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Article ; Online: Anatomic pattern of perforator arteries from proper digital arteries in human triphalangeal digits.

Navío-Fernández, Fernando / Corella, Fernando / Ocampos, Montserrat / Pastor-Fernández, Esther / Vázquez, Teresa

2024 Volume 54 Suppl 7, Page(s) 111062

Abstract: Introduction: The localization of the perforator artery for the performance of digital artery perforator (DAP) flaps poses a challenge. This study aims to describe the anatomical pattern of the perforator arteries originating from the proper digital ... ...

Abstract	Introduction: The localization of the perforator artery for the performance of digital artery perforator (DAP) flaps poses a challenge. This study aims to describe the anatomical pattern of the perforator arteries originating from the proper digital artery in fresh cadaveric triphalangeal digits and to use this pattern as a point of reference for performing these flaps. Material and method: We performed a descriptive anatomical study on 28 fresh cadaveric hands (14 male, 14 female; 10 right hands, 18 left hands) after injecting the arterial system with latex. Digital photographs were taken of each specimen after dissection and the number of perforator arteries in each finger (second to fifth), phalanx (proximal, middle and distal) and finger side (radial or ulnar) were obtained by analysis in Adobe Photoshop CS6. Results: We obtained statistically significant results when comparing the means of the number of perforator arteries between fingers, phalanx, finger side, gender and laterality. When analyzing the number of perforator arteries in each phalanx third in each finger, we found that more than 75% of specimens had at least one perforator artery in the two distal thirds of the proximal phalanx and the three-thirds of the middle phalanx and more than 50% had at least one in the proximal third of the distal phalanx. Conclusions: We present a homogeneous perforator artery anatomic pattern, by finger, phalanx, finger side, gender and laterality, consisting of a high density of perforator arteries in the distal proximal phalanx region, throughout the middle phalanx and in the proximal distal phalanx region, which would be the areas of greatest certainty to help predict the favorable evolution of a digital artery perforator flap in the fingers.
MeSH term(s)	Humans ; Male ; Female ; Fingers/surgery ; Hand ; Perforator Flap/blood supply ; Ulnar Artery ; Cadaver ; Finger Injuries/surgery
Language	English
Publishing date	2024-01-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	218778-4
ISSN	1879-0267 ; 0020-1383
ISSN (online)	1879-0267
ISSN	0020-1383
DOI	10.1016/j.injury.2023.111062
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Article: Trends in psychiatric hospitalization for alcohol and drugs in Castilla y León between 2005 and 2015.

Llanes-Álvarez, Carlos / Andrés-de Llano, Jesús María / Álvarez-Navares, Ana I / Pastor-Hidalgo, M Teresa / Roncero, Carlos / Franco-Martín, Manuel A

Adicciones

2022 Volume 34, Issue 3, Page(s) 189–196

Abstract: It has been estimated that alcohol, tobacco, and illicit drugs were responsible for more than 10 million deaths worldwide in 2016, and there are many opportunities for improvement. Regarding innovative data analysis, advances have been made in the ... ...

Title translation	Tendencias en la hospitalización psiquiátrica por alcohol y drogas en Castilla y León entre 2005 y 2015.
Abstract	It has been estimated that alcohol, tobacco, and illicit drugs were responsible for more than 10 million deaths worldwide in 2016, and there are many opportunities for improvement. Regarding innovative data analysis, advances have been made in the extraction of information from administrative databases for analytics purposes. We studied trends in hospitalization rates for alcohol and drug abuse over eleven years with Joinpoint Trend Analysis software. This is a descriptive study of cross-associations in 3,758 hospital admissions of patients admitted with a main diagnosis of alcohol and drug abuse or dependence in psychiatry units of public health centres of Castilla y León (Spain) between 2005 and 2015. Hospitalization trends for alcohol and drug related conditions declined over the eleven-year period. Separately, there was a statistically significant decrease in alcohol and cocaine related conditions, but a strong upward trend in cannabis related conditions between 2013 and 2015. Alcohol was the main cause of admission to psychiatric units with a diagnosis of addiction. In the 11 years researched, there was a progressive and constant reduction in admissions for substance use except for cannabis. The innovative statistical methodology has already proven to be useful for identifying trends and changes in different pathologies over time.
MeSH term(s)	Alcohol Drinking/trends ; Ethanol ; Hospitalization ; Humans ; Illicit Drugs ; Spain ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/therapy ; Tobacco Use
Chemical Substances	Illicit Drugs ; Ethanol (3K9958V90M)
Language	Spanish
Publishing date	2022-07-01
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2018873-0
ISSN	0214-4840
ISSN	0214-4840
DOI	10.20882/adicciones.1405
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Article ; Online: Double blocking of carbon metabolism causes a large increase of Calvin-Benson cycle compounds in cyanobacteria.

