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  1. Article: [The terms in the Jiu Zhen Shi Er Yuan in Ling Shu].

    Zhang, L

    Zhonghua yi shi za zhi (Beijing, China : 1980)

    2023  Volume 53, Issue 3, Page(s) 131–135

    Abstract: This paper examined unearthed and handed down documents through terms and relative words in the section ... ...

    Abstract This paper examined unearthed and handed down documents through terms and relative words in the section of
    MeSH term(s) Acupuncture ; Acupuncture Therapy ; China
    Language Chinese
    Publishing date 2023-07-18
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1052411-3
    ISSN 0255-7053
    ISSN 0255-7053
    DOI 10.3760/cma.j.cn112155-20221007-00138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4688: Show issues Location:
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  2. Article ; Online: Non-targeted metabolomics strategy reveals the role of Geng-Nian-Shu in regulating ferroptosis in perimenopausal syndrome.

    Lv, Xinyan / Bi, Anqi / Zhang, Zhan / Li, Jinyan / Wei, Yingbo / Wan, Meiqi / Wang, Jinyu / Yan, Tingxu / Jia, Ying

    Journal of pharmaceutical and biomedical analysis

    2024  Volume 241, Page(s) 115980

    Abstract: ... have shown that Geng-Nian-Shu (GNS) plays an important regulatory role in perimenopausal syndrome (PMS ...

    Abstract Ovariectomy (OVX) is usually accompanied by the occurrence of metabolic syndrome. Previous studies have shown that Geng-Nian-Shu (GNS) plays an important regulatory role in perimenopausal syndrome (PMS) rats. GNS is a traditional Chinese medicine (TCM) prescription which composed of Suanzaoren Decoction and Ganmai Dazao Decoction in "Jingui Yaolue" and Siwu Decoction in "Heji Jufang". Recently, metabolomics analysis has been used to identify slight changes in the metabolic profile and to help understand disease progression and therapeutic interventions in PMS. However, the mechanism of GNS in the treatment of PMS is still unknown. We purposed to study the metabolic characteristics of PMS by serum and fecal metabolomics, and revealed the internal mechanism of GNS regulating ferroptosis against PMS. The PMS model was established by surgical removal of 4/5 ovaries of rats. HPLC-Q-TOF/MS was used to analyze the metabolomics of rat plasma and feces to explore the potential mechanism of GNS in PMS. The expression of ferroptosis-related proteins in rat ovaries was detected by tissue Prussian blue staining, Elisa kit and Western blotting. Cluster analysis of differential metabolites in plasma and feces between the control group and the model group showed that organic acids and their derivatives, lipids and lipid molecules were mainly disturbed during PMS in rats. After GNS administration, 17 differential metabolites were adjusted, involving several major pathways, such as the tricarboxylic acid (TCA) cycle, biosynthesis of amino acids and biosynthesis of unsaturated fatty acids. Further, we found that GNS affected ferroptosis in ovarian cells by regulating endogenous substances in OVX rats. Our study provides new insights into the mechanism of OVX-induced metabolic syndrome based on non-targeted metabolomics. It provides new ideas for the development and application of GNS and the diagnosis and treatment of PMS.
    MeSH term(s) Female ; Rats ; Animals ; Metabolic Syndrome ; Ferroptosis ; Perimenopause ; Metabolomics ; Metabolome ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2024.115980
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  3. Article: Exploring the chemical components of Kuanchang-Shu granule and its protective effects of postoperative ileus in rats by regulating AKT/HSP90AA1/eNOS pathway.

    Duan, Wen-Qian / Cai, Ming-Chen / Ma, Qi-Qi / Huang, Peng / Zhang, Jia-Hui / Wei, Tian-Fu / Shang, Dong / Leng, Ai-Jing / Qu, Jia-Lin

    Chinese medicine

    2024  Volume 19, Issue 1, Page(s) 29

    Abstract: ... by almost all abdominal operations that seriously strokes the quality of life of patients. Kuanchang-Shu ...

