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  1. Article ; Online: Abnormal Fundus Autofluorescence in Eyes with Morquio Syndrome.

    Hirono, Kazushi / Maruyama-Inoue, Maiko / Kadonosono, Kazuaki

    Ophthalmology. Retina

    2022  Volume 6, Issue 11, Page(s) 1097

    MeSH term(s) Humans ; Mucopolysaccharidosis IV ; Fundus Oculi ; Fluorescein Angiography ; Optical Imaging
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Journal Article
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2022.08.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Visual outcomes of intraocular inflammation after brolucizumab injection in Japanese patients with neovascular age-related macular degeneration.

    Hirono, Kazushi / Maruyama-Inoue, Maiko / Yanagi, Yasuo / Kadonosono, Kazuaki

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0302295

    Abstract: Purpose: This study investigates the visual outcomes of neovascular age-related macular degeneration (nAMD) patients who developed intraocular inflammation (IOI) after intravitreal brolucizumab injection (IVBr).: Methods: We studied 285 eyes of 279 ... ...

    Abstract Purpose: This study investigates the visual outcomes of neovascular age-related macular degeneration (nAMD) patients who developed intraocular inflammation (IOI) after intravitreal brolucizumab injection (IVBr).
    Methods: We studied 285 eyes of 279 cases diagnosed with nAMD and focused on 18 eyes (6.3%) of 17 cases which developed IOI after IVBr. IVBr was performed either on the initial treatment or for switching of other anti-vascular endothelial growth factor agents during January 2020 to December 2021. We evaluated clinical features and the course of treatment of a 6-month follow-up after IOI occurred.
    Results: Of 17 cases, 9 cases were male, 8 cases were female. Baseline logarithm of the minimum angle of resolution(logMAR) best-corrected visual acuity (BCVA) was 0.36, BCVA before IOI occurred was 0.30, and BCVA when IOI occurred was 0.43. 16 eyes (88.9%) had symptoms such as visual loss or floaters when IOI occurred. On the other hand, the remaining 2 eyes (11.1%) had no symptoms. 11 eyes (61.1%) had only IOI, while the remaining 7 eyes (38.9%) had IOI and perivascular sheathing. Steroid sub-tenon injection was performed on 1 eye (5.6%), steroid eye drops were used in 11 eyes (61.1%), and 6 eyes (33.3%) were followed-up without treatment. Neovascular AMD recurred in 16 eyes (88.9%) after IOI occurred and were treated with aflibercept. VA at 3 and 6 months after IOI occurred were significantly improved to 0.34 and 0.30, respectively (P = 0.09 at 3 months and P = 0.02 at 6 months). The symptoms of patients were improved in all cases. We were able to stop steroid treatment in all cases.
    Conclusions: IOI occurred in 6.3% of nAMD patients after IVBr treatment. All of which showed significant improvement from logMAR of 0.43 to 0.30 with steroid treatment or without any treatment. We should consider the possibility of IOI after IVBr as a complication, however, they have a relatively good prognosis if treated at an early stage.
    MeSH term(s) Humans ; Female ; Male ; Angiogenesis Inhibitors/adverse effects ; Japan ; Vascular Endothelial Growth Factor A ; Visual Acuity ; Wet Macular Degeneration/drug therapy ; Uveitis ; Inflammation/drug therapy ; Intravitreal Injections ; Steroids ; Receptors, Vascular Endothelial Growth Factor ; Antibodies, Monoclonal, Humanized
    Chemical Substances brolucizumab (XSZ53G39H5) ; Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A ; Steroids ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0302295
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  3. Article ; Online: Ocular clonus.

    Yoshidome, Ai / Yamasato, Kazushi / Harada, Taku / Ozawa, Hidehiro / Inoue, Tetsuya / Nakai, Mori

    Journal of the American College of Emergency Physicians open

    2023  Volume 4, Issue 5, Page(s) e13055

    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article
    ISSN 2688-1152
    ISSN (online) 2688-1152
    DOI 10.1002/emp2.13055
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  4. Article ; Online: Aberrant Expression of p14

    Inoue, Kazushi / Fry, Elizabeth A

    Tumor & microenvironment

    2019  Volume 1, Issue 2, Page(s) 37–44

    Abstract: ... ...

    Abstract The
    Language English
    Publishing date 2019-02-04
    Publishing country India
    Document type Journal Article
    ISSN 2395-7182
    ISSN (online) 2395-7182
    DOI 10.4103/tme.tme_24_17
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  5. Article: Aberrant expression of p16

    Inoue, Kazushi / Fry, Elizabeth A

    Cancer reports and reviews

    2018  Volume 2, Issue 2

    Abstract: ... ...

    Abstract The
    Language English
    Publishing date 2018-01-15
    Publishing country England
    Document type Journal Article
    ISSN 2513-9290
    ISSN 2513-9290
    DOI 10.15761/CRR.1000145
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  6. Article ; Online: Partial Trisomy 9p with Clinical Symptoms Resembling Interferonopathies.

