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  1. Article ; Online: Coffee as chemoprotectant in fatty liver disease: caffeine-dependent and caffeine-independent effects.

    Dranoff, Jonathan A

    American journal of physiology. Gastrointestinal and liver physiology

    2023  Volume 324, Issue 6, Page(s) G419–G421

    Abstract: Coffee consumption is associated with a variety of positive health outcomes in patients with chronic liver disease, including decreased liver-related mortality. The evidence for this has come from a wide variety of epidemiological studies over the past ... ...

    Abstract Coffee consumption is associated with a variety of positive health outcomes in patients with chronic liver disease, including decreased liver-related mortality. The evidence for this has come from a wide variety of epidemiological studies over the past decade and remains consistent. Because coffee contains a large number of constituent molecules, many of which vary based on coffee source, roasting approach, and preparation, it has been difficult to identify the mechanisms by which coffee improves liver-related health. The caffeine hypothesis suggests that the primary active ingredient in coffee in this context is caffeine, which is an antagonist of liver adenosine receptors. However, some lines of data suggest caffeine-independent effects as well. This review examines the biological plausibility for caffeine-independent effects in the context of a recent publication in this journal.
    MeSH term(s) Humans ; Coffee/adverse effects ; Caffeine/adverse effects ; Liver Cirrhosis/chemically induced ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/chemically induced
    Chemical Substances Coffee ; Caffeine (3G6A5W338E)
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    DOI 10.1152/ajpgi.00026.2023
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  2. Article ; Online: Coffee, adenosine, and the liver.

    Dranoff, Jonathan A

    Purinergic signalling

    2023  Volume 20, Issue 1, Page(s) 21–28

    Abstract: A variety of observational studies have demonstrated that coffee, likely acting through caffeine, improves health outcomes in patients with chronic liver disease. The primary pharmacologic role of caffeine is to act as an inhibitor of adenosine receptors. ...

    Abstract A variety of observational studies have demonstrated that coffee, likely acting through caffeine, improves health outcomes in patients with chronic liver disease. The primary pharmacologic role of caffeine is to act as an inhibitor of adenosine receptors. Because key liver cells express adenosine receptors linked to liver injury, regeneration, and fibrosis, it is plausible that the biological effects of coffee are explained by effects of caffeine on adenosinergic signaling in the liver. This review is designed to help the reader make sense of that hypothesis, highlighting key observations in the literature that support or dispute it.
    MeSH term(s) Humans ; Coffee ; Caffeine/pharmacology ; Liver Cirrhosis ; Adenosine/pharmacology ; Liver ; Receptors, Purinergic P1
    Chemical Substances Coffee ; Caffeine (3G6A5W338E) ; Adenosine (K72T3FS567) ; Receptors, Purinergic P1
    Language English
    Publishing date 2023-09-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2172143-9
    ISSN 1573-9546 ; 1573-9538
    ISSN (online) 1573-9546
    ISSN 1573-9538
    DOI 10.1007/s11302-023-09968-5
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  3. Article: Coffee Consumption and Prevention of Cirrhosis: In Support of the Caffeine Hypothesis.

    Dranoff, Jonathan A

    Gene expression

    2017  Volume 18, Issue 1, Page(s) 1–3

    Abstract: Coffee is acknowledged as the most widely used drug worldwide. Coffee is also a foodstuff, so its use is often used to satisfy dietary urges. When used as a drug, coffee is normally consumed as a stimulant rather than to treat or prevent particular ... ...

    Abstract Coffee is acknowledged as the most widely used drug worldwide. Coffee is also a foodstuff, so its use is often used to satisfy dietary urges. When used as a drug, coffee is normally consumed as a stimulant rather than to treat or prevent particular diseases. Recently, coffee consumption has been inversely related to progression of liver fibrosis to cirrhosis and even hepatocellular carcinoma. Experiments in cellular and animal models have provided biological plausibility for coffee as an antifibrotic agent in the liver. A recent article examined one of the key questions regarding the antifibrotic role of coffee-specifically what is the primary antifibrotic agent in coffee? This article briefly reviews the relevant issues with regard to coffee as an antifibrotic agent for patients with chronic liver disease.
    MeSH term(s) Animals ; Caffeine/pharmacology ; Coffee/metabolism ; Humans ; Liver/drug effects ; Liver/metabolism ; Liver Cirrhosis/epidemiology ; Liver Cirrhosis/prevention & control
    Chemical Substances Coffee ; Caffeine (3G6A5W338E)
    Language English
    Publishing date 2017-09-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1151108-4
    ISSN 1052-2166 ; 1052-2116
    ISSN 1052-2166 ; 1052-2116
    DOI 10.3727/105221617X15046391179559
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  4. Article ; Online: COVID-19 and the liver: a narrative review of the present state of knowledge.

