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Article ; Online: Scrutinizing the causal link between excited delirium syndrome and restraint: a commentary on 'The role of restraint in fatal excited delirium: a research synthesis and pooled analysis' by E.M.F. Strömmer, W. Leith, M.P. Zeegers, and M.D. Freeman.

de Boer, Hans H / Fronczek, Judith / Archer, Melanie S

Forensic science, medicine, and pathology

2023 Volume 19, Issue 4, Page(s) 613–616

MeSH term(s)	Humans ; Delirium ; Causality ; Restraint, Physical/adverse effects ; Police
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2195904-3
ISSN	1556-2891 ; 1547-769X
ISSN (online)	1556-2891
ISSN	1547-769X
DOI	10.1007/s12024-023-00589-3
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Conference proceedings: The use of in vitro somatic embryogenesis in grapevine improvement (in: Goussard, P. G.; Archer, E.; Saayman, D.; Tromp, A.; Wyk, J. van (Eds.): Proceedings of the First SASEV International Congress, Cape Town, South Africa, 8-10 November 1995)

Goussard, P. G. / Wiid, J. / Archer, E. / Saayman, D. / Tromp, A. / Wyk, J. van (Eds.)

1995 , Page(s) 58–60

Abstract: ... of the culturing temperature up to 35 DEG C during the first 60 d resulted in complete elimination of all viruses ...

Institution	Univ. of Stellenbosch, Department of Viticulture and Oenology, 7602 Matieland, Republic of South Africa
Event/congress	Proceedings of the First SASEV International Congress
Abstract	The effectiveness of somatic embryogenesis in eliminating viruses (GFkV, GLRaV, GFLV and its yellow mosaic serotype YM) was investigated. Dormant canes from field vines showing visual symptoms of above viruses were collected and the virus status was confirmed by immunosorbent electron microscopy (ISEM) with decoration and ELISA. Development of inflorescences on forced canes was promoted by the removal of all vegetative tissues. Anthers on ovaries were cultured on NN medium supplemented with growth regulators. Proembryogenic masses were transferred to hormone-free medium. Somatic plantlets developed from germinated embryos were acclimatised and transferred to soil. GLRaV and GFkV were not translocated from infected tissue via proliferating callus to embryoids, but other 2 viruses could not be eliminated. Raising of the culturing temperature up to 35 DEG C during the first 60 d resulted in complete elimination of all viruses. The effectiveness and less expenses of this technique comparing the conventional procedure (heat therapy combined with shoot-apex method) were emphasized. (R. Hollo, Eger) [A 3262]
Keywords	in vitro culture ; embryo ; virus ; variety of vine
Language	English
Document type	Conference proceedings
Database	Viticulture and Oenology Abstracts

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Conference proceedings: Biological control of Botrytis cinerea (in: Goussard, P. G.; Archer, E.; Saayman, D.; Tromp, A.; Wyk, J. van (Eds.): Proceedings of the First SASEV International Congress, Cape Town, South Africa, 8-10 November 1995)

Dicks, L. M. / Bence, J. K. / Goussard, P. G. / Archer, E. / Saayman, D. / Tromp, A. / Wyk, J. van (Eds.)

1995 , Page(s) 75–77

Abstract: A protein isolated and purified from a cell-free medium of a wine strain of Latobacillus sp. caused granulation of the cytoplasm of the mycelium of B. cinerea, leakage of amino acids and K ions through the plasmamembrane, and enhancement of the ... ...

Event/congress	Proceedings of the First SASEV International Congress
Abstract	A protein isolated and purified from a cell-free medium of a wine strain of Latobacillus sp. caused granulation of the cytoplasm of the mycelium of B. cinerea, leakage of amino acids and K ions through the plasmamembrane, and enhancement of the incorporation of EXP35S-methionine into intracellular protein. The antifungal protein is hydrophobic and >10 kDa. It is also active against several Gram +ve bacteria, and Rhizophus and Monilinia spp. (W.R. Jarvis, Harrow) [A 3262]
Keywords	botrytis ; biological plant protection
Language	English
Document type	Conference proceedings
Database	Viticulture and Oenology Abstracts

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Article ; Online: Evaluation of clinical prediction models (part 2): how to undertake an external validation study.

