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Article ; Online: Stability and context of intercalated motifs (i-motifs) for biological applications.

Irving, Kelly L / King, Jessica J / Waller, Zoë A E / Evans, Cameron W / Smith, Nicole M

2022 Volume 198, Page(s) 33–47

Abstract: DNA is naturally dynamic and can self-assemble into alternative secondary structures including the intercalated motif (i-motif), a four-stranded structure formed in cytosine-rich DNA sequences. Until recently, i-motifs were thought to be unstable in ... ...

Abstract	DNA is naturally dynamic and can self-assemble into alternative secondary structures including the intercalated motif (i-motif), a four-stranded structure formed in cytosine-rich DNA sequences. Until recently, i-motifs were thought to be unstable in physiological cellular environments. Studies demonstrating their existence in the human genome and role in gene regulation are now shining light on their biological relevance. Herein, we review the effects of epigenetic modifications on i-motif structure and stability, and biological factors that affect i-motif formation within cells. Furthermore, we highlight recent progress in targeting i-motifs with structure-specific ligands for biotechnology and therapeutic purposes.
MeSH term(s)	Base Sequence ; Cytosine/chemistry ; DNA/chemistry ; Epigenesis, Genetic ; Humans ; Nucleotide Motifs
Chemical Substances	Cytosine (8J337D1HZY) ; DNA (9007-49-2)
Language	English
Publishing date	2022-03-06
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	120345-9
ISSN	1638-6183 ; 0300-9084
ISSN (online)	1638-6183
ISSN	0300-9084
DOI	10.1016/j.biochi.2022.03.001
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Article ; Online: Correction: Genomic insights from Monoglobus pectinilyticus: a pectin-degrading specialist bacterium in the human colon.

Kim, Caroline C / Lunken, Genelle R / Kelly, William J / Patchett, Mark L / Jordens, Zoe / Tannock, Gerald W / Sims, Ian M / Bell, Tracey J / Hedderley, Duncan / Henrissat, Bernard / Rosendale, Douglas I

The ISME journal

2023 Volume 17, Issue 9, Page(s) 1520

Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Published Erratum
ZDB-ID	2406536-5
ISSN	1751-7370 ; 1751-7362
ISSN (online)	1751-7370
ISSN	1751-7362
DOI	10.1038/s41396-023-01419-8
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Article ; Online: Battling the unknown

Rachel L Knight / Kelly A Mackintosh / Joanne Hudson / James Shelley / Zoe L Saynor / Melitta A McNarry

PLoS ONE, Vol 18, Iss 4, p e

Using composite vignettes to portray lived experiences of COVID-19 and long-COVID.

2023 Volume 0284710

Abstract: Understanding the day-to-day lived experiences of individuals who have had or are still recovering from Coronavirus Disease-19 (COVID-19), whilst a complex challenge, presents the opportunity to listen and learn. Composite vignettes provide a novel ... ...

Abstract	Understanding the day-to-day lived experiences of individuals who have had or are still recovering from Coronavirus Disease-19 (COVID-19), whilst a complex challenge, presents the opportunity to listen and learn. Composite vignettes provide a novel approach to explore and present descriptive portrayals of the most commonly derived experiences and recovery journeys. The thematic analysis of 47 shared accounts (semi-structured interviews with adults aged ≥18 years; 40 females; 6-11 months post-COVID-19 infection) produced a series of four intricate character stories written through the lens of a single individual. Each vignette gives a voice to and captures a different experience trajectory. From the point of initial symptom development onwards, the vignettes depict how COVID-19 has affected everyday lives, focusing on the secondary non-biological socio-psychological effects and implications. The vignettes highlight in participants' own words: i) the potential negative implications of not addressing the psychological effects of COVID-19; ii) the lack of symptom and recovery linearity; iii) the ongoing 'lottery' of access to healthcare services; and iv) the highly variable, yet generally devastating, impacts that COVID-19 and consequent long-COVID has had across multiple facets of daily living.
Keywords	Medicine ; R ; Science ; Q
Subject code	360
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Alcohol-involved sexual assault in the US military: a scoping review.

Miggantz, Erin L / Orchowski, Lindsay M / Beltran, Jessica L / Walter, Kristen H / Hollingsworth, Julia C / Cue Davis, Kelly / Zong, Zoe Y / Meza-Lopez, Richard / Hutchins, Anna / Gilmore, Amanda K

European journal of psychotraumatology

2023 Volume 14, Issue 2, Page(s) 2282020

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; United States/epidemiology ; Sex Offenses ; Military Personnel ; Veterans ; Risk Factors ; Substance-Related Disorders
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2586642-4
ISSN	2000-8066 ; 2000-8066
ISSN (online)	2000-8066
ISSN	2000-8066
DOI	10.1080/20008066.2023.2282020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Stability and context of intercalated motifs (i-motifs) for biological applications

Irving, Kelly L. / King, Jessica J. / Waller, Zoë A.E. / Evans, Cameron W. / Smith, Nicole M.

