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  1. Article ; Online: E-textile tooling

    Posch, Irene

    Journal of innovation and entrepreneurship : JIE Vol. 6, No. 10 , p. 1-19

    new tools-new culture?

    2017  Volume 6, Issue 10, Page(s) 1–19

    Abstract: Background: The maker movement in recent years has shed light on the blurring boundaries between crafts, creativity, and technology. Tools are a key part of the creation process, shaping both our process of making and the objects we make. They do so ... ...

    Author's details Irene Posch
    Abstract Background: The maker movement in recent years has shed light on the blurring boundaries between crafts, creativity, and technology. Tools are a key part of the creation process, shaping both our process of making and the objects we make. They do so through their form and material influence, the matter they can handle, as well as the skills needed to utilize them. Often, tools also evoke stereotypical associations of who is using them and what is being produced with them. Findings and Conclusions: In the following, I focus on needlework tools and the crafting of electronic textiles. I introduce research into the shape and aesthetics of needlework tools that incorporate the functionality of electronic probes. On a functional level, they can be used to construct pieces of textile crafts as well as to connect and test their electrical functions while making. On a metaphorical level, they allude to a possible alternative realm of creating electronic devices and components. In connecting the skills and aesthetics of textile crafting to electronic objects, we want to spark an exchange between different making cultures and enable diverse approaches for expression.
    Keywords Making ; Maker culture ; Electronics ; Crafting ; Tools ; Diversity ; Materiality ; Design
    Language English
    Size Online-Ressource
    Publisher SpringerOpen
    Publishing place Heidelberg
    Document type Article ; Online
    ZDB-ID 2679760-4
    ISSN 2192-5372
    ISSN 2192-5372
    DOI 10.1186/s13731-017-0067-y
    Database ECONomics Information System

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  2. Article ; Online: Mortality in Recreational Mountain-Biking in the Austrian Alps: A Retrospective Study over 16 Years.

    Pocecco, Elena / Wafa, Hamed / Burtscher, Johannes / Paal, Peter / Plattner, Peter / Posch, Markus / Ruedl, Gerhard

    International journal of environmental research and public health

    2022  Volume 19, Issue 19

    Abstract: Despite recreational mountain-biking's growing popularity worldwide, the literature on mortality in this leisure sporting activity is scarce. Therefore, the aim of the present study was to investigate the characteristics of fatal accidents as well as ... ...

    Abstract Despite recreational mountain-biking's growing popularity worldwide, the literature on mortality in this leisure sporting activity is scarce. Therefore, the aim of the present study was to investigate the characteristics of fatal accidents as well as resulting dead victims during recreational mountain-biking in the Austrian Alps over the past 16 years. For this purpose, a retrospective study based on Austrian institutional documentation from 2006 to 2021 was conducted. In total, 97 fatalities (1 woman) with a mean age of 55.6 ± 13.9 years were recorded by the Austrian Alpine Police. Of those, 54.6% died due to a non-traumatic (mostly cardio-vascular) and 41.2% due to a traumatic event. Mountain-bikers fatally accidented for non-traumatic reasons frequently belonged to older age classes (
    MeSH term(s) Accidents ; Adult ; Aged ; Austria/epidemiology ; Bicycling ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Sports
    Language English
    Publishing date 2022-09-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph191911965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A novel method to estimate the response of habitat types to nitrogen deposition.

    Wamelink, G W W / Goedhart, P W / Roelofsen, H D / Bobbink, R / Posch, M / van Dobben, H F / Biurrun, I / Bonari, G / Dengler, J / Dítě, D / Garbolino, E / Jansen, J / Jašková, A K / Lenoir, J / Peterka, T

    Environmental pollution (Barking, Essex : 1987)

    2024  Volume 349, Page(s) 123844

    Abstract: Increasing nitrogen depositions adversely affect European landscapes, including habitats within the Natura2000 network. Critical loads for nitrogen deposition have been established to quantify the loss of habitat quality. When the nitrogen deposition ... ...