Domínguez-Lobo, María Teresa / Roldán, Miguel / Gutiérrez-Diánez, Alba María / Florencio, Francisco Javier / Muro-Pastor, MaríaIsabel

Plant physiology

2024

Abstract: Carbon-flow-regulator A (CfrA) adapts carbon flux to nitrogen conditions in non-diazotrophic cyanobacteria. Under nitrogen deficiency, CfrA leads to the storage of excess carbon, which cannot combine with nitrogen, mainly as glycogen. cfrA overexpression ...

Abstract	Carbon-flow-regulator A (CfrA) adapts carbon flux to nitrogen conditions in non-diazotrophic cyanobacteria. Under nitrogen deficiency, CfrA leads to the storage of excess carbon, which cannot combine with nitrogen, mainly as glycogen. cfrA overexpression from the arsenite-inducible, nitrogen-independent ParsB promoter allows analysis of the metabolic effects of CfrA accumulation. Considering that the main consequence of cfrA overexpression is glycogen accumulation, we examined carbon distribution in response to cfrA expression in Synechocystis sp. PCC 6803 strains impaired in synthesizing this polymer. We carried out a comparative phenotypic analysis to evaluate cfrA overexpression in the wild-type strain and in a mutant of ADP-glucose pyrophosphorylase (ΔglgC), which is unable to synthesize glycogen. The accumulation of CfrA in the wild-type background caused a photosynthetic readjustment although growth was not affected. However, in a ΔglgC strain, growth decreased depending on CfrA accumulation and photosynthesis was severely affected. An elemental analysis of the H, C, and N content of cells revealed that cfrA expression in the wildtype caused an increase in the C/N ratio, due to decreased nitrogen assimilation. Metabolomic study indicated that these cells store sucrose and glycosylglycerol, in addition to the previously described glycogen accumulation. However, cells deficient in glycogen synthesis accumulated large amounts of Calvin-Benson cycle intermediates as cfrA was expressed. These cells also showed increased levels of some amino acids, mainly alanine, serine, valine, isoleucine and leucine. The findings suggest that by controlling cfrA expression, in different conditions and strains, we could change the distribution of fixed carbon, with potential biotechnological benefits.
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1093/plphys/kiae083
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Article ; Online: Lhs1 dependent ERAD is determined by transmembrane domain context.

Sukhoplyasova, Maria / Keith, Abigail M / Perrault, Emma M / Vorndran, Hannah E / Jordahl, Alexa S / Yates, Megan E / Pastor, Ashutosh / Li, Zachary / Freaney, Michael L / Deshpande, Riddhi A / Adams, David B / Guerriero, Christopher J / Shi, Shujie / Kleyman, Thomas R / Kashlan, Ossama B / Brodsky, Jeffrey L / Buck, Teresa M

The Biochemical journal

2023 Volume 480, Issue 18, Page(s) 1459–1473

Abstract: Transmembrane proteins have unique requirements to fold and integrate into the endoplasmic reticulum (ER) membrane. Most notably, transmembrane proteins must fold in three separate environments: extracellular domains fold in the oxidizing environment of ... ...

