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  1. Article ; Online: Substance use and spine density: a systematic review and meta-analysis of preclinical studies.

    Oliva, Henrique Nunes Pereira / Prudente, Tiago Paiva / Nunes, Eric J / Cosgrove, Kelly P / Radhakrishnan, Rajiv / Potenza, Marc N / Angarita, Gustavo A

    Molecular psychiatry

    2024  

    Abstract: The elucidation of synaptic density changes provides valuable insights into the underlying brain mechanisms of substance use. In preclinical studies, synaptic density markers, like spine density, are altered by substances of abuse (e.g., alcohol, ... ...

    Abstract The elucidation of synaptic density changes provides valuable insights into the underlying brain mechanisms of substance use. In preclinical studies, synaptic density markers, like spine density, are altered by substances of abuse (e.g., alcohol, amphetamine, cannabis, cocaine, opioids, nicotine). These changes could be linked to phenomena including behavioral sensitization and drug self-administration in rodents. However, studies have produced heterogeneous results for spine density across substances and brain regions. Identifying patterns will inform translational studies given tools that now exist to measure in vivo synaptic density in humans. We performed a meta-analysis of preclinical studies to identify consistent findings across studies. PubMed, ScienceDirect, Scopus, and EBSCO were searched between September 2022 and September 2023, based on a protocol (PROSPERO: CRD42022354006). We screened 6083 publications and included 70 for meta-analysis. The meta-analysis revealed drug-specific patterns in spine density changes. Hippocampal spine density increased after amphetamine. Amphetamine, cocaine, and nicotine increased spine density in the nucleus accumbens. Alcohol and amphetamine increased, and cannabis reduced, spine density in the prefrontal cortex. There was no convergence of findings for morphine's effects. The effects of cocaine on the prefrontal cortex presented contrasting results compared to human studies, warranting further investigation. Publication bias was small for alcohol or morphine and substantial for the other substances. Heterogeneity was moderate-to-high across all substances. Nonetheless, these findings inform current translational efforts examining spine density in humans with substance use disorders.
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Systematic Review
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-024-02519-3
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    Zs.A 4812: Show issues Location:
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  2. Article ; Online: A dinâmica regional dos royalties do petróleo no território rural Sertão Central Cabugi e Litoral Norte, Rio Grande do Norte

    Emanoel Márcio Nunes / Ellen Sarah da Silva Azevedo / Daiane Kelly de Queiroz

    Geosul, Vol 38, Iss

    2023  Volume 87

    Abstract: O objetivo é analisar os reflexos da distribuição dos royalties do petróleo sobre a dinâmica regional de crescimento e de desenvolvimento do território rural Sertão Central Cabugi e Litoral Norte, no Rio Grande do Norte. Como metodologia foi realizado um ...

    Abstract O objetivo é analisar os reflexos da distribuição dos royalties do petróleo sobre a dinâmica regional de crescimento e de desenvolvimento do território rural Sertão Central Cabugi e Litoral Norte, no Rio Grande do Norte. Como metodologia foi realizado um teste de correlação do Índice FIRJAN de Desenvolvimento Municipal (IFDM) com os royalties do petróleo e o Produto Interno Bruto (PIB). Os dados utilizados foram de fonte secundária e consistiu no período de 2010 a 2016, gerando uma análise descritiva dos mesmos. Foram coletados através do endereço eletrônico do Instituto Brasileiro de Geografia e Estatística (IBGE), InfoRoyalties, a partir de Agência Nacional do Petróleo (ANP), extraídos diretamente do banco de dados, e do O Índice FIRJAN de Desenvolvimento Municipal (IFDM), extraídos da base de dados do Sistema Firjan. Os resultados mostraram que os municípios de Galinhos, Guamaré e Macau obtiveram o maior valor em arrecadação de royalties. Assim, foi possível concluir que houve uma relação linear entre o IFDM e os royalties e entre os PIB e os royalties, através do teste de correlação.
    Keywords Royalties do Petróleo ; Desenvolvimento ; Crescimento ; Território ; Human ecology. Anthropogeography ; GF1-900 ; Physical geography ; GB3-5030 ; Geography (General) ; G1-922
    Language Portuguese
    Publishing date 2023-08-01T00:00:00Z
    Publisher Universidade Federal de Santa Catarina
    Document type Article ; Online
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  3. Article ; Online: Does static stretching change uniformly the quadriceps elasticity in physically actives subjects?

