LIVIVO - Search results -

Search results

Result 1 - 10 of total 952

Search options

Article ; Online: A primer and overview of the role of artificial intelligence in oral and maxillofacial radiology.

Tyndall, Donald A

Oral surgery, oral medicine, oral pathology and oral radiology

2024

Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2650843-6
ISSN	2212-4411 ; 2212-4403
ISSN (online)	2212-4411
ISSN	2212-4403
DOI	10.1016/j.oooo.2024.02.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ul III Zs.121: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: S-217622, a 3CL Protease Inhibitor and Clinical Candidate for SARS-CoV-2.

Tyndall, Joel D A

Journal of medicinal chemistry

2022 Volume 65, Issue 9, Page(s) 6496–6498

Abstract: The coronavirus disease (COVID-19) pandemic has highlighted the ability of scientists to quickly react to the immense challenge presented to the world. The orally available 3CL protease inhibitor S-217622 is currently progressing through clinical trials ... ...

Abstract	The coronavirus disease (COVID-19) pandemic has highlighted the ability of scientists to quickly react to the immense challenge presented to the world. The orally available 3CL protease inhibitor S-217622 is currently progressing through clinical trials and its discovery via structure-based drug design, screening and optimization by Shionogi and Hokkaido University is presented here.
MeSH term(s)	Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Coronavirus 3C Proteases ; Humans ; Protease Inhibitors/pharmacology ; Protease Inhibitors/therapeutic use ; SARS-CoV-2
Chemical Substances	Antiviral Agents ; Protease Inhibitors ; Coronavirus 3C Proteases (EC 3.4.22.28)
Language	English
Publishing date	2022-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.2c00624
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Hematopoietic Stem Cell Transplantation for Systemic Sclerosis: Review of Current Status.

Tyndall, Alan

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

2019 Volume 33, Issue 4, Page(s) 401–409

Abstract: Three prospective controlled clinical trials and numerous small series and case reports have confirmed that durable, drug-free remission in systemic sclerosis is possible via an autologous hematopoietic stem cell transplantation. Similar results have ... ...

Abstract	Three prospective controlled clinical trials and numerous small series and case reports have confirmed that durable, drug-free remission in systemic sclerosis is possible via an autologous hematopoietic stem cell transplantation. Similar results have been seen in other autoimmune diseases. The exact mechanism by which this immune "reset" was achieved in some but not all cases remains elusive, but includes major reduction of autoreactive immune competent cells, re-establishment of T- and B cell regulatory networks and normalization of tissue niche function, particularly vascular. Some aspects regarding mobilization, conditioning and graft manipulation still remain open, but clearly a significant toxicity is associated with all effective regimens at present, and therefore patient selection remains a key issue. In the hematology/oncology arena, major efforts are being made to reduce genotoxic and other collateral toxicity induced by current mobilization and conditioning protocols, which may also translate to autoimmune disease. These include developments in rapid mobilization and antibody drug conjugate conditioning technology. If effective, such low-toxicity regimens might be applied to autoimmune disease at an earlier stage before chronicity of autoimmunity has been established, thus changing the therapeutic paradigm.
MeSH term(s)	Controlled Clinical Trials as Topic ; Graft vs Host Disease/immunology ; Graft vs Host Disease/prevention & control ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Immunoconjugates/therapeutic use ; Prospective Studies ; Scleroderma, Systemic/immunology ; Scleroderma, Systemic/therapy ; Transplantation Conditioning/methods ; Transplantation, Autologous/adverse effects ; Transplantation, Autologous/methods ; Transplantation, Homologous/adverse effects ; Transplantation, Homologous/methods ; Treatment Outcome
Chemical Substances	Immunoconjugates
Language	English
Publishing date	2019-07-14
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	1364202-9
ISSN	1179-190X ; 1173-8804
ISSN (online)	1179-190X
ISSN	1173-8804
DOI	10.1007/s40259-019-00364-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4112: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Hematopoietic stem cell transplantation for autoimmune diseases: more than just prolonged immunosuppression.

Tyndall, Alan

Current opinion in hematology

2018 Volume 25, Issue 6, Page(s) 433–440

Abstract: Purpose of review: To summarize the current clinical experience in the use of autologous hematopoietic stem cell transplantation (HSCT) in autoimmune disease and to explore the concept of durable remission induction and tissue de-remodeling via ... ...

