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  1. Article ; Online: A Needs Assessment for the Future of Otolaryngology Education.

    Chen, Jenny X / Yu, Sophie E / Miller, Lauren E / Gray, Stacey T

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2023  Volume 169, Issue 1, Page(s) 192–193

    Abstract: The field of otolaryngology-head and neck surgery is rapidly changing, and surgical education must keep pace. In the face of recent advances in medical knowledge, surgical technique, and novel technology, educators may find it increasingly difficult to ... ...

    Abstract The field of otolaryngology-head and neck surgery is rapidly changing, and surgical education must keep pace. In the face of recent advances in medical knowledge, surgical technique, and novel technology, educators may find it increasingly difficult to identify the evolving educational needs of otolaryngology residents. To better align training activities with modern practice patterns, we propose conducting a longitudinal needs assessment by designing a standardized specialty-specific survey for practicing otolaryngologists. This recurring survey could be implemented alongside accreditation or other continuing medical education activities. The outcomes would report what contemporary otolaryngologists see and do in everyday practice to guide educational reforms to better prepare trainees for future practice.
    MeSH term(s) Humans ; Internship and Residency ; Needs Assessment ; Curriculum ; Otolaryngology/education ; Education, Medical, Graduate/methods
    Language English
    Publishing date 2023-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/01945998221128292
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  2. Article: Factors and framing effects in support for net zero policies in the United Kingdom.

    Poortinga, Wouter / Whitmarsh, Lorraine / Steentjes, Katharine / Gray, Emily / Thompson, Sophie / Brisley, Rachel

    Frontiers in psychology

    2023  Volume 14, Page(s) 1287188

    Abstract: Achieving ambitious carbon reduction targets requires transformative change to society, with behaviour change playing an important role. Climate change mitigation ('net zero') policies are needed to accelerate and support such behaviour change. This ... ...

    Abstract Achieving ambitious carbon reduction targets requires transformative change to society, with behaviour change playing an important role. Climate change mitigation ('net zero') policies are needed to accelerate and support such behaviour change. This study examined factors and framing effects in public support for net zero policies in the United Kingdom (UK), making use of a large probability sample (n
    Language English
    Publishing date 2023-12-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1287188
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  3. Article ; Online: Advocating, Unlearning, Tearing It All Down? How BIPOC Young Adults with Mental Health Concerns Perceive and Engage with the Media.

    To, Sophie B / Gray, Jaz / Jain, Parul / Porter, Jeannette H / Comello, Maria Leonora G

    Health communication

    2023  , Page(s) 1–13

    Abstract: The COVID-19 pandemic has increased the salience of issues related to social justice, mental health, and health equity. During this time, the media have been instrumental in amplifying social movements but also in spreading mis/disinformation, violence, ... ...

    Abstract The COVID-19 pandemic has increased the salience of issues related to social justice, mental health, and health equity. During this time, the media have been instrumental in amplifying social movements but also in spreading mis/disinformation, violence, and hatred. Among communities who have been affected heavily during this time are Black, Indigenous, and People of Color (BIPOC) young adults who have a mental illness/significant mental health concerns. As frequent engagers and creators of media, their perspectives are critical to informing what aspects of the media should be leveraged to promote the health, well-being, and safety of people who have been marginalized. Thus, our study asks:
    Language English
    Publishing date 2023-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1038723-7
    ISSN 1532-7027 ; 1041-0236
    ISSN (online) 1532-7027
    ISSN 1041-0236
    DOI 10.1080/10410236.2023.2290882
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  4. Article ; Online: A census-based housing vulnerability index for typhoon hazards in the Philippines

    Sarah Healey / Sophie Lloyd / Jasmine Gray / Aaron Opdyke

    Progress in Disaster Science, Vol 13, Iss , Pp 100211- (2022)

    2022  

    Abstract: The Sendai Framework for Disaster Risk Reduction recognises housing as an important element of vulnerability, however, there remains limited understanding of how sub-national housing vulnerability varies spatially. This research sought to develop a ... ...