    Nonnenmacher, Carolina Holz / Nunes, Iohana / de Moura, Bruno Monteiro / Diefenthaeler, Fernando / Lima, Kelly Mônica Marinho E

    Journal of ultrasound

    2022  Volume 25, Issue 4, Page(s) 915–921

    Abstract: Purpose: Verify the acute responses of static stretching (SS) on the rectus femoris (RF), vastus medialis (VM), and vastus lateralis (VL) elasticity and knee/hip range of motion (ROM). Additionally, to investigate if there are consistency among ... ...

    Abstract Purpose: Verify the acute responses of static stretching (SS) on the rectus femoris (RF), vastus medialis (VM), and vastus lateralis (VL) elasticity and knee/hip range of motion (ROM). Additionally, to investigate if there are consistency among quadriceps muscle elasticity after SS.
    Methods: Acute effect of SS on pre-post-intervention design. Thirtheen healthy participants (both genders) proposed for a pre-post experimental design. RF, VM, and VL elasticity (strain ratio, SR) was evaluated bilaterally by ultrasound with quasi-static elastography. Higher SR values refer to more rigid tissues. A SS protocol of 3 series of 30 s was applied at right lower limb. The left lower limb was considered as control group. Also, photogrammetry evaluated the knee/hip ROM.
    Results: For SR muscle comparisons, VM was lower (less stiff) than VL and RF at pre- and post-SS. For time comparisons, no differences were observed for SR and ROM at pre- and post-SS. However, the effect size of the quadriceps SR at SS lower limb was higher than control.
    Conclusion: Acute effects of SS did not change the quadriceps SR or knee/hip ROM in healthy and active subjects. Non-uniform quadriceps SR are observed (VM < VL and RF) independently of SS. Future studies should consider different protocols, muscles, and populations.
    MeSH term(s) Humans ; Female ; Male ; Quadriceps Muscle/diagnostic imaging ; Muscle Stretching Exercises ; Knee/physiology ; Knee Joint/diagnostic imaging ; Elasticity ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/physiology
    Language English
    Publishing date 2022-04-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2365426-0
    ISSN 1876-7931 ; 1971-3495
    ISSN (online) 1876-7931
    ISSN 1971-3495
    DOI 10.1007/s40477-021-00649-w
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  4. Article ; Online: Importance of land use and rainfall in the dynamics of the Caatinga vegetation cover in Northeastern Brazil

    Lucas Nunes de Araujo / Fernanda Kelly Gomes da Silva / Maria Betânia Ribeiro Gonçalves Medeiros / Dilma Maria de Brito Melo Trovão

    Acta Scientiarum: Biological Sciences, Vol 45, Iss

    2023  Volume 1

    Abstract: Many factors, such as climate, land use, and cultural and social aspects, influence the vegetation cover dynamics. We aimed to analyze the vegetation cover dynamics in three municipalities of the Brazilian semi-arid region (Aroeiras, Boqueirão, and Congo, ...

