro / Graceffa, Giuseppa / Vigneri, Paolo / Gebbia, Vittorio / Valerio, Maria Rosaria

    Anticancer research

    2023  Volume 43, Issue 10, Page(s) 4643–4649

    Abstract: Background/aim: Clinical trials have shown that the sentinel lymph node biopsy (SLNB) is feasible for patients with cN1 breast carcinoma treated with neoadjuvant chemotherapy (NAC). This study aimed to evaluate the technical outcomes of SLNB by ... ...

    Abstract Background/aim: Clinical trials have shown that the sentinel lymph node biopsy (SLNB) is feasible for patients with cN1 breast carcinoma treated with neoadjuvant chemotherapy (NAC). This study aimed to evaluate the technical outcomes of SLNB by assessing the volume of residual nodal disease.
    Patients and methods: All patients with cT1-3 cN1 breast cancer undergoing NAC from January 2018 to December 2021 were retrospectively identified from our institutional database. We assessed the outcomes of preoperative clinical examination, ultrasonography, and other imaging to predict the axillary nodal status after NAC for patients converted to cN0 and undergoing SLNB; both adequate mapping and false-negative rate (FNR) at intraoperative evaluation of SLN were assessed.
    Results: Overall 160 patients were included in the study; 98 were converted to cN0 and underwent SLNB. No difference was found in the adequate mapping rate nor in the mean number of SLNs retrieved compared to the residual LN burden. The intraoperative SLN FNR was 38.2%, with smaller nodal volume being associated with lower FNR (p<0.01). The positive predictive values of physical examination and imaging-based nodal assessment post-NAC were 87.1% and 68.2%, respectively.
    Conclusion: In a significant percentage of patients with cN1 disease converted to cN0 after NAC, it was possible to recover three or more SLNs. The residual volume of LN disease did not impact the SLN mapping rate. However, we found a high FNR for intraoperative SLN evaluation, particularly for patients with small residual nodal disease. It seems that only a small proportion of patients eligible for SLNB after NAC can be spared ALND.
    Language English
    Publishing date 2023-07-17
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Two Cases of Proliferative Glomerulonephritis With Monoclonal IgG Deposits Treated With Renin Angiotensin Inhibition Alone With Long-term Follow-up.

    Rosenstock, Jordan L / Vynnyk, Marianna / DeVita, Maria V / D'Agati, Vivette D

    Kidney international reports

    2021  Volume 6, Issue 8, Page(s) 2218–2222

    Language English
    Publishing date 2021-05-17
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2021.05.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Authors' Reply.

    Sethi, Sanjeev / Rajkumar, Vincent / D'Agati, Vivette D

    Journal of the American Society of Nephrology : JASN

    2018  Volume 29, Issue 12, Page(s) 2902

    MeSH term(s) Humans ; Kidney ; Kidney Diseases
    Language English
    Publishing date 2018-11-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2018101003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3344: Show issues Location:
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  7. Article ; Online: Correlation between sentinel lymph node biopsy and non-sentinel lymph node metastasis in patients with cN0 breast carcinoma: comparison of invasive ductal carcinoma and invasive lobular carcinoma.

    Cipolla, Calogero / Lupo, Simona / Grassi, Nello / Tutino, Giuseppe / Greco, Martina / Eleonora, D'Agati / Gebbia, Vittorio / Valerio, Maria Rosaria

    World journal of surgical oncology

    2024  Volume 22, Issue 1, Page(s) 100

    Abstract: Background: Some studies have suggested that axillary lymph node dissection (ALND) can be avoided in women with cN0 breast cancer with 1-2 positive sentinel nodes (SLNs). However, these studies included only a few patients with invasive lobular ... ...

    Abstract Background: Some studies have suggested that axillary lymph node dissection (ALND) can be avoided in women with cN0 breast cancer with 1-2 positive sentinel nodes (SLNs). However, these studies included only a few patients with invasive lobular carcinoma (ILC), so the validity of omitting ALDN in these patients remains controversial. This study compared the frequency of non-sentinel lymph nodes (non-SLNs) metastases in ILC and invasive ductal carcinoma (IDC).
    Materials methods: Data relating to a total of 2583 patients with infiltrating breast carcinoma operated at our institution between 2012 and 2023 were retrospectively analyzed: 2242 (86.8%) with IDC and 341 (13.2%) with ILC. We compared the incidence of metastasis to SLNs and non-SLNs between the ILC and IDC cohorts and examined factors that influenced non-SLNs metastasis.
    Results: SLN biopsies were performed in 315 patients with ILC and 2018 patients with IDC. Metastases to the SLNs were found in 78/315 (24.8%) patients with ILC and in 460 (22.8%) patients with IDC (p = 0.31). The incidence of metastases to non-SLNs was significantly higher (p = 0.02) in ILC (52/78-66.7%) compared to IDC (207/460 - 45%). Multivariate analysis showed that ILC was the most influential predictive factor in predicting the presence of metastasis to non-SLNs.
    Conclusions: ILC cases have more non-SLNs metastases than IDC cases in SLN-positive patients. The ILC is essential for predicting non-SLN positivity in macro-metastases in the SLN. The option of omitting ALND in patients with ILC with 1-2 positive SLNs still requires further investigation.
    MeSH term(s) Humans ; Female ; Sentinel Lymph Node Biopsy ; Lymphatic Metastasis/pathology ; Carcinoma, Lobular/pathology ; Retrospective Studies ; Carcinoma, Ductal, Breast/pathology ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Sentinel Lymph Node/surgery ; Sentinel Lymph Node/pathology ; Lymph Node Excision ; Lymph Nodes/pathology ; Axilla/pathology
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118383-1
    ISSN 1477-7819 ; 1477-7819
    ISSN (online) 1477-7819
    ISSN 1477-7819
    DOI 10.1186/s12957-024-03375-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: COVID-19 booster enhances IgG mediated viral neutralization by human milk

