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Article ; Online: Surviving the Storm: The Role of Poly- and Depolyploidization in Tissues and Tumors.

Zhao, Yucui / He, Sijia / Zhao, Minghui / Huang, Qian

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 , Page(s) e2306318

Abstract: Polyploidization and depolyploidization are critical processes in the normal development and tissue homeostasis of diploid organisms. Recent investigations have revealed that polyaneuploid cancer cells (PACCs) exploit this ploidy variation as a survival ... ...

Abstract	Polyploidization and depolyploidization are critical processes in the normal development and tissue homeostasis of diploid organisms. Recent investigations have revealed that polyaneuploid cancer cells (PACCs) exploit this ploidy variation as a survival strategy against anticancer treatment and for the repopulation of tumors. Unscheduled polyploidization and chromosomal instability in PACCs enhance malignancy and treatment resistance. However, their inability to undergo mitosis causes catastrophic cellular death in most PACCs. Adaptive ploid reversal mechanisms, such as multipolar mitosis, centrosome clustering, meiosis-like division, and amitosis, counteract this lethal outcome and drive cancer relapse. The purpose of this work is to focus on PACCs induced by cytotoxic therapy, highlighting the latest discoveries in ploidy dynamics in physiological and pathological contexts. Specifically, by emphasizing the role of "poly-depolyploidization" in tumor progression, the aim is to identify novel therapeutic targets or paradigms for combating diseases associated with aberrant ploidies.
Language	English
Publishing date	2024-04-17
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202306318
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The unfolding story of dying tumor cells during cancer treatment.

He, Sijia / Huang, Qian / Cheng, Jin

Frontiers in immunology

2023 Volume 14, Page(s) 1073561

Abstract: Generally, the demise of cancer cells in different ways enables the body to clear these harmful cells. However, cancer cells obtain unlimited replication and immortality from successful circumvention of cell ... ...

Abstract	Generally, the demise of cancer cells in different ways enables the body to clear these harmful cells. However, cancer cells obtain unlimited replication and immortality from successful circumvention of cell death
MeSH term(s)	Humans ; Neoplasms/pathology ; Immunotherapy ; Cell Death ; Tumor Microenvironment
Language	English
Publishing date	2023-03-13
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1073561
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of needle loops on shielding effectiveness of electromagnetic shielding knitted fabrics

He, Sijia / Liu, Zhe / Wang, Haoyu / Wang, Xiuchen

Textile Research Journal. 2023 Feb., v. 93, no. 3-4 p.691-700

2023

Abstract: Knitted electromagnetic shielding fabric is widely used for its excellent extensibility and permeability. However, the influence law and mechanism of the effect of needle loops on the shielding effectiveness of fabrics is still unclear. In this paper, we ...

Abstract	Knitted electromagnetic shielding fabric is widely used for its excellent extensibility and permeability. However, the influence law and mechanism of the effect of needle loops on the shielding effectiveness of fabrics is still unclear. In this paper, we designed five kinds of knitted fabrics. They are plain single jersey, ‘1 × 1’ rib knitted fabric, ‘2 × 2’ rib knitted fabric, interlock knitted fabric, and full Milano structure. The shielding effectiveness adopts the flange coaxial test. Based on the electromagnetic theory principle, the influence law and mechanism of needle loop arrangement form, needle loop length, metal material, and metal amount on the shielding effectiveness of knitted fabrics were analyzed. Therefore, it can be concluded that the arrangement of needle loops dramatically influences the frequency band and shielding performance of knitted fabrics. When there is fewer intermeshing points of needle loops, the less is the shielding effectiveness of the fabric. The needle loop’s length mainly affects the shielding effectiveness of knitted fabric. The small needle loop length has great shielding effectiveness on knitted fabric. Metallic yarns with high amounts and low -resistance are beneficial for improving the shielding effect of the clothing. It provides a reference for the design, production, and related research of electromagnetic shielding knitted fabrics.
Keywords	clothing ; extensibility ; knitted fabrics ; permeability ; research ; Knitted electromagnetic shielding fabric ; needle loops ; shielding effectiveness ; needle loop intermeshing ; needle loop effect ; surface resistance
Language	English
Dates of publication	2023-02
Size	p. 691-700.
Publishing place	SAGE Publications
Document type	Article ; Online
ZDB-ID	2209596-2
ISSN	1746-7748 ; 0040-5175
ISSN (online)	1746-7748
ISSN	0040-5175
DOI	10.1177/00405175221122579
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies.