    Abstract Many factors, such as climate, land use, and cultural and social aspects, influence the vegetation cover dynamics. We aimed to analyze the vegetation cover dynamics in three municipalities of the Brazilian semi-arid region (Aroeiras, Boqueirão, and Congo, state of Paraíba, Brazil) and to check for the influence of land use and inter-annual variations in rainfall. We selected 18 Landsat satellite images between 1995 and 2017. We performed supervised classification based on pre-established regions of interest: Closed or conserved vegetation, Sparse or disturbed vegetation, Exposed soil, Water bodies, clouds, and shadows, according to color, shape, and texture criteria. In addition, we collected data from the IBGE's Agricultural Census and annual rainfall. Variations in land use and rainfall variations worked synergistically on vegetation cover dynamics. In the municipality of Congo, very wet years were associated with higher percentages of closed vegetation and decreased soil exposure. High percentages of land use were related to a higher cover of sparse vegetation and exposed soil. In Boqueirão, we observed the opposite phenomenon, with drier years associated with higher percentages of closed vegetation and exposed soil. In Aroeiras, we identified no clear relationship between rainfall and variations in vegetation cover. Similar to that observed in the other municipalities, the abandonment of agricultural and cattle ranching activities increased dense vegetation. Our results show that the analysis of land use and vegetation cover dynamics in the semi-arid region represents a complex task ranging from regional factors, such as climate, characterized by inter-annual rainfall variations, to local factors, such as land use intensity and demographic/social aspects.
    Keywords temporal analysis ; remote sensing ; semi-arid ; Landsat ; Biology (General) ; QH301-705.5 ; Microbiology ; QR1-502
    Subject code 910
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Universidade Estadual de Maringá
    Document type Article ; Online
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  5. Article ; Online: Telehealth cognitive behaviour therapy for the management of sleep disturbance in women with early breast cancer receiving chemotherapy: a feasibility study.

    Carson, Emma-Kate / Dhillon, Haryana M / Vardy, Janette L / Brown, Chris / Nunes-Zlotkowski, Kelly Ferrao / Della-Fiorentina, Stephen / Khan, Sarah / Parsonson, Andrew / Roncoloato, Felicia / Pearson, Antonia / Barnes, Tristan / Kiely, Belinda E

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2024  Volume 32, Issue 6, Page(s) 375

    Abstract: Purpose: Sleep quality commonly deteriorates in people receiving chemotherapy for breast cancer (BC). We aimed to determine feasibility and acceptability of telehealth-delivered cognitive behaviour therapy for insomnia (CBT-I) in people with early BC ... ...

    Abstract Purpose: Sleep quality commonly deteriorates in people receiving chemotherapy for breast cancer (BC). We aimed to determine feasibility and acceptability of telehealth-delivered cognitive behaviour therapy for insomnia (CBT-I) in people with early BC receiving (neo)adjuvant chemotherapy.
    Methods: Multi-centre, single arm, phase 2 feasibility trial. People with stage I-III BC received 4 sessions of telehealth CBT-I over 8 weeks, during chemotherapy. Participants completed Pittsburgh Sleep Quality Index (PSQI) and other Patient Reported Outcome Measures (PROMs) at baseline, post-program (week 9) and post-chemotherapy (week 24); and an Acceptability Questionnaire at week 9. Primary endpoint was proportion completing 4 sessions of telehealth CBT-I.
    Results: In total, 41 participants were recruited: mean age 51 years (range 31-73). All 4 CBT-I sessions were completed by 35 (85%) participants. Acceptability of the program was high and 71% reported 'the program was useful'. There was no significant difference in the number of poor sleepers (PSQI score ≥ 5) at baseline 29/40 (73%) and week 24 17/25 (68%); or in the mean PSQI score at baseline (7.43, SD 4.06) and week 24 (7.48, SD 4.41). From baseline to week 24, 7/25 (28%) participants had a ≥ 3 point improvement in sleep quality on PSQI, and 5/25 (20%) had a ≥ 3 point deterioration. There was no significant difference in mean PROM scores.
    Conclusion: It is feasible to deliver telehealth CBT-I to people with early BC receiving chemotherapy. Contrary to literature predictions, sleep quality did not deteriorate. Telehealth CBT-I has a potential role in preventing and managing sleep disturbance during chemotherapy. Australian New Zealand Clinical Trials Registry (ANZCTR) registration number: ACTRN12620001379909 and date 22/12/2020.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/complications ; Breast Neoplasms/therapy ; Telemedicine ; Middle Aged ; Feasibility Studies ; Aged ; Adult ; Cognitive Behavioral Therapy/methods ; Sleep Wake Disorders/etiology ; Sleep Wake Disorders/therapy ; Sleep Initiation and Maintenance Disorders/etiology ; Sleep Initiation and Maintenance Disorders/therapy ; Surveys and Questionnaires ; Sleep Quality ; Patient Reported Outcome Measures
    Language English
    Publishing date 2024-05-23
    Publishing country Germany
    Document type Journal Article ; Multicenter Study ; Clinical Trial, Phase II
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-024-08554-8
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    Zs.A 3697: Show issues Location:
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  6. Article ; Online: HLA imputation, what is it good for?