    Valcarce, Vivian / Stafford, Lauren Stewart / Neu, Josef / Parker, Leslie / Vicuna, Valeria / Cross, Tyler / D'Agati, Olivia / Diakite, Sisse / Haley, Addison / Feigenbaum, Jake / Al Mahmoud, Mahmoud Y / Visvalingam, Anjali / Cacho, Nicole / Kosik, Ivan / Yewdell, Jonathan W / Larkin, Joseph

    Frontiers in nutrition

    2024  Volume 11, Page(s) 1289413

    Abstract: Background: Facilitated by the inability to vaccinate, and an immature immune system, COVID-19 remains a leading cause of death among children. Vaccinated lactating mothers produce specific SARS-CoV-2 antibodies in their milk, capable of neutralizing ... ...

    Abstract Background: Facilitated by the inability to vaccinate, and an immature immune system, COVID-19 remains a leading cause of death among children. Vaccinated lactating mothers produce specific SARS-CoV-2 antibodies in their milk, capable of neutralizing the virus
    Methods: Thirty-nine mothers and 25 infants were enrolled from December 2020 to May 2022. Milk, maternal plasma, and infants' stool were collected at various time-points up to 12 months following mRNA COVID-19 vaccination. A subgroup of 14 mothers received a booster dose. SARS-CoV-2 antibody levels and their neutralization capacities were assessed.
    Results: Booster vaccination led to significantly higher IgG levels within human milk and breastfed infants' stool.
    Discussion: The substantial increase in neutralizing IgG levels in milk and breastfed infants' stool post-booster, coupled with the decrease in milk neutralization capabilities upon IgG depletion, underscores the efficacy of booster doses in augmenting the immune response against SARS-CoV-2 in human milk.
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2024.1289413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Podocyte injury can be catching.

    D'Agati, Vivette

    Journal of the American Society of Nephrology : JASN

    2011  Volume 22, Issue 7, Page(s) 1181–1183

    MeSH term(s) Animals ; Glomerulosclerosis, Focal Segmental/etiology ; Glomerulosclerosis, Focal Segmental/pathology ; Podocytes/pathology
    Language English
    Publishing date 2011-07
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2011050486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Intestinal TLR9 deficiency exacerbates hepatic IR injury via altered intestinal inflammation and short-chain fatty acid synthesis.

    Han, Sang Jun / Kim, Mihwa / Novitsky, Ella / D'Agati, Vivette / Lee, H Thomas

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2020  Volume 34, Issue 9, Page(s) 12083–12099

    Abstract: Mice deficient in intestinal epithelial TLR9 develop small intestinal Paneth cell hyperplasia and higher Paneth cell IL-17A levels. Since small intestinal Paneth cells and IL-17A play critical roles in hepatic ischemia reperfusion (IR) injury, we tested ... ...

    Abstract Mice deficient in intestinal epithelial TLR9 develop small intestinal Paneth cell hyperplasia and higher Paneth cell IL-17A levels. Since small intestinal Paneth cells and IL-17A play critical roles in hepatic ischemia reperfusion (IR) injury, we tested whether mice lacking intestinal TLR9 have increased hepatic IR injury. Mice lacking intestinal TLR9 had profoundly increased liver injury after hepatic IR compared to WT mice with exacerbated hepatocyte necrosis, apoptosis, neutrophil infiltration, and inflammatory cytokine generation. Moreover, we observed increased small intestinal inflammation and apoptosis after hepatic IR in intestinal TLR9 deficient mice. As a potential explanation for increased hepatic IR injury, fecal short-chain fatty acids butyrate and propionate levels were lower in intestinal TLR9 deficient mice. Suggesting a potential therapy for hepatic IR, exogenous administration of butyrate or propionate protected against hepatic IR injury in intestinal TLR9 deficient mice. Mechanistically, butyrate induced small intestinal IL-10 expression and downregulated the claudin-2 expression. Finally, IL-10 neutralization abolished the protective effects of butyrate against hepatic IR injury. Our studies show intestinal TLR9 deficiency results in exacerbated hepatic IR injury with increased small intestinal apoptosis and inflammation. Furthermore, short-chain fatty acids butyrate and propionate protect against hepatic IR injury and intestinal apoptosis/inflammation in intestinal TLR9 deficient mice.
    MeSH term(s) Animals ; Apoptosis/genetics ; Apoptosis/immunology ; Fatty Acids/genetics ; Fatty Acids/immunology ; Hepatocytes/immunology ; Hepatocytes/pathology ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/pathology ; Interleukin-10/genetics ; Interleukin-10/immunology ; Intestine, Small/immunology ; Intestine, Small/pathology ; Liver Diseases/genetics ; Liver Diseases/immunology ; Liver Diseases/pathology ; Mice ; Mice, Knockout ; Reperfusion Injury/genetics ; Reperfusion Injury/immunology ; Reperfusion Injury/pathology ; Toll-Like Receptor 9/deficiency ; Toll-Like Receptor 9/immunology
    Chemical Substances Fatty Acids ; IL10 protein, mouse ; Tlr9 protein, mouse ; Toll-Like Receptor 9 ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2020-08-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202000314R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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