Zheng, Liyao / He, Shipei / Wang, Hong / Li, Jinling / Liu, Yuanyuan / Liu, Sijia

Aging and disease

2024

Abstract: Cellular senescence is characterized by the permanent arrest of cell proliferation and is a response to endogenous and exogenous stress. The continuous accumulation of senescent cells (SnCs) in the body leads to the development of aging and age-related ... ...

Abstract	Cellular senescence is characterized by the permanent arrest of cell proliferation and is a response to endogenous and exogenous stress. The continuous accumulation of senescent cells (SnCs) in the body leads to the development of aging and age-related diseases (such as neurodegenerative diseases, cancer, metabolic diseases, cardiovascular diseases, and osteoarthritis). In the face of the growing challenge of aging and age-related diseases, several compounds have received widespread attention for their potential to target SnCs. As a result, senolytics (compounds that selectively eliminate SnCs) and senomorphics (compounds that alter intercellular communication and modulate the behavior of SnCs) have become hot research topics in the field of anti-aging. In addition, strategies such as combination therapies and immune-based approaches have also made significant progress in the field of anti-aging therapy. In this article, we discuss the latest research on anti-aging targeting SnCs and gain a deeper understanding of the mechanism of action and impact of different anti-aging strategies on aging and age-related diseases, with the aim of providing more effective references and therapeutic ideas for clinical anti-aging treatment in the face of the ever-grave challenges of aging and age-related diseases.
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2625789-0
ISSN	2152-5250 ; 2152-5250
ISSN (online)	2152-5250
ISSN	2152-5250
DOI	10.14336/AD.2024.0206
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Main Mechanisms of Mesenchymal Stem Cell-Based Treatments against COVID-19.

Li, Jinling / He, Shipei / Yang, Hang / Zhang, Lizeai / Xiao, Jie / Liang, Chaoyi / Liu, Sijia

Tissue engineering and regenerative medicine

2024

Abstract: Background: Coronavirus disease 2019 (COVID-19) has a clinical manifestation of hypoxic respiratory failure and acute respiratory distress syndrome. However, COVID-19 still lacks of effective clinical treatments so far. As a promising potential ... ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) has a clinical manifestation of hypoxic respiratory failure and acute respiratory distress syndrome. However, COVID-19 still lacks of effective clinical treatments so far. As a promising potential treatment against COVID-19, stem cell therapy raised recently and had attracted much attention. Here we review the mechanisms of mesenchymal stem cell-based treatments against COVID-19, and provide potential cues for the effective control of COVID-19 in the future. Methods: Literature is obtained from databases PubMed and Web of Science. Key words were chosen for COVID- 19, acute respiratory syndrome coronavirus 2, mesenchymal stem cells, stem cell therapy, and therapeutic mechanism. Then we summarize and critically analyze the relevant articles retrieved. Results: Mesenchymal stem cell therapy is a potential effective treatment against COVID-19. Its therapeutic efficacy is mainly reflected in reducing severe pulmonary inflammation, reducing lung injury, improving pulmonary function, protecting and repairing lung tissue of the patients. Possible therapeutic mechanisms might include immunoregulation, anti-inflammatory effect, tissue regeneration, anti-apoptosis effect, antiviral, and antibacterial effect, MSC - EVs, and so on. Conclusion: Mesenchymal stem cells can effectively treat COVID-19 through immunoregulation, anti-inflammatory, tissue regeneration, anti-apoptosis, anti-virus and antibacterial, MSC - EVs, and other ways. Systematically elucidating the mechanisms of mesenchymal stem cell-based treatments for COVID-19 will provide novel insights into the follow-up research and development of new therapeutic strategies in next step.
Language	English
Publishing date	2024-04-04
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2677535-9
ISSN	2212-5469 ; 1738-2696
ISSN (online)	2212-5469
ISSN	1738-2696
DOI	10.1007/s13770-024-00633-5
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Article ; Online: L-arginine alleviates heat stress-induced mammary gland injury through modulating CASTOR1-mTORC1 axis mediated mitochondrial homeostasis.

