LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 325

Search options

  1. Article ; Online: Safety of minimally invasive procedures in patients with lung diseases treated with non-vitamin K antagonist oral anticoagulants: a single-center case series.

    Wołoch, Sabina / Kurnik, Joanna / Szlubowski, Artur / Gnass, Maciej / Koprowski, Marek / Undas, Anetta

    Polish archives of internal medicine

    2021  Volume 131, Issue 12

    MeSH term(s) Anticoagulants/adverse effects ; Atrial Fibrillation/therapy ; Humans ; Lung Diseases/drug therapy ; Lung Diseases/surgery ; Minimally Invasive Surgical Procedures
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-10-26
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16131
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Warfarin and vitamin K intake in the era of pharmacogenetics.

    Lurie, Yael / Loebstein, Ronen / Kurnik, Daniel / Almog, Shlomo / Halkin, Hillel

    British journal of clinical pharmacology

    2010  Volume 70, Issue 2, Page(s) 164–170

    Abstract: ... of warfarin, and are often overlooked. Among these factors, dietary and supplemental vitamin K consumption is ... In this commentary we review the current role of vitamin K in warfarin anticoagulation therapy, with emphasis ... on the following: 1 The effect of dietary and supplemental vitamin K on warfarin anticoagulation, beyond the impact ...

    Abstract The considerable variability in the warfarin dose-response relationship between individuals, is explained mainly by genetic variation in its major metabolic (CYP2C9) and target (VKORC1) enzymes. Despite the predominance of pharmacogenetics, environmental factors also affect the pharmacokinetics and pharmacodynamics of warfarin, and are often overlooked. Among these factors, dietary and supplemental vitamin K consumption is a controllable contributor to within-, and between-patient variability of warfarin sensitivity. In this commentary we review the current role of vitamin K in warfarin anticoagulation therapy, with emphasis on the following: 1 The effect of dietary and supplemental vitamin K on warfarin anticoagulation, beyond the impact of genetic variability in CYP2C9 and VKORC1. We deal separately with the effects of vitamin K on warfarin dose requirements during the induction of therapy, as opposed to its effect on stability of anticoagulation control during maintenance therapy. 2 The role of vitamin K supplementation in warfarin treated patients with vitamin K deficiency as well as in patients with unstable warfarin anticoagulation, and 3 The role of therapeutic vitamin K in cases of warfarin over-anticoagulation.
    MeSH term(s) Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; Aryl Hydrocarbon Hydroxylases/genetics ; Blood Coagulation/drug effects ; Blood Coagulation/genetics ; Cytochrome P-450 CYP2C9 ; Dietary Supplements ; Dose-Response Relationship, Drug ; Drug Interactions ; Humans ; Mixed Function Oxygenases/genetics ; Mutation ; Vitamin K/administration & dosage ; Vitamin K/pharmacology ; Vitamin K Deficiency/drug therapy ; Vitamin K Epoxide Reductases ; Warfarin/pharmacokinetics ; Warfarin/pharmacology ; Warfarin/therapeutic use
    Chemical Substances Anticoagulants ; Vitamin K (12001-79-5) ; Warfarin (5Q7ZVV76EI) ; Mixed Function Oxygenases (EC 1.-) ; CYP2C9 protein, human (EC 1.14.13.-) ; Cytochrome P-450 CYP2C9 (EC 1.14.13.-) ; Aryl Hydrocarbon Hydroxylases (EC 1.14.14.1) ; VKORC1 protein, human (EC 1.17.4.4) ; Vitamin K Epoxide Reductases (EC 1.17.4.4)
    Language English
    Publishing date 2010-12-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/j.1365-2125.2010.03672.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: The autonomic nervous system in anorexia nervosa - an implication for the fat tissue.

    Boryczko, Andrzej / Skowron, Kamil / Kurnik-Łucka, Magdalena / Gil, Krzysztof

    Folia medica Cracoviensia

    2024  Volume 63, Issue 3, Page(s) 75–90

    Abstract: Eating disorders are a heterogeneous group of diseases affecting mainly young people in developed countries. Among them, anorexia nervosa (AN) is the one with the highest mortality, up to five times higher compared to healthy individuals. The etiology of ...

    Abstract Eating disorders are a heterogeneous group of diseases affecting mainly young people in developed countries. Among them, anorexia nervosa (AN) is the one with the highest mortality, up to five times higher compared to healthy individuals. The etiology of this medical condition is complex and still un- certain. However, disturbances of the autonomic nervous system (ANS) and increased lipolysis resulting in a decrease of the adipose tissue volume are common findings among AN patients. Since ANS is directly connected to adipocyte tissue, thus significantly affecting the body's metabolic homeostasis, we suspect that this relationship may be a potential pathophysiological underpinning for the development of AN. In this narrative review, we have analyzed scientific reports on ANS activity in AN considering different phases of the disease in humans as well as animal models. Due to the different effects of the disease itself on the ANS as well as specific variations within animal models, the common feature seems to be dysregulation of its function without the identification of one universal pattern. Nonetheless, higher norepinephrine concentrations have been reported in adipocyte tissue, suggesting local dominance of the sym- pathetic nervous system. Further studies should explore in depth the modulation of sympathetic in adipose tissue factor and help answer key questions that arise during this brief narrative review.
    MeSH term(s) Animals ; Humans ; Adolescent ; Anorexia Nervosa ; Autonomic Nervous System/physiology ; Adipose Tissue ; Norepinephrine ; Heart Rate/physiology
    Chemical Substances Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2024-02-04
    Publishing country Poland
    Document type Review ; Journal Article
    ZDB-ID 412415-7
    ISSN 0015-5616
    ISSN 0015-5616
    DOI 10.24425/fmc.2023.147215
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Book: Gerinnungsstörungen im Kindesalter

    Kurnik, Karin / Bidlingmaier, Christoph

    Diagnostik und Therapie - auf einen Blick ; 43 Tabellen

    2008  

    Author's details Karin Kurnik ; Christoph Bidlingmaier
    Subject code 618.92157
    Language German
    Size 32 S. : graph. Darst., 20 cm
    Publisher Ligatur
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT015890335
    ISBN 978-3-940407-00-9 ; 3-940407-00-3
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

  5. Article: Combined genetic profiles of components and regulators of the vitamin K-dependent gamma-carboxylation system affect individual sensitivity to warfarin.

    Vecsler, Manuela / Loebstein, Ronen / Almog, Shlomo / Kurnik, Daniel / Goldman, Boleslav / Halkin, Hillel / Gak, Eva

    Thrombosis and haemostasis

    2006  Volume 95, Issue 2, Page(s) 205–211

    Abstract: We examined the influence of combined genotypes on interindividual variability in warfarin dose-response. In 100 anticoagulated patients we quantified the effects of polymorphisms in: CYP2C9, VKORC1, calumenin (CALU), gamma-glutamyl carboxylase (GGCX) ... ...

    Abstract We examined the influence of combined genotypes on interindividual variability in warfarin dose-response. In 100 anticoagulated patients we quantified the effects of polymorphisms in: CYP2C9, VKORC1, calumenin (CALU), gamma-glutamyl carboxylase (GGCX) and microsomal epoxide hydrolase (EPHX1) on warfarin dose requirements. The G(1542)C VKORC1 polymorphism was associated with decreased warfarin doses in the hetero- and homozygous mutant patients (21% and 50% lower, respectively; p < 0.0001). Warfarin daily dose was predominantly determined by VKORC1 and CYP2C9 genotypes (partial r(2) = 0.21; 0.20, respectively). Together with age and body weight, these two genotypes explained 63% of the dose variance. A single patient, homozygous for G(11)A CALU mutant allele, required an exceptionally high warfarin dose (20 mg/day) and the prevalence of heterozygous (11)A allele carriers in the upper 10(th) dose percentile was significantly higher (0.27 vs. 0.18, p < 0.02). Combined genotype analysis revealed that CYP2C9 andVKORC1 wild type and CALU mutant patients required the highest warfarin doses (7.8 +/- 1.5mg/day; n = 9) as compared to the CYP2C9 and VKORC1 mutant and CALU wild type genotypes (2.8 +/- 0.3 mg/day; n = 18; p < 0.01). The odds ratio for doses <3mg/day was 5.9 (1.9-18.4) for this genotype. Compound genetic profiles comprising VKORC1, CALU and CYP2C9 improve categorization of individual warfarin dose requirements in more than 25% of patients at steady-state anticoagulation.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aryl Hydrocarbon Hydroxylases/genetics ; Calcium-Binding Proteins/genetics ; Carbon-Carbon Ligases/genetics ; Cytochrome P-450 CYP2C9 ; Dose-Response Relationship, Drug ; Drug Resistance/genetics ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Mixed Function Oxygenases/genetics ; Pharmacogenetics ; Polymorphism, Genetic ; Vitamin K/metabolism ; Vitamin K Epoxide Reductases ; Warfarin/administration & dosage ; Warfarin/pharmacokinetics
    Chemical Substances CALU protein, human ; Calcium-Binding Proteins ; Vitamin K (12001-79-5) ; Warfarin (5Q7ZVV76EI) ; Mixed Function Oxygenases (EC 1.-) ; CYP2C9 protein, human (EC 1.14.13.-) ; Cytochrome P-450 CYP2C9 (EC 1.14.13.-) ; Aryl Hydrocarbon Hydroxylases (EC 1.14.14.1) ; VKORC1 protein, human (EC 1.17.4.4) ; Vitamin K Epoxide Reductases (EC 1.17.4.4) ; Carbon-Carbon Ligases (EC 6.4.-) ; glutamyl carboxylase (EC 6.4.-)
    Language English
    Publishing date 2006-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 0340-6245
    ISSN 0340-6245
    DOI 10.1160/TH05-06-0446
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Effectiveness of psychoeducation for children, adolescents and caregivers in the treatment of eating disorders: A systematic review.

    Kurnik Mesarič, Katja / Damjanac, Žiga / Debeljak, Tjaš / Kodrič, Jana

    European eating disorders review : the journal of the Eating Disorders Association

    2023  Volume 32, Issue 1, Page(s) 99–115

    Abstract: Background: Eating disorders in childhood and adolescence negatively affect many areas of development and functioning of children, adolescents, and their families. Psychoeducation has an important role in management and treatment of eating disorders.: ...

    Abstract Background: Eating disorders in childhood and adolescence negatively affect many areas of development and functioning of children, adolescents, and their families. Psychoeducation has an important role in management and treatment of eating disorders.
    Methods: A systematic literature review was performed using multiple databases (PsycInfo, PubMed, and Web of Science). The inclusion criteria comprised empirical studies of psychoeducation for patients with eating disorders or their caregivers. The study reporting quality was assessed with the revised Cochrane Collaboration's risk of bias tool and the Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields for non-randomized studies.
    Results: Ten studies met the inclusion criteria, in three of which the interventions were patient-centred and in seven of which the interventions were caregiver-centred. The studies differed in terms of methodology, outcome measures, and quality. The results suggest that psychoeducation is an effective intervention for children, adolescents and caregivers in the treatment of eating disorders. It may lead to weight gain, a decrease in eating disorder symptoms, and a reduction in caregiver burden.
    Conclusions: There is a need for more randomized controlled trials to determine the effectiveness of psychoeducation for children, adolescents and caregivers in treatment of eating disorders.
    MeSH term(s) Child ; Humans ; Adolescent ; Caregivers ; Feeding and Eating Disorders/therapy ; Outcome Assessment, Health Care ; Weight Gain
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1159507-3
    ISSN 1099-0968 ; 1067-1633 ; 1072-4133
    ISSN (online) 1099-0968
    ISSN 1067-1633 ; 1072-4133
    DOI 10.1002/erv.3028
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Breast surgery in patients with hypermobile Ehlers-Danlos syndrome.

    Morris, Bryn E / Ishimoto, Alyssa K / Casey, William J / Rebecca, Alanna M / Kurnik, Nicole M

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2023  Volume 88, Page(s) 109–111

    MeSH term(s) Humans ; Female ; Ehlers-Danlos Syndrome/complications ; Ehlers-Danlos Syndrome/surgery ; Patients ; Mastectomy ; Breast Neoplasms
    Language English
    Publishing date 2023-10-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2023.10.120
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: The Impact of Prenatal Alcohol Exposure on the Autonomic Nervous System and Cardiovascular System in Rats in a Sex-Specific Manner.

    Jurczyk, Michał / Król, Magdalena / Midro, Aleksandra / Dyląg, Katarzyna / Kurnik-Łucka, Magdalena / Skowron, Kamil / Gil, Krzysztof

    Pediatric reports

    2024  Volume 16, Issue 2, Page(s) 278–287

    Abstract: Background: Fetal Alcohol Spectrum Disorder (FASD) is a consequence of prenatal alcohol exposure (PAE) associated with a range of effects, including dysmorphic features, prenatal and/or postnatal growth problems, and neurodevelopmental difficulties. ... ...

    Abstract Background: Fetal Alcohol Spectrum Disorder (FASD) is a consequence of prenatal alcohol exposure (PAE) associated with a range of effects, including dysmorphic features, prenatal and/or postnatal growth problems, and neurodevelopmental difficulties. Despite advances in treatment methods, there are still gaps in knowledge that highlight the need for further research. The study investigates the effect of PAE on the autonomic system, including sex differences that may aid in early FASD diagnosis, which is essential for effective interventions.
    Methods: During gestational days 5 to 20, five pregnant female Wistar rats were orally administered either glucose or ethanol. After 22 days, 26 offspring were born and kept with their mothers for 21 days before being isolated. Electrocardiographic recordings were taken on the 29th and 64th day. Heart rate variability (HRV) parameters were collected, including heart rate (HR), standard deviation (SD), standard deviation of normal-to-normal intervals (SDNN), and the root mean square of successive differences between normal heartbeats (RMSSD). Additionally, a biochemical analysis of basic serum parameters was performed on day 68 of the study.
    Results: The study found that PAE had a significant impact on HRV. While electrolyte homeostasis remained mostly unaffected, sex differences were observed across various parameters in both control and PAE groups, highlighting the sex-specific effects of PAE. Specifically, the PAE group had lower mean heart rates, particularly among females, and higher SDNN and RMSSD values. Additionally, there was a shift towards parasympathetic activity and a reduction in heart rate entropy in the PAE group. Biochemical changes induced by PAE were also observed, including elevated levels of alanine transaminase (ALT) and aspartate aminotransferase (AST), especially in males, increased creatinine concentration in females, and alterations in lipid metabolism.
    Conclusions: PAE negatively affects the development of the autonomic nervous system, resulting in decreased heart rate and altered sympathetic activity. PAE also induces cardiovascular abnormalities with sex-specific effects, highlighting a relationship between PAE consequences and sex. Elevated liver enzymes in the PAE group may indicate direct toxic effects, while increased creatinine levels, particularly in females, may suggest an influence on nephrogenesis and vascular function. The reduced potassium content may be linked to hypothalamus-pituitary-adrenal axis overactivity.
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2036-749X
    ISSN 2036-749X
    DOI 10.3390/pediatric16020024
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: Combined genetic profiles of components and regulators of the vitamin K-dependent γ-carboxylation system affect individual sensitivity to warfarin

    Vecsler, Manuela / Loebstein, Ronen / Almog, Shlomo / Kurnik, Daniel / Goldman, Boleslav / Halkin, Hillel / Gak, Eva

    Thrombosis and Haemostasis

    2006  Volume 95, Issue 02, Page(s) 205–211

    Abstract: We examined the influence of combined genotypes on interindividual variability in warfarin dose-response. In 100 anticoagulated patients we quantified the effects of polymorphisms in: CYP2C9 VKORC1, calumenin (CALU), γ-glutamyl carboxylase ( GGCX ) and ...

    Abstract We examined the influence of combined genotypes on interindividual variability in warfarin dose-response. In 100 anticoagulated patients we quantified the effects of polymorphisms in: CYP2C9 VKORC1, calumenin (CALU), γ-glutamyl carboxylase ( GGCX ) and microsomal epoxide hydrolase (EPHX1) on warfarin dose requirements. The G 1542 C VKORC1 polymorphism was associated with decreased warfarin doses in the heteroand homozygous mutant patients (21% and 50% lower, respectively; p<0.0001). Warfarin daily dose was predominantly determined by VKORC1 and CYP2C9 genotypes (partial r 2 = 0.21; 0.20, respectively). Together with age and body weight, these two genotypes explained 63% of the dose variance. A single patient, homozygous for G 11 A CALU mutant allele, required an excep tionally high warfarin dose (20mg/day) and the prevalence of heterozygous 11 A allele carriers in the upper 10 th dose percentile was significantly higher (0.27 vs. 0.18, p<0.02). Combined genotype analysis revealed that CYP2C9 and VKORC1 wild type and CALU mutant patients required the highest warfarin doses (7. 8±1. 5mg/day; n=9) as compared to the CYP2C9 and VKORC1 mutant and CALU wild type genotypes (2. 8±0. 3mg/day; n=18; p<0.01). The odds ratio for doses <3mg/day was 5. 9 (1.9–18. 4) for this genotype. Compound genetic profiles comprising VKORC1 CALU and CYP2C9 improve categorization of individual warfarin dose requirements in more than 25% of patients at steady-state anticoagulation.
    Keywords warfarin (coumarin) sensitivity ; vitamin K cycle ; single nucleotide polymorphisms (SNPs) ; combined genotype ; pharmacogenetics
    Language English
    Publishing date 2006-01-01
    Publisher Schattauer GmbH
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1160/TH05-06-0446
    Database Thieme publisher's database

    More links

    Kategorien

  10. Article ; Online: Care for children with haemophilia during COVID-19: Data of the PedNet study group.

    Álvarez-Román, María Teresa / Kurnik, Karin

    Haemophilia : the official journal of the World Federation of Hemophilia

    2021  Volume 27, Issue 4, Page(s) e537–e539

    MeSH term(s) COVID-19/epidemiology ; Child ; Disease Management ; Hemophilia A/prevention & control ; Hemophilia A/therapy ; Hospitals, Special ; Humans ; Patient Care ; Telemedicine
    Language English
    Publishing date 2021-03-08
    Publishing country England
    Document type Letter
    ZDB-ID 1229713-6
    ISSN 1365-2516 ; 1351-8216 ; 1355-0691
    ISSN (online) 1365-2516
    ISSN 1351-8216 ; 1355-0691
    DOI 10.1111/hae.14286
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top