    Abstract The Sendai Framework for Disaster Risk Reduction recognises housing as an important element of vulnerability, however, there remains limited understanding of how sub-national housing vulnerability varies spatially. This research sought to develop a municipal-level housing vulnerability index for typhoon hazards, applied at a national scale in the Philippines. We first selected 25 housing vulnerability indicators from the 2015 Philippines census, which were reduced into seven underlying dimensions of typhoon-related housing vulnerability using principal component analysis: housing density, housing quality, crowdedness, tenure security, extreme substandard housing, drinking water source, and structural integrity. These components were then aggregated to create a relative housing vulnerability index. We applied spatial clustering analysis to test for patterns, finding increasing housing vulnerability from north to south, with nuance in municipalities that defy these national trends. Our results offer a more granular view of housing vulnerability which may assist in unpacking how localised housing conditions contribute to disaster risk and assist researchers and government agencies in targeting disaster interventions.
    Keywords Philippines ; Housing vulnerability ; Spatial mapping ; Social vulnerability ; Environmental sciences ; GE1-350 ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  5. Article ; Online: Urban and rural patterns of typhoon mortality in the Philippines

    Jasmine Gray / Sophie Lloyd / Sarah Healey / Aaron Opdyke

    Progress in Disaster Science, Vol 14, Iss , Pp 100234- (2022)

    2022  

    Abstract: Storms continue to be the deadliest type of weather-related disasters globally. The Philippines is one of the most at risk countries to disasters, yet there continues to be gaps in understanding where and why people are killed in typhoons – the country's ...

    Abstract Storms continue to be the deadliest type of weather-related disasters globally. The Philippines is one of the most at risk countries to disasters, yet there continues to be gaps in understanding where and why people are killed in typhoons – the country's most prominent natural hazard. This research sought to understand how typhoon mortality varies across the Philippines at the municipal level, focusing on differences in rural and urban municipalities between 2005 and 2015. Generalised linear regression models (GLMs), including Poisson and negative binomial (NB), were used to analyse the relationship between typhoon mortality and level of urbanisation while controlling for social vulnerability and typhoon exposure. Findings indicate that typhoon mortality is disproportionality concentrated in emerging, rather than established, urban centres. Deaths from typhoons were significantly higher per capita in older age groups and amongst men, with drowning accounting for 71% of deaths, although there is uncertainty in these later trends which show the need for investment in national disaster databases. Our results make contributions to understanding of urban-rural patterns of disaster risk and the determinants of typhoon mortality in the Philippines.
    Keywords Disasters ; Mortality ; Typhoons ; Storms ; Philippines ; Environmental sciences ; GE1-350 ; Social sciences (General) ; H1-99
    Subject code 910
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  6. Article ; Online: Improving Diversity and Inclusion in GI.

    Anyane-Yeboa, Adjoa / Balzora, Sophie / Gray, Darrell M

    The American journal of gastroenterology

    2020  Volume 115, Issue 8, Page(s) 1147–1149

    MeSH term(s) Cultural Diversity ; Gastroenterology ; Humans ; Physicians ; United States
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000000647
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  7. Article ; Online: Health equity in focus: introducing the Association of Black Gastroenterologists and Hepatologists.

    Gray, Darrell M / Anyane-Yeboa, Adjoa / Issaka, Rachel B / Balzora, Sophie

    The lancet. Gastroenterology & hepatology

    2021  Volume 6, Issue 5, Page(s) 348

    MeSH term(s) African Americans ; Career Mobility ; Faculty, Medical ; Gastroenterologists ; Health Equity ; Humans ; Societies, Medical ; United States
    Language English
    Publishing date 2021-08-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(21)00106-0
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  8. Article ; Online: A case series of patients with filamin-C truncating variants attending a specialized cardiac genetic clinic.

    Hespe, Sophie / Isbister, Julia C / Duflou, Johan / Puranik, Raj / Bagnall, Richard D / Semsarian, Christopher / Gray, Belinda / Ingles, Jodie

    European heart journal. Case reports

    2023  Volume 7, Issue 12, Page(s) ytad572

    Abstract: Background: FLNC: Case summary: Retrospective review of medical records, including cardiac investigations, was performed for families attending a specialized clinic with a : Discussion: ... ...

    Abstract Background: FLNC
    Case summary: Retrospective review of medical records, including cardiac investigations, was performed for families attending a specialized clinic with a
    Discussion: The
    Language English
    Publishing date 2023-11-17
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad572
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  9. Article ; Online: What deubiquitinating enzymes, oncogenes, and tumor suppressors actually do: Are current assumptions supported by patient outcomes?

    Gregoire-Mitha, Sophie / Gray, Douglas A

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2021  Volume 43, Issue 4, Page(s) e2000269

    Abstract: Context can determine whether a given gene acts as an oncogene or a tumor suppressor. Deubiquitinating enzymes (DUBs) regulate the stability of many components of the pathways dictating cell fate so it would be expected that alterations in the levels or ... ...

    Abstract Context can determine whether a given gene acts as an oncogene or a tumor suppressor. Deubiquitinating enzymes (DUBs) regulate the stability of many components of the pathways dictating cell fate so it would be expected that alterations in the levels or activity of these enzymes may have oncogenic or tumor suppressive consequences. In the current review we survey publications reporting that genes encoding DUBs are oncogenes or tumor suppressors. For many DUBs both claims have been made. For such "double agents," the effects of gain or loss of function will depend on the overall status of a complex of molecular signaling networks subject to extensive crosstalk. As the TGF-β paradox makes clear context is critical in cell fate decisions, and the disconnect between experimental findings and patient survival outcomes can in part be attributed to disparities between culture conditions and the microenvironment in vivo. Convincing claims for oncogene or tumor suppressor roles require the documentation of gene alterations in patient samples; survival curves are alone inadequate.
    MeSH term(s) Carcinogenesis ; Deubiquitinating Enzymes ; Genes, Tumor Suppressor ; Humans ; Oncogenes/genetics ; Signal Transduction/genetics ; Tumor Microenvironment
    Chemical Substances Deubiquitinating Enzymes (EC 3.4.19.12)
    Language English
    Publishing date 2021-01-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.202000269
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    Zs.A 2024: Show issues Location:
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  10. Article: Shifting equilibriums in Alzheimer's disease: the complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis.

    Gray, Sophie C / Kinghorn, Kerri J / Woodling, Nathaniel S

    Neural regeneration research

    2020  Volume 15, Issue 7, Page(s) 1208–1219

    Abstract: Alzheimer's disease is the leading cause of dementia. Its increased prevalence in developed countries, due to the sharp rise in ageing populations, presents one of the costliest challenges to modern medicine. In order to find disease-modifying therapies ... ...

    Abstract Alzheimer's disease is the leading cause of dementia. Its increased prevalence in developed countries, due to the sharp rise in ageing populations, presents one of the costliest challenges to modern medicine. In order to find disease-modifying therapies to confront this challenge, a more complete understanding of the pathogenesis of Alzheimer's disease is necessary. Recent studies have revealed increasing evidence for the roles played by microglia, the resident innate immune system cells of the brain. Reflecting the well-established roles of microglia in reacting to pathogens and inflammatory stimuli, there is now a growing literature describing both protective and detrimental effects for individual cytokines and chemokines produced by microglia in Alzheimer's disease. A smaller but increasing number of studies have also addressed the divergent roles played by microglial neurotrophic and neurogenic factors, and how their perturbation may play a key role in the pathogenesis of Alzheimer's disease. Here we review recent findings on the roles played by microglia in neuroinflammation, neuronal survival and neurogenesis in Alzheimer's disease. In each case, landmark studies have provided evidence for the divergent ways in which microglia can either promote neuronal function and survival, or perturb neuronal function, leading to cell death. In many cases, the secreted molecules of microglia can lead to divergent effects depending on the magnitude and context of microglial activation. This suggests that microglial functions must be maintained in a fine equilibrium, in order to support healthy neuronal function, and that the cellular microenvironment in the Alzheimer's disease brain disrupts this fine balance, leading to neurodegeneration. Thus, an understanding of microglial homeostasis, both in health and across the trajectory of the disease state, will improve our understanding of the pathogenic mechanisms underlying Alzheimer's disease, and will hopefully lead to the development of microglial-based therapeutic strategies to restore equilibrium in the Alzheimer's disease brain.
    Language English
    Publishing date 2020-02-11
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.272571
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