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Article ; Online: Populismos del siglo XXI, ¿nueva fase luego del giro nacional-popular de principios de siglo?

Soledad Stoessel / Martín Retamozo

Cuestiones de Sociología, Iss 28, Pp e150-e

2023 Volume 150

Abstract: El texto introduce el dossier a partir de situar el debate en torno al estatus de la categoría de populismo para pensar los vigentes procesos políticos en la región latinoamericana. Propone distintos usos críticos de la teoría del populismo a la que se ... ...

Abstract	El texto introduce el dossier a partir de situar el debate en torno al estatus de la categoría de populismo para pensar los vigentes procesos políticos en la región latinoamericana. Propone distintos usos críticos de la teoría del populismo a la que se adicionan nociones clave de la teoría/ciencia política ‒como Estado, hegemonía, lo nacional-popular, derechas radicales‒, para interrogar el fenómeno político actual enmarcado en una nueva ola de gobiernos progresistas en América Latina, luego de la primera suscitada a inicios del siglo XXI. El texto sostiene que la teoría del populismo desplegada en tres dimensiones puede operar como un recurso para comprender el devenir de estos gobiernos: como proceso histórico, como productor de sujetos e identidades y como tipo de gobierno que gestiona el orden social. A partir de esta conceptualización, el dossier aborda el nuevo giro nacional-popular, distinguiendo dos bloques de países: el primero compuesto por aquellos como Colombia y México que no formaron parte de la llamada "marea rosa", y el segundo, formado por aquellos caracterizados por un “retorno populista”, como Argentina, Bolivia y Brasil, que presentan marcadas diferencias respecto de las experiencias de principio de siglo.
Keywords	populismo ; giro nacional-popular ; ola progresista ; américa latina ; Sociology (General) ; HM401-1281 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Universidad Nacional de La Plata
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hacer nuestro tiempo

Soledad Stoessel / Martín Retamozo

Cuestiones de Sociología, Iss 28, Pp e161-e

la disputa por los horizontes predictivos de la sociedad. Entrevista a Álvaro García Linera

2023 Volume 161

Abstract: Esta entrevista a Álvaro García Linea presenta una aguda reflexión en torno a la relación entre lo nacional-popular y el populismo, dos conceptos clave para analizar la política latinoamericana. La preferencia de García Linera por el primero estriba en ... ...

Abstract	Esta entrevista a Álvaro García Linea presenta una aguda reflexión en torno a la relación entre lo nacional-popular y el populismo, dos conceptos clave para analizar la política latinoamericana. La preferencia de García Linera por el primero estriba en su extraordinaria capacidad explicativa para comprender las heterógeneas luchas sociales, la construcción de sujetos políticos y las transformaciones revolucionarias. Nutrido del debate gramsciano de los años ochenta, García Linera lo conjuga con la discusión marxista para dar cuenta de la configuración de las clases sociales que en América Latina, y especialmente en Bolivia, tiene una profunda carga étnica. Lo nacional-popular es la manera de realización histórica práctica de las luchas de clases plebeyas por su autonomía y autodeterminación, cuyas características y destino no están preestablecidos más allá del curso mismo de la acción política. Es el momento plebeyo, que siempre estalla como desborde estatal, aunque paradójicamente necesita instituirse temporalmente en el Estado, para consolidarse y universalizarse. Según García Linera, lo nacional-popular solo surge en momentos de crisis de régimen de dominación y régimen de acumulación. Durante este interregno, se produce lo que denomina “debilitamiento del horizonte predictivo”, al tiempo que se activa la “disponibilidad colectiva a revocar creencias”.
Keywords	nacional-popular ; populismo ; potencia plebeya ; horizonte predictivo ; Sociology (General) ; HM401-1281 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Universidad Nacional de La Plata
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Síndrome de Sjögren.

Brito-Zerón, Pilar / Retamozo, Soledad / Ramos-Casals, Manuel

Medicina clinica

2022 Volume 160, Issue 4, Page(s) 163–171

Abstract: In 1933, the Swedish ophthalmologist Hendrik Sjögren was the first to suggest that behind the dryness that several of his patients presented, there could be a systemic disease related to an abnormal immune response. Since then, the term Sjögren's ... ...

