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  1. Article: Long-read genome assemblies reveal a

    Tu, Guang-Xian / Zhang, Xin-Shuang / Jiang, Rui-Run / Zhang, Long / Lai, Cheng-Jun / Yan, Zhu-Yue / Lv, Yan-Rong / Weng, Shao-Ping / Zhang, Li / He, Jian-Guo / Wang, Muhua

    Zoological research

    2023  Volume 44, Issue 2, Page(s) 287–302

    Abstract: Due to the difficulty in accurately identifying structural variants (SVs) across genomes, their impact ... ...

    Abstract Due to the difficulty in accurately identifying structural variants (SVs) across genomes, their impact on
    MeSH term(s) Animals ; Fishes/genetics ; Genome ; Phenotype ; Biological Evolution
    Language English
    Publishing date 2023-02-08
    Publishing country China
    Document type Journal Article
    ISSN 2095-8137
    ISSN 2095-8137
    DOI 10.24272/j.issn.2095-8137.2022.462
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  2. Article: Long-Term

    Wu, Guangfu / Zhang, Eric T / Qiang, Yingqi / Esmonde, Colin / Chen, Xingchi / Wei, Zichao / Song, Yang / Zhang, Xincheng / Schneider, Michael J / Li, Huijie / Sun, He / Weng, Zhengyan / Santaniello, Sabato / He, Jie / Lai, Rebecca Y / Li, Yan / Bruchas, Michael R / Zhang, Yi

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Long-term, real-time molecular monitoring in complex biological environments is critical ...

    Abstract Long-term, real-time molecular monitoring in complex biological environments is critical for our ability to understand, prevent, diagnose, and manage human diseases. Aptamer-based electrochemical biosensors possess the promise due to their generalizability and a high degree of selectivity. Nevertheless, the operation of existing aptamer-based biosensors
    Language English
    Publishing date 2023-10-20
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.18.562080
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  3. Article ; Online: Long non-coding RNA

    Zuo, You / He, Jiaqian / Zhou, Zheng / Sun, Jingjing / Ouyang, Can / Huang, Hui / Wang, Yajuan / Liu, Hairong / Reed, Simon H

    Non-coding RNA research

    2024  Volume 9, Issue 3, Page(s) 649–658

    Abstract: In recent years, various long non-coding RNAs (lncRNAs) involved in DNA damage response (DDR) have ...

    Abstract In recent years, various long non-coding RNAs (lncRNAs) involved in DNA damage response (DDR) have been identified and studied to deepen our understanding. However, there are rare reports on the association between lncRNAs and base excision repair (BER). Our designed DNA microarray identified dozens of functionally unknown lncRNAs, and their transcription levels significantly increased upon exposure to DNA damage inducers. One of them, named
    Language English
    Publishing date 2024-03-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2468-0540
    ISSN (online) 2468-0540
    DOI 10.1016/j.ncrna.2024.03.010
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  4. Article ; Online: Long-Tailed Food Classification.

    He, Jiangpeng / Lin, Luotao / Eicher-Miller, Heather A / Zhu, Fengqing

    Nutrients

    2023  Volume 15, Issue 12

    Abstract: ... of foods in each input image. However, foods in real-world scenarios are typically long-tail distributed ... imbalance issue and hinders the overall performance. In addition, none of the existing long-tailed ... intra-class diversity between food images. In this work, two new benchmark datasets for long-tailed food ...

    Abstract Food classification serves as the basic step of image-based dietary assessment to predict the types of foods in each input image. However, foods in real-world scenarios are typically long-tail distributed, where a small number of food types are consumed more frequently than others, which causes a severe class imbalance issue and hinders the overall performance. In addition, none of the existing long-tailed classification methods focus on food data, which can be more challenging due to the inter-class similarity and intra-class diversity between food images. In this work, two new benchmark datasets for long-tailed food classification are introduced, including Food101-LT and VFN-LT, where the number of samples in VFN-LT exhibits real-world long-tailed food distribution. Then, a novel two-phase framework is proposed to address the problem of class imbalance by (1) undersampling the head classes to remove redundant samples along with maintaining the learned information through knowledge distillation and (2) oversampling the tail classes by performing visually aware data augmentation. By comparing our method with existing state-of-the-art long-tailed classification methods, we show the effectiveness of the proposed framework, which obtains the best performance on both Food101-LT and VFN-LT datasets. The results demonstrate the potential to apply the proposed method to related real-life applications.
    MeSH term(s) Food/classification
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15122751
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  5. Article ; Online: Long noncoding RNA (lncRNA)

