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Article: Serum total bilirubin, an indicator for the impact of hemoglobin catabolism on outcome of patients with the acute respiratory distress syndrome.

Graw, Jan A

2022 Volume 11, Issue 2, Page(s) 31

Language	English
Publishing date	2022-12-26
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-22-6024
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Article ; Online: Stress shielding effect after total hip arthroplasty varies between combinations of stem design and stiffness-a comparing biomechanical finite element analysis.

Burchard, Rene / Graw, Jan A / Soost, Christian / Schmitt, Jan

International orthopaedics

2023 Volume 47, Issue 8, Page(s) 1981–1987

Abstract: Purpose: Total hip arthroplasty (THA) has become a highly frequent orthopaedic procedure. Multiple approaches have been made to design the femoral component for THA with a mechanical behaviour as close as possible to a natural femur. The aim of this ... ...

Abstract	Purpose: Total hip arthroplasty (THA) has become a highly frequent orthopaedic procedure. Multiple approaches have been made to design the femoral component for THA with a mechanical behaviour as close as possible to a natural femur. The aim of this study was to compare different combinations of design and biomechanical properties of THA prostheses and their impact on stress shielding of the periprosthetic bone. Methods: Virtual implantation of different stem designs (straight standard stem, straight short stem, anatomical short stem) by finite element analysis based on in vivo data from computer tomography was performed. For each stem, three grades of stiffness were generated, followed by a strain analysis. Results: Reduction of stem stiffness led to less stress shielding. Implantation of an anatomical short-stem prosthesis with low stiffness provided the most physiological strain-loading effect (p < 0.001). Conclusion: A combination of a short and an anatomically designed stem with a low stiffness might provide a more physiological strain transfer during THA. Biomechanical properties of the femoral component for THA should be considered as a multifactorial function of dimensions, design, and stiffness.
MeSH term(s)	Humans ; Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Hip/methods ; Finite Element Analysis ; Prosthesis Design ; Hip Prosthesis/adverse effects ; Femur/surgery ; Stress, Mechanical ; Biomechanical Phenomena
Language	English
Publishing date	2023-06-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80384-4
ISSN	1432-5195 ; 0341-2695
ISSN (online)	1432-5195
ISSN	0341-2695
DOI	10.1007/s00264-023-05825-7
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Zs.A 1324: Show issues

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Article: Completion Rates of Advance Directives in a Trauma Emergency Room: Association with Age.

Graw, Jan A / Burchard, René

Emergency medicine international

2021 Volume 2021, Page(s) 5537599

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2021-04-20
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2596429-X
ISSN	2090-2859 ; 2090-2840
ISSN (online)	2090-2859
ISSN	2090-2840
DOI	10.1155/2021/5537599
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Article ; Online: Large Animal Models for Simulating Physiology of Transfusion of Red Cell Concentrates-A Scoping Review of The Literature.

Berndt, Melanie / Buttenberg, Maximilian / Graw, Jan A

Medicina (Kaunas, Lithuania)

2022 Volume 58, Issue 12

Abstract: Background and ... ...

Abstract	Background and Objectives
Language	English
Publishing date	2022-11-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina58121735
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Zs.A 6270: Show issues

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Article ; Online: Atraumatische Instabilität des vorderen Kreuzbandes durch eine intraligamentäre Zyste.

Burchard, René / Graw, Jan A

Sportverletzung Sportschaden : Organ der Gesellschaft fur Orthopadisch-Traumatologische Sportmedizin

2020 Volume 35, Issue 2, Page(s) 115–118

Abstract: A 28-year-old man reported that he has a feeling of "giving away" in his knee while playing soccer. He has had no previous injury. At a physical examination, the results of Lachman's test and the pivot shift test were pathological. Magnetic resonance ... ...

Title translation	Atraumatic instability of the anterior cruciate ligament caused by an intraligamentous cyst.
Abstract	A 28-year-old man reported that he has a feeling of "giving away" in his knee while playing soccer. He has had no previous injury. At a physical examination, the results of Lachman's test and the pivot shift test were pathological. Magnetic resonance imaging revealed an intraligamentous cyst of the anterior cruciate ligament (ACL). During arthroscopy it became evident that the cyst had destroyed the ACL. After ACL reconstruction, physiological stability of the knee joint was achieved. Joint cysts are rare and frequently cause pain and a limited range of motion. An association between intraligamentous cysts and instabilities of the affected joint has not been described so far. Preventive resection of asymptomatic and incidentally found intraligamentous cysts should be discussed.
MeSH term(s)	Adult ; Anterior Cruciate Ligament/diagnostic imaging ; Anterior Cruciate Ligament/surgery ; Anterior Cruciate Ligament Injuries/diagnosis ; Anterior Cruciate Ligament Injuries/surgery ; Anterior Cruciate Ligament Reconstruction ; Cysts ; Humans ; Joint Instability/diagnosis ; Joint Instability/etiology ; Joint Instability/surgery ; Knee Joint ; Male ; Range of Motion, Articular
Language	German
Publishing date	2020-08-20
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	639120-5
ISSN	1439-1236 ; 0932-0555
ISSN (online)	1439-1236
ISSN	0932-0555
DOI	10.1055/a-1222-3235
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Zs.A 2244: Show issues

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Article: Rate of Complications after Hip Fractures Caused by Prolonged Time-to-Surgery Depends on the Patient's Individual Type of Fracture and Its Treatment.

