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  1. Book ; Thesis: Customized CRISPR/Cas9 screens to identify novel targets for soft-tissue sarcoma therapy

    Michelhans, Michelle / Angel, Peter / Fröhling, Stefan

    2023  

    Institution Universität Heidelberg
    Author's details presented by M. Sc. Michelle Michelhans ; referees: Prof. Dr. Peter Angel, Prof. Dr. Stefan Fröhling
    Subject code 610 ; 570
    Language English
    Size XII, 139 Seiten, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-University Heidelberg, 2023
    Note Text Englisch, Zusammenfassung in englischer und deutscher Sprache
    HBZ-ID HT030654553
    Database Catalogue ZB MED Medicine, Health

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    2024 E 375 order for loan Magazin

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  2. Article ; Online: Toward defining the clinically actionable genome of metastatic breast cancer.

    Fröhling, Stefan

    Med (New York, N.Y.)

    2022  Volume 3, Issue 12, Page(s) 818–819

    Abstract: Genomics-guided therapies are transforming oncology, but selecting patients who are candidates for drugs matched to their tumor's biological profile is difficult. André et al. ...

    Abstract Genomics-guided therapies are transforming oncology, but selecting patients who are candidates for drugs matched to their tumor's biological profile is difficult. André et al.
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 2666-6340
    ISSN (online) 2666-6340
    DOI 10.1016/j.medj.2022.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sarcoma ecotypes determine immunotherapy benefit.

    Wagner, Johanna / Fröhling, Stefan

    Nature cancer

    2024  Volume 5, Issue 4, Page(s) 536–538

    MeSH term(s) Humans ; Immunotherapy/methods ; Sarcoma/therapy ; Sarcoma/immunology ; Treatment Outcome
    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Journal Article
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-024-00762-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Measuring Progress in Precision Oncology.

    Horak, Peter / Fröhling, Stefan

    Cancer discovery

    2024  Volume 14, Issue 1, Page(s) 18–19

    Abstract: Summary: In this issue of Cancer Discovery, Suehnholz and colleagues describe their efforts to quantify the gradual yet steady progress of precision oncology by surveying the regulatory approvals of targeted cancer therapies, and thus the actionability ... ...

    Abstract Summary: In this issue of Cancer Discovery, Suehnholz and colleagues describe their efforts to quantify the gradual yet steady progress of precision oncology by surveying the regulatory approvals of targeted cancer therapies, and thus the actionability of corresponding molecular alterations in clinical practice, over more than 20 years. Their work also suggests a relationship between the discovery of candidate therapeutic targets through comprehensive tumor profiling and molecularly guided cancer drug development. See related article by Suehnholz et al., p. 49 (5).
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Precision Medicine ; Medical Oncology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Molecular Targeted Therapy
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-23-1237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Interdisciplinary team science to understand and intercept rare cancers.

    Fröhling, Stefan

    Molecular & cellular oncology

    2021  Volume 8, Issue 6, Page(s) 1997331

    Abstract: For most rare cancers, precision oncology approaches are not established because these entities are poorly understood and their investigation requires the collaboration of many centers. The MASTER precision oncology network demonstrates that clinical ... ...

    Abstract For most rare cancers, precision oncology approaches are not established because these entities are poorly understood and their investigation requires the collaboration of many centers. The MASTER precision oncology network demonstrates that clinical whole-genome/exome and RNA sequencing yield molecular mechanism-aware treatments that benefit a substantial proportion of patients with advanced rare cancers and will prepare the ground for future clinical trials.
    Language English
    Publishing date 2021-11-23
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2021.1997331
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  6. Article ; Online: Präzisionsonkologie und molekulare Tumorboards.

    Mack, Elisabeth / Horak, Peter / Fröhling, Stefan / Neubauer, Andreas

    Innere Medizin (Heidelberg, Germany)

    2024  Volume 65, Issue 5, Page(s) 462–471

    Abstract: Precision oncology is a field of personalized medicine in which tumor biology forms the basis for tailored treatments. The preferred approach currently applied in clinical practice is based on the concept of malignant tumors as genetic diseases that are ... ...

    Title translation Precision oncology and molecular tumor boards.
    Abstract Precision oncology is a field of personalized medicine in which tumor biology forms the basis for tailored treatments. The preferred approach currently applied in clinical practice is based on the concept of malignant tumors as genetic diseases that are caused by mutations in oncogenes and tumor suppressors. On the one hand, these can be targeted by molecular drugs, while on the other hand, next-generation sequencing allows for comprehensive analysis of all relevant aberrations, thus enabling the matching of appropriate treatments across entities based on molecular information. Rational molecular therapies are developed and annotated with supporting evidence by molecular tumor boards, which have been established at various academic centers in recent years. Advancing precision oncology to a new standard of care requires improved applicability of personalized molecular therapies and thorough scientific evaluation of precision oncology programs.
    MeSH term(s) Humans ; Precision Medicine/methods ; Neoplasms/genetics ; Neoplasms/therapy ; Medical Oncology/methods ; Medical Oncology/trends ; Molecular Targeted Therapy/methods ; High-Throughput Nucleotide Sequencing
    Language German
    Publishing date 2024-04-23
    Publishing country Germany
    Document type Journal Article ; Review ; English Abstract
    ISSN 2731-7099
    ISSN (online) 2731-7099
    DOI 10.1007/s00108-024-01689-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Many Roads Lead to snoRNAs: The Ever-Expanding Universe of Non-Coding RNAs in Acute Myeloid Leukemia.

    Fröhling, Stefan

    HemaSphere

    2017  Volume 1, Issue 1, Page(s) e14

    Language English
    Publishing date 2017-12-20
    Publishing country United States
    Document type Editorial
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Thesis: Molekularzytogenetische Analyse von Deletionen und Translokationen der chromosomalen Bande 7q22 bei myeloischen Leukämien

    Fröhling, Stefan

    1998  

    Author's details vorgelegt von Stefan Fröhling
    Language German
    Size 79 Bl. : Ill.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 1998
    HBZ-ID HT010185161
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    99 E 829 order for loan Magazin

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  9. Article ; Online: Precision medicine in cancer: A paradigm shift.

    Rosenquist, Richard / Fröhling, Stefan / Stamatopoulos, Kostas

    Seminars in cancer biology

    2022  Volume 84, Page(s) 1–2

    MeSH term(s) Humans ; Neoplasms/genetics ; Neoplasms/therapy ; Precision Medicine
    Language English
    Publishing date 2022-05-18
    Publishing country England
    Document type Editorial
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2022.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 2922: Show issues Location:
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  10. Article ; Online: National Center for Tumor Diseases Precision Oncology Thesaurus for Drugs: A Curated Database for Drugs, Drug Classes, and Drug Targets in Precision Cancer Medicine.

    Kreutzfeldt, Simon / Horak, Peter / Hübschmann, Daniel / Knurr, Alexander / Fröhling, Stefan

    JCO clinical cancer informatics

    2023  Volume 7, Page(s) e2200147

    MeSH term(s) Humans ; Neoplasms/drug therapy ; Precision Medicine ; Medical Oncology ; Molecular Targeted Therapy ; Vocabulary, Controlled
    Language English
    Publishing date 2023-02-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2473-4276
    ISSN (online) 2473-4276
    DOI 10.1200/CCI.22.00147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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