    Abstract Background: Postoperative ileus (POI) is a common obstruction of intestinal content passage caused by almost all abdominal operations that seriously strokes the quality of life of patients. Kuanchang-Shu granule (KCSG), a classic modified prescription based on "Da-Cheng-Qi Decoction", has obtained satisfactory efficacy in the clinical therapeutics of POI. However, its material basis and holistic molecular mechanism against POI have not been revealed.
    Methods: The chemical ingredients of KCSG were first characterized by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS). Subsequently, an integration strategy of the network pharmacology and molecular docking based on above identified ingredients was performed to unveil the potential targets involved in the treatment of KCSG on POI. Finally, intestinal manipulation induced rat POI model was constructed to verify the efficacy and predicted mechanism of KCSG against POI.
    Results: In total, 246 ingredients mainly including organic acids, flavonoids, quinones, alkaloids, terpenoids, phenylpropanoids and phenols were identified. 41 essential ingredients, 24 crucial targets as well as 15 relevant signaling pathways were acquired based on network pharmacology analysis. Pharmacodynamic research showed that KCSG treatment could protect intestinal histological damage, promote the recovery of measurement of gastrointestinal transit disorder and inhibit the secretion of myeloperoxidase in the distal ileum tissues. The up-regulated expression of p-AKT and down-regulated expression of p-eNOS and HSP9OAA1 predicted by molecular docking and validated by western blotting showed that AKT/eNOS/HSP90AA1 pathway may be one of the crucial mechanisms that mediates the protective effect of KCSG.
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2260322-0
    ISSN 1749-8546
    ISSN 1749-8546
    DOI 10.1186/s13020-024-00892-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comment on "Diagnosis, prevalence, and mortality of sarcopenia in dialysis patients: a systematic review and meta-analysis" by Shu et al.

    Zhang, Fan / Zhang, Huachun

    Journal of cachexia, sarcopenia and muscle

    2023  Volume 14, Issue 6, Page(s) 2984

    MeSH term(s) Humans ; Sarcopenia/diagnosis ; Sarcopenia/epidemiology ; Sarcopenia/etiology ; Prevalence ; Renal Dialysis/adverse effects
    Language English
    Publishing date 2023-09-27
    Publishing country Germany
    Document type Meta-Analysis ; Systematic Review ; Letter
    ZDB-ID 2586864-0
    ISSN 2190-6009 ; 2190-5991
    ISSN (online) 2190-6009
    ISSN 2190-5991
    DOI 10.1002/jcsm.13113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Biomarkers based on multiplatform comprehensive analysis: A systematic analysis of Geng-Nian-Shu in perimenopausal syndrome.

    Lv, Xinyan / Xu, Qinghua / Zhang, Zhiqin / Wang, Jinyu / Wan, Meiqi / Zhang, Xiaoying / Wu, Bo / Yan, Tingxu / Jia, Ying

    Journal of separation science

    2023  Volume 46, Issue 17, Page(s) e2300011

    Abstract: Although Geng-Nian-Shu has been shown to be clinically effective in perimenopausal syndrome ... biomarkers of Geng-Nian-Shu in treating perimenopausal syndrome, a total of 135 chemical constituents ... for the PhosphoInositide-3 Kinase/Akt pathway, suggesting that it may be the main regulatory pathway for the Geng-Nian-Shu ...