Biochimie. 2022 July, v. 198

2022

Abstract	DNA is naturally dynamic and can self-assemble into alternative secondary structures including the intercalated motif (i-motif), a four-stranded structure formed in cytosine-rich DNA sequences. Until recently, i-motifs were thought to be unstable in physiological cellular environments. Studies demonstrating their existence in the human genome and role in gene regulation are now shining light on their biological relevance. Herein, we review the effects of epigenetic modifications on i-motif structure and stability, and biological factors that affect i-motif formation within cells. Furthermore, we highlight recent progress in targeting i-motifs with structure-specific ligands for biotechnology and therapeutic purposes.
Keywords	DNA ; biotechnology ; epigenetics ; genes ; humans ; ligands ; therapeutics
Language	English
Dates of publication	2022-07
Size	p. 33-47.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	120345-9
ISSN	0300-9084
ISSN	0300-9084
DOI	10.1016/j.biochi.2022.03.001
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Article ; Online: Battling the unknown: Using composite vignettes to portray lived experiences of COVID-19 and long-COVID.

Knight, Rachel L / Mackintosh, Kelly A / Hudson, Joanne / Shelley, James / Saynor, Zoe L / McNarry, Melitta A

PloS one

2023 Volume 18, Issue 4, Page(s) e0284710

Abstract	Understanding the day-to-day lived experiences of individuals who have had or are still recovering from Coronavirus Disease-19 (COVID-19), whilst a complex challenge, presents the opportunity to listen and learn. Composite vignettes provide a novel approach to explore and present descriptive portrayals of the most commonly derived experiences and recovery journeys. The thematic analysis of 47 shared accounts (semi-structured interviews with adults aged ≥18 years; 40 females; 6-11 months post-COVID-19 infection) produced a series of four intricate character stories written through the lens of a single individual. Each vignette gives a voice to and captures a different experience trajectory. From the point of initial symptom development onwards, the vignettes depict how COVID-19 has affected everyday lives, focusing on the secondary non-biological socio-psychological effects and implications. The vignettes highlight in participants' own words: i) the potential negative implications of not addressing the psychological effects of COVID-19; ii) the lack of symptom and recovery linearity; iii) the ongoing 'lottery' of access to healthcare services; and iv) the highly variable, yet generally devastating, impacts that COVID-19 and consequent long-COVID has had across multiple facets of daily living.
MeSH term(s)	Adult ; Female ; Humans ; Adolescent ; COVID-19 ; Post-Acute COVID-19 Syndrome ; Qualitative Research
Language	English
Publishing date	2023-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0284710
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 and Changes in Child Obesity.

Jenssen, Brian P / Kelly, Mary Kate / Powell, Maura / Bouchelle, Zoe / Mayne, Stephanie L / Fiks, Alexander G

Pediatrics

2021 Volume 147, Issue 5

MeSH term(s)	Adolescent ; Body Mass Index ; COVID-19/complications ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Male ; Pediatric Obesity/complications ; Pediatric Obesity/epidemiology ; Pediatric Obesity/ethnology ; Pennsylvania/epidemiology ; Prevalence ; Risk Factors ; SARS-CoV-2 ; Socioeconomic Factors
Language	English
Publishing date	2021-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2021-050123
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Article ; Online: 3D-Printing Physical Activity in Youth: An Autotopographical Approach to Behaviour Change.

McNarry, Melitta A / Knight, Rachel L / Crossley, Sam G M / Foscarini-Craggs, Paula / Knowles, Zoe R / Eslambolchilar, Parisa / Mackintosh, Kelly A

International journal of environmental research and public health

2023 Volume 20, Issue 2

Abstract: The conceptualisation and visualisation of physical activity through 3D-printed objects offers a unique means by which to elicit positive behaviour change. This study aimed to explore whether 3D-printed models of physical activity obtain ... ...

Abstract	The conceptualisation and visualisation of physical activity through 3D-printed objects offers a unique means by which to elicit positive behaviour change. This study aimed to explore whether 3D-printed models of physical activity obtain autotopographical meaning in youths and the influence of such models on their sense of personal and social identity. Following participation in a seven-week faded intervention, whereby habitual physical activity was measured and used to create individual 3D models, the views of 61 participants (36 boys; 10.9 ± 3.0 years) were explored via semi-structured focus groups. Within the over-arching theme of '3D-Printed Models', key emergent sub-themes were structured around 'Autotopography', 'Reflection', 'In-group norms', and 'Significant others'. Investing meaning in the material representations facilitated social activation and self-reflection on their own behaviour, both of which are key elements of identity formation. The influential role of significant others (familial and peers) within initial model interpretation and their potential long-term efficacy as a behaviour change approach was highlighted. 3D-printed models present a novel concept and intervention approach and may represent a useful component within behaviour change engagement strategies in children and adolescents.
MeSH term(s)	Male ; Child ; Humans ; Adolescent ; Exercise ; Peer Group ; Focus Groups ; Men ; Printing, Three-Dimensional
Language	English
Publishing date	2023-01-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20021530
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Article: Evaluation in Ayres Sensory Integration® (EASI) Tactile Perception Tests: Construct Validity and Internal Reliability.