    Thandassery, Ragesh B / Dranoff, Jonathan A / Perisetti, Abhilash / Taddei, Tamar

    Translational gastroenterology and hepatology

    2022  Volume 7, Page(s) 40

    Abstract: Novel corona virus disease (COVID-19) is an ongoing pandemic that has spread across the globe. The virus primarily infects type-2 pneumocytes in alveoli and causes lung disease, with severity ranging from mild pneumonia to acute respiratory distress ... ...

    Abstract Novel corona virus disease (COVID-19) is an ongoing pandemic that has spread across the globe. The virus primarily infects type-2 pneumocytes in alveoli and causes lung disease, with severity ranging from mild pneumonia to acute respiratory distress syndrome. The virus also invades gastrointestinal epithelial cells, hepatocytes, and biliary epithelial cells. Derangement of liver function tests is noted in about one third of patients and appears to correlate with more severe disease. There are multiple mechanisms by which the virus can cause liver injury; immune-mediated inflammation and direct viral cytotoxicity are believed to be the predominant mechanisms. Liver injury appears to be transient, usually recovering with resolution of illness. Limited available studies and experience from prior corona virus pandemics seem to suggest that immunosuppressed patients have similar outcomes compared to non-immunosuppressed patients. Age and comorbid conditions seem to influence outcome, irrespective of immune status. Additionally, patients with preexisting comorbid conditions are more prone to acquire infection and should strictly adhere to travel and social distancing advisories. Telemedicine should be utilized to provide uninterrupted care for patients with liver disease, and clinic or hospital visits should be advised only in sick patients with advanced liver disease. In conclusion, liver dysfunction is not uncommon in COVID-19, it generally improves with resolution of disease, and patients with chronic liver disease (CLD) need continued follow up, uninterrupted by the ongoing pandemic, preferably in virtual clinic settings.
    Language English
    Publishing date 2022-10-25
    Publishing country China
    Document type Journal Article ; Review
    ISSN 2415-1289
    ISSN (online) 2415-1289
    DOI 10.21037/tgh-20-243
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  5. Article ; Online: Macrophage heterogeneity in liver injury: you are now leaving Kupffertown.

    Dranoff, Jonathan A

    Gastroenterology

    2014  Volume 147, Issue 6, Page(s) 1430–1431

    MeSH term(s) Animals ; Aptamers, Nucleotide/pharmacology ; Chemokine CCL2/antagonists & inhibitors ; Chemokine CCL2/immunology ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/immunology ; Macrophages/immunology ; Male
    Chemical Substances Aptamers, Nucleotide ; Chemokine CCL2
    Language English
    Publishing date 2014-12
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2014.10.020
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  6. Article ; Online: Obesity, but not glycemic control, predicts liver steatosis in children with type 1 diabetes.

    Tas, Emir / Bai, Shasha / Mak, Daniel / Diaz, Eva C / Dranoff, Jonathan A

    Journal of diabetes and its complications

    2022  Volume 36, Issue 12, Page(s) 108341

    Abstract: Objective: Nonalcoholic fatty liver disease (NAFLD), the most common liver disease in children, is strongly associated with obesity and insulin resistance. Although type 1 diabetes (T1D) is characterized by insulin deficiency, increasing obesity rates ... ...