    Abstract Increasing nitrogen depositions adversely affect European landscapes, including habitats within the Natura2000 network. Critical loads for nitrogen deposition have been established to quantify the loss of habitat quality. When the nitrogen deposition rises above a habitat-specific critical load, the quality of the focal habitat is expected to be negatively influenced. Here, we investigate how the quality of habitat types is affected beyond the critical load. We calculated response curves for 60 terrestrial habitat types in the Netherlands to the estimated nitrogen deposition (EMEP-data). The curves for habitat types are based on the occurrence of their characteristic plant species in North-Western Europe (plot data from the European Vegetation Archive). The estimated response curves were corrected for soil type, mean annual temperature and annual precipitation. Evaluation was carried out by expert judgement, and by comparison with gradient deposition field studies. For 39 habitats the response to nitrogen deposition was judged to be reliable by five experts, while out of the 41 habitat types for which field studies were available, 25 showed a good agreement. Some of the curves showed a steep decline in quality and some a more gradual decline with increasing nitrogen deposition. We compared the response curves with both the empirical and modelled critical loads. For 41 curves, we found a decline already starting below the critical load.
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2024.123844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Heat tolerance of a tropical-subtropical rainforest tree species Polyscias elegans: time-dependent dynamic responses of physiological thermostability and biochemistry.

    Zhu, Lingling / Scafaro, Andrew P / Vierling, Elizabeth / Ball, Marilyn C / Posch, Bradley C / Stock, Frederike / Atkin, Owen K

    The New phytologist

    2023  Volume 241, Issue 2, Page(s) 715–731

    Abstract: Heat stress interrupts physiological thermostability and triggers biochemical responses that are essential for plant survival. However, there is limited knowledge on the speed plants adjust to heat in hours and days, and which adjustments are crucial. ... ...

    Abstract Heat stress interrupts physiological thermostability and triggers biochemical responses that are essential for plant survival. However, there is limited knowledge on the speed plants adjust to heat in hours and days, and which adjustments are crucial. Tropical-subtropical rainforest tree species (Polyscias elegans) were heated at 40°C for 5 d, before returning to 25°C for 13 d of recovery. Leaf heat tolerance was quantified using the temperature at which minimal chl a fluorescence sharply rose (T
    MeSH term(s) Heat-Shock Proteins/metabolism ; Plants/metabolism ; Rainforest ; Temperature ; Thermotolerance ; Trees/metabolism ; Tropical Climate
    Chemical Substances Heat-Shock Proteins
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    DOI 10.1111/nph.19356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Fetal sex and maternal fasting glucose affect neonatal cord blood-derived endothelial progenitor cells.

    Weiss, Elisa / Leopold-Posch, Barbara / Schrüfer, Anna / Cvitic, Silvija / Hiden, Ursula

    Pediatric research

    2022  Volume 92, Issue 6, Page(s) 1590–1597

    Abstract: Background: Maternal cardiovascular risk factors (CVRF) in pregnancy, i.e., obesity and ... maternal metabolic parameters.: Results: Male ECFC grew out earlier (-20.57% days; p = 0.031 ... at midpregnancy increased the time required for colony outgrowth (OR: 1.019; p = 0.030), which, after stratifying ...

    Abstract Background: Maternal cardiovascular risk factors (CVRF) in pregnancy, i.e., obesity and hyperglycemia, transmit to the fetus and affect placental and fetal endothelial function. Moreover, a sex dimorphism in endothelial function and susceptibility towards CVRF exists already in utero. Endothelial colony-forming cells (ECFC) are circulating endothelial progenitors highly present in neonatal cord blood and sensitive to CVRF. This study investigated whether fetal sex or subtle maternal metabolic changes within healthy range alter fetal ECFC outgrowth.
    Methods: Outgrowth of ECFC from cord blood of male (n = 31) and female (n = 26) neonates was analyzed after healthy pregnancies and related to fetal sex and maternal metabolic parameters.
    Results: Male ECFC grew out earlier (-20.57% days; p = 0.031) than female. Although all women were non-diabetic, higher levels of fasting plasma glucose (FPG) at midpregnancy increased the time required for colony outgrowth (OR: 1.019; p = 0.030), which, after stratifying for fetal sex, was significant only in the males. Gestational weight gain and BMI did not affect outgrowth. Colony number was unchanged by all parameters.
    Conclusions: Fetal sex and maternal FPG within normal range alter ECFC function in utero. A role of ECFC in postnatal angiogenesis and vasculogenesis has been suggested, which may be affected by altered outgrowth dynamics.
    Impact: This study is the first to report that a sexual dimorphism exists in ECFC function, as cells of female progeny require a longer period of time until colony outgrowth than ECFC of male progeny. Our data show that ECFC function is highly sensitive and affected by maternal glucose levels even in a normal, non-diabetic range. Our data raise the question of whether maternal plasma glucose in pregnancy should be considered to play a critical role even in the non-diabetic setting.
    MeSH term(s) Infant, Newborn ; Humans ; Female ; Male ; Pregnancy ; Endothelial Progenitor Cells ; Glucose ; Fetal Blood ; Blood Glucose/metabolism ; Cells, Cultured ; Placenta ; Fasting
    Chemical Substances Glucose (IY9XDZ35W2) ; Blood Glucose
    Language English
    Publishing date 2022-02-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-022-01966-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Learning From Limited Data: Towards Best Practice Techniques for Antimicrobial Resistance Prediction From Whole Genome Sequencing Data.