    Liao, Junyi / Chen, Bowen / Zhu, Zhenglin / Du, Chengcheng / Gao, Shengqiang / Zhao, Guozhi / Zhao, Piao / Wang, Yonghui / Wang, Annie / Schwartz, Zander / Song, Lily / Hong, Jeffrey / Wagstaff, William / Haydon, Rex C / Luu, Hue H / Fan, Jiaming / Reid, Russell R / He, Tong-Chuan / Shi, Lewis /
    Hu, Ning / Huang, Wei

    Genes & diseases

    2023  Volume 10, Issue 4, Page(s) 1351–1366

    Abstract: ... to the production of large amounts of noncoding RNAs (ncRNAs). It has been shown that ncRNAs, especially long non ...

    Abstract Recent advances in deep sequencing technologies have revealed that, while less than 2% of the human genome is transcribed into mRNA for protein synthesis, over 80% of the genome is transcribed, leading to the production of large amounts of noncoding RNAs (ncRNAs). It has been shown that ncRNAs, especially long non-coding RNAs (lncRNAs), may play crucial regulatory roles in gene expression. As one of the first isolated and reported lncRNAs,
    Language English
    Publishing date 2023-03-24
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2023.02.008
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  6. Article ; Online: Injectable isoniazid-loaded bone cement based on hydrazone bonds achieving long-term release and decent mechanical properties.

    Xu, Yang / Lin, Hao / Gao, Zhe / Guo, Rui / Kan, Yu-Chen / Han, Lu-Yang / Bu, Wen-Han / Wang, Zhi / Asilebieke, Ayakuzi / Han, Long-Xu / Li, Chuang / He, Fang / Chu, Jian-Jun

    Journal of materials chemistry. B

    2024  

    Abstract: A robust and easily manufactured high-strength and long-term release hydrazone-based isoniazid ...

    Abstract A robust and easily manufactured high-strength and long-term release hydrazone-based isoniazid acrylic (HIA) bone cement is reported. The mechanical strength of HIA bone cement is similar to that of normal polymethyl methacrylate (PMMA) bone cement, far surpassing that of traditional isoniazid-containing antibiotic-loaded bone cement (INH bone cement). Isoniazid is connected to the bone cement through bioorthogonal hydrazone chemistry, and it possesses release properties superior to those of INH bone cement, allowing for the sustained release of isoniazid for up to 12 weeks.
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb02661b
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  7. Article ; Online: Preoperative anemia: impact on short- and long-term outcomes following curative-intent resection of gastroenteropancreatic neuroendocrine tumors.

    Xiang, Jun-Xi / Nan, Yang-Long / He, Jin / Lopez-Aguiar, Alexandra G / Poultsides, George / Rocha, Flavio / Weber, Sharon / Fields, Ryan / Idrees, Kamran / Cho, Cliff / Maithel, Shishir K / Lv, Yi / Zhang, Xu-Feng / Pawlik, Timothy M

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2024  

    Abstract: ... This study aimed to characterize how preoperative anemia affected short- and long-term outcomes of patients ... strongly associated with a higher risk of postoperative morbidity and worse long-term outcomes. ...