Riley, Richard D / Archer, Lucinda / Snell, Kym I E / Ensor, Joie / Dhiman, Paula / Martin, Glen P / Bonnett, Laura J / Collins, Gary S

BMJ (Clinical research ed.)

2024 Volume 384, Page(s) e074820

MeSH term(s)	Humans ; Models, Statistical ; Prognosis
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj-2023-074820
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Article ; Conference proceedings: T-shape mucosal incision as an alternative for Z-POEM

Archer, S. / Falcão, D. / Isabel, P. / Küttner-Magalhães, R.

Endoscopy

2023 Volume 55, Issue S 02

Event/congress	ESGE Days 2023, Dublin, Ireland, 2023-04-20
Language	English
Publishing date	2023-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0043-1765929
Database	Thieme publisher's database

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Article ; Online: Clinical prediction models and the multiverse of madness.

Riley, Richard D / Pate, Alexander / Dhiman, Paula / Archer, Lucinda / Martin, Glen P / Collins, Gary S

BMC medicine

2023 Volume 21, Issue 1, Page(s) 502

Abstract: Background: Each year, thousands of clinical prediction models are developed to make predictions (e.g. estimated risk) to inform individual diagnosis and prognosis in healthcare. However, most are not reliable for use in clinical practice.: Main body!# ...

Abstract	Background: Each year, thousands of clinical prediction models are developed to make predictions (e.g. estimated risk) to inform individual diagnosis and prognosis in healthcare. However, most are not reliable for use in clinical practice. Main body: We discuss how the creation of a prediction model (e.g. using regression or machine learning methods) is dependent on the sample and size of data used to develop it-were a different sample of the same size used from the same overarching population, the developed model could be very different even when the same model development methods are used. In other words, for each model created, there exists a multiverse of other potential models for that sample size and, crucially, an individual's predicted value (e.g. estimated risk) may vary greatly across this multiverse. The more an individual's prediction varies across the multiverse, the greater the instability. We show how small development datasets lead to more different models in the multiverse, often with vastly unstable individual predictions, and explain how this can be exposed by using bootstrapping and presenting instability plots. We recommend healthcare researchers seek to use large model development datasets to reduce instability concerns. This is especially important to ensure reliability across subgroups and improve model fairness in practice. Conclusions: Instability is concerning as an individual's predicted value is used to guide their counselling, resource prioritisation, and clinical decision making. If different samples lead to different models with very different predictions for the same individual, then this should cast doubt into using a particular model for that individual. Therefore, visualising, quantifying and reporting the instability in individual-level predictions is essential when proposing a new model.
MeSH term(s)	Humans ; Prognosis ; Models, Statistical ; Reproducibility of Results
Language	English
Publishing date	2023-12-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2131669-7
ISSN	1741-7015 ; 1741-7015
ISSN (online)	1741-7015
ISSN	1741-7015
DOI	10.1186/s12916-023-03212-y
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Article ; Online: "I'm on an island": A qualitative study of underperforming surgical trainee perspectives on remediation.

McLeod, Kathryn / Woodward-Kron, Robyn / Rashid, Prem / Archer, Julian / Nestel, Debra

American journal of surgery

2024

Abstract: Background: There is a significant gap in the literature regarding trainees' perceptions of remediation. This study aims to explore surgical trainees' experiences and perspectives of remediation.: Methods: This qualitative study used semi-structured ... ...