    Meyer, Diogo / Nunes, Kelly

    Human immunology

    2017  Volume 78, Issue 3, Page(s) 239–241

    MeSH term(s) Computational Biology ; Computer Simulation ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; HLA Antigens/genetics ; High-Throughput Nucleotide Sequencing ; Histocompatibility Testing ; Humans ; Linkage Disequilibrium ; Polymorphism, Single Nucleotide
    Chemical Substances HLA Antigens
    Language English
    Publishing date 2017-03-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 801524-7
    ISSN 1879-1166 ; 0198-8859
    ISSN (online) 1879-1166
    ISSN 0198-8859
    DOI 10.1016/j.humimm.2017.02.007
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    Zs.A 1597: Show issues Location:
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  7. Article: Biallelic EPCAM deletions induce tissue-specific DNA repair deficiency and cancer predisposition.

    Forster, V J / Aronson, M / Zhang, C / Chung, J / Sudhaman, S / Galati, M A / Kelly, J / Negm, L / Ercan, A B / Stengs, L / Durno, C / Edwards, M / Komosa, M / Oldfield, L E / Nunes, N M / Pedersen, S / Wellum, J / Siddiqui, I / Bianchi, V /
    Weil, B R / Fox, V L / Pugh, T J / Kamihara, J / Tabori, U

    NPJ precision oncology

    2024  Volume 8, Issue 1, Page(s) 69

    Abstract: We report a case of Mismatch Repair Deficiency (MMRD) caused by germline homozygous EPCAM deletion leading to tissue-specific loss of MSH2. Through the use of patient-derived cells and organoid technologies, we performed stepwise in vitro differentiation ...

    Abstract We report a case of Mismatch Repair Deficiency (MMRD) caused by germline homozygous EPCAM deletion leading to tissue-specific loss of MSH2. Through the use of patient-derived cells and organoid technologies, we performed stepwise in vitro differentiation of colonic and brain organoids from reprogrammed EPCAM
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ISSN 2397-768X
    ISSN 2397-768X
    DOI 10.1038/s41698-024-00537-6
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  8. Article: Online but not remote: Adapting field-based ecology laboratories for online learning.

    Richter, Christoph F / Lortie, Christopher J / Kelly, Tamara L / Filazzola, Alessandro / Nunes, Krystal A / Sarkar, Raani

    Ecology and evolution

    2020  Volume 11, Issue 8, Page(s) 3616–3624

    Abstract: Teaching ecology effectively and experientially has become more challenging for at least two reasons today. Most experiences of our students are urban, and we now face the near immediate and continuing need to deliver courses (either partially or wholly) ...

    Abstract Teaching ecology effectively and experientially has become more challenging for at least two reasons today. Most experiences of our students are urban, and we now face the near immediate and continuing need to deliver courses (either partially or wholly) online because of COVID-19. Therefore, providing a learning experience that connects students to their environment within an ecological framework remains crucial and perhaps therapeutic to mental health. Here, we describe how prior to the pandemic we adapted our field-based laboratories to include data collection, analysis, and interpretation, along with the development of a citizen-science approach for online delivery. This design is simple to implement, does not require extensive work, and maintains the veracity of original learning outcomes. Collaboration online following field data collection in ecology courses within the context of cities offers further options to adapt to student experience levels, resource availability, and accessibility, as well as bringing instructors and students together to build an open well-curated data set that can be used in ecology courses where no laboratories are available. Finally, it promotes an open collaboration among ecology instructors that can drive lasting conversations about ecology curriculum.
    Language English
    Publishing date 2020-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.7008
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  9. Article ; Online: Physıologıcal benefıts of resıstance traınıng ın depressıve persons

    Kelly Cristina Nunes Silva / Maria Gisele Santos

    International Journal of Medical Reviews and Case Reports, Vol 3, Iss

    a lıterature revıew

    2019  Volume 4

    Abstract: The current society, due to the technological advance, excessive collections, reigning individualism, among others, is faced with a significant increase of individuals with depression. Some authors conceptualize depression as a disease where the ... ...