Title translation	Sjögren syndrome.
Abstract	In 1933, the Swedish ophthalmologist Hendrik Sjögren was the first to suggest that behind the dryness that several of his patients presented, there could be a systemic disease related to an abnormal immune response. Since then, the term Sjögren's syndrome (SjS) has been used and it has been considered a minor and infrequent disorder compared to other systemic autoimmune diseases (SAD) and, consequently, with little progress both in clinical and therapeutic research. The emergence of new technologies at the end of the 20th century rapidly promoted the development of international projects of great impact and diffusion, which have completely changed this scenario, and in the last 20 years significant progress has been made in understanding the main epidemiological determinants and pathogenic mechanisms to increase the diagnostic accuracy and to design specific and individualized therapeutic strategies. Currently, SjS should be considered one of the most frequent SADs with an undoubtedly systemic phenotype beyond dryness, in which the identification of prognostic factors can allow personalized follow-up and, therefore, early therapeutic interventions that avoid severe, irreversible outcomes.
MeSH term(s)	Humans ; Sjogren's Syndrome/complications ; Sjogren's Syndrome/diagnosis ; Sjogren's Syndrome/therapy ; Phenotype
Language	Spanish
Publishing date	2022-12-15
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2022.10.007
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Article ; Online: Crioglobulinemia.

Retamozo, Soledad / Quartuccio, Luca / Ramos-Casals, Manuel

Medicina clinica

2022 Volume 158, Issue 10, Page(s) 478–487

Abstract: Cryoglobulins are immunoglobulins that precipitate in vitro at temperatures below 37 ̊C. Cryoglobulin-associated disease is heterogeneous, as not all patients present with it, includes various syndromic presentations (vasculitis is the most common, ... ...

Title translation	Cryoglobulinemia.
Abstract	Cryoglobulins are immunoglobulins that precipitate in vitro at temperatures below 37 ̊C. Cryoglobulin-associated disease is heterogeneous, as not all patients present with it, includes various syndromic presentations (vasculitis is the most common, hyperviscosity syndrome is more exceptional), and can be associated with acute clinical pictures with high mortality. Until the appearance of specific antiviral treatments, the main aetiology has been chronic HCV infection, and currently it is mainly associated with systemic autoimmune diseases, malignant neoplasms and cases with no identified aetiology (essential cryoglobulinemia). Treatment should be modulated according to the predominant etiopathogenesis (vasculitis or hyperviscosity), the severity of internal organ involvement and, especially, the associated underlying disease. Due to the complex aetiological, clinical and pathological scenario of cryoglobulinaemia, early recognition of the most common clinical presentations, a comprehensive clinical assessment of the different organs that may be affected, and multidisciplinary work led by a unit specialised in systemic autoimmune diseases is essential.
MeSH term(s)	Antiviral Agents/therapeutic use ; Autoimmune Diseases/complications ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/drug therapy ; Cryoglobulinemia/diagnosis ; Cryoglobulinemia/etiology ; Cryoglobulinemia/therapy ; Humans ; Immunoglobulins ; Vasculitis/diagnosis ; Vasculitis/etiology ; Vasculitis/therapy
Chemical Substances	Antiviral Agents ; Immunoglobulins
Language	Spanish
Publishing date	2022-02-22
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2021.11.017
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Article ; Online: An update of targeted therapeutic options for primary Sjögren syndrome: current status and future development.

Retamozo, Soledad / Sisó-Almirall, Antoni / Flores-Chávez, Alejandra / Ramos-Casals, Manuel / Brito-Zerón, Pilar

Expert opinion on pharmacotherapy

2021 Volume 22, Issue 17, Page(s) 2359–2371

Abstract: ... ...

Abstract	Introduction
MeSH term(s)	Humans ; Sjogren's Syndrome/drug therapy
Language	English
Publishing date	2021-07-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2001535-5
ISSN	1744-7666 ; 1465-6566
ISSN (online)	1744-7666
ISSN	1465-6566
DOI	10.1080/14656566.2021.1951224
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Article: SARS-CoV-2 infection in patients with systemic autoimmune diseases.

Brito-Zerón, Pilar / Sisó-Almirall, Antoni / Flores-Chavez, Alejandra / Retamozo, Soledad / Ramos-Casals, Manuel

Clinical and experimental rheumatology

2021 Volume 39, Issue 3, Page(s) 676–687

Abstract: Systemic autoimmune diseases (SAD) are a heterogeneous group of diseases with a common aetiopathogenic basis affecting all ages characterised by a systemic phenotypic expression with a wide range of severity and outcomes that often require ... ...