    Lüftinger, Lukas / Májek, Peter / Beisken, Stephan / Rattei, Thomas / Posch, Andreas E

    Frontiers in cellular and infection microbiology

    2021  Volume 11, Page(s) 610348

    Abstract: Antimicrobial resistance prediction from whole genome sequencing data (WGS) is an emerging application of machine learning, promising to improve antimicrobial resistance surveillance and outbreak monitoring. Despite significant reductions in sequencing ... ...

    Abstract Antimicrobial resistance prediction from whole genome sequencing data (WGS) is an emerging application of machine learning, promising to improve antimicrobial resistance surveillance and outbreak monitoring. Despite significant reductions in sequencing cost, the availability and sampling diversity of WGS data with matched antimicrobial susceptibility testing (AST) profiles required for training of WGS-AST prediction models remains limited. Best practice machine learning techniques are required to ensure trained models generalize to independent data for optimal predictive performance. Limited data restricts the choice of machine learning training and evaluation methods and can result in overestimation of model performance. We demonstrate that the widely used random k-fold cross-validation method is ill-suited for application to small bacterial genomics datasets and offer an alternative cross-validation method based on genomic distance. We benchmarked three machine learning architectures previously applied to the WGS-AST problem on a set of 8,704 genome assemblies from five clinically relevant pathogens across 77 species-compound combinations collated from public databases. We show that individual models can be effectively ensembled to improve model performance. By combining models
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial/genetics ; Genome, Bacterial/genetics ; Microbial Sensitivity Tests ; Whole Genome Sequencing
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-02-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.610348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: HLA-DRB3*02:61Q , a novel HLA-DRB3 allele identified in a volunteer bone marrow donor.

    Ulrich, S / Matzhold, E / Posch, U / Schlenke, P / Helmberg, W

    HLA

    2017  Volume 90, Issue 3, Page(s) 186–187

    Abstract: HLA-DRB3*02:61Q , a novel HLA-DRB3 allele identified in a volunteer bone marrow donor. ...

    Abstract HLA-DRB3*02:61Q , a novel HLA-DRB3 allele identified in a volunteer bone marrow donor.
    MeSH term(s) Alleles ; Bone Marrow ; HLA-DRB3 Chains/genetics ; Humans ; Tissue Donors
    Chemical Substances HLA-DRB3 Chains
    Language English
    Publishing date 2017-06-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2845111-9
    ISSN 2059-2310 ; 2059-2302
    ISSN (online) 2059-2310
    ISSN 2059-2302
    DOI 10.1111/tan.13061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Ruxolitinib, IV Immunoglobulin, and High-Dose Glucocorticoids for Critically Ill Adults With Secondary Hemophagocytic Lymphohistiocytosis: A Single-Center Observational Pilot Study.

    Scholz, Laura / Posch, Florian / Schulz, Eduard / Gornicec, Max / Wölfler, Albert / Reisinger, Alexander C / Reinisch, Andreas / Eller, Philipp / Eisner, Florian / Kreuzer, Philipp / Stradner, Martin / Rosenkranz, Alexander R / Krammer, Florian / Schilcher, Gernot / Krause, Robert / Hatzl, Stefan

    Critical care explorations

    2024  Volume 6, Issue 2, Page(s) e1046

    Abstract: Objectives: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a cytokine-driven inflammatory syndrome that is associated with substantial morbidity and mortality and frequently leads to ICU admission. Overall survival in adults with sHLH remains ... ...

    Abstract Objectives: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a cytokine-driven inflammatory syndrome that is associated with substantial morbidity and mortality and frequently leads to ICU admission. Overall survival in adults with sHLH remains poor, especially in those requiring intensive care. Classical chemotherapeutic treatment exhibits myelosuppression and toxicity. Recently, inhibition of Janus kinase signaling by ruxolitinib has shown efficacy in pediatric HLH. We therefore aimed to determine the activity and safety of a ruxolitinib-based regimen, in critically ill adults with sHLH.
    Design: Observational pilot study.
    Setting: Single-center tertiary academic ICU.
    Patients: Nine adults (≥ 18 yr) who fulfilled at least five of the eight HLH-2004 criteria.
    Intervention: Triplet regimen combining: 1) ruxolitinib, 2) polyvalent human IV immunoglobulins (IVIG) at a dose of 1 g/kg bodyweight for 5 days, and 3) high-dose corticosteroids (CSs, dexamethasone 10 mg/m² body surface area, or methylprednisolone equivalent) with subsequent tapering according to the HLH-2004 protocol.
    Measurement and main results: Nine patients (median age: 42 yr [25th-75th percentile: 32-54]; male:
    Conclusion: In this small case series, a triplet regimen of ruxolitinib in combination with IVIG and CS was highly effective and save for treating critically ill adults with sHLH.
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000001046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Improving Spatial Hearing when Wearing Ski Helmets in Order to Increase Safety on Ski Slopes.

    Seebacher, Josef / Posch, Markus / Zelger, Philipp / Pocecco, Elena / Burtscher, Martin / Zorowka, Patrick G / Ruedl, Gerhard

    International journal of environmental research and public health

    2022  Volume 19, Issue 23

    Abstract: This study investigated the effect of a new type of ear pads for ski helmets on the hearing performance of 13 young adults (mean age: 22 years). Free-field hearing thresholds and sound localization performance of the subjects were assessed in three ... ...

    Abstract This study investigated the effect of a new type of ear pads for ski helmets on the hearing performance of 13 young adults (mean age: 22 years). Free-field hearing thresholds and sound localization performance of the subjects were assessed in three conditions: without helmet, with a conventional helmet and with the modified helmet. Results showed that the modified helmet was superior to the conventional helmet in all respects, but did not allow for a performance level observed without a helmet. Considering the importance of precise hearing and sound localization during alpine skiing, acoustically improved ear pads of ski helmets, as demonstrated in this study, can essentially contribute to enhancing the safety on ski slopes.
    Language English
    Publishing date 2022-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192315905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Atrial fibrillation and cancer: prevalence and relative risk from a nationwide study.

    Ay, Cihan / Grilz, Ella / Nopp, Stephan / Moik, Florian / Königsbrügge, Oliver / Klimek, Peter / Thurner, Stefan / Posch, Florian / Pabinger, Ingrid

    Research and practice in thrombosis and haemostasis

    2022  Volume 7, Issue 1, Page(s) 100026

    Abstract: Background: Atrial fibrillation (AF) is an increasingly recognized codiagnosis in patients with cancer.: Objectives: This study aimed to provide a robust and contemporary estimate on the coprevalence and relative risk of AF in patients with cancer.!## ...

    Abstract Background: Atrial fibrillation (AF) is an increasingly recognized codiagnosis in patients with cancer.
    Objectives: This study aimed to provide a robust and contemporary estimate on the coprevalence and relative risk of AF in patients with cancer.
    Methods: We conducted a nationwide analysis, utilizing diagnosis codes from the Austrian Association of Social Security Providers dataset. Estimates of the coprevalence of cancer and AF and the relative risk of AF in patients with cancer compared with individuals without cancer were obtained as point prevalences with binomial exact confidence intervals and summarized across age groups and cancer types with random-effects models.
    Results: Overall, 8,306,244 persons were included in the present analysis, of whom 158,675 (prevalence estimate, 1.91%; 95% CI, 1.90-1.92) had a cancer diagnosis code and 112,827 (1.36%; 95% CI, 1.35-1.36) an AF diagnosis code, respectively. The prevalence estimate for AF in patients with cancer was 9.77% (95% CI, 9.63-9.92) and 1.19% (95% CI, 1.19-1.20) in the noncancer population. Conversely, 13.74% (95% CI, 13.54-13.94) of patients with AF had a concurrent cancer diagnosis. The corresponding age-stratified random-effects relative risk ratio for AF in patients with cancer compared with no cancer diagnosis was 10.45 (95% CI, 7.47-14.62). The strongest associations between cancer and AF were observed in younger persons and patients with hematologic malignancies.
    Conclusion: Cancer and AF have a substantial coprevalence in the population. This finding corroborates the concept that cancer and AF have common risk factors and pathophysiology.
    Language English
    Publishing date 2022-12-23
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2022.100026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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