Abstract	Purpose of review: To summarize the current clinical experience in the use of autologous hematopoietic stem cell transplantation (HSCT) in autoimmune disease and to explore the concept of durable remission induction and tissue de-remodeling via restoration of normal niche function and "immune reset.' Recent findings: Controlled clinical trials in systemic sclerosis, multiple sclerosis, and Crohn's disease as well as extensive uncontrolled trial and registry data have established the unique role of HSCT in selected cases. Although HSCT for multiple sclerosis and systemic sclerosis has recently entered several official treatment guidelines, mechanistic studies are few but indicate some possible modes of action, for example, increase of regulatory T cells. Toxicity of HSCT remains high but is improving with protocol modifications and more precise patient selection. Summary: For the first time, it has been demonstrated that strategies exist which may permanently reprogram an autoaggressive immune system to one of self-tolerance independent of ongoing immunosuppression. In addition, some tissues have the capacity to repair damage via normal regenerative processes. The exact mechanism(s) as to how this is achieved in certain cases and not others are emerging. Such knowledge, together with adoption of recently developed less toxic and more targeted regimens from the hematology/oncology field may translate to a safer yet still effective treatment for autoimmune disease.
MeSH term(s)	Autoimmune Diseases/therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunosuppression
Language	English
Publishing date	2018-10-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1153887-9
ISSN	1531-7048 ; 1065-6251
ISSN (online)	1531-7048
ISSN	1065-6251
DOI	10.1097/MOH.0000000000000466
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3703: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Surveying the landscape of diagnostic imaging in dentistry's future: Four emerging technologies with promise.

Tyndall, Donald A / Price, Jeffery B / Gaalaas, Laurence / Spin-Neto, Rubens

Journal of the American Dental Association (1939)

2024

Abstract: Background: Advances in digital radiography for both intraoral and panoramic imaging and cone-beam computed tomography have led the way to an increase in diagnostic capabilities for the dental care profession. In this article, the authors provide ... ...

Abstract	Background: Advances in digital radiography for both intraoral and panoramic imaging and cone-beam computed tomography have led the way to an increase in diagnostic capabilities for the dental care profession. In this article, the authors provide information on 4 emerging technologies with promise. Types of studies reviewed: The authors feature the following: artificial intelligence in the form of deep learning using convolutional neural networks, dental magnetic resonance imaging, stationary intraoral tomosynthesis, and second-generation cone-beam computed tomography sources based on carbon nanotube technology and multispectral imaging. The authors review and summarize articles featuring these technologies. Results: The history and background of these emerging technologies are previewed along with their development and potential impact on the practice of dental diagnostic imaging. The authors conclude that these emerging technologies have the potential to have a substantial influence on the practice of dentistry as these systems mature. The degree of influence most likely will vary, with artificial intelligence being the most influential of the 4. Conclusions and practical implications: The readers are informed about these emerging technologies and the potential effects on their practice going forward, giving them information on which to base decisions on adopting 1 or more of these technologies. The 4 technologies reviewed in this article have the potential to improve imaging diagnostics in dentistry thereby leading to better patient care and heightened professional satisfaction.
Language	English
Publishing date	2024-03-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	220622-5
ISSN	1943-4723 ; 0002-8177 ; 1048-6364
ISSN (online)	1943-4723
ISSN	0002-8177 ; 1048-6364
DOI	10.1016/j.adaj.2024.01.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ul III Zs.72: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Comparison of incidental findings on cone beam computed tomographic and 2-dimensional images.

Crockett, Benjamin / Broome, Angela / Tawil, Peter / Tyndall, Don

General dentistry

2023 Volume 71, Issue 4, Page(s) 64–71

Abstract: Cone beam computed tomography (CBCT) provides a 3-dimensional (3D) view of the patient and has a high frequency of incidental findings (IFs) that do not relate to the area of interest. Many of these IFs are not always visible on 2-dimensional (2D) ... ...