Abstract	Systemic autoimmune diseases (SAD) are a heterogeneous group of diseases with a common aetiopathogenic basis affecting all ages characterised by a systemic phenotypic expression with a wide range of severity and outcomes that often require immunosuppressive therapies, leaving patients at high risk of infection. Knowledge of the impact of COVID-19 in patients with SAD is limited because most are included in studies carried out in patients with autoimmune and rheumatic diseases (mainly inflammatory arthritis). Most studies supported an increased risk of SARS-Cov-2 infection in patients with AD and SAD. Although case-control studies reported no significant differences in the rate of poor outcomes between patients with and without AD, large population-based studies analysing baseline risk factors reported a 2-3 times higher rate of poor outcomes in patients with AD, especially in those with SAD. Individual risk factors associated with poor outcomes included gender male, older age, and underlying comorbidities and therapies (glucocorticoids, sulfasalazine, immunosuppressants and rituximab). Patients with SAD had less favourable COVID-19 outcomes than those with inflammatory arthritis, possibly due to a differentiated underlying therapeutic approach (glucocorticoids, immunosuppressants and B-cell depleting agents for most SAD, anti-cytokine therapies and JAK inhibitors for inflammatory arthritis). Despite the limited evidence, most studies suggest that patients with SAD have an increased risk of a worse evolution of SARS-CoV-2 infection, including a greater risk of hospitalisation/ICU admission and worse survival rates and, therefore, should be considered a high-risk group for COVID-19.
MeSH term(s)	Aged ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/epidemiology ; COVID-19 ; Glucocorticoids/therapeutic use ; Humans ; Male ; Rheumatic Diseases ; SARS-CoV-2
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2021-05-05
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
DOI	10.55563/clinexprheumatol/lekp1y
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Article: Practical diagnostic tips for the Sjögren Clinic: pearls, myths and mistakes.

Brito-Zerón, Pilar / Retamozo, Soledad / Flores-Chávez, Alejandra / Akasbi, Miriam / Sisó-Almirall, Antoni / Ramos-Casals, Manuel

Clinical and experimental rheumatology

2022

Abstract: More than 90 years have passed since Hendrik Sjögren began to consider that behind the dryness that several of his patients presented, there could be a systemic disease potentially linked to abnormal immune responses. For many years, the disease was ... ...

Abstract	More than 90 years have passed since Hendrik Sjögren began to consider that behind the dryness that several of his patients presented, there could be a systemic disease potentially linked to abnormal immune responses. For many years, the disease was mostly considered a minor syndrome compared with other systemic autoimmune diseases such as systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and vasculitis, and advances in its understanding were slow and little recognised. The irruption of new technologies at the end of the 20th century rapidly promoted the development of international projects with a wide impact and diffusion. In the last 20 years, a significant improvement has been achieved in epidemiological determinants, pathogenic mechanisms, diagnostic accuracy, and a standardised therapeutic approach for patients with Sjögren's syndrome (SS). These developments have provided the tools for an early diagnosis and personalised management for most patients. However, a significant number of early myths and ongoing controversies are still making the appropriate management of SS difficult in daily clinical practice. This review provides a selection of pearls, myths, and mistakes that may serve as practical diagnostic tips for the Sjögren Clinic in four specific scenarios: defining the appropriate epidemiological background, enabling the earliest diagnostic suspicion as possible, improving the systemic characterisation of the disease, and designing an optimal follow-up of patients.
Language	English
Publishing date	2022-10-05
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
DOI	10.55563/clinexprheumatol/3bvq48
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Article: Phenotyping Sjögren's syndrome: towards a personalised management of the disease.

Brito-Zerón, Pilar / Retamozo, Soledad / Ramos-Casals, Manuel

Clinical and experimental rheumatology

2018 Volume 36 Suppl 112, Issue 3, Page(s) 198–209

Abstract: Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly targets the exocrine glands. The disease overwhelmingly affects women around 30-60 years old, and more than 95% of patients present with oral and/or ocular dryness, although they may ... ...