Gai, Zhongchao / Hu, Songhao / He, Yujiao / Yan, Sijia / Wang, Ranran / Gong, Guoli / Zhao, Jieqiong

The Science of the total environment

2024 Volume 926, Page(s) 172017

Abstract: As global warming intensifies, extreme heat is becoming increasingly frequent. These extreme heatwaves have decreased the milk production of dairy animals such as cows and goats and have caused significant damage to the entire dairy industry. It is known ...

Abstract	As global warming intensifies, extreme heat is becoming increasingly frequent. These extreme heatwaves have decreased the milk production of dairy animals such as cows and goats and have caused significant damage to the entire dairy industry. It is known that heat stress (HS) can induce the apoptosis and autophagy of mammary epithelial cells (MECs), leading to a decrease in lactating MECs. L-arginine can effectively attenuate HS-induced decreases in milk yield, but the exact mechanisms are not fully understood. In this study, we found that HS upregulated the arginine sensor CASTOR1 in mouse MECs. Arginine activated mTORC1 activity through CASTOR1 and promoted mitochondrial biogenesis through the mTORC1/PGC-1α/NRF1 pathway. Moreover, arginine inhibited mitophagy through the CASTOR1/PINK1/Parkin pathway. Mitochondrial homeostasis ensures ATP synthesis and a stable cellular redox state for MECs under HS, further alleviating HS-induced damage and improving the lactation performance of MECs. In conclusion, these findings reveal the molecular mechanisms by which L-arginine relieves HS-induced mammary gland injury, and suggest that the intake of arginine-based feeds or feed additives is a promising method to increase the milk yield of dairy animals in extreme heat conditions.
MeSH term(s)	Female ; Animals ; Cattle ; Mice ; Lactation ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Milk/metabolism ; Heat-Shock Response ; Heat Stress Disorders ; Homeostasis ; Arginine/metabolism
Chemical Substances	Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2024-03-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.172017
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chiral Supramolecular Nanofibers Regulated Tumor-Derived Exosomes Secretion for Constructing an Anti-Tumor Extracellular Microenvironment.

Wu, Beibei / Dou, Xiaoqiu / Zhao, Yu / Wang, Xueqian / Zhao, Changli / Xia, Jingyi / Xing, Chao / He, Sijia / Feng, Chuanliang

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2308335

Abstract: Tumor-derived exosomes (TDEs) induced extracellular microenvironment has recently been validated to be critical for tumor progression and metastasis, however, remodeling it for oncotherapy still remains a major challenge due to difficulty in regulation ... ...

Abstract	Tumor-derived exosomes (TDEs) induced extracellular microenvironment has recently been validated to be critical for tumor progression and metastasis, however, remodeling it for oncotherapy still remains a major challenge due to difficulty in regulation of TDEs secretion. Herein, the supramolecular chiral nanofibers, composed of
Language	English
Publishing date	2024-02-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202308335
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Management Measures Implemented at the West China Hospital may help Prevent and Contain COVID-19 and Similar Outbreaks.

Liu, Sijia / He, Chengqi

Disaster medicine and public health preparedness

2021 Volume 17, Page(s) e93

Abstract: This article presents management processes for dealing with the novel coronavirus disease 2019 (COVID-19) outbreak at the West China Hospital of Sichuan University. From January to March 2020, the West China Hospital of Sichuan University established ... ...

