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  1. Article ; Online: Abemaciclib for malignant pleural mesothelioma.

    Nardone, Valerio / Porta, Camillo / Giannicola, Rocco / Correale, Pierpaolo / Mutti, Luciano

    The Lancet. Oncology

    2022  Volume 23, Issue 6, Page(s) e237

    MeSH term(s) Aminopyridines/therapeutic use ; Benzimidazoles/adverse effects ; Humans ; Mesothelioma, Malignant/drug therapy
    Chemical Substances Aminopyridines ; Benzimidazoles ; abemaciclib (60UAB198HK)
    Language English
    Publishing date 2022-06-22
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00276-5
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    Zs.A 5696: Show issues Location:
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  2. Article ; Online: CONFIRM trial: what is the real efficacy of second-line immunotherapy in mesothelioma?

    Correale, Pierpaolo / Pentimalli, Francesca / Nardone, Valerio / Giordano, Antonio / Mutti, Luciano

    The Lancet. Oncology

    2021  Volume 23, Issue 1, Page(s) e13

    Language English
    Publishing date 2021-12-30
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(21)00702-6
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  3. Article ; Online: RAMES study: is there really a role for VEGF inhibition in mesothelioma?

    Porta, Camillo / Nardone, Valerio / Gray, Steven G / Correale, Pierpaolo / Mutti, Luciano

    The Lancet. Oncology

    2021  Volume 22, Issue 12, Page(s) e532

    MeSH term(s) Humans ; Mesothelioma/drug therapy ; Mesothelioma, Malignant ; Vascular Endothelial Growth Factor A
    Chemical Substances Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2021-12-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(21)00640-9
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  4. Article ; Online: The Optimal Choice of Local Therapy for Stage IIIA-N2 NSCLC: Is Radiotherapy Inferior to Surgery?

    Nardone, Valerio / Correale, Pierpaolo / Guida, Cesare

    The Annals of thoracic surgery

    2019  Volume 108, Issue 3, Page(s) 961–962

    MeSH term(s) Carcinoma, Non-Small-Cell Lung/surgery ; Humans ; Lung Neoplasms/surgery ; Neoplasm Staging ; Network Meta-Analysis ; Pneumonectomy
    Language English
    Publishing date 2019-03-07
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2019.01.071
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    Zs.A 252: Show issues Location:
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  5. Article ; Online: Comparing Addition of Radiotherapy in EGFR- and ALK-Positive NSCLC With Brain Metastases: Are We Evaluating the Optimal End Point?

    Nardone, Valerio / Correale, Pierpaolo / Mutti, Luciano / Desideri, Isacco / Romeo, Caterina / Pastina, Pierpaolo / Tagliaferri, Pierosandro / Caraglia, Michele / Reginelli, Alfonso / Pirtoli, Luigi / Cappabianca, Salvatore

    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

    2022  Volume 17, Issue 2, Page(s) e10–e12

    MeSH term(s) Brain Neoplasms/radiotherapy ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; ErbB Receptors/genetics ; Humans ; Lung Neoplasms/radiotherapy ; Receptor Protein-Tyrosine Kinases
    Chemical Substances EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2432037-7
    ISSN 1556-1380 ; 1556-0864
    ISSN (online) 1556-1380
    ISSN 1556-0864
    DOI 10.1016/j.jtho.2021.09.019
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  6. Article: Is There Already a Need of Reckoning on Cancer Immunotherapy?

    Correale, Pierpaolo / Pentimalli, Francesca / Baglio, Giovanni / Krstic-Demonacos, Marjia / Saladino, Rita Emilena / Giordano, Antonio / Mutti, Luciano

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 638279

    Language English
    Publishing date 2021-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.638279
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  7. Article ; Online: Aromatase Inhibitors-Induced Musculoskeletal Disorders: Current Knowledge on Clinical and Molecular Aspects.