Abstract	Transmembrane proteins have unique requirements to fold and integrate into the endoplasmic reticulum (ER) membrane. Most notably, transmembrane proteins must fold in three separate environments: extracellular domains fold in the oxidizing environment of the ER lumen, transmembrane domains (TMDs) fold within the lipid bilayer, and cytosolic domains fold in the reducing environment of the cytosol. Moreover, each region is acted upon by a unique set of chaperones and monitored by components of the ER associated quality control machinery that identify misfolded domains in each compartment. One factor is the ER lumenal Hsp70-like chaperone, Lhs1. Our previous work established that Lhs1 is required for the degradation of the unassembled α-subunit of the epithelial sodium channel (αENaC), but not the homologous β- and γENaC subunits. However, assembly of the ENaC heterotrimer blocked the Lhs1-dependent ER associated degradation (ERAD) of the α-subunit, yet the characteristics that dictate the specificity of Lhs1-dependent ERAD substrates remained unclear. We now report that Lhs1-dependent substrates share a unique set of features. First, all Lhs1 substrates appear to be unglycosylated, and second they contain two TMDs. Each substrate also contains orphaned or unassembled TMDs. Additionally, interfering with inter-subunit assembly of the ENaC trimer results in Lhs1-dependent degradation of the entire complex. Finally, our work suggests that Lhs1 is required for a subset of ERAD substrates that also require the Hrd1 ubiquitin ligase. Together, these data provide hints as to the identities of as-yet unconfirmed substrates of Lhs1 and potentially of the Lhs1 homolog in mammals, GRP170.
MeSH term(s)	Animals ; Endoplasmic Reticulum-Associated Degradation ; Cytosol ; Endoplasmic Reticulum ; Lipid Bilayers ; Membrane Proteins/genetics ; Mammals
Chemical Substances	Lipid Bilayers ; Membrane Proteins
Language	English
Publishing date	2023-09-13
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2969-5
ISSN	1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021
ISSN (online)	1470-8728
ISSN	0006-2936 ; 0306-3275 ; 0264-6021
DOI	10.1042/BCJ20230075
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Article ; Online: Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function.

Patnaik, Praveen K / Beaupere, Carine / Barlit, Hanna / Romero, Antonia María / Tsuchiya, Mitsuhiro / Muir, Michael / Martínez-Pastor, María Teresa / Puig, Sergi / Kaeberlein, Matt / Labunskyy, Vyacheslav M

Cell reports

2022 Volume 40, Issue 3, Page(s) 111113

Abstract: Iron dyshomeostasis contributes to aging, but little information is available about the molecular mechanisms. Here, we provide evidence that in Saccharomyces cerevisiae, aging is associated with altered expression of genes involved in iron homeostasis. ... ...

Abstract	Iron dyshomeostasis contributes to aging, but little information is available about the molecular mechanisms. Here, we provide evidence that in Saccharomyces cerevisiae, aging is associated with altered expression of genes involved in iron homeostasis. We further demonstrate that defects in the conserved mRNA-binding protein Cth2, which controls stability and translation of mRNAs encoding iron-containing proteins, increase lifespan by alleviating its repressive effects on mitochondrial function. Mutation of the conserved cysteine residue in Cth2 that inhibits its RNA-binding activity is sufficient to confer longevity, whereas Cth2 gain of function shortens replicative lifespan. Consistent with its function in RNA degradation, Cth2 deficiency relieves Cth2-mediated post-transcriptional repression of nuclear-encoded components of the electron transport chain. Our findings uncover a major role of the RNA-binding protein Cth2 in the regulation of lifespan and suggest that modulation of iron starvation signaling can serve as a target for potential aging interventions.
MeSH term(s)	Gene Expression Regulation, Fungal ; Iron/metabolism ; Longevity ; Mitochondria/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Tristetraprolin/genetics ; Tristetraprolin/metabolism
Chemical Substances	RNA, Messenger ; RNA-Binding Proteins ; Saccharomyces cerevisiae Proteins ; TIS11 protein, S cerevisiae ; Tristetraprolin ; Iron (E1UOL152H7)
Language	English
Publishing date	2022-07-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2022.111113
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Article ; Online: Predictive value of computed tomography scoring systems evolution in adults with cystic fibrosis.

Zorzo, Cristina / Caballero, Paloma / Diab, Layla / Pastor, M Teresa / Gómez-Punter, Rosa M / Girón, Rosa M

European radiology

2020 Volume 30, Issue 7, Page(s) 3634–3640

Abstract: Objectives: To assess whether the evolution of two consecutive high-resolution computed tomography (HRCT) scores in patients with cystic fibrosis (CF) has prognostic value.: Methods: A longitudinal retrospective study was performed to research adult ... ...

