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Article ; Online: Investigating locations of recurrences with MRI after CRS-HIPEC for colorectal peritoneal metastases.

Rijsemus, C J V / Kok, N F M / Aalbers, A G J / Grotenhuis, B A / Berardi, E / Snaebjornsson, P / Lambregts, D M J / Beets-Tan, R G H / Lahaye, M J

European journal of radiology

2024 Volume 175, Page(s) 111478

Abstract: ... where the peritoneum was damaged due to earlier resections or other surgical procedures (e.g. inserted surgical ...

Abstract	Purpose: Patients with colorectal peritoneal metastases (PM) treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are at high risk of recurrent disease. Understanding where and why recurrences occur is the first step in finding solutions to reduce recurrence rates. Although diffusion-weighted (DW) MRI is not routinely used in the follow-up of CRC patients, it has a clear advantage over CT in detecting the location and spread of (recurrent) PM. This study aimed to identify common locations of recurrence in CRC patients after CRS-HIPEC with MRI. Method: This was a single-centre retrospective study of patients with recurrent PM after CRS-HIPEC performed between January 2016 and August 2020. Patients were eligible for inclusion if they had both an MRI preoperatively (MRI1) and at the time of recurrent disease (MRI2). Two abdominal radiologists reviewed in consensus and categorized recurrences according to their location on MRI2 and in correlation with previous disease location on prior imaging (MRI1) and the surgical report of the CRS-HIPEC. Results: Thirty patients were included, with a median surgical PCI of 7 (range 3-21) at the time of primary CRS-HIPEC. In total, 68 recurrent metastases were detected on MRI2, of which 14 were extra-peritoneal. Of the remaining 54 PM, 42 (78%) occurred where the peritoneum was damaged due to earlier resections or other surgical procedures (e.g. inserted surgical abdominal drains). Most recurrent metastases were found in the mesentery, lower abdomen/pelvis and abdominal wall (87%). Conclusions: Most recurrent PMs appeared in the mesentery, lower abdomen/pelvis and abdominal wall, especially where the peritoneum was previously damaged.
Language	English
Publishing date	2024-04-22
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2024.111478
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Article ; Online: Imaging in the era of risk-adapted treatment in Colon cancer.

Lahaye, Max J / Lambregts, Doenja M J / Aalbers, Arend G J / Snaebjornsson, Petur / Beets-Tan, R G H / Kok, Niels F M

The British journal of radiology

2024

Abstract: The treatment landscape for patients with colon cancer is continuously evolving. Risk-adapted treatment strategies, including neoadjuvant chemotherapy and immunotherapy, are slowly finding their way into clinical practice and guidelines. Radiologists are ...

Abstract	The treatment landscape for patients with colon cancer is continuously evolving. Risk-adapted treatment strategies, including neoadjuvant chemotherapy and immunotherapy, are slowly finding their way into clinical practice and guidelines. Radiologists are pivotal in guiding clinicians toward the most optimal treatment for each colon cancer patient. This review provides an overview of recent and upcoming advances in the diagnostic management of colon cancer and the radiologist's role in the multidisciplinary approach to treating colon cancer.
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1093/bjr/tqae061
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Article ; Online: Whole-body MRI with diffusion-weighted imaging as an adjunct to

Willemse, Jeroen R J / Lahaye, Max J / Kok, Niels F M / Grotenhuis, Brechtje A / Aalbers, Arend G J / Beets, Geerard L / Rijsemus, Charlotte / Maas, Monique / van Golen, Larissa W / Beets-Tan, Regina G H / Lambregts, Doenja M J

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2023 Volume 26, Issue 2, Page(s) 290–299

Abstract: Aim: The aim was to explore how findings of whole-body MRI including diffusion-weighted imaging (DW-MRI) compared to the routine diagnostic workup with CT and/or : Method: This was an exploratory retrospective analysis of 55 patients with a clinical ... ...

