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Article: Microbial Complexity of Oral Cavity of Healthy Dogs Identified by Mass Spectrometry and Next-Generation Sequencing.

Portilho, Fábio V R / Nóbrega, Juliano / de Almeida, Beatriz O / Mota, André R / de Paula, Carolina L / Listoni, Fernando J P / Bosco, Sandra M G / Oliveira, Alana L / Cunha, Maria de Lourdes R S / Ribeiro, Márcio G

Animals : an open access journal from MDPI

2023 Volume 13, Issue 15

Abstract: The high complexity of the oral microbiota of healthy dogs and the close exposure of humans to companion animals represent a risk of the transmission of potential zoonotic microorganisms to humans, especially through dog bites, including multidrug- ... ...

Abstract	The high complexity of the oral microbiota of healthy dogs and the close exposure of humans to companion animals represent a risk of the transmission of potential zoonotic microorganisms to humans, especially through dog bites, including multidrug-resistant ones. Nonetheless, a limited number of comprehensive studies have focused on the diversity of the microorganisms that inhabit the oral cavities of healthy dogs, particularly based on modern molecular techniques. We investigated bacterial and fungal organisms in the oral cavities of 100 healthy dogs based on a combination of conventional and selective microbiological culture, mass spectrometry (MALDI-TOF MS), and next-generation sequencing. In addition, in vitro antimicrobial susceptibility patterns of isolates and
Language	English
Publishing date	2023-07-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13152467
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Article ; Online: Host metabolomic responses in recurrent P. vivax malaria.

Yakubu, Michael N / Mwangi, Victor I / Netto, Rebeca L A / Alecrim, Maria G C / Alves, Jessica R S / Almeida, Anne C G / Santos, Gabriel F / Lima, Gesiane S / Machado, Lucas S / Koolen, Hector H F / Guimarães, Tiago P / Chaves, Andrea R / Vaz, Boniek G / Monteiro, Wuelton M / Costa, Fabio T M / Lacerda, Marcus V G / Gardinassi, Luiz G / de Melo, Gisely C

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7249

Abstract: Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as a promising tool for combating the disease. The study evaluated plasma metabolomic profiles of ... ...

Abstract	Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as a promising tool for combating the disease. The study evaluated plasma metabolomic profiles of patients with recurrent and non-recurrent P. vivax malaria in the Brazilian Amazon. Metabolites extracted from the plasma of P. vivax-infected patients were subjected to LC-MS analysis. Untargeted metabolomics was applied to investigate the metabolic profile of the plasma in the two groups. Overall, 51 recurrent and 59 non-recurrent patients were included in the study. Longitudinal metabolomic analysis revealed 52 and 37 significant metabolite features from the recurrent and non-recurrent participants, respectively. Recurrence was associated with disturbances in eicosanoid metabolism. Comparison between groups suggest alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism, 3-oxo-10-octadecatrienoate β-oxidation, and alkaloid biosynthesis II. Integrative network analysis revealed enrichment of other metabolic pathways for the recurrent phenotype, including the butanoate metabolism, aspartate and asparagine metabolism, and N-glycan biosynthesis. The metabolites and metabolic pathways predicted in our study suggest potential biomarkers of recurrence and provide insights into targets for antimalarial development against P. vivax.
MeSH term(s)	Humans ; Malaria, Vivax/parasitology ; Metabolomics ; Malaria/parasitology ; Metabolome ; Antimalarials/therapeutic use
Chemical Substances	Antimalarials
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54231-5
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Article ; Online: Do changes in the water regime determine the abundance of the copepod trophic group in a Neotropical floodplain?

Lenin Medeiros de Almeida Lino / Tatiane Mantovano / Vanessa G. Tibúrcio / Fábio Amodêo Lansac-Tôha

Acta Limnologica Brasiliensia, Vol

2021 Volume 33

Abstract: Abstract Aim Our study evaluated the effects of extreme weather events and environmental conditions on the trophic groups of copepods (herbivores and omnivores) in the upper Paraná River floodplain. Methods The zooplankton were collected and Copepods and ...

Abstract	Abstract Aim Our study evaluated the effects of extreme weather events and environmental conditions on the trophic groups of copepods (herbivores and omnivores) in the upper Paraná River floodplain. Methods The zooplankton were collected and Copepods and Rotifers were analyzed in nine environments of the upper Paraná River floodplain during 2000 and 2010, during which time the La Niña (drought) and El Niño (flood) climatic events occurred, respectively. Results The results suggest that in periods of extreme drought productivity-related variables act as determining forces on abundance of copepod trophic groups due to the contraction of aquatic ecosystems. Although the abundance of trophic groups is associated with system productivity, the responses between them differ, since herbivore abundance was associated with chlorophyll-a and total phosphorus and omnivores with rotifer abundance. In extreme flood (El Niño), no significant relationship was found between environmental variables and any trophic group. Conclusions In general, it is believed that in periods of extreme drought the variables associated with productivity act as determining forces on the abundance of trophic groups of copepods due to the contraction of aquatic ecosystems. According to the results found, it is suggested that other works be carried out with a greater number of extreme events to corroborate our results and, and also to extrapolate to other aquatic communities.
Keywords	climate events ; microcrustaceans ; trophic guilds ; floodplain ; Ecology ; QH540-549.5
Subject code	550 ; 333
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Associação Brasileira de Limnologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Teaching NeuroImages: Persistent anterograde amnesia due to sequential, bilateral vascular damage to the Papez circuit.

Porto, Fábio H G / de Almeida, Pedro L / Daffner, Kirk R

Neurology

2019 Volume 92, Issue 24, Page(s) e2838–e2839

MeSH term(s)	Amnesia, Anterograde/diagnostic imaging ; Amnesia, Anterograde/etiology ; Anterior Thalamic Nuclei/blood supply ; Anterior Thalamic Nuclei/diagnostic imaging ; Brain Infarction/complications ; Brain Infarction/diagnostic imaging ; Hippocampus/blood supply ; Hippocampus/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neural Pathways/blood supply ; Neural Pathways/diagnostic imaging
Language	English
Publishing date	2019-04-17
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000007658
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Article ; Online: Selective, broad-spectrum antiviral photodynamic disinfection with dicationic imidazolyl chlorin photosensitizers.

Arnaut, Zoe A / Pinto, Sara M A / Aroso, Rafael T / Amorim, Anita S / Lobo, Catarina S / Schaberle, Fabio A / Pereira, Dina / Núñez, Jisette / Nunes, Sandra C C / Pais, Alberto A C C / Rodrigues-Santos, Paulo / de Almeida, Luis Pereira / Pereira, Mariette M / Arnaut, Luis G

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology

2023 Volume 22, Issue 11, Page(s) 2607–2620

Abstract: The COVID-19 pandemic exposes our vulnerability to viruses that acquire the ability to infect our cells. Classical disinfection methods are limited by toxicity. Existing medicines performed poorly against SARS-CoV-2 because of their specificity to ... ...

Abstract	The COVID-19 pandemic exposes our vulnerability to viruses that acquire the ability to infect our cells. Classical disinfection methods are limited by toxicity. Existing medicines performed poorly against SARS-CoV-2 because of their specificity to targets in different organisms. We address the challenge of mitigating known and prospective viral infections with a new photosensitizer for antimicrobial photodynamic therapy (aPDT). Photodynamic inactivation is based on local oxidative stress, which is particularly damaging to enveloped viruses. We synthesized a cationic imidazolyl chlorin that reduced by > 99.999% of the percentage inhibition of amplification of SARS-CoV-2 collected from patients at 0.2 µM concentration and 4 J cm
MeSH term(s)	Humans ; Photosensitizing Agents/chemistry ; Disinfection ; Pandemics ; HEK293 Cells ; Prospective Studies ; Photochemotherapy/methods ; SARS-CoV-2 ; Anti-Infective Agents ; Antiviral Agents/pharmacology
Chemical Substances	Photosensitizing Agents ; chlorin (2683-84-3) ; Anti-Infective Agents ; Antiviral Agents
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2072584-X
ISSN	1474-9092 ; 1474-905X
ISSN (online)	1474-9092
ISSN	1474-905X
DOI	10.1007/s43630-023-00476-4
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Article ; Online: Microbial Complexity of Oral Cavity of Healthy Dogs Identified by Mass Spectrometry and Next-Generation Sequencing

Portilho, Fábio V. R. / Nóbrega, Juliano / de Almeida, Beatriz O. / Mota, André R. / de Paula, Carolina L. / Listoni, Fernando J. P. / Bosco, Sandra M. G. / Oliveira, Alana L. / Cunha, Maria de Lourdes R. S. / Ribeiro, Márcio G.

Animals. 2023 July 31, v. 13, no. 15

2023

Abstract	The high complexity of the oral microbiota of healthy dogs and the close exposure of humans to companion animals represent a risk of the transmission of potential zoonotic microorganisms to humans, especially through dog bites, including multidrug-resistant ones. Nonetheless, a limited number of comprehensive studies have focused on the diversity of the microorganisms that inhabit the oral cavities of healthy dogs, particularly based on modern molecular techniques. We investigated bacterial and fungal organisms in the oral cavities of 100 healthy dogs based on a combination of conventional and selective microbiological culture, mass spectrometry (MALDI-TOF MS), and next-generation sequencing. In addition, in vitro antimicrobial susceptibility patterns of isolates and mecA resistance gene were assessed. A total of 213 bacteria and 20 fungi were isolated. Staphylococcus pseudintermedius (40/100 = 40%), α-hemolytic Streptococcus (37/100 = 37%), and Pasteurella stomatis (22/100 = 22%) were the most prevalent bacteria diagnosed by microbiological culture and MALDI-TOF MS, whereas Aspergillus (10/100 = 10%) was the most common fungi identified. Based on next-generation sequencing of selected 20 sampled dogs, Porphyromonas (32.5%), Moraxella (16.3%), Fusobacterium (12.8%), Conchiformibius (9.5%), Bergeyella (5%), Campylobacter (3.8%), and Capnocytophaga (3.4%) genera were prevalent. A high multidrug resistance rate was observed in Staphylococcus pseudintermedius isolates, particularly to azithromycin (19/19 = 100%), penicillin (15/19 = 78.9%), and sulfamethoxazole/trimethoprim (15/19 = 78.9%). In addition, the mecA resistance gene was detected in 6.1% (3/49) of coagulase-positive staphylococci. Here, we highlight the microbial complexity of the oral mucosa of healthy dogs, including potential zoonotic microorganisms and multidrug-resistant bacteria, contributing with the investigation of the microbiota and antimicrobial resistance patterns of the microorganisms that inhabit the oral cavity of healthy dogs.
Keywords	Aspergillus ; Bergeyella ; Campylobacter ; Capnocytophaga ; Fusobacterium ; Moraxella ; Pasteurella stomatis ; Porphyromonas ; Staphylococcus pseudintermedius ; Streptococcus ; antibiotic resistance ; azithromycin ; dogs ; fungi ; mass spectrometry ; mouth ; mucosa ; multiple drug resistance ; penicillins ; resistance genes ; risk ; sulfamethoxazole ; trimethoprim
Language	English
Dates of publication	2023-0731
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13152467
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Article ; Online: An improved drop casting electrochemical strategy for furosemide quantification in natural waters exploiting chemically reduced graphene oxide on glassy carbon electrodes.

Vasconcelos, Sancler C / Rodrigues, Eduardo M / de Almeida, Leonardo G / Lepri, Fábio G / Pacheco, Wagner F / Semaan, Felipe S / Dornellas, Rafael M

Analytical and bioanalytical chemistry

2020 Volume 412, Issue 26, Page(s) 7123–7130

Abstract: This work exploits the applicability of a chemically reduced graphene oxide (CRGO) modification on the electrochemical response of a glassy carbon electrode (GCE) for the first-time sensitive determination of furosemide in natural waters. The batch ... ...

Abstract	This work exploits the applicability of a chemically reduced graphene oxide (CRGO) modification on the electrochemical response of a glassy carbon electrode (GCE) for the first-time sensitive determination of furosemide in natural waters. The batch injection analysis (BIA) is proposed as an analytical method, where CRGO-GCE is coupled to a BIA cell for amperometric measurements. Acetate buffer (0.1 μmol L
MeSH term(s)	Carbon/chemistry ; Chromatography, High Pressure Liquid/methods ; Diuretics/analysis ; Electrochemical Techniques/methods ; Electrodes ; Furosemide/analysis ; Graphite/chemistry ; Limit of Detection ; Oxidation-Reduction ; Reproducibility of Results ; Spectrophotometry, Ultraviolet/methods ; Water Pollutants, Chemical/analysis
Chemical Substances	Diuretics ; Water Pollutants, Chemical ; graphene oxide ; Carbon (7440-44-0) ; Graphite (7782-42-5) ; Furosemide (7LXU5N7ZO5)
Language	English
Publishing date	2020-07-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-020-02845-9
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Book ; Online: Evaluation of Different Annotation Strategies for Deployment of Parking Spaces Classification Systems

Hochuli, Andre G. / Britto Jr., Alceu S. / de Almeida, Paulo R. L. / Alves, Williams B. S. / Cagni, Fabio M. C.

2022

Abstract: When using vision-based approaches to classify individual parking spaces between occupied and empty, human experts often need to annotate the locations and label a training set containing images collected in the target parking lot to fine-tune the system. ...

Abstract	When using vision-based approaches to classify individual parking spaces between occupied and empty, human experts often need to annotate the locations and label a training set containing images collected in the target parking lot to fine-tune the system. We propose investigating three annotation types (polygons, bounding boxes, and fixed-size squares), providing different data representations of the parking spaces. The rationale is to elucidate the best trade-off between handcraft annotation precision and model performance. We also investigate the number of annotated parking spaces necessary to fine-tune a pre-trained model in the target parking lot. Experiments using the PKLot dataset show that it is possible to fine-tune a model to the target parking lot with less than 1,000 labeled samples, using low precision annotations such as fixed-size squares. Comment: Work submitted to be published on IEEE IJCNN 2022 / WCCI 2022 (July/22)
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	006
Publishing date	2022-07-22
Publishing country	us
Document type	Book ; Online
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Article ; Online: Oral squamous cell carcinoma outcome in adolescent/young adult: Systematic review and meta-analysis.

Kaminagakura, Estela / Tango, Rubens Nisie / Cruz-Perez, Danyel / Bonan, Roberta / Yamamoto de Almeida, Luciana / de Almeida Lança, Maria Letícia / Bonan, Paulo / Martins, Hélder / Takahama, Ademar / Ito, Fábio Augusto / Coutinho-Camillo, Cláudia Malheiros / Lourenço, Silvia Vanessa / Caneppele, Taciana / Sikora, Andrew G / Kowalski, Luiz Paulo / Young, Simon

Head & neck

2021 Volume 44, Issue 2, Page(s) 548–561

Abstract: To perform a systematic review focusing on the prognosis of oral cavity squamous cell carcinoma (OSCC) in young patients (≤40 years old) compared to older (>40 years old). Four databases were used in our search strategy. First, all titles were ... ...

Abstract	To perform a systematic review focusing on the prognosis of oral cavity squamous cell carcinoma (OSCC) in young patients (≤40 years old) compared to older (>40 years old). Four databases were used in our search strategy. First, all titles were systematically organized using the Covidence platform online. In the second phase, 118 full texts of potentially eligible studies were analyzed by reviewers independently and in pairs. Twelve studies were considered eligible for data extraction. The relapse was higher in the young than in controls (pooled relative risk (RR) = 1.31; 95% CI [1.10-1.56]). The 5-year disease-free survival (DFS) was worse in young group (pooled hazard ratio (HR) = 0.73; 95% CI [0.63-0.85]) but the 5-year overall survival (OS) estimate was similar between the groups (pooled HR = 0.84; 95% CI [0.70-1.00]). While the 5-year OS was similar between groups, the number of relapses and 5-year DFS were worse in patients with OSCC ≤40 years old.
MeSH term(s)	Adolescent ; Adult ; Carcinoma, Squamous Cell/therapy ; Head and Neck Neoplasms ; Humans ; Mouth Neoplasms/therapy ; Neoplasm Recurrence, Local ; Prognosis ; Squamous Cell Carcinoma of Head and Neck ; Young Adult
Language	English
Publishing date	2021-11-22
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.26940
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Article ; Online: Lemon gum: Non-toxic arabinogalactan isolated from Citrus × latifolia with antiproliferative property against human prostate adenocarcinoma cells.

Ribeiro, Fábio de Oliveira Silva / Oliveira, Fátima de Cássia Evangelista de / Pessoa, Claudia / Dias, Jhones do Nascimento / Albuquerque, Patrícia / Sousa, Edymilaís da Silva / Lima, Sidney Gonçalo de / Lima, Laís Ramos Monteiro de / Sombra, Venicios G / Paula, Regina Célia Monteiro de / Alves, Even Herlany Pereira / Vasconcelos, Daniel Fernando Pereira / Fontenele, Darllan Damasceno / Iles, Bruno / Medeiros, Jand Venes Rolim / Araújo, Alyne Rodrigues de / da Silva, Durcilene Alves / Leite, José Roberto de Souza de Almeida

International journal of biological macromolecules

2023 Volume 232, Page(s) 123058

Abstract: Lemon gum (LG) obtained from Citrus × latifolia in Brazil was isolated and characterized. In addition, gum biocompatibility was evaluated in vitro and in vivo by Galleria mellonella and mice model. The cytotoxicity against tumor cells was also evaluated. ...

Abstract	Lemon gum (LG) obtained from Citrus × latifolia in Brazil was isolated and characterized. In addition, gum biocompatibility was evaluated in vitro and in vivo by Galleria mellonella and mice model. The cytotoxicity against tumor cells was also evaluated. The ratio of arabinose:galactose: rhamnose:4-OMe-glucuronic acid was 1:0.65:0.06:0.15. Small traces of protein were detected, emphasizing the isolate purity. Molar mass was 8.08 × 10
MeSH term(s)	Male ; Animals ; Mice ; Humans ; Citrus ; Prostate ; Galactans ; Adenocarcinoma/drug therapy
Chemical Substances	arabinogalactan (SL4SX1O487) ; Galactans
Language	English
Publishing date	2023-01-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.12.277
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