Abstract	Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly targets the exocrine glands. The disease overwhelmingly affects women around 30-60 years old, and more than 95% of patients present with oral and/or ocular dryness, although they may also develop a wide number of organ-specific systemic manifestations. The variable presentation is often linked to the influence of multiple personal determinants. In this review, we analyse the main geoepidemiological, immunological and histopathological determinants involved in the phenotypic expression of SS. With respect to sicca involvement, some patients (Asian, young-onset diagnosis, males and Ro-carriers) present with a less pronounced involvement in contrast to others with more pronounced dryness (seronegative, isolated La-carriers). With respect to the risk of developing systemic disease/poor outcomes, we propose a phenotypic-driven prognostic classification into patients at low risk (elderly-onset diagnosis, seronegative, isolated La-carriers), moderate risk (Black/African-american, young-onset diagnosis, Ro-carriers) and high risk (males, high focus score or presence of germinal centers in histopathological studies, RF-carriers, cryoglobulinaemic and hypocomplementaemic patients). Phenotype-based clustering of systemic autoimmune diseases may help physicians to offer a more personalised, cost-effective medical care of patients affected by these complex chronic diseases.
MeSH term(s)	Adult ; Clinical Decision-Making ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Phenotype ; Precision Medicine ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Sjogren's Syndrome/epidemiology ; Sjogren's Syndrome/genetics ; Sjogren's Syndrome/immunology ; Sjogren's Syndrome/therapy ; Treatment Outcome
Language	English
Publishing date	2018-07-25
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Using Autoantibodies to Diagnose Systemic Autoimmune Diseases Triggered by Immune Checkpoint Inhibitors: A Clinical Perspective.

Flores-Chávez, Alejandra / Brito-Zerón, Pilar / Retamozo, Soledad / Bitoun, Samuel / Fisher, Benjamin A / Liew, David / Suijkerbuijk, Karijn / Chatzidionysiou, Katerina / Suárez-Almazor, María / Lambotte, Olivier / Mariette, Xavier / Ramos-Casals, Manuel

Critical reviews in immunology

2023 Volume 42, Issue 4, Page(s) 21–36

Abstract: Immunotherapies, such as immune checkpoint inhibitors (ICIs), have significantly advanced the treatment of cancer and other conditions. However, these therapies can also cause immune-related adverse events (irAEs), which are unintended side effects due ... ...

Abstract	Immunotherapies, such as immune checkpoint inhibitors (ICIs), have significantly advanced the treatment of cancer and other conditions. However, these therapies can also cause immune-related adverse events (irAEs), which are unintended side effects due to their effects on the immune system of the treated patient. These effects can be classified as organ-specific or systemic, with the latter being of particular interest due to their potential overlap with systemic autoimmune diseases (SADs). Autoantibodies, which are proteins produced by the immune system that react with self components, are often used to diagnose and classify SAD. However, the diagnostic value of autoantibodies in the context of systemic irAEs (sirAEs) triggered by ICIs is not well understood. This review aims to evaluate the diagnostic value of conventional autoantibodies in the identification and classification of sirAEs. A comprehensive search of the literature was conducted using the PubMed database, with a focus on articles published in the past 10 years. The results of the review suggest that, although autoantibodies can be useful in the diagnosis and classification of some SAD triggered by ICIs, there is a clear predominance of seronegative irAEs. The lack of traditional autoantibodies may suggest a unique mechanism for sirAEs and increases the already complex diagnostic approach of these manifestations, requiring evaluation by multidisciplinary teams with extensive experience in immunomediated diseases. Further research is needed to fully understand the diagnostic value of autoantibodies in this context and to determine the optimal approach for their detection and interpretation.
MeSH term(s)	Humans ; Autoantibodies ; Immune Checkpoint Inhibitors/adverse effects ; Neoplasms/diagnosis ; Neoplasms/drug therapy ; Drug-Related Side Effects and Adverse Reactions/drug therapy ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/drug therapy
Chemical Substances	Autoantibodies ; Immune Checkpoint Inhibitors
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1353116-5
ISSN	1040-8401
ISSN	1040-8401
DOI	10.1615/CritRevImmunol.2023047272
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Article ; Online: Shrinking lung syndrome and pleural effusion as an initial manifestation of primary Sjögren's syndrome.

Baenas, Diego Federico / Retamozo, Soledad / Pirola, Juan Pablo / Caeiro, Francisco

Reumatologia clinica

2018 Volume 16, Issue 1, Page(s) 65–68

Title translation	Síndrome de pulmón encogido y derrame pleural como manifestación inicial de síndrome de Sjögren primario.
MeSH term(s)	Apnea/etiology ; Chest Pain/etiology ; Diaphragm/diagnostic imaging ; Female ; Humans ; Lung/diagnostic imaging ; Middle Aged ; Pleural Effusion/diagnostic imaging ; Pleural Effusion/etiology ; Pulmonary Atelectasis/diagnostic imaging ; Pulmonary Atelectasis/etiology ; Sjogren's Syndrome/complications ; Sjogren's Syndrome/diagnosis ; Syndrome ; Walk Test
Language	Spanish
Publishing date	2018-02-19
Publishing country	Spain
Document type	Case Reports ; Letter ; Review
ISSN	2173-5743
ISSN (online)	2173-5743
DOI	10.1016/j.reuma.2018.01.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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