Abstract	Aim: The aim was to explore how findings of whole-body MRI including diffusion-weighted imaging (DW-MRI) compared to the routine diagnostic workup with CT and/or Method: This was an exploratory retrospective analysis of 55 patients with a clinical suspicion of recurrent CRC who underwent DW-MRI following CT and/or FDG-PET/CT. Two readers in consensus interpreted all clinical imaging reports and converted each described lesion into a confidence score (1 = definitely benign to 5 = definitely malignant). DW-MRI findings were compared to the most recent previous CT or PET/CT. Any discrepant or additional DW-MRI findings were documented and compared with histology and/or clinical follow-up (if available). Results: Whole-body MRI including diffusion-weighted imaging (DW-MRI) resulted in discrepant/additional findings in 26/55 (47%) cases; 23/37 (62%) compared to previous CT and 3/18 (17%) compared to previous PET/CT. These included 10 cases where DW-MRI converted previously inconclusive CT (n = 8) or PET/CT (n = 2) findings into a conclusive diagnosis, one where it contradicted a previous CT diagnosis of recurrence, five where DW-MRI diagnosed recurrent disease not previously reported on CT and 10 cases where DW-MRI detected additional lesions compared to CT (n = 9) or PET/CT (n = 1). Eighty-eight per cent of cases with discrepant/additional findings concerned patients with recurrent/metachronous peritoneal metastases. In total, DW-MRI resulted in 42 discrepant/additional lesions; the DW-MRI diagnosis was correct in 76% of these lesions and incorrect (false positive) in 7%. In the remaining 17%, no standard of reference was available. Conclusions: This explorative study suggests that DW-MRI may be of added value to patients with a clinical suspicion for recurrent CRC, in particular to identify patients with peritoneal metastases. DW-MRI mainly has potential as a 'problem-solver' in patients with inconclusive or negative findings on previous imaging (in particular CT) and to detect additional disease sites in patients already diagnosed with recurrent disease.
MeSH term(s)	Humans ; Diffusion Magnetic Resonance Imaging/methods ; Positron Emission Tomography Computed Tomography/methods ; Fluorodeoxyglucose F18 ; Retrospective Studies ; Peritoneal Neoplasms ; Magnetic Resonance Imaging ; Positron-Emission Tomography/methods ; Colorectal Neoplasms/diagnostic imaging ; Colorectal Neoplasms/pathology ; Radiopharmaceuticals
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
Language	English
Publishing date	2023-12-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.16840
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Book ; Online: Deliverable 6

Aalbers, C.B.E.M. / Gerritsen, A.L. / Nuesink, J.G. / Oomkens, Jeroen / Korteweg, Lisa

Final “To-be situation” voor de aanpak van riviergebiedsbeheer

2022

Keywords	Life Science
Language	Dutch
Publisher	Trinomics
Publishing country	nl
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Correction: Groen et al. Use of Image-Guided Surgical Navigation during Resection of Locally Recurrent Rectal Cancer.

Groen, Harald C / den Hartog, Anne G / Heerink, Wouter J / Kuhlmann, Koert F D / Kok, Niels F M / van Veen, Ruben / Hiep, Marijn A J / Snaebjornsson, Petur / Grotenhuis, Brechtje A / Beets, Geerard L / Aalbers, Arend G J / Ruers, Theo J M

Life (Basel, Switzerland)

2023 Volume 13, Issue 3

Abstract: The authors wish to make the following corrections to this paper [ ... ]. ...

Abstract	The authors wish to make the following corrections to this paper [...].
Language	English
Publishing date	2023-03-02
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13030678
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Book ; Online: Deliverable 3

Aalbers, C.B.E.M. / Gerritsen, A.L. / Nuesink, J.G. / Oomkens, Jeroen / Korteweg, Lisa

Identificeren van einddoelstellingen voor het gebiedsbeheer van de Noordwaard

2022

Keywords	Life Science
Language	Dutch
Publisher	Trinomics
Publishing country	nl
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evolution of clinical nature, treatment and survival of locally recurrent rectal cancer: Comparative analysis of two national cross-sectional cohorts.

van Geffen, E G M / Langhout, J M A / Hazen, S J A / Sluckin, T C / van Dieren, S / Beets, G L / Beets-Tan, R G H / Borstlap, W A A / Burger, J W A / Horsthuis, K / Intven, M P W / Aalbers, A G J / Havenga, K / Marinelli, A W K S / Melenhorst, J / Nederend, J / Peulen, H M U / Rutten, H J T / Schreurs, W H /

Tuynman, J B / Verhoef, C / de Wilt, J H W / Marijnen, C A M / Tanis, P J / Kusters, M / On Behalf Of The Dutch Snapshot Research Group

European journal of cancer (Oxford, England : 1990)

2024 Volume 202, Page(s) 114021

Abstract: Background: In the Netherlands, use of neoadjuvant radiotherapy for rectal cancer declined after guideline revision in 2014. This decline is thought to affect the clinical nature and treatability of locally recurrent rectal cancer (LRRC). Therefore, ... ...