    Abstract Objective: Nonalcoholic fatty liver disease (NAFLD), the most common liver disease in children, is strongly associated with obesity and insulin resistance. Although type 1 diabetes (T1D) is characterized by insulin deficiency, increasing obesity rates among children with T1D is a major risk factor for NAFLD in this patient population. Predisposing factors for NAFLD in children with T1D are not known.
    Study design: This is a cross-sectional study comparing children with T1D across the range of body mass index (BMI) to the BMI-matched obese group without T1D. Hepatic steatosis was semi-quantitatively measured via the vibration-controlled transient elastogram (VCTE) method. Linear regression analysis was performed to assess the relationship between controlled-attenuated parameter (CAP) scores and clinical parameters. Receiver-operator curve (ROC) analysis was used to evaluate the diagnostic performance of several clinical parameters against NAFLD status determined via CAP.
    Results: Two-thirds of subjects with obesity had CAP scores suggestive of NAFLD, while 16 % (n = 6) of T1D patients without obesity had elevated CAP. Obese subjects were different from non-obese subjects in many laboratory and clinical characteristics, regardless of T1D status. CAP score was significantly associated with BMI, HDL-Cholesterol (HDL-c), and HbA1c in all subjects as well as the T1D-only subgroup. Among subjects with obesity only, age, HDL-cand ALT were the most significant predictors. Diagnostic performance of BMI, HDL-c, and BMI/HDL ratio were in the good to the excellent range for predicting NAFLD among all subjects, while performance varied for T1D-only or obesity-only groups.
    Conclusion: The clinical and imaging findings of children with T1D and obesity are comparable to non-diabetic children with a similar degree of obesity. Obesity is the major risk factor for NAFLD in pediatric T1D. BMI, HDL-c, and BMI/HDL ratio may be helpful markers to determine further workup for NAFLD in children with T1D, particularly those with obesity.
    MeSH term(s) Humans ; Child ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Diabetes Mellitus, Type 1/complications ; Cross-Sectional Studies ; Obesity/complications ; Obesity/epidemiology ; Body Mass Index ; Cholesterol, HDL ; Liver
    Chemical Substances Cholesterol, HDL
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1105840-7
    ISSN 1873-460X ; 1056-8727
    ISSN (online) 1873-460X
    ISSN 1056-8727
    DOI 10.1016/j.jdiacomp.2022.108341
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  7. Article ; Online: AASLD Practice Guideline on blood-based non-invasive liver disease assessments of hepatic fibrosis and steatosis.

    Sterling, Richard K / Patel, Keyur / Duarte-Rojo, Andres / Asrani, Sumeet K / Alsawas, Mouaz / Dranoff, Jonathan A / Fiel, Maria Isabel / Murad, M Hassan / Leung, Daniel H / Levine, Deborah / Taddei, Tamar H / Taouli, Bachir / Rockey, Don C

    Hepatology (Baltimore, Md.)

    2024  

    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000845
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  8. Article ; Online: AASLD Practice Guideline on imaging-based non-invasive liver disease assessments of hepatic fibrosis and steatosis.

    Sterling, Richard K / Duarte-Rojo, Andres / Patel, Keyur / Asrani, Sumeet K / Alsawas, Mouaz / Dranoff, Jonathan A / Fiel, Maria Isabel / Murad, M Hassan / Leung, Daniel H / Levine, Deborah / Taddei, Tamar H / Taouli, Bachir / Rockey, Don C

    Hepatology (Baltimore, Md.)

    2024  

    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000843
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  9. Article ; Online: AASLD Practice Guideline on non-invasive liver disease assessments of portal hypertension.

    Sterling, Richard K / Asrani, Sumeet K / Levine, Deborah / Duarte-Rojo, Andres / Patel, Keyur / Fiel, Maria Isabel / Leung, Daniel H / Taouli, Bachir / Alsawas, Mouaz / Murad, M Hassan / Dranoff, Jonathan A / Taddei, Tamar H / Rockey, Don C

    Hepatology (Baltimore, Md.)

    2024  

    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000844
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  10. Article ; Online: Beyond scar formation: portal myofibroblast-mediated angiogenesis in the fibrotic liver.

    Fausther, Michel / Dranoff, Jonathan A

    Hepatology (Baltimore, Md.)

    2015  Volume 61, Issue 3, Page(s) 766–768

    MeSH term(s) Animals ; Cell-Derived Microparticles/secretion ; Humans ; Liver/cytology ; Liver Cirrhosis/etiology ; Male ; Myofibroblasts/physiology ; Vascular Remodeling
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.27653
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