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  1. Book: T-helper cells

    Annunziato, Francesco / Maggi, Laura / Mazzoni, Alessio

    methods and protocols

    (Methods in molecular biology ; 2285 ; Springer protocols)

    2021  

    Author's details edited by Francesco Annunziato, Laura Maggi, Alessio Mazzoni
    Series title Methods in molecular biology ; 2285
    Springer protocols
    Collection
    Keywords T cells
    Subject code 571.966
    Language English
    Size xii, 388 Seiten, Illustrationen, 26 cm
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020920980
    ISBN 978-1-0716-1310-8 ; 9781071613115 ; 1-0716-1310-3 ; 1071613111
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -2285- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Alarming inflammation: The TGFβ1-Nrp1 pathway upregulates the IL-33 axis in lung ILC2s.

    Salvati, Lorenzo / Mazzoni, Alessio

    Allergy

    2022  Volume 77, Issue 11, Page(s) 3471–3472

    MeSH term(s) Humans ; Animals ; Mice ; Interleukin-33/genetics ; Interleukin-33/metabolism ; Immunity, Innate ; Lymphocytes/metabolism ; Lung/metabolism ; Inflammation/genetics ; Inflammation/metabolism ; Cytokines/metabolism ; Mice, Inbred C57BL
    Chemical Substances Interleukin-33 ; Cytokines
    Language English
    Publishing date 2022-08-20
    Publishing country Denmark
    Document type News
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: T lymphocytes-related cell network in the pathogenesis of juvenile idiopathic arthritis: a key point for personalized treatment.

    Mazzoni, Alessio / Annunziato, Francesco / Maggi, Laura

    Current opinion in rheumatology

    2023  Volume 36, Issue 1, Page(s) 40–45

    Abstract: Purpose of review: Juvenile idiopathic arthritis (JIA) is a heterogeneous group of arthritis of unknown origin occurring in children under 16 years of age and persisting for at least 6 weeks. Given that JIA is an inflammatory disorder, treatment ... ...

    Abstract Purpose of review: Juvenile idiopathic arthritis (JIA) is a heterogeneous group of arthritis of unknown origin occurring in children under 16 years of age and persisting for at least 6 weeks. Given that JIA is an inflammatory disorder, treatment strategies, including also biologicals, are focused on suppressing excessive inflammation. The finding that different patients display different responses to biological drugs supports the concept that different pathogenic mechanisms can exist in JIA, with specific cellular and molecular mechanisms driving inflammation in each patient. The aim of this review is to highlight the most recent advances in understanding the role of immune cells in JIA pathogenesis.
    Recent findings: This review encompasses the role of the different cell subsets involved in sustaining inflammation in JIA, with a particular emphasis on T cells, as they orchestrate both innate and adaptive auto-reactive immunity in affected joints.
    Summary: The characterization of the cellular and molecular pathways supporting inflammation will be crucial to design novel therapeutic approaches in the context of personalized medicine.
    MeSH term(s) Child ; Humans ; Arthritis, Juvenile/drug therapy ; T-Lymphocytes ; Precision Medicine ; Adaptive Immunity ; Inflammation
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Targeting immune checkpoints in juvenile idiopathic arthritis: accumulating evidence.

    Mazzoni, Alessio / Cimaz, Rolando

    Pediatric research

    2021  Volume 90, Issue 4, Page(s) 720–721

    MeSH term(s) Adolescent ; Arthritis, Juvenile/drug therapy ; Arthritis, Juvenile/immunology ; Child ; Evidence-Based Medicine ; Humans ; Immune Checkpoint Inhibitors/therapeutic use
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2021-07-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-021-01650-z
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    Zs.MO 373: Show issues

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  5. Article ; Online: Reaching and Grasping Movements in Parkinson's Disease: A Review.

    Fasano, Alessio / Mazzoni, Alberto / Falotico, Egidio

    Journal of Parkinson's disease

    2022  Volume 12, Issue 4, Page(s) 1083–1113

    Abstract: Parkinson's disease (PD) is known to affect the brain motor circuits involving the basal ganglia (BG) and to induce, among other signs, general slowness and paucity of movements. In upper limb movements, PD patients show a systematic prolongation of ... ...

    Abstract Parkinson's disease (PD) is known to affect the brain motor circuits involving the basal ganglia (BG) and to induce, among other signs, general slowness and paucity of movements. In upper limb movements, PD patients show a systematic prolongation of movement duration while maintaining a sufficient level of endpoint accuracy. PD appears to cause impairments not only in movement execution, but also in movement initiation and planning, as revealed by abnormal preparatory activity of motor-related brain areas. Grasping movement is affected as well, particularly in the coordination of the hand aperture with the transport phase. In the last fifty years, numerous behavioral studies attempted to clarify the mechanisms underlying these anomalies, speculating on the plausible role that the BG-thalamo-cortical circuitry may play in normal and pathological motor control. Still, many questions remain open, especially concerning the management of the speed-accuracy tradeoff and the online feedback control. In this review, we summarize the literature results on reaching and grasping in parkinsonian patients. We analyze the relevant hypotheses on the origins of dysfunction, by focusing on the motor control aspects involved in the different movement phases and the corresponding role played by the BG. We conclude with an insight into the innovative stimulation techniques and computational models recently proposed, which might be helpful in further clarifying the mechanisms through which PD affects reaching and grasping movements.
    MeSH term(s) Basal Ganglia ; Hand ; Humans ; Motor Cortex ; Movement/physiology ; Parkinson Disease ; Psychomotor Performance/physiology
    Language English
    Publishing date 2022-03-07
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2620609-2
    ISSN 1877-718X ; 1877-7171
    ISSN (online) 1877-718X
    ISSN 1877-7171
    DOI 10.3233/JPD-213082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Human T-Cell Cloning by Limiting Dilution.