Abstract	Background: In the Netherlands, use of neoadjuvant radiotherapy for rectal cancer declined after guideline revision in 2014. This decline is thought to affect the clinical nature and treatability of locally recurrent rectal cancer (LRRC). Therefore, this study compared two national cross-sectional cohorts before and after the guideline revision with the aim to determine the changes in treatment and survival of LRRC patients over time. Methods: Patients who underwent resection of primary rectal cancer in 2011 (n = 2094) and 2016 (n = 2855) from two nationwide cohorts with a 4-year follow up were included. Main outcomes included time to LRRC, synchronous metastases at time of LRRC diagnosis, intention of treatment and 2-year overall survival after LRRC. Results: Use of neoadjuvant (chemo)radiotherapy for the primary tumour decreased from 88.5% to 60.0% from 2011 to 2016. The 3-year LRRC rate was not significantly different with 5.1% in 2011 (n = 114, median time to LRRC 16 months) and 6.3% in 2016 (n = 202, median time to LRRC 16 months). Synchronous metastasis rate did not significantly differ (27.2% vs 33.7%, p = 0.257). Treatment intent of the LRRC shifted towards more curative treatment (30.4% vs. 47.0%, p = 0.009). In the curatively treated group, two-year overall survival after LRRC diagnoses increased from 47.5% to 78.7% (p = 0.013). Conclusion: Primary rectal cancer patients in 2016 were treated less often with neoadjuvant (chemo)radiotherapy, while LRRC rates remained similar. Those who developed LRRC were more often candidate for curative intent treatment compared to the 2011 cohort, and survival after curative intent treatment also improved substantially.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Neoplasm Recurrence, Local/pathology ; Rectal Neoplasms/therapy ; Rectal Neoplasms/pathology ; Combined Modality Therapy ; Neoadjuvant Therapy ; Retrospective Studies
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2024.114021
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Azacytidine Treatment for VEXAS Syndrome.

Raaijmakers, Marc H G P / Hermans, Maud / Aalbers, Anna / Rijken, Melissa / Dalm, Virgil A S H / van Daele, Paul / Valk, Peter J M

HemaSphere

2021 Volume 5, Issue 12, Page(s) e661

Language	English
Publishing date	2021-11-17
Publishing country	United States
Document type	Journal Article
ISSN	2572-9241
ISSN (online)	2572-9241
DOI	10.1097/HS9.0000000000000661
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Article ; Online: Diagnostic performance of MRI for staging peritoneal metastases in patients with colorectal cancer after neoadjuvant chemotherapy.

Rijsemus, C J V / Kok, N F M / Aalbers, A G J / Buffart, T E / Fijneman, R J A / Snaebjornsson, P / Engbersen, M P / Lambregts, D M J / Beets-Tan, R G H / Lahaye, M J

European journal of radiology

2022 Volume 149, Page(s) 110225

Abstract: Introduction: MRI improves the selection of patients with colorectal cancer (CRC) and peritoneal metastases (PM) for cytoreductive surgery by accurately assessing the extent of PM reflected as the peritoneal cancer index (PCI). The performance of MRI ... ...