    Abstract Background: The effect of preoperative anemia on clinical outcomes of patients undergoing resection of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) has not been previously investigated. This study aimed to characterize how preoperative anemia affected short- and long-term outcomes of patients undergoing curative-intent resection of GEP-NETs.
    Methods: Patients who underwent curative-intent resection for GEP-NETs between January 1990 and December 2020 were identified from 8 major institutions. The last preoperative hemoglobin level was recorded; anemia was defined as <13.5 g/dL in males or <12.0 g/dL in females based on the guides of the American Society of Hematology. The effect of anemia on postoperative outcomes was assessed on uni- and multivariate analyses.
    Results: Among 1559 patients, the median age was 58 years (IQR, 48-66), and roughly one-half of the cohort was male (796 [51.1%]). Most patients had a pancreatic tumor (1040 [66.7%]), followed by small bowel (259 [16.6%]), duodenum (103 [6.6%]), stomach (66 [4.2%]), appendix (53 [3.4%]), and other locations (38 [2.6%]). The median preoperative hemoglobin level was 13.4 g/dL (IQR, 12.2-14.5). Overall, 101 (6.7%) and 119 (8.5%) patients received an intra- or postoperative packed red blood cell (pRBC) transfusion, respectively. A total of 972 patients (44.5%) experienced a postoperative complication. Although the overall incidence of complications was no different among patients who did (anemic: 48.7%) vs patients who did not (nonanemic: 47.3%) have anemia (P = .597), patients with preoperative anemia were more likely to develop a major (Clavien-Dindo grade ≥IIIa: 48.9% [anemic] vs 38.0% [nonanemic]; P = .006) and multiple (≥3 types of complications: 32.2% [anemic] vs 19.7% [anemic]; P < .001) complications. Of note, 1-, 3-, and 5-year overall survival (OS) rates were 96.7%, 90.5%, and 86.6%, respectively. On multivariable analysis, anemia (hazard ratio, 2.0; 95% CI, 1.2-3.2; P = .006) remained associated with worse OS; postoperative pRBC transfusion was associated with an OS (5-year OS: 75.0% vs 87.7%; P = .017) and recurrence-free survival (RFS; 5-year RFS: 66.9% vs 76.5%; P = .047).
    Conclusion: Preoperative anemia was commonly identified in roughly 1 in 3 patients who underwent curative-intent resection for GEP-NETs. Preoperative anemia was strongly associated with a higher risk of postoperative morbidity and worse long-term outcomes.
    Language English
    Publishing date 2024-03-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1016/j.gassur.2024.03.014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5207: Show issues Location:
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  8. Article: Polymer Delivery Systems for Long-Acting Antiretroviral Drugs.

    Nayan, Mohammad Ullah / Panja, Sudipta / Sultana, Ashrafi / Zaman, Lubaba A / Vora, Lalitkumar K / Sillman, Brady / Gendelman, Howard E / Edagwa, Benson

    Pharmaceutics

    2024  Volume 16, Issue 2

    Abstract: The success of long-acting (LA) drug delivery systems (DDSs) is linked to their biocompatible ...

    Abstract The success of long-acting (LA) drug delivery systems (DDSs) is linked to their biocompatible polymers. These are used for extended therapeutic release. For treatment or prevention of human immune deficiency virus type one (HIV-1) infection, LA DDSs hold promise for improved regimen adherence and reduced toxicities. Current examples include Cabenuva, Apretude, and Sunlenca. Each is safe and effective. Alternative promising DDSs include implants, prodrugs, vaginal rings, and microarray patches. Each can further meet patients' needs. We posit that the physicochemical properties of the formulation chemical design can optimize drug release profiles. We posit that the strategic design of LA DDS polymers will further improve controlled drug release to simplify dosing schedules and improve regimen adherence.
    Language English
    Publishing date 2024-01-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16020183
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  9. Article ; Online: Associations of Long-Term Exposure to PM

    Zheng, Yiquan / He, Yaling / Kang, Ning / Zhang, Caiyun / Liao, Wei / Yuchi, Yinghao / Liu, Xiaotian / Hou, Jian / Mao, Zhenxing / Huo, Wenqian / Zhang, Kai / Tian, Hezhong / Lin, Hualiang / Wang, Chongjian

    Toxics

    2023  Volume 11, Issue 11

    Abstract: Evidence on the effect of long-term exposure to fine particulate matter (PM ...

    Abstract Evidence on the effect of long-term exposure to fine particulate matter (PM
    Language English
    Publishing date 2023-10-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11110885
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  10. Article: Long-term economic evaluation of the recombinant

    Diao, Sha / Liu, Zheng / Liu, Dan / Cheng, Xiao / Zeng, Linan / Jiao, Xue-Feng / Chen, Zhe / Ni, Xiaofeng / He, Siyi / Wu, Bin / Kang, Deying / Wan, Chaomin / Zhao, Rongsheng / Wang, Huiqing / Zhang, Lingli

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1161526

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-05-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1161526
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