Abstract	Cone beam computed tomography (CBCT) provides a 3-dimensional (3D) view of the patient and has a high frequency of incidental findings (IFs) that do not relate to the area of interest. Many of these IFs are not always visible on 2-dimensional (2D) intraoral or panoramic radiographs. Thus, the aim of the present study was to assess the IFs that did or did not appear on 3D vs 2D images. Significant IFs were recorded from a review of 510 CBCT reports by board-certified oral and maxillofacial radiologists. The IFs on CBCTs with 5-, 8-, and 11-cm fields of view (n = 170 per group) were recorded. A subset of these significant IFs was also viewed on intra-oral and panoramic radiographs to determine whether they were or were not visible in 2D imaging. A total of 677 significant IFs were discovered on 302 (59.2%) of the 510 reports. When a subset of 293 IFs was reviewed on intraoral and panoramic imaging, 112 (38.2%) were not visible on 2D radiographs, while 50 (17.1%) could not be confirmed with certainty. The frequency of significant IFs on CBCT imaging is high and increases with larger fields of view. A substantial number of these findings could not be seen on 2D radiographs, implying that many IFs are visible only on 3D images. Clinicians who order CBCT scans need to carefully review the volume in its entirety, regardless of previous imaging, so as not to miss any significant and relevant findings.
MeSH term(s)	Humans ; Incidental Findings ; Radiography, Panoramic ; Cone-Beam Computed Tomography/methods ; Imaging, Three-Dimensional
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	603650-8
ISSN	0363-6771
ISSN	0363-6771
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2262: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: FHIR Healthcare Directories: Adopting Shared Interfaces to Achieve Interoperable Medical Device Data Integration.

Tyndall, Timothy / Tyndall, Ayami

Studies in health technology and informatics

2018 Volume 249, Page(s) 181–184

Abstract: Healthcare directories are vital for interoperability among healthcare providers, researchers and patients. Past efforts at directory services have not provided the tools to allow integration of the diverse data sources. Many are overly strict, ... ...

Abstract	Healthcare directories are vital for interoperability among healthcare providers, researchers and patients. Past efforts at directory services have not provided the tools to allow integration of the diverse data sources. Many are overly strict, incompatible with legacy databases, and do not provide Data Provenance. A more architecture-independent system is needed to enable secure, GDPR-compatible (8) service discovery across organizational boundaries. We review our development of a portable Data Provenance Toolkit supporting provenance within Health Information Exchange (HIE) systems. The Toolkit has been integrated with client software and successfully leveraged in clinical data integration. The Toolkit validates provenance stored in a Blockchain or Directory record and creates provenance signatures, providing standardized provenance that moves with the data. This healthcare directory suite implements discovery of healthcare data by HIE and EHR systems via FHIR. Shortcomings of past directory efforts include the ability to map complex datasets and enabling interoperability via exchange endpoint discovery. By delivering data without dictating how it is stored we improve exchange and facilitate discovery on a multi-national level through open source, fully interoperable tools. With the development of Data Provenance resources we enhance exchange and improve security and usability throughout the health data continuum.
MeSH term(s)	Computer Systems ; Databases, Factual ; Delivery of Health Care ; Electronic Health Records ; Humans ; Software ; Systems Integration
Language	English
Publishing date	2018-06-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	0926-9630
ISSN	0926-9630
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Digital Interventions to Save Lives From the Opioid Crisis Prior and During the SARS COVID-19 Pandemic: A Scoping Review of Australian and Canadian Experiences.

Donnell, Andrea / Unnithan, Chandana / Tyndall, Jessica / Hanna, Fahad

Frontiers in public health

2022 Volume 10, Page(s) 900733

Abstract: Background: The potential for digital initiatives for opioid harm reduction is boundless. Synthesized evidence on current interventions and their efficacy are emerging. This scoping review is an effort to aggregate Canadian and Australian digital health ...