Abstract	Introduction: MRI improves the selection of patients with colorectal cancer (CRC) and peritoneal metastases (PM) for cytoreductive surgery by accurately assessing the extent of PM reflected as the peritoneal cancer index (PCI). The performance of MRI after neoadjuvant chemotherapy (NACT) for staging PM, however is unknown. The purpose of this study was to determine whether MRI could also accurately determine the PCI after NACT. Materials and methods: This was a single-centre, retrospective study of patients with PM from CRC or appendiceal origin who received NACT followed by diffusion-weighted (DW)-MRI and surgery from January 2016 to February 2021. Two radiologists assessed the PCI on restaging DW-MRI (mriPCI). The reference standard was the surgical PCI (sPCI). The main outcome was the diagnostic performance of restaging DW-MRI in predicting whether patients were eligible for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), defined as a PCI < 21 with metastases on resectable locations. If CRS-HIPEC was performed, the resected peritoneal lesions were assessed and correlated with the final pathological PCI (pPCI). Results: Thirty-three patients were included. Both readers correctly detected all 23 patients with resectable disease. Eight out of ten patients with unresectable disease during staging surgery were detected by both readers with MRI. The intraclass correlation (ICC) between both readers was excellent (0⋅87 (95% CI: 0⋅75 to 0⋅93)). The ICC between pPCI and mriPCI was 0⋅74 (0⋅49-0⋅88) and 0⋅82 (0⋅66-0⋅91) for the 2 readers. Surgical PCI (sPCI) had a similar correlation as mriPCI with pPCI 0⋅82 (0⋅62- 0⋅92)) and 0⋅81 (0⋅57-0⋅92)). Conclusion: DW-MRI is a promising tool to reassess the peritoneal cancer index after neoadjuvant chemotherapy.
MeSH term(s)	Colorectal Neoplasms/pathology ; Combined Modality Therapy ; Cytoreduction Surgical Procedures ; Diffusion Magnetic Resonance Imaging ; Humans ; Hyperthermia, Induced ; Magnetic Resonance Imaging ; Neoadjuvant Therapy ; Peritoneal Neoplasms/diagnostic imaging ; Peritoneal Neoplasms/drug therapy ; Retrospective Studies ; Survival Rate
Language	English
Publishing date	2022-02-19
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2022.110225
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Article ; Online: Perioperative Systemic Therapy Versus Cytoreductive Surgery and HIPEC Alone for Resectable Colorectal Peritoneal Metastases: Patient-Reported Outcomes of a Randomized Phase II Trial.

Bakkers, C / Rovers, K P / Rijken, A / Simkens, G A A M / Bonhof, C S / Nienhuijs, S W / Burger, J W A / Creemers, G J M / Brandt-Kerkhof, A R M / Tuynman, J B / Aalbers, A G J / Wiezer, M J / de Reuver, P R / van Grevenstein, W M U / Hemmer, P H J / Punt, C J A / Tanis, P J / Mols, F / de Hingh, I H J T

Annals of surgical oncology

2023 Volume 30, Issue 5, Page(s) 2678–2688

Abstract: Background: As part of a randomized phase II trial in patients with isolated resectable colorectal peritoneal metastases (CPMs), the present study compared patient-reported outcomes (PROs) of patients treated with perioperative systemic therapy versus ... ...

Abstract	Background: As part of a randomized phase II trial in patients with isolated resectable colorectal peritoneal metastases (CPMs), the present study compared patient-reported outcomes (PROs) of patients treated with perioperative systemic therapy versus cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) alone. Also, PROs of patients receiving perioperative systemic therapy were explored. Patients and methods: Eligible patients were randomized to perioperative systemic therapy (experimental) or CRS-HIPEC alone (control). PROs were assessed using EORTC QLQ-C30, QLQ-CR29, and EQ-5D-5L questionnaires at baseline, after neoadjuvant treatment (experimental), and at 3 and 6 months postoperatively. Linear mixed modeling was used to compare five predefined PROs (visual analog scale, global health status, physical functioning, fatigue, C30 summary score) between arms and to longitudinally analyze PROs in the experimental arm. Results: Of 79 analyzed patients, 37 (47%) received perioperative systemic therapy. All predefined PROs were comparable between arms at all timepoints and returned to baseline at 3 or 6 months postoperatively. The experimental arm had worsening of fatigue [mean difference (MD) + 14, p = 0.001], loss of appetite (MD + 15, p = 0.003), hair loss (MD + 18, p < 0.001), and loss of taste (MD + 27, p < 0.001) after neoadjuvant treatment. Except for loss of appetite, these PROs returned to baseline at 3 or 6 months postoperatively. Conclusions: In patients with resectable CPM randomized to perioperative systemic therapy or CRS-HIPEC alone, PROs were comparable between arms and returned to baseline postoperatively. Together with the trial's previously reported feasibility and safety data, these findings show acceptable tolerability of perioperative systemic therapy in this setting.
MeSH term(s)	Humans ; Hyperthermic Intraperitoneal Chemotherapy ; Peritoneal Neoplasms/secondary ; Colorectal Neoplasms/pathology ; Cytoreduction Surgical Procedures ; Hyperthermia, Induced ; Combined Modality Therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Patient Reported Outcome Measures ; Survival Rate
Language	English
Publishing date	2023-02-08
Publishing country	United States
Document type	Randomized Controlled Trial ; Clinical Trial, Phase II ; Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-023-13116-z
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