    Abstract Although Geng-Nian-Shu has been shown to be clinically effective in perimenopausal syndrome, its active components and mechanism have not yet been elucidated. To demonstrate the mechanism-based biomarkers of Geng-Nian-Shu in treating perimenopausal syndrome, a total of 135 chemical constituents including 52 prototype blood constituents were identified via high-performance liquid chromatography-quadrupole-time of flight/mass spectrometry. Then, network pharmacology showed significant enrichment for the PhosphoInositide-3 Kinase/Akt pathway, suggesting that it may be the main regulatory pathway for the Geng-Nian-Shu treatment of the perimenopausal syndrome. Subsequently, multivariate analysis was performed between the Geng-Nian-Shu sham-treated and Geng-Nian-Shu ovariectomy-treated groups and further screened out 18 prototype blood constituents by correlation analysis with plasma estrogen levels to identify potential biomarkers associated with Geng-Nian-Shu treat the ovariectomy-induced perimenopausal syndrome. Finally, the results of pharmacological experimental verification and Pearson correlation analysis indicated that catalpol, ligustilide, paeoniflorin, and gallic acid were selected as biomarkers of Geng-Nian-Shu which were strongly and positively correlated with PhosphoInositide-3 Kinase/Akt signaling pathway. In this study, based on high-performance liquid chromatography-quadrupole-time of flight/mass spectrometry combined with pharmacodynamics, network pharmacology, pharmacology, and other disciplines, we explored the effects and mechanisms of Geng-Nian-Shu in the treatment of perimenopausal syndrome at multiple levels. Using multiplatform technology to investigate the role of Geng-Nian-Shu represents a new strategy for the selection and verification of biomarkers of Geng-Nian-Shu and provides a basis for further development and utilization of Geng-Nian-Shu.
    MeSH term(s) Female ; Humans ; Drugs, Chinese Herbal/analysis ; Perimenopause ; Proto-Oncogene Proteins c-akt ; Biomarkers/analysis ; Phosphatidylinositols
    Chemical Substances Drugs, Chinese Herbal ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Biomarkers ; Phosphatidylinositols
    Language English
    Publishing date 2023-06-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2047990-6
    ISSN 1615-9314 ; 1615-9306
    ISSN (online) 1615-9314
    ISSN 1615-9306
    DOI 10.1002/jssc.202300011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Shu

    Sima, Qian / Pei, Yin / Sima, Zhen / Zhang, Shoujie

    (Shi ji : 史記 ; / Si ma qian zhuan; pei yin ji jie; si ma zhen suo yin; zhang shou jie zheng yi ; 4)

    1970  

    Series title Shi ji : 史記
    / Si ma qian zhuan; pei yin ji jie; si ma zhen suo yin; zhang shou jie zheng yi ; 4
    Language Chinese
    Size S. 1157-1443
    Publisher Zhong hua shu ju
    Publishing place Bei jing
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  7. Article: Acupuncture at Back-Shu point improves insomnia by reducing inflammation and inhibiting the ERK/NF-κB signaling pathway.

    Zhang, Ming-Ming / Zhao, Jing-Wei / Li, Zhi-Qiang / Shao, Jing / Gao, Xi-Yan

    World journal of psychiatry

    2023  Volume 13, Issue 6, Page(s) 340–350

    Abstract: ... mechanism of acupuncture at Back-Shu point for the treatment of insomnia.: Methods: We first prepared ... These findings suggest that acupuncture at Back-Shu point can inhibit the ERK/NF-κB signaling pathway and treat ...

    Abstract Background: Insomnia is a disease where individuals cannot maintain a steady and stable sleep state or fail to fall asleep. Western medicine mainly uses sedatives and hypnotic drugs to treat insomnia, and long-term use is prone to drug resistance and other adverse reactions. Acupuncture has a good curative effect and unique advantages in the treatment of insomnia.
    Aim: To explore the molecular mechanism of acupuncture at Back-Shu point for the treatment of insomnia.
    Methods: We first prepared a rat model of insomnia, and then carried out acupuncture for 7 consecutive days. After treatment, the sleep time and general behavior of the rats were determined. The Morris water maze test was used to assess the learning ability and spatial memory ability of the rats. The expression levels of inflammatory cytokines in serum and the hippocampus were detected by ELISA. qRT-PCR was used to detect the mRNA expression changes in the ERK/NF-κB signaling pathway. Western blot and immunohistochemistry were carried out to evaluate the protein expression levels of RAF-1, MEK-2, ERK1/2 and NF-κB.
    Results: Acupuncture can prolong sleep duration, and improve mental state, activity, diet volume, learning ability and spatial memory. In addition, acupuncture increased the release of 1L-1β, 1L-6 and TNF-α in serum and the hippocampus and inhibited the mRNA and protein expression of the ERK/NF-κB signaling pathway.
    Conclusion: These findings suggest that acupuncture at Back-Shu point can inhibit the ERK/NF-κB signaling pathway and treat insomnia by increasing the release of inflammatory cytokines in the hippo-campus.
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article
    ISSN 2220-3206
    ISSN 2220-3206
    DOI 10.5498/wjp.v13.i6.340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Shu-Xie decoction alleviates oxidative stress and colon injury in acute sleep-deprived mice by suppressing p62/KEAP1/NRF2/HO1/NQO1 signaling.