Schaaf, Roseann C / Wright, Kelly Auld / Mailloux, Zoe / Grady, Patricia / Parham, L Diane / Roley, Susanne Smith / Bundy, Anita

The American journal of occupational therapy : official publication of the American Occupational Therapy Association

2023 Volume 77, Issue 1

Abstract: Importance: Assessment of tactile perception is foundational for addressing aspects of occupational performance.: Objective: To evaluate the construct validity and internal reliability of four new tactile perception tests.: Design: Causal ... ...

Abstract	Importance: Assessment of tactile perception is foundational for addressing aspects of occupational performance. Objective: To evaluate the construct validity and internal reliability of four new tactile perception tests. Design: Causal comparative groups design. Settings: Homes, schools, and therapy practices across the United States. Participants: Children ages 3 to 12 yr: typically developing (n = 174) and those with sensory integration concerns (n = 153). Outcomes and measures: Rasch analyses to evaluate construct validity; analysis of covariance to evaluate group differences. Results: The Rasch model confirmed evidence of construct validity for each of the four tests. The typically developing group scored significantly higher than the clinical group on all tests (η2p = .040-.105, p < .001). Person reliability indices and strata indicated moderate to strong internal reliability (Rasch person reliability indices = .69-.87; strata = 2.33-3.82). Conclusions and relevance: The Evaluation in Ayres Sensory Integration® (EASI) Tactile Perception Tests are reliable and valid measures for assessing tactile perception in children ages 3 to 12 yr. Findings suggest that these tests are likely to be clinically useful and appropriate for children in this age range and may provide critical information regarding underlying sensory functions necessary for optimal occupational performance. What This Article Adds: This article provides data supporting the reliability and validity of the EASI Tactile Perception Tests in a U.S. Sample: These assessments can be used by therapists trained in their administration to assess tactile functions that may affect participation in activities, tasks, and occupations.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Reproducibility of Results ; Touch Perception ; Touch ; Occupational Therapy
Language	English
Publishing date	2023-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	219403-x
ISSN	1943-7676 ; 0272-9490 ; 0161-326X
ISSN (online)	1943-7676
ISSN	0272-9490 ; 0161-326X
DOI	10.5014/ajot.2023.050053
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Article ; Online: How cost-effective is nutrition care delivered in primary healthcare settings? A systematic review of trial-based economic evaluations.

Barnes, Katelyn A / Szewczyk, Zoe / Kelly, Jaimon T / Campbell, Katrina L / Ball, Lauren E

Nutrition reviews

2021 Volume 80, Issue 6, Page(s) 1480–1496

Abstract: Context: Nutrition care is an effective lifestyle intervention for the treatment and prevention of many noncommunicable diseases. Primary care is a high-value setting in which to provide nutrition care.: Objective: The objective of this review was to ...

Abstract	Context: Nutrition care is an effective lifestyle intervention for the treatment and prevention of many noncommunicable diseases. Primary care is a high-value setting in which to provide nutrition care. Objective: The objective of this review was to evaluate the cost-effectiveness of nutrition care interventions provided in primary care settings. Data sources: Medline, Embase, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), the Cochrane Central Register of Controlled Trials, EconLit, and the National Health Service Economic Evaluation Database (NHS EED) were searched from inception to May 2021. Data extraction: Data extraction was guided by the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) reporting guidelines. Randomized trials of nutrition interventions in primary care settings were included in the analysis if incremental cost-effectiveness ratios were reported. The main outcome variable incremental cost-effectiveness ratios (ICERs) and reported interpretations were used to categorize interventions by the cost-effectiveness plane quadrant. Results: Of 6837 articles identified, 10 were included (representing 9 studies). Eight of the 9 included studies found nutrition care in primary care settings to be more costly and more effective than usual care. High study heterogeneity limited further conclusions. Conclusion: Nutrition care in primary care settings is effective, though it requires investment; it should, therefore, be considered in primary care planning. Further studies are needed to evaluate the long-term cost-effectiveness of providing nutrition care in primary care settings. Systematic review registration: PROSPERO registration no. CRD42020201146.
MeSH term(s)	Cost-Benefit Analysis ; Humans ; Life Style ; Primary Health Care ; State Medicine
Language	English
Publishing date	2021-10-01
Publishing country	United States
Document type	Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	82067-2
ISSN	1753-4887 ; 0029-6643
ISSN (online)	1753-4887
ISSN	0029-6643
DOI	10.1093/nutrit/nuab082
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