Abstract	Objectives: To assess whether the evolution of two consecutive high-resolution computed tomography (HRCT) scores in patients with cystic fibrosis (CF) has prognostic value. Methods: A longitudinal retrospective study was performed to research adult patients with CF. Two consecutive HRCT studies were scored using Bhalla and Brody II scoring scales by two senior radiologists. Annual scoring changes for each scale were calculated and correlated with annual FEV1% decline, with pulmonary exacerbations and number of antibiotic treatments. Results: We selected sixty-four adult patients. The median interval between the two HRCTs was 3.88 ± 1.59 years. The mean spirometric values showed dynamic lung volumes lower than the general population; globally, there was a worsening of respiratory function over time. The change in the annual HRCT scores was positive on both scales, indicating a worse structural situation over time. The Brody II scale annual change showed a significant statistical correlation with a decline in the annual FEV1%, exacerbations and number of oral antibiotic treatments. In contrast, for the Bhalla scale, the relationship was moderately inverse with exacerbations and with the number of oral treatments. No statistically significant relationships were found for the change in the annual FEV1% and exacerbations or number of antibiotic treatments. The interobservational and intraobservational agreements were very strong in both scales. Conclusions: The annual evolution of the Brody II HRCT scoring system demonstrated a predictive value and correlated with FEV1% decline, pulmonary exacerbations and oral antibiotic treatments. Key points: • HRCT evolution has prognostic value in cystic fibrosis. • Temporal evolution for the Brody II score is useful for clinical follow-up. • Brody II score changes correlate with FEV1% decline, pulmonary exacerbations and number of antibiotic treatments.
MeSH term(s)	Adult ; Algorithms ; Anti-Bacterial Agents/therapeutic use ; Cystic Fibrosis/diagnostic imaging ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/physiopathology ; Disease Progression ; Female ; Forced Expiratory Volume ; Humans ; Longitudinal Studies ; Lung/diagnostic imaging ; Lung/physiopathology ; Male ; Prognosis ; Retrospective Studies ; Spirometry/methods ; Tomography, X-Ray Computed/methods ; Young Adult
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-03-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-020-06759-z
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Article ; Online: Exhaled volatile organic compounds analysis in clinical pediatrics: a systematic review.

Sola Martínez, Rosa A / Pastor Hernández, José M / Yanes Torrado, Óscar / Cánovas Díaz, Manuel / de Diego Puente, Teresa / Vinaixa Crevillent, María

Pediatric research

2020 Volume 89, Issue 6, Page(s) 1352–1363

Abstract: Background: Measured exhaled volatile organic compounds (VOCs) in breath also referred to as exhaled volatilome have been long claimed as a potential source of non-invasive and clinically applicable biomarkers. However, the feasibility of using exhaled ... ...

Abstract	Background: Measured exhaled volatile organic compounds (VOCs) in breath also referred to as exhaled volatilome have been long claimed as a potential source of non-invasive and clinically applicable biomarkers. However, the feasibility of using exhaled volatilome in clinical practice remains to be demonstrated, particularly in pediatrics where the need for improved non-invasive diagnostic and monitoring methods is most urgent. This work presents the first formal evidence-based judgment of the clinical potential of breath volatilome in the pediatric population. Methods: A rigorous systematic review across Web of Science, SCOPUS, and PubMed databases following the PRISMA statement guidelines. A narrative synthesis of the evidence was conducted and QUADAS-2 was used to assess the quality of selected studies. Results: Two independent reviewers deemed 22 out of the 229 records initially found to satisfy inclusion criteria. A summary of breath VOCs found to be relevant for several respiratory, infectious, and metabolic pathologies was conducted. In addition, we assessed their associated metabolism coverage through a functional characterization analysis. Conclusion: Our results indicate that current research remains stagnant in a preclinical exploratory setting. Designing exploratory experiments in compliance with metabolomics practice should drive forward the clinical translation of VOCs breath analysis. Impact: What is the key message of your article? Metabolomics practice could help to achieve the clinical utility of exhaled volatilome analysis. What does it add to the existing literature? This work is the first systematic review focused on disease status discrimination using analysis of exhaled breath in the pediatric population. A summary of the reported exhaled volatile organic compounds is conducted together with a functional characterization analysis. What is the impact? Having noted challenges preventing the clinical translation, we summary metabolomics practices and the experimental designs that are closer to clinical practice to create a framework to guide future trials.
MeSH term(s)	Breath Tests/methods ; Child ; Exhalation ; Humans ; Metabolomics ; Pediatrics ; Volatile Organic Compounds/analysis
Chemical Substances	Volatile Organic Compounds
Language	English
Publishing date	2020-09-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-020-01116-8
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Zs.A 564: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Book ; Online: Chapter Mobile Systems as a Challenge for Neurological Diseases Management - The Case of Parkinson's Disease

Pastorino, Matteo / Teresa Arredondo Waldmeyer, Maria / Pansera, Mario / Cancela, Jorge / Pastor-Sanz, Laura

2011

Keywords	Physiological & neuro-psychology, biopsychology ; Society & social sciences
Size	1 Online-Ressource
Publisher	InTechOpen
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021047230
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Zein Nanoparticles Containing Arginine-Based Surfactants: Physicochemical Characterization and Effect on the Biological Properties.