    Wang, Mengyuan / Li, Bo / Liu, Yijiang / Zhang, Mengting / Huang, Caoxin / Cai, Teng / Jia, Yibing / Huang, Xiaoqing / Ke, Hongfei / Liu, Suhuan / Yang, Shuyu

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1107507

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1107507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Post-marketing safety surveillance and re-evaluaiton of Shu-Xue-Ning injection: a real-world study based on 30,122 cases.

    Xinyao, Jin / Yifan, Zhang / Keyi, Wang / Wentai, Pang / Chunyang, Wang / Hui, Wang / Chunxiang, Liu / Yunhua, Xue / Wenke, Zheng

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1194367

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1194367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cardioprotective efficacy of Xin-shu-bao tablet in heart failure with reduced ejection fraction by modulating THBD/ARRB1/FGF1/STIM1 signaling.

    Zhang, Fengrong / Xu, Xingyue / Hou, Jinli / Xiao, Honghe / Guo, Feifei / Li, Xianyu / Yang, Hongjun

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 165, Page(s) 115119

    Abstract: ... therapeutic efficacy of Xin-shu-bao (XSB) at different stages of HF following induction ...

    Abstract Traditional Chinese medicine offer unique advantages in mitigating and preventing early or intermediate stage for treating heart failure (HF). The purpose of this study was to assess the in vivo therapeutic efficacy of Xin-shu-bao (XSB) at different stages of HF following induction of a myocardial infarction (MI) in mice and use mass spectrometry-based proteomics to identify potential therapeutic targets for different stages of HF based on the molecular changes following XSB treatment. XSB had high cardioprotective efficacy in the pre-HF with reduced ejection fraction (HFrEF) stages, but had a weak or no effect in the post-HFrEF stages. This was supported by echocardiographic measurements showing that XSB decreased ejection fraction and fractional shortening in HF. XSB administration improved cardiac function in the pre- and post-HFrEF mouse model, ameliorated deleterious changes to the morphology and subcellular structure of cardiomyocytes, and reduced cardiac fibrosis. Proteomics analysis showed that XSB intervention exclusively targeted thrombomodulin (THBD) and stromal interaction molecule 1 (STIM1) proteins when administered to the mice for both 8 and 6 weeks. Furthermore, XSB intervention for 8, 6, and 4 weeks after MI induction increased the expression of fibroblast growth factor 1 (FGF1) and decreased arrestin β1 (ARRB1), which are classic biomarkers of cardiac fibroblast transformation and collagen synthesis, respectively. Overall, the study suggests that early intervention with XSB could be an effective strategy for preventing HFrEF and highlights potential therapeutic targets for further investigation into HFrEF remediation strategies.
    MeSH term(s) Animals ; Mice ; Heart Failure/drug therapy ; Heart Failure/metabolism ; Stroke Volume ; Fibroblast Growth Factor 1/metabolism ; Arrestin/metabolism ; Stromal Interaction Molecule 1 ; Thrombomodulin ; Myocardial Infarction/drug therapy
    Chemical Substances Fibroblast Growth Factor 1 (104781-85-3) ; Arrestin ; Stromal Interaction Molecule 1 ; Thrombomodulin ; THBD protein, mouse
    Language English
    Publishing date 2023-07-07
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.115119
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