    Maggi, Laura / Capone, Manuela / Mazzoni, Alessio

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2285, Page(s) 165–172

    Abstract: Human T cells represent a heterogeneous population, including cells with different phenotypical and function properties. Despite, in the last years, several technologies were developed to investigate phenotypical properties of T cells at single cell ... ...

    Abstract Human T cells represent a heterogeneous population, including cells with different phenotypical and function properties. Despite, in the last years, several technologies were developed to investigate phenotypical properties of T cells at single cell level, in vitro T cell clone 's culture remains the only way to perform functional study on T cells at single cell levels. Here, we describe the method to obtain human T cell clones by limiting dilution in the presence of feeder cells and to maintain them in culture for further investigations.
    MeSH term(s) Clone Cells ; Coculture Techniques ; Feeder Cells ; Flow Cytometry ; Humans ; Phenotype ; Research Design ; Single-Cell Analysis ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Workflow
    Language English
    Publishing date 2021-04-30
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1311-5_14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Study of Signal Transduction Pathways by Phospho-Protein Evaluation.

    Capone, Manuela / Mazzoni, Alessio / Maggi, Laura

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2285, Page(s) 191–200

    Abstract: Flow cytometric evaluation of phosphorylation status of signal transduction molecules is a useful method to study T-cell signaling pathways. As mutations occurring in TCR complex molecules, common gamma chain family's cytokines, their receptors or ... ...

    Abstract Flow cytometric evaluation of phosphorylation status of signal transduction molecules is a useful method to study T-cell signaling pathways. As mutations occurring in TCR complex molecules, common gamma chain family's cytokines, their receptors or molecules involved in these pathways can lead to severe immune system defects, the study of T-cell signal transduction can be applied to both basic and clinical/translational research areas. In the present chapter, we show two different protocols for the study of T- cell response to an antigen-like stimulus and to IL-2.
    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Cells, Cultured ; Flow Cytometry ; Humans ; Interleukin-2/pharmacology ; Phosphoproteins/metabolism ; Phosphorylation ; Receptors, Antigen, T-Cell/agonists ; Receptors, Antigen, T-Cell/metabolism ; Research Design ; Signal Transduction/drug effects ; Tetradecanoylphorbol Acetate/pharmacology ; Workflow
    Chemical Substances IL2 protein, human ; Interleukin-2 ; Phosphoproteins ; Receptors, Antigen, T-Cell ; Tetradecanoylphorbol Acetate (NI40JAQ945)
    Language English
    Publishing date 2021-04-30
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1311-5_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Human and Murine T-Helper Cell Recovery from Organs and Tissues.

    Siracusa, Francesco / Lahmann, Annette / Vanni, Anna / Cortesi, Filippo / Mazzoni, Alessio

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2285, Page(s) 1–25

    Abstract: Isolation of cells from organs and tissues represents a challenge for many researchers. Cell yield, purity, and cell death are common problems associated with it, which greatly affect experimental results in terms of reproducibility and biological ... ...

    Abstract Isolation of cells from organs and tissues represents a challenge for many researchers. Cell yield, purity, and cell death are common problems associated with it, which greatly affect experimental results in terms of reproducibility and biological observations. Here, we describe state-of-the-art protocols of how to isolate CD4
    MeSH term(s) Animals ; Biomarkers/metabolism ; Cell Separation ; Cell Survival ; Enzymes/metabolism ; Flow Cytometry ; Humans ; Immunomagnetic Separation ; Lymphoid Tissue/cytology ; Mice, Inbred C57BL ; Phenotype ; Research Design ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/metabolism ; Workflow ; Mice
    Chemical Substances Biomarkers ; Enzymes
    Language English
    Publishing date 2021-04-09
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1311-5_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Hallmarks of immune response in COVID-19: Exploring dysregulation and exhaustion.

    Mazzoni, Alessio / Salvati, Lorenzo / Maggi, Laura / Annunziato, Francesco / Cosmi, Lorenzo

    Seminars in immunology

    2021  Volume 55, Page(s) 101508

    Abstract: One and half year following the occurrence of COVID-19 pandemic, significant efforts from laboratories all over the world generated a huge amount of data describing the prototypical features of immunity in the course of SARS-CoV-2 infection. In this ... ...

    Abstract One and half year following the occurrence of COVID-19 pandemic, significant efforts from laboratories all over the world generated a huge amount of data describing the prototypical features of immunity in the course of SARS-CoV-2 infection. In this Review, we rationalize and organize the main observations, trying to define a "core" signature of immunity in COVID-19. We identified six hallmarks describing the main alterations occurring in the early infection phase and in the course of the disease, which predispose to severe illness. The six hallmarks are dysregulated type I IFN activity, hyperinflammation, lymphopenia, lymphocyte impairment, dysregulated myeloid response, and heterogeneous adaptive immunity to SARS-CoV-2. Dysregulation and exhaustion came out as the trait d'union, connecting abnormalities affecting both innate and adaptive immunity, humoral and cellular responses.
    MeSH term(s) Adaptive Immunity ; COVID-19 ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-10-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2021.101508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Serum NMR Profiling Reveals Differential Alterations in the Lipoproteome Induced by Pfizer-BioNTech Vaccine in COVID-19 Recovered Subjects and Naïve Subjects.

    Ghini, Veronica / Maggi, Laura / Mazzoni, Alessio / Spinicci, Michele / Zammarchi, Lorenzo / Bartoloni, Alessandro / Annunziato, Francesco / Turano, Paola

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 839809

    Abstract: ... ...

    Abstract 1
    Language English
    Publishing date 2022-04-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.839809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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