    Tenti, Sara / Correale, Pierpaolo / Cheleschi, Sara / Fioravanti, Antonella / Pirtoli, Luigi

    International journal of molecular sciences

    2020  Volume 21, Issue 16

    Abstract: Aromatase inhibitors (AIs) have radically changed the prognosis of hormone receptor positive breast cancer (BC) in post-menopausal women, and are a mainstay of the adjuvant therapy for BC after surgery in place of, or following, Tamoxifen. However, AIs ... ...

    Abstract Aromatase inhibitors (AIs) have radically changed the prognosis of hormone receptor positive breast cancer (BC) in post-menopausal women, and are a mainstay of the adjuvant therapy for BC after surgery in place of, or following, Tamoxifen. However, AIs aren't side effect-free; frequent adverse events involve the musculoskeletal system, in the form of bone loss, AI-associated arthralgia (AIA) syndrome and autoimmune rheumatic diseases. In this narrative review, we reported the main clinical features of these three detrimental conditions, their influence on therapy adherence, the possible underlying molecular mechanisms and the available pharmacological and non-pharmacological treatments. The best-known form is the AIs-induced osteoporosis, whose molecular pathway and therapeutic possibilities were extensively investigated in the last decade. AIA syndrome is a high prevalent joint pain disorder which often determines a premature discontinuation of the therapy. Several points still need to be clarified, as a universally accepted diagnostic definition, the pathogenetic mechanisms and satisfactory management strategies. The association of AIs therapy with autoimmune diseases is of the utmost interest. The related literature has been recently expanded, but many issues remain to be explored, the first being the molecular mechanisms.
    MeSH term(s) Animals ; Aromatase Inhibitors/adverse effects ; Aromatase Inhibitors/pharmacology ; Aromatase Inhibitors/therapeutic use ; Breast Neoplasms/drug therapy ; Clinical Trials as Topic ; Estrogens/biosynthesis ; Estrogens/metabolism ; Female ; Humans ; Musculoskeletal Diseases/chemically induced ; Musculoskeletal Diseases/pathology ; Musculoskeletal Diseases/physiopathology
    Chemical Substances Aromatase Inhibitors ; Estrogens
    Language English
    Publishing date 2020-08-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21165625
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  8. Article ; Online: Aromatase Inhibitors—Induced Musculoskeletal Disorders

    Sara Tenti / Pierpaolo Correale / Sara Cheleschi / Antonella Fioravanti / Luigi Pirtoli

    International Journal of Molecular Sciences, Vol 21, Iss 5625, p

    Current Knowledge on Clinical and Molecular Aspects

    2020  Volume 5625

    Abstract: Aromatase inhibitors (AIs) have radically changed the prognosis of hormone receptor positive breast cancer (BC) in post-menopausal women, and are a mainstay of the adjuvant therapy for BC after surgery in place of, or following, Tamoxifen. However, AIs ... ...

    Abstract Aromatase inhibitors (AIs) have radically changed the prognosis of hormone receptor positive breast cancer (BC) in post-menopausal women, and are a mainstay of the adjuvant therapy for BC after surgery in place of, or following, Tamoxifen. However, AIs aren’t side effect-free; frequent adverse events involve the musculoskeletal system, in the form of bone loss, AI-associated arthralgia (AIA) syndrome and autoimmune rheumatic diseases. In this narrative review, we reported the main clinical features of these three detrimental conditions, their influence on therapy adherence, the possible underlying molecular mechanisms and the available pharmacological and non-pharmacological treatments. The best-known form is the AIs-induced osteoporosis, whose molecular pathway and therapeutic possibilities were extensively investigated in the last decade. AIA syndrome is a high prevalent joint pain disorder which often determines a premature discontinuation of the therapy. Several points still need to be clarified, as a universally accepted diagnostic definition, the pathogenetic mechanisms and satisfactory management strategies. The association of AIs therapy with autoimmune diseases is of the utmost interest. The related literature has been recently expanded, but many issues remain to be explored, the first being the molecular mechanisms.
    Keywords aromatase inhibitors ; breast cancer ; aromatase inhibitors-associated arthralgia ; autoimmune rheumatic diseases ; musculoskeletal disorders ; hormonal anti-estrogen therapy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: HLA-B*44 and C*01 Prevalence Correlates with Covid19 Spreading across Italy.