Abstract	Background: The potential for digital initiatives for opioid harm reduction is boundless. Synthesized evidence on current interventions and their efficacy are emerging. This scoping review is an effort to aggregate Canadian and Australian digital health initiatives used to prevent opioid-related deaths and minimize harm, prior to and particularly during the pandemic of SARs-COVID-19, when the crisis escalated. Methods: The Joanna Briggs Institute's methodological framework for conducting scoping reviews was used. Peer reviewed and gray literature published between January 2016 to October 2021 were included. Search translation was performed across CINAHL, Cochrane, SCOPUS, MEDLINE Complete, and ProQuest Public Health with consistent use of key search terms. Citation checks were also conducted. Studies included were written in English and reported on digital technologies to prevent opioid-related harm and/or mortality in participants aged 18 years or older in Australia and Canada. Results: A total of 16 publications were included in the final analysis (Australia = 5; Canada = 11). The most frequently reported digital technologies were telehealth to support access to treatment ( Conclusions: Digital interventions to minimize opioid crisis related harm and overdose prevention are fast emerging in Australia and Canada. During the pandemic, the crisis escalated in both countries as a public health emergency, and different initiatives were trialed. Digital harm reduction solutions via mobile apps (or SaaS solutions) were found to have the potential to prevent accidental overdose deaths and save lives, if rendered through privacy preserved, secure and trust enabled methods that empower users. Knowledge sharing between the two countries, relating to suitable interventions, may add significant value in combatting the escalating opioid crisis in the post pandemic era.
MeSH term(s)	Analgesics, Opioid/therapeutic use ; Australia/epidemiology ; COVID-19/epidemiology ; Canada/epidemiology ; Drug Overdose/epidemiology ; Drug Overdose/prevention & control ; Humans ; Opioid Epidemic ; Pandemics
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2022-07-12
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.900733
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Exploring North Carolina's Transition to Whole-Person, Integrated Care From the Provider Perspective: Results From an Exploratory Survey.

Tyndall, Lisa / Muse, Amelia / Herrity, Sara

North Carolina medical journal

2022 Volume 83, Issue 6, Page(s) 461–466

Abstract: ... ...

Abstract	BACKGROUND
MeSH term(s)	Humans ; North Carolina ; Surveys and Questionnaires ; Delivery of Health Care, Integrated
Language	English
Publishing date	2022-11-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	422795-5
ISSN	0029-2559
ISSN	0029-2559
DOI	10.18043/ncm.83.6.461
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 169: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Mesenchymal stromal cells and rheumatic disorders.

Tyndall, Alan

Immunology letters

2015 Volume 168, Issue 2, Page(s) 201–207

Abstract: Mesenchymal stromal cells (MSC), often incorrectly called stem cells, have been the intense focus of in vitro studies and animal models of rheumatic and other diseases over more than a decade. Despite multiple plausible mechanisms of action and a ... ...

Abstract	Mesenchymal stromal cells (MSC), often incorrectly called stem cells, have been the intense focus of in vitro studies and animal models of rheumatic and other diseases over more than a decade. Despite multiple plausible mechanisms of action and a plethora of positive in vivo animal studies, few randomised controlled clinical trials have demonstrated meaningful clinical benefit in any condition so far. This could be due to confusion in cell product terminology, complexity of clinical study design and execution or agreement on meaningful outcome measures. It could also indicate that MSC as currently employed are ineffective. Within the rheumatic diseases, SLE, rheumatoid arthritis (RA) and osteoarthritis (OA) have received most attention. Uncontrolled multiple trial data from over 300 SLE patients have been published from one centre suggesting a positive outcome; one single centre comparative study in 172 RA was positive and no human studies have compared intra-articular MSC therapy to non-MSC techniques for osteoarthritis in the absence of surgery. Two randomised studies suggested benefit from the addition of bone marrow derived MSC and peripheral blood mononuclear cells added to surgical "standard of care" in knee OA and knee focal cartilage defects, respectively. The possible reasons for this apparent mismatch between expectation and clinical reality will be discussed.
MeSH term(s)	Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/therapy ; Cell Communication/immunology ; Clinical Trials as Topic ; Humans ; Immune System/immunology ; Immune System/pathology ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/therapy ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stromal Cells/cytology ; Mesenchymal Stromal Cells/immunology ; Models, Immunological ; Osteoarthritis/immunology ; Osteoarthritis/therapy ; Treatment Outcome
Language	English
Publishing date	2015-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	445150-8
ISSN	1879-0542 ; 0165-2478
ISSN (online)	1879-0542
ISSN	0165-2478
DOI	10.1016/j.imlet.2015.05.017
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1512: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito