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  1. Article ; Online: One-dimensional Ga

    Han, Xue / Yang, Yun / Chen, Rui / Zhou, Jiaqi / Yang, Xupeng / Wang, Xuyu / Ji, Hongbing

    Journal of colloid and interface science

    2024  Volume 666, Page(s) 76–87

    Abstract: The pressing demand for propylene has spurred intensive research on the catalytic dehydrogenation of propane to produce propylene. Gallium-based catalysts are regarded as highly promising due to their exceptional dehydrogenation activity in the presence ... ...

    Abstract The pressing demand for propylene has spurred intensive research on the catalytic dehydrogenation of propane to produce propylene. Gallium-based catalysts are regarded as highly promising due to their exceptional dehydrogenation activity in the presence of CO
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2024.03.171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Long non-coding RNA HOTAIR: from pan-cancer analysis to colorectal cancer-related uridine metabolism.

    Chen, Xuyu / Wang, Siying / Jiang, Xin / Zhang, Min / Ding, Yanbing

    Aging

    2024  Volume 16

    Abstract: Long non-coding RNAs (lncRNAs) are involved significantly in the development of human cancers. lncRNA HOTAIR has been reported to play an oncogenic role in many human cancers. Its specific regulatory role is still elusive. And it might have enormous ... ...

    Abstract Long non-coding RNAs (lncRNAs) are involved significantly in the development of human cancers. lncRNA HOTAIR has been reported to play an oncogenic role in many human cancers. Its specific regulatory role is still elusive. And it might have enormous potential to interpret the malignant progression of tumors in a broader perspective, that is, in pan-cancer. We comprehensively investigated the effect of HOTAIR expression on tumor prognosis across human malignancies by analyzing multiple cancer-related databases like The Cancer Genome Atlas (TCGA) and Tumor Immune Estimation Resource (TIMER). Bioinformatics data indicated that HOTAIR was overexpressed in most of these human malignancies and was significantly associated with the prognosis of patients with cancer, especially in colorectal cancer (CRC). Subsequently, this study further clarified the utility of HOTAIR that downregulation of its expression could result in reduced proliferation and invasion of CRC cells. Mechanistically, HOTAIR upregulated the metabolic enzymes UPP1 by recruiting histone methyltransferase EZH2, thereby increasing the tumor progression. Our results highlight the essential role of HOTAIR in pan-cancer and uridine bypass, suggesting that the HOTAIR/EZH2/UPP1 axis might be a novel target for overcoming CRC. We anticipate that the role of HOTAIR in metabolism could be important in the context of CRC and even exploited for therapeutic purposes.
    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Journal Article
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Comprehensive Bioinformatic Analysis for Identification of Myeloid-Associated Differentiation Marker as a Potential Negative Prognostic Biomarker in Non-Small-Cell Lung Cancer.

    Zhou, Min / Chen, Yan / Gu, Xuyu / Wang, Cailian

    Pathology oncology research : POR

    2022  Volume 28, Page(s) 1610504

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Antigens, Differentiation ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Computational Biology ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/pathology ; Prognosis
    Chemical Substances Antigens, Differentiation ; Biomarkers, Tumor
    Language English
    Publishing date 2022-08-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1375979-6
    ISSN 1532-2807 ; 1219-4956
    ISSN (online) 1532-2807
    ISSN 1219-4956
    DOI 10.3389/pore.2022.1610504
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    Zs.A 4936: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: High glucose promotes macrophage M1 polarization through miR-32/Mef2d/cAMP signaling pathway.

    Chen, Cong / Cao, Jingsong / Gao, Yan / Xie, Xiaoping / Zhao, Zhibo / Yuan, Qing / He, Yuqi / Zu, Xuyu / Liu, Jianghua

    Genes & diseases

    2023  Volume 11, Issue 2, Page(s) 539–541

    Language English
    Publishing date 2023-05-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2023.03.029
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  5. Article ; Online: Cardiac conduction block during secukinumab treatment.

    Tang, Xin / Zheng, Xuyu / Hu, Li / Wang, Ping / Chen, Aijun / Huang, Kun

    Dermatologic therapy

    2022  Volume 35, Issue 7, Page(s) e15504

    MeSH term(s) Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized/adverse effects ; Humans ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; secukinumab (DLG4EML025)
    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Letter
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.15504
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5181: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: High Expression of

    Chen, Yan / Zhou, Min / Gu, Xuyu / Wang, Longfei / Wang, Cailian

    Disease markers

    2022  Volume 2022, Page(s) 8789515

    Abstract: Background: Lung adenocarcinoma (LUAD) has been recognized as one of the commonest aggressive malignant tumors occurring in humans. The transforming acidic coiled-coil-containing protein 3 (: Methods: Premised on the data accessed from The Cancer ... ...