Abstract	Background: There is a significant gap in the literature regarding trainees' perceptions of remediation. This study aims to explore surgical trainees' experiences and perspectives of remediation. Methods: This qualitative study used semi-structured interviews with 11 doctors who have experienced formal remediation as a surgical trainee. Reflexive thematic analysis was used for data analysis. Results: In this study, trainees perceived remediation as a harrowing and isolating experience, with long-lasting emotions. There was a perceived lack of clarity regarding explanations of underperformance and subjective goals. Remediation was viewed as a 'performance' and tick-box exercise with superficial plans, with challenging trainee/supervisor dynamics. Conclusions: These findings about trainees' perspectives on remediation show a need for trainees to be better emotionally supported during remediation and that remediation plans must be improved to address deficits. Integrating the perspectives and experiences of surgical trainees who have undergone remediation should help improve remediation outcomes and patient care.
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2024.01.033
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Article ; Online: A first report of Pseudosuccinea columella (Say, 1817), an alien intermediate host for liver fluke, in Malawi.

Jones, S / Juhász, A / Makaula, P / Cunningham, L J / Archer, J / Nkolokosa, C / Namacha, G / Kambewa, E / Lally, D / Kapira, D R / Chammudzi, P / Kayuni, S A / Musaya, J / Stothard, J Russell

Parasites & vectors

2024 Volume 17, Issue 1, Page(s) 186

Abstract: ... 2023, P. columella was also noted at single sites within Mangochi and Chikwawa Districts, and again ... molluscs in this lake. While P. columella is a well-known intermediate snail host for human and animal ...

Abstract	Starting in October 2021, quarterly malacological surveys have been undertaken in Malawi, with the sampling of 12 specified freshwater habitats throughout a calendar year. Each survey monitors the presence of aquatic intermediate snail hosts of medical and veterinary importance. In March 2023, the alien lymnaeid species Pseudosuccinea columella was encountered for the first time in the surveys, in Nsanje District. This species identity was later confirmed upon DNA analysis of mitochondrial ribosomal 16S sequences. In July 2023, P. columella was also noted at single sites within Mangochi and Chikwawa Districts, and again in Nsanje District, with an additional location observed. Of particular importance, our sampled location in Mangochi District was directly connected to Lake Malawi, which expands the species list of invasive molluscs in this lake. While P. columella is a well-known intermediate snail host for human and animal fascioliasis, screening collected snails for trematode cercariae, alongside molecular xenomonitoring, did not yield equivocal evidence of active fluke infection. However, the newly recognized presence of this alien intermediate snail host within Lake Malawi, and along the Shire River Valley, flags a new concern in altered local transmission potential for human and animal fascioliasis.
MeSH term(s)	Animals ; Humans ; Fasciola hepatica/genetics ; Fascioliasis/veterinary ; Malawi ; Snails
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-024-06241-5
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Article ; Online: The Emerging Cloud: a survey of vapers, their health and utilization of healthcare within the UK.

Sund, L J / Dargan, P I / Archer, J R H / Blundell, M S / Wood, D M

QJM : monthly journal of the Association of Physicians

2023 Volume 116, Issue 12, Page(s) 993–1001

Abstract: Background: Recent work in the UK estimated the prevalence of current cannabinoid-based vaping to be higher than in the USA, a factor previously associated with e-cigarette or vaping-associated lung injury (EVALI). Research in the USA has demonstrated ... ...

Abstract	Background: Recent work in the UK estimated the prevalence of current cannabinoid-based vaping to be higher than in the USA, a factor previously associated with e-cigarette or vaping-associated lung injury (EVALI). Research in the USA has demonstrated that attendances to emergency departments relating to e-cigarettes began to rise before the EVALI outbreak, suggesting that vapers also experience milder forms of vaping-related illness. Aim: Quantify symptom prevalence and healthcare utilization amongst current UK vapers. Design: Voluntary online survey of individuals aged 16 and over within the UK. Methods: Anonymized data were collected on demographics, vaping/smoking status and vaping substances used. Current vapers were asked about the presence of 10 prevalent symptoms from previous US EVALI case series, healthcare attendances and diagnoses given. Risk-ratios were calculated to compare the likelihood of symptoms and attendances between substances. Results: A total of 2477 complete responses were analysed. In all, 397 respondents were current vapers. Symptom prevalence within the previous 12 months ranged from 3.8% to 30.5% (bloody sputum, cough). Healthcare attendances per symptomatic respondent ranged from 0.1 to 1.4 (bloody sputum, shortness of breath). Current vapers of cannabinoid-based products (alone/in combination) had the most attendances per symptomatic respondent for 9/10 symptoms and were more likely to report symptoms aside from 'cough' (nicotine-free e-liquids [risk ratio = 1.7]). Clinicians reportedly never diagnosed vaping-related illness. Conclusions: UK vapers experience symptoms previously reported in EVALI cases for which they also seek healthcare. Users of cannabinoid-based products were more likely to report symptoms and accounted for a higher healthcare burden. UK vapers may also experience vaping-related illness that does not meet EVALI case criteria.
MeSH term(s)	Humans ; Smokers ; Electronic Nicotine Delivery Systems ; Lung Injury ; Surveys and Questionnaires ; Delivery of Health Care ; Cannabinoids ; United Kingdom/epidemiology
Chemical Substances	Cannabinoids
Language	English
Publishing date	2023-09-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1199985-8
ISSN	1460-2393 ; 0033-5622 ; 1460-2725
ISSN (online)	1460-2393
ISSN	0033-5622 ; 1460-2725
DOI	10.1093/qjmed/hcad210
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Article ; Online: Future Change in Urban Flooding Using New Convection‐Permitting Climate Projections

Archer, L. / Hatchard, S. / Devitt, L. / Neal, J. C. / Coxon, G. / Bates, P. D. / Kendon, E. J. / Savage, J.

Water Resources Research. 2024 Jan., v. 60, no. 1 p.e2023WR035533-

2024

Abstract: Rainfall intensity in the United Kingdom is projected to increase under climate change with significant implications for rainfall‐driven (combined pluvial and fluvial) flooding. In the UK, the current recommended best practice for estimating changes in ... ...

Abstract	Rainfall intensity in the United Kingdom is projected to increase under climate change with significant implications for rainfall‐driven (combined pluvial and fluvial) flooding. In the UK, the current recommended best practice for estimating changes in pluvial flood hazard under climate change involves applying a simple percentage uplift to spatially uniform catchment rainfall, despite the known importance of the spatial and temporal characteristics of rainfall in the generation of pluvial floods. The UKCP Local Convective Permitting Model (CPM) has for the first time provided the capacity to assess changes in flood hazard using hourly, 2.2 km CPM precipitation data that varies in space and time. Here, we use an event set of ∼13,500 precipitation events across the three UKCP Local epochs (1981–2000, 2021–2040, and 2061–2080) to simulate rainfall‐driven flooding using the LISFLOOD‐FP hydrodynamic model at 20 m resolution over a 750 km² area of Bristol and Bath, UK. We find that both the event set and uplift approaches indicate an increase in flood hazard under near‐term (2021–2040) and future (2061–2080) climate change. However, the event set produces markedly higher estimates of flood hazard when compared to the uplift approach, ranging from 19% to 49% higher depending on the return period. This suggests including the full spatiotemporal rainfall variability and its future change in rainfall‐driven flood modeling is critical for future flood risk assessment.
Keywords	climate ; climate change ; hydrologic models ; rain ; rain intensity ; risk assessment ; space and time ; water ; watersheds ; United Kingdom
Language	English
Dates of publication	2024-01
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	5564-5
ISSN	1944-7973 ; 0043-1397
ISSN (online)	1944-7973
ISSN	0043-1397
DOI	10.1029/2023WR035533
Database	NAL-Catalogue (AGRICOLA)

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