    Correale, Pierpaolo / Mutti, Luciano / Pentimalli, Francesca / Baglio, Giovanni / Saladino, Rita Emilena / Sileri, Pierpaolo / Giordano, Antonio

    International journal of molecular sciences

    2020  Volume 21, Issue 15

    Abstract: The spread of COVID-19 is showing huge, unexplained, differences between northern and southern Italy. We hypothesized that the regional prevalence of specific class I human leukocyte antigen (HLA) alleles, which shape the anti-viral immune response, ... ...

    Abstract The spread of COVID-19 is showing huge, unexplained, differences between northern and southern Italy. We hypothesized that the regional prevalence of specific class I human leukocyte antigen (HLA) alleles, which shape the anti-viral immune response, might partly underlie these differences. Through an ecological approach, we analyzed whether a set of HLA alleles (A, B, C), known to be involved in the immune response against infections, correlates with COVID-19 incidence. COVID-19 data were provided by the National Civil Protection Department, whereas HLA allele prevalence was retrieved through the Italian Bone-Marrow Donors Registry. Among all the alleles, HLA-A*25, B*08, B*44, B*15:01, B*51, C*01, and C*03 showed a positive log-linear correlation with COVID-19 incidence rate fixed on 9 April 2020 in proximity of the national outbreak peak (Pearson's coefficients between 0.50 and 0.70,
    MeSH term(s) COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/genetics ; Coronavirus Infections/immunology ; Gene Frequency ; HLA-B44 Antigen/genetics ; HLA-C Antigens/genetics ; Humans ; Italy/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/genetics ; Pneumonia, Viral/immunology ; Prevalence ; Registries ; Regression Analysis
    Chemical Substances HLA-B44 Antigen ; HLA-C Antigens
    Keywords covid19
    Language English
    Publishing date 2020-07-23
    Publishing country Switzerland
    Document type Journal Article ; Observational Study
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21155205
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  10. Article ; Online: Music therapy and radiation oncology: State of art and future directions.

    Nardone, Valerio / Vinciguerra, Claudia / Correale, Pierpaolo / Guida, Cesare / Tini, Paolo / Reginelli, Alfonso / Cappabianca, Salvatore

    Complementary therapies in clinical practice

    2020  Volume 39, Page(s) 101124

    Abstract: Background: Effectiveness of music-based interventions (Music therapy, MT) on cancer patients' is a current research theme. Oncology patients may respond to radiation treatment (RT) with anxiety expressed as stress, fear, depression, and frustration.: ...

    Abstract Background: Effectiveness of music-based interventions (Music therapy, MT) on cancer patients' is a current research theme. Oncology patients may respond to radiation treatment (RT) with anxiety expressed as stress, fear, depression, and frustration.
    Objectives: The aim of this review is to discuss the effectiveness of MT in patients undergoing RT.
    Data sources: All English medical papers registered in the Web of Knowledge, PubMed, Google Scholar and ScienceDirect from March 1999 to March 2019.
    Inclusion and exclusion criteria: We selected all the articles concerning the use of MT in pre-RT anxiety and distress during RT treatment.
    Results: Out of 1184 articles selected, 132 abstracts were analyzed and 13 papers were finally evaluated for the current analysis, for a total of 946 participants.
    Discussion: We investigated the role and the efficacy of MT for patients receiving RT and the future challenges in the clinical management of oncology patients before and during radiotherapy.
    MeSH term(s) Anxiety/therapy ; Depression/therapy ; Humans ; Music Therapy/methods ; Neoplasms/psychology ; Radiation Oncology
    Language English
    Publishing date 2020-02-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2182834-9
    ISSN 1873-6947 ; 1744-3881
    ISSN (online) 1873-6947
    ISSN 1744-3881
    DOI 10.1016/j.ctcp.2020.101124
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