    Inoue, Yuzaburo / Yamamoto, Takeshi / Honda, Yoshitaka / Izawa, Kazushi / Yasumi, Takahiro

    Journal of clinical immunology

    2021  Volume 42, Issue 1, Page(s) 203–205

    MeSH term(s) Chromosomes, Human, Pair 9/genetics ; Humans ; Karyotyping ; Trisomy/diagnosis ; Trisomy/genetics
    Language English
    Publishing date 2021-10-18
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-021-01153-w
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    Zs.A 1640: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY IN DETERMINATION OF ENTRY SITE FOR VITRECTOMY IN HIGHLY MYOPIC EYES.

    Hirono, Kazushi / Inoue, Maiko / Tanaka, Shin / Uchio, Eiichi / Yanagi, Yasuo / Kadonosono, Kazuaki

    Retina (Philadelphia, Pa.)

    2023  Volume 43, Issue 5, Page(s) 733–738

    Abstract: Purpose: To evaluate the efficacy of anterior segment optical coherent tomography (AS OCT) in estimating the length of the pars plana and optimizing the sclerotomy entry site in vitrectomy for highly myopic eyes, facilitating membrane peeling.: ... ...

    Abstract Purpose: To evaluate the efficacy of anterior segment optical coherent tomography (AS OCT) in estimating the length of the pars plana and optimizing the sclerotomy entry site in vitrectomy for highly myopic eyes, facilitating membrane peeling.
    Methods: Twenty-three eyes with myopic traction maculopathy were studied. The pars plana was examined using two methods: preoperative AS OCT and intraoperative measurement. The distance from the limbus to the ora serrata in two groups was measured to compare differences in length. The actual length of the entry site from the limbus and forceps used were noted in all eyes studied.
    Results: The mean axial length was 29.2 ± 2.3 mm for all 23 eyes. The average length between the limbus and ora serrata measured with AS OCT and intraoperative examination was 6,710 µ m (SD ± 459) and 6,671 µ m (SD ± 402), respectively, in the superotemporal region ( P > 0.05), and 6,340 µ m (SD ± 321) and 6,204 µ m (SD ± 402), respectively, in the superonasal region ( P >0.05). The mean length of the entry site from the limbus was 6.2 mm, and 28-mm forceps were used in 17 of 23 eyes (77%).
    Conclusion: The length of the pars plana varies depending on the axial length of the eye. Preoperative AS OCT enables accurate measurement of the pars plana in eyes with high myopia. AS OCT examination can help determine the optimal site for sclerotomy, allowing easier access to the macular region for membrane peeling in highly myopic eyes.
    MeSH term(s) Humans ; Vitrectomy/methods ; Tomography, Optical Coherence/methods ; Myopia, Degenerative/complications ; Myopia, Degenerative/diagnosis ; Myopia, Degenerative/surgery ; Retinoschisis/diagnosis ; Retrospective Studies ; Visual Acuity ; Basement Membrane/surgery
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000003736
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    Zs.A 1724: Show issues Location:
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  8. Article ; Online: Effects of a co-stimulation with S-PRG filler eluate and muramyl dipeptide (MDP) on matrix metalloproteinase-1 production by human dental pulp fibroblast-like cells.

    Moroto, Hidetoshi / Inoue, Hiroshi / Morikawa, Yuto / Tanimoto, Hiroaki / Yoshikawa, Kazushi / Goda, Seiji / Yamamoto, Kazuyo

    Dental materials journal

    2023  Volume 42, Issue 3, Page(s) 375–382

    Abstract: The present study investigated the effects of a co-stimulation with surface reaction-type pre-reacted glass-ionomer (S-PRG) filler eluate and muramyl dipeptide (MDP) on matrix metalloproteinase (MMP)-1 production by human dental pulp fibroblast-like ... ...