Abstract	This article presents management processes for dealing with the novel coronavirus disease 2019 (COVID-19) outbreak at the West China Hospital of Sichuan University. From January to March 2020, the West China Hospital of Sichuan University established response structures and protocols, as well as integrated out-of-hospital resources, to deal with the COVID-19 outbreak. A total of 8066 patients were screened, and 345 COVID-19 patients were isolated for treatment. Hospital command systems, emergency management protocols, as well as process, space, and personnel management, strengthening material reserves, and social responsibility strategies were implemented. Outbreak management aspects that required improvement included estimates of the anticipated number of cases, timely collection of patient information and feedback on the effect of outreach and online consultation methods.
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; Hospitals ; China/epidemiology ; Disease Outbreaks/prevention & control
Language	English
Publishing date	2021-12-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2375268-3
ISSN	1938-744X ; 1935-7893
ISSN (online)	1938-744X
ISSN	1935-7893
DOI	10.1017/dmp.2021.366
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chiral Supramolecular Assemblies: Controllable Construction and Biological Activity.

He, Sijia / Jiang, Zichao / Dou, Xiaoqiu / Gao, Laiben / Feng, Chuanliang

ChemPlusChem

2023 Volume 88, Issue 7, Page(s) e202300226

Abstract: Chiral supramolecular assemblies with helical structures (e. g., proteins with α-helix, DNA with double helix, collagen with triple-helix) as the central structure motifs in biological systems play a crucial role in various physiological activities of ... ...

Abstract	Chiral supramolecular assemblies with helical structures (e. g., proteins with α-helix, DNA with double helix, collagen with triple-helix) as the central structure motifs in biological systems play a crucial role in various physiological activities of living organisms. Variations in chiral structure can cause many abnormal physiological activities. To gain insight into the construction, structural transition, and related physiological functions of these complex helix in natural systems, it is necessary to fabricate artificial supramolecular assemblies with controllable helix orientation as research platform. This review discusses recent advances in chiral supramolecular assembly, including the precise construction and regulation of assembled chiral nanostructures with tunable chirality. Chiral structure-dependent biological activities, including cell proliferation, cell differentiation, antibacterial activity and tissue regeneration, are also discussed. This review not only contributes to further understanding of the importance of chirality in the physiological environment, but also plays an important role in the development of chiral biomedical materials for the treatment of diseases (e. g., tissue engineering regeneration, stem cell transplantation therapy).
MeSH term(s)	Stereoisomerism ; Nanostructures/chemistry
Language	English
Publishing date	2023-07-12
Publishing country	Germany
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ISSN	2192-6506
ISSN (online)	2192-6506
DOI	10.1002/cplu.202300226
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Targeting Protein Kinase C for Cancer Therapy.

He, Sijia / Li, Qi / Huang, Qian / Cheng, Jin

Cancers

2022 Volume 14, Issue 5

Abstract: Protein kinase C (PKC) isoforms, a group of serine-threonine kinases, are important regulators in carcinogenesis. Numerous studies have demonstrated that PKC isoforms exert both positive and negative effects on cancer cell demise. In this review, we ... ...

Abstract	Protein kinase C (PKC) isoforms, a group of serine-threonine kinases, are important regulators in carcinogenesis. Numerous studies have demonstrated that PKC isoforms exert both positive and negative effects on cancer cell demise. In this review, we systematically summarize the current findings on the architecture, activity regulation and biological functions of PKCs, especially their relationship with anti-cancer therapy-induced cell death. Additionally, we elaborate on current knowledge of the effects of PKCs on tumor metabolism and microenvironment, which have gained increasing attention in oncology-related areas. Furthermore, we underscore the basic experimental and clinical implications of PKCs as a target for cancer therapy to evaluate their therapeutic benefits and potential applications.
Language	English
Publishing date	2022-02-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14051104
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