    Abstract Background: Lung adenocarcinoma (LUAD) has been recognized as one of the commonest aggressive malignant tumors occurring in humans. The transforming acidic coiled-coil-containing protein 3 (
    Methods: Premised on the data accessed from The Cancer Genome Atlas- (TCGA-) LUAD, we carried out bioinformatics analysis. The
    Results: The outcomes illustrated that
    Conclusion: The findings from this research offer robust proof that the expression of
    MeSH term(s) Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/metabolism ; Adenocarcinoma of Lung/pathology ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Prognosis
    Chemical Substances Cell Cycle Proteins ; Microtubule-Associated Proteins ; TACC3 protein, human
    Language English
    Publishing date 2022-07-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604951-5
    ISSN 1875-8630 ; 0278-0240
    ISSN (online) 1875-8630
    ISSN 0278-0240
    DOI 10.1155/2022/8789515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1856: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)
    Einzelsignatur: Show issues

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  7. Article: Mechanisms of NAT10 as ac4C writer in diseases.

    Xie, Lihua / Zhong, Xiaolin / Cao, Wenyu / Liu, Jianghua / Zu, Xuyu / Chen, Ling

    Molecular therapy. Nucleic acids

    2023  Volume 32, Page(s) 359–368

    Abstract: In the early stage, N4-acetylcytidine (ac4C) was regarded as a conservative nucleoside present on tRNA and rRNA. Recently, studies have shown that ac4C also exists in human and yeast mRNA. N-Acetyltransferase-like protein 10 (NAT10) is the first enzyme ... ...

    Abstract In the early stage, N4-acetylcytidine (ac4C) was regarded as a conservative nucleoside present on tRNA and rRNA. Recently, studies have shown that ac4C also exists in human and yeast mRNA. N-Acetyltransferase-like protein 10 (NAT10) is the first enzyme to be found to catalyze ac4C production in eukaryotic RNA and has acetyltransferase activity and RNA-binding activity. Here, we first describe the structure and cellular localization of NAT10. Then, we conclude the active roles of NAT10 as the ac4C "writer" in mRNA stability and translation efficiency, oocyte maturation, bone remodeling, and fatty acid metabolism. With respect to disease, we focused on the promoting functions of NAT10 in proliferation, metastasis, and apoptosis in multiple tumors. The immune regulatory role of NAT10 in systemic lupus erythematosus and the maintenance role of NAT10 in virus RNA stability and replication in influenza A virus are also introduced. This review identifies NAT10 as a potential target for diagnosis, therapy, and prognosis in clinical application.
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2023.03.023
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  8. Article ; Online: Comparative Efficacy of P-CAB vs Proton Pump Inhibitors for Grade C/D Esophagitis: A Systematic Review and Network Meta-analysis.

    Zhuang, Qianjun / Chen, Songfeng / Zhou, Xuyu / Jia, Xingyu / Zhang, Mengyu / Tan, Niandi / Chen, Fangfei / Zhang, Zhanye / Hu, Junnan / Xiao, Yinglian

    The American journal of gastroenterology

    2024  Volume 119, Issue 5, Page(s) 803–813

    Abstract: Introduction: Los Angeles grade C/D esophagitis is a severe manifestation of gastroesophageal reflux disease that require active treatment and close follow-up. Potassium competitive acid blockers (P-CAB) are promising alternatives to proton pump ... ...

    Abstract Introduction: Los Angeles grade C/D esophagitis is a severe manifestation of gastroesophageal reflux disease that require active treatment and close follow-up. Potassium competitive acid blockers (P-CAB) are promising alternatives to proton pump inhibitors (PPI). We aimed to compare the efficacy and safety of P-CAB and PPI in healing grade C/D esophagitis to aid clinical decision-making.
    Methods: A systematic literature search was performed using PubMed, MEDLINE, and Cochrane Central Register of Controlled Trials. Randomized controlled trials were eligible for inclusion if efficacy of P-CAB and PPI in healing grade C/D esophagitis was reported. Pooled risk ratios and risk difference with 95% credible intervals were used to summarize estimated effect of each comparison. The benefit of treatments was ranked using the surface under the cumulative probability ranking score.
    Results: Of 5,876 articles identified in the database, 24 studies were eligible. Studies included incorporated 3 P-CAB (vonoprazan, tegoprazan, and keverprazan) and 6 PPI (lansoprazole, esomeprazole, omeprazole, rabeprazole extended-release (ER), pantoprazole, and dexlansoprazole). Based on the failure to achieve mucosal healing, 20 mg of vonoprazan q.d. ranked the first among PPI in initial and maintained healing of grade C/D esophagitis (surface under the cumulative probability ranking score = 0.89 and 0.87, respectively). Vonoprazan had similar risk of incurring adverse events, severe adverse events, and withdrawal to drug when compared with PPI. For those who attempted lower maintenance treatment dose, 10 mg of vonoprazan q.d. was a reasonable choice, considering its moderate efficacy and safety.
    Discussion: Vonoprazan has considerable efficacy in initial and maintained healing of grade C/D esophagitis compared with PPI, with moderate short-term and long-term safety.
    MeSH term(s) Humans ; Proton Pump Inhibitors/therapeutic use ; Network Meta-Analysis ; Esophagitis/drug therapy ; Gastroesophageal Reflux/drug therapy ; Treatment Outcome ; Randomized Controlled Trials as Topic ; Esophagitis, Peptic/drug therapy ; Pyrroles ; Sulfonamides
    Chemical Substances Proton Pump Inhibitors ; 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine ; Pyrroles ; Sulfonamides
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article ; Systematic Review ; Meta-Analysis ; Comparative Study
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002714
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui V Zs.36: Show issues Location:
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  9. Article ; Online: Knee osteoarthritis: A review of animal models and intervention of traditional Chinese medicine.

    Song, Xuyu / Liu, Ying / Chen, Siyi / Zhang, Lei / Zhang, Huijie / Shen, Xianhui / Du, Hang / Sun, Rong

    Animal models and experimental medicine

    2024  

    Abstract: Background: Knee osteoarthritis (KOA) characterized by degeneration of knee cartilage and subsequent bone hyperplasia is a prevalent joint condition primarily affecting aging adults. The pathophysiology of KOA remains poorly understood, as it involves ... ...

    Abstract Background: Knee osteoarthritis (KOA) characterized by degeneration of knee cartilage and subsequent bone hyperplasia is a prevalent joint condition primarily affecting aging adults. The pathophysiology of KOA remains poorly understood, as it involves complex mechanisms that result in the same outcome. Consequently, researchers are interested in studying KOA and require appropriate animal models for basic research. Chinese herbal compounds, which consist of multiple herbs with diverse pharmacological properties, possess characteristics such as multicomponent, multipathway, and multitarget effects. The potential benefits in the treatment of KOA continue to attract attention.
    Purpose: This study aims to provide a comprehensive overview of the advantages, limitations, and specific considerations in selecting different species and methods for KOA animal models. This will help researchers make informed decisions when choosing an animal model.
    Methods: Online academic databases (e.g., PubMed, Google Scholar, Web of Science, and CNKI) were searched using the search terms "knee osteoarthritis," "animal models," "traditional Chinese medicine," and their combinations, primarily including KOA studies published from 2010 to 2023.
    Results: Based on literature retrieval, this review provides a comprehensive overview of the methods of establishing KOA animal models; introduces the current status of advantages and disadvantages of various animal models, including mice, rats, rabbits, dogs, and sheep/goats; and presents the current status of methods used to establish KOA animal models.
    Conclusion: This study provides a review of the animal models used in recent KOA research, discusses the common modeling methods, and emphasizes the role of traditional Chinese medicine compounds in the treatment of KOA.
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2576-2095
    ISSN (online) 2576-2095
    DOI 10.1002/ame2.12389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Peripheral Blood Markers Predictive of Progression-Free Survival in Advanced Esophageal Squamous Cell Carcinoma Patients Treated With PD-1 Inhibitors Plus Chemotherapy as First-Line Therapy.

    Chen, Wei / Li, Dapeng / Bian, Xuyu / Wu, Yan / Xu, Mengdan / Wu, Mengyao / Tao, Min

    Nutrition and cancer

    2022  Volume 75, Issue 1, Page(s) 207–218

    Abstract: Aim: ...

    Abstract Aim:
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 424433-3
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2022.2123533
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    Zs.A 1496: Show issues Location:
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