    Abstract The current society, due to the technological advance, excessive collections, reigning individualism, among others, is faced with a significant increase of individuals with depression. Some authors conceptualize depression as a disease where the individual feels inferior to everything and everyone, with no capacity and willingness to face the challenges, because it presents a feeling of fear of failure, thus promoting a reduction of the feeling of pleasure, irritability, feelings of guilt and, in more serious cases, suicidal thoughts.The concept of depression is applied to a mood disorder, encompassing cognitive, behavioral, physiological, social, economic and religious factors, since depression is considered an evil that is rooted in the individual's "I" interfering in a negative way the course of their thoughts and decisions. In addition to these characteristic feelings of depression, points out that depression also generates disorders at the brain level, due to the dysregulation of essential neurotransmitters, as well as the reduction of cognitive function, which promotes the formulation and decision of an adequate response front to a stressor event.Resistance training, which presents a voluntary action of the skeletal muscle against a resistance, through stimuli, promoting metabolic stress and developing different types of strength in the individual, from neuromuscular and hormonal adaptations and cognitive function, when associated to an organized training program, considering questions related to the load, volume, order and interval of the exercises. Therefore, with this literature review, we see the importance of including resistance training to the treatment of depression, since regular and long-term exercises promote hormonal and cognitive benefits, helping and improving the individual's ability to generate responses to the stressor event , developing self-confidence.
    Keywords depression ; resistance training ; force ; mood disorder ; physiological benefits ; physical exercises ; Medicine ; R
    Subject code 150
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher Bulgarian Association of Young Surgeons
    Document type Article ; Online
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  10. Article ; Online: Influence of Teachers' Vocal Quality on Students' Learning and/or Cognition: A Scoping Review.

    da Silva, Kelly / Ribeiro, Vanessa Veis / Santos, Allicia Diely Nunes / Almeida, Sabryna Beatriz Santos / Cruz, Pablo Jordão Alcântara / Behlau, Mara

    Journal of voice : official journal of the Voice Foundation

    2023  

    Abstract: Objective: To verify if the teacher's vocal quality can influence the student's cognition.: Methods: The present study is a scoping review performed to answer the research question: Can the teacher's vocal quality influence the student's learning and ...

    Abstract Objective: To verify if the teacher's vocal quality can influence the student's cognition.
    Methods: The present study is a scoping review performed to answer the research question: Can the teacher's vocal quality influence the student's learning and cognition?. To verify if the teacher's vocal quality can influence the student's cognition. The electronic search was performed in PubMed, Lilacs, SciELO, Scopus, Web of Science, Embase, and databases, in addition to a manual search in citation and gray literature. Two independent authors performed selection and extraction. Data were extracted about the study design: the sample, the cognitive tests used, the assessed cognitive skills, the type of altered voice (real or simulated), the assessment of the vocal quality, alone or associated with environmental noise, and the main outcomes evaluated.
    Results: The initial research identified 476 articles, and 13 were selected for analysis. Seven (54%) studies evaluated the impact of altered voices in an isolated way on cognitive abilities. From these, they verified that the altered voices could negatively influence children's cognitive performance. Other 6 studies (46%) associated altered voices with competitive noise in their analysis, and 4 concluded that competitive noise rather than altered voices influenced students' cognitive performance.
    Conclusion: The altered voice seems to affect the cognitive tasks involved in the learning process. The competitive noise associated with the presentation of deviant voices had a stronger influence on cognitive performance than altered voice alone, demonstrating that cognitive performance is sensitive to the stages of information acquisition (input of acoustic signals).
    Language English
    Publishing date 2023-05-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 17459-2
    ISSN 1873-4588 ; 1557-8658 ; 0892-1997
    ISSN (online) 1873-4588 ; 1557-8658
    ISSN 0892-1997
    DOI 10.1016/j.jvoice.2023.02.022
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