    Abstract The present study investigated the effects of a co-stimulation with surface reaction-type pre-reacted glass-ionomer (S-PRG) filler eluate and muramyl dipeptide (MDP) on matrix metalloproteinase (MMP)-1 production by human dental pulp fibroblast-like cells (hDPFs). S-PRG filler eluate contains 6 ions (F, Na, Al, B, Sr, and Si) released from S-PRG filler. Each S-PRG filler eluate and MDP stimulation enhanced MMP-1 production by hDPFs. The co-stimulation with S-PRG filler eluate and MDP enhanced MMP-1 production more than the MDP stimulation alone. A similar stimulation induced the phosphorylation of ERK 1/2. The increased secretion of MMP-1 and enhanced phosphorylation of ERK 1/2 by the co-stimulation with S-PRG filler eluate and MDP were suppressed by the selective and potent CaSR antagonist NPS 2143. Since strontium binds to CaSR, these results suggest that the enhanced production of MMP-1 by the co-stimulation with S-PRG filler eluate and MDP was due to the effects of strontium.
    MeSH term(s) Humans ; Matrix Metalloproteinase 1 ; Acetylmuramyl-Alanyl-Isoglutamine/pharmacology ; Dental Pulp ; Strontium ; Glass Ionomer Cements/pharmacology
    Chemical Substances Matrix Metalloproteinase 1 (EC 3.4.24.7) ; Acetylmuramyl-Alanyl-Isoglutamine (53678-77-6) ; Strontium (YZS2RPE8LE) ; Glass Ionomer Cements
    Language English
    Publishing date 2023-02-10
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 605650-7
    ISSN 1881-1361 ; 0287-4547
    ISSN (online) 1881-1361
    ISSN 0287-4547
    DOI 10.4012/dmj.2022-201
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    Zs.B 2687: Show issues Location:
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  9. Article ; Online: Tumor suppression by the EGR1, DMP1, ARF, p53, and PTEN Network.

    Inoue, Kazushi / Fry, Elizabeth A

    Cancer investigation

    2018  Volume 36, Issue 9-10, Page(s) 520–536

    Abstract: Recent studies have indicated that EGR1 is a direct regulator of tumor suppressors including TGFβ1, PTEN, and p53. The Myb-like transcription factor Dmp1 is a physiological regulator of the Arf-p53 pathway through transactivation of ... ...

    Abstract Recent studies have indicated that EGR1 is a direct regulator of tumor suppressors including TGFβ1, PTEN, and p53. The Myb-like transcription factor Dmp1 is a physiological regulator of the Arf-p53 pathway through transactivation of the
    Language English
    Publishing date 2018-11-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 604942-4
    ISSN 1532-4192 ; 0735-7907
    ISSN (online) 1532-4192
    ISSN 0735-7907
    DOI 10.1080/07357907.2018.1533965
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    Zs.A 1862: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: c-MYB and DMTF1 in Cancer.

    Fry, Elizabeth A / Inoue, Kazushi

    Cancer investigation

    2019  Volume 37, Issue 1, Page(s) 46–65

    Abstract: The c-Myb gene encodes a transcription factor that regulates cell proliferation, differentiation, and apoptosis through protein-protein interaction and transcriptional regulation of signaling pathways. The protein is frequently overexpressed in human ... ...

    Abstract The c-Myb gene encodes a transcription factor that regulates cell proliferation, differentiation, and apoptosis through protein-protein interaction and transcriptional regulation of signaling pathways. The protein is frequently overexpressed in human leukemias, breast cancers, and other solid tumors suggesting that it is a bona fide oncogene. c-MYB is often overexpressed by translocation in human tumors with t(6;7)(q23;q34) resulting in c-MYB-TCRβ in T cell ALL, t(X;6)(p11;q23) with c-MYB-GATA1 in acute basophilic leukemia, and t(6;9)(q22-23;p23-24) with c-MYB-NF1B in adenoid cystic carcinoma. Antisense oligonucleotides to c-MYB were developed to purge bone marrow cells to eliminate tumor cells in leukemias. Recently, small molecules that inhibit c-MYB activity have been developed to disrupt its interaction with p300. The Dmp1 (cyclin D binding myb-like protein 1; Dmtf1) gene was isolated through its virtue for binding to cyclin D2. It is a transcription factor that has a Myb-like repeat for DNA binding. The Dmtf1 protein directly binds to the Arf promoter for transactivation and physically interacts with p53 to activate the p53 pathway. The gene is hemizygously deleted in 35-42% of human cancers and is associated with longer survival. The significances of aberrant expression of c-MYB and DMTF1 proteins in human cancers and their clinical significances are discussed.
    MeSH term(s) ADP-Ribosylation Factors/genetics ; Gene Expression Regulation, Neoplastic ; Hemizygote ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Oligonucleotides, Antisense/pharmacology ; Oligonucleotides, Antisense/therapeutic use ; Promoter Regions, Genetic ; Proto-Oncogene Proteins c-myb/genetics ; Proto-Oncogene Proteins c-myb/metabolism ; Small Molecule Libraries/pharmacology ; Small Molecule Libraries/therapeutic use ; Survival Analysis ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Translocation, Genetic ; Up-Regulation
    Chemical Substances DMTF1 protein, human ; MYB protein, human ; Oligonucleotides, Antisense ; Proto-Oncogene Proteins c-myb ; Small Molecule Libraries ; Transcription Factors ; ADP-Ribosylation Factors (EC 3.6.5.2)
    Language English
    Publishing date 2019-01-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 604942-4
    ISSN 1532-4192 ; 0735-7907
    ISSN (online) 1532-4192
    ISSN 0735-7907
    DOI 10.1080/07357907.2018.1550090
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