Daginnus, Alina / Schmitt, Jan / Graw, Jan Adriaan / Soost, Christian / Burchard, Rene

Journal of personalized medicine

2023 Volume 13, Issue 10

Abstract: Introduction: Hip fractures are common injuries in the elderly and are usually treated with timely surgery. While severe postoperative complications are reported for up to 10% of patients, many studies identified predictive factors for the occurrence of ...

Abstract	Introduction: Hip fractures are common injuries in the elderly and are usually treated with timely surgery. While severe postoperative complications are reported for up to 10% of patients, many studies identified predictive factors for the occurrence of complications postoperatively. A controversially discussed factor is "time-to-surgery". The aim of the study was to examine if time-to-surgery was associated with the occurrence of complications and if the complication rate differed between the patient individual fracture types of intracapsular on the one hand and extracapsular hip fractures on the other hand. We hypothesized that time-to-surgery had less impact on complications in intracapsular hip fractures compared to extracapsular ones, and therefore, guidelines should pay attention to the patient individual case scenario. Materials and methods: All patients who were admitted to the Department of Trauma and Orthopaedic Surgery of an academic teaching hospital for hip fracture surgery ( Results: Patients with an extracapsular fracture, which was treated with intramedullary nailing (44.5%), rarely suffered a serious complication when surgery was performed within 24 h after injury. However, when the interval of the time-to-surgery was longer than 24 h, the complication rate increased significantly (8.63% vs. 25.0%, Conclusions: The occurrence of complications after surgical treatment of hip fractures is associated with the time interval between injury and surgery. A 24 h time interval between injury and surgical procedure seems to play a major role only in extracapsular fractures treated with osteosynthesis but not in intracapsular fractures treated with arthroplasty. Therefore, guidelines should take notice of the patient individual case scenario and, in particular, the individual hip fracture type.
Language	English
Publishing date	2023-10-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13101470
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Article ; Online: Biomechanical comparison of different implants for PIP arthrodesis.

Döhner, Claudia / Beyerle, Hanna / Graw, Jan A / Soost, Christian / Burchard, Rene

Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons

2023 Volume 29, Issue 7, Page(s) 518–524

Abstract: Background: Surgical correction of hammertoe deformities with arthrodesis of the proximal interphalangeal joint (PIP) is one of the most frequent forefoot procedures. Recently, new intramedullary fixation devices for PIP arthrodesis have been introduced. ...

Abstract	Background: Surgical correction of hammertoe deformities with arthrodesis of the proximal interphalangeal joint (PIP) is one of the most frequent forefoot procedures. Recently, new intramedullary fixation devices for PIP arthrodesis have been introduced. The aim of this study was to compare a newly developed absorbable intramedullary implant made of magnesium (mm.PIP), an already available intramedullary implant made of titanium (PipTree), and the classical Kirschner-wire (K-wire). Methods: The three intramedullary devices (mm.PIP, PipTree, and K-wire) for PIP arthrodesis were compared. A classical arthrodesis of the PIP joint was performed on fifty-four composite synthetic bone pairs. After arthrodesis, torsional load, weight-bearing and cyclic load tests were performed, and stability of the synthetic bone pairs was analyzed. Results: The mm.PIP was the most torsion resistant (mm.PIP vs. PipTree and K-wire, p < 0.001). The PipTree showed the best overall stability during cyclic weight-bearing simulation (PipTree vs. mm.PIP and K-wire, p < 0.001). K-wire demonstrated the highest breaking loads during bending tests (K-wire vs. mm-PIP and PipTree, p < 0.001). Conclusion: Biomechanical properties of two new intramedullar implants, the bioresorbable mm.PIP made of magnesium and the PipTree made of titanium, were found to be comparable to the biomechanical properties of a K-wire which is commonly used for this procedure. Future work should be directed towards a clinical assessment of the bioabsorbable fixation devices for hammertoe procedures.
MeSH term(s)	Humans ; Magnesium ; Titanium ; Arthrodesis/methods ; Bone Wires ; Hammer Toe Syndrome/surgery ; Absorbable Implants
Chemical Substances	Magnesium (I38ZP9992A) ; Titanium (D1JT611TNE)
Language	English
Publishing date	2023-02-23
Publishing country	France
Document type	Journal Article
ZDB-ID	1424533-4
ISSN	1460-9584 ; 1268-7731
ISSN (online)	1460-9584
ISSN	1268-7731
DOI	10.1016/j.fas.2023.02.008
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Zs.A 4246: Show issues

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Article ; Online: Standardized High-Quality Processes for End-of-Life-Decision Making in the Intensive Care Unit Remain Robust during an Unprecedented New Pandemic-A Single-Center Experience.

Marsch, Fanny / Spies, Claudia D / Francis, Roland C E / Graw, Jan A

International journal of environmental research and public health

2022 Volume 19, Issue 22

Abstract: Due to the global COVID-19 pandemic, a concomitant increase in awareness for end-of-life decisions (EOLDs) and advance care planning has been noted. Whether the dynamic pandemic situation impacted EOLD-processes on the intensive care unit (ICU) and ... ...

Abstract	Due to the global COVID-19 pandemic, a concomitant increase in awareness for end-of-life decisions (EOLDs) and advance care planning has been noted. Whether the dynamic pandemic situation impacted EOLD-processes on the intensive care unit (ICU) and patient-sided advance