Pérez, Lourdes / Sentís, Adrià / Hafidi, Zakaria / Pinazo, Aurora / García, Maria Teresa / Martín-Pastor, Manuel / de Sousa, Francisco Fábio Oliveira

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: Cationic surfactants carry antimicrobial activity, based on their interaction and disruption of cell membranes. Nonetheless, their intrinsic toxicity limits their applicability. To overcome this issue, a feasible strategy consists of using solid ... ...

Abstract	Cationic surfactants carry antimicrobial activity, based on their interaction and disruption of cell membranes. Nonetheless, their intrinsic toxicity limits their applicability. To overcome this issue, a feasible strategy consists of using solid nanoparticles to improve their delivery. The zein nanoparticles were loaded with four cationic arginine-based surfactants: one single chain Nα-lauroyl-arginine (LAM) and three Gemini surfactants Nα Nω-Bis (Nα-lauroyl-arginine) α, ω-diamide) (C
MeSH term(s)	Zein ; Surface-Active Agents/pharmacology ; Surface-Active Agents/chemistry ; Arginine/chemistry ; Molecular Docking Simulation ; Bacteria ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/chemistry ; Nanoparticles
Chemical Substances	Zein (9010-66-6) ; Surface-Active Agents ; Arginine (94ZLA3W45F) ; Anti-Infective Agents
Language	English
Publishing date	2023-01-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032568
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Article ; Online: Getting Cartilage Thickness Measurements Right: A Systematic Inter-Method Comparison Using MRI Data from the Osteoarthritis Initiative.

Nolte, Teresa / Westfechtel, Simon / Schock, Justus / Knobe, Matthias / Pastor, Torsten / Pfaehler, Elisabeth / Kuhl, Christiane / Truhn, Daniel / Nebelung, Sven

Cartilage

2023 Volume 14, Issue 1, Page(s) 26–38

Abstract: Objective: Magnetic resonance imaging is the standard imaging modality to assess articular cartilage. As the imaging surrogate of degenerative joint disease, cartilage thickness is commonly quantified after tissue segmentation. In lack of a standard ... ...

Abstract	Objective: Magnetic resonance imaging is the standard imaging modality to assess articular cartilage. As the imaging surrogate of degenerative joint disease, cartilage thickness is commonly quantified after tissue segmentation. In lack of a standard method, this study systematically compared five methods for automatic cartilage thickness measurements across the knee joint and as a function of region and sub-region: 3D mesh normals (3D-MN), 3D nearest neighbors (3D-NN), 3D ray tracing (3D-RT), 2D centerline normals (2D-CN), and 2D surface normals (2D-SN). Design: Based on the manually segmented femoral and tibial cartilage of 507 human knee joints, mean cartilage thickness was computed for the entire femorotibial joint, 4 joint regions, and 20 subregions using these methods. Inter-method comparisons of mean cartilage thickness and computation times were performed by one-way analysis of variance (ANOVA), Bland-Altman analyses and Lin's concordance correlation coefficient (CCC). Results: Mean inter-method differences in cartilage thickness were significant in nearly all subregions ( Conclusions: In automatic cartilage thickness determination, quantification accuracy and computational burden are largely affected by the underlying method. Mesh and surface normals or nearest neighbor searches should be used because they accurately capture variable geometries while being time-efficient.
MeSH term(s)	Humans ; Knee Joint/diagnostic imaging ; Knee Joint/pathology ; Cartilage, Articular/diagnostic imaging ; Cartilage, Articular/pathology ; Femur/diagnostic imaging ; Femur/pathology ; Magnetic Resonance Imaging/methods ; Osteoarthritis/pathology
Language	English
Publishing date	2023-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2515870-3
ISSN	1947-6043 ; 1947-6035
ISSN (online)	1947-6043
ISSN	1947-6035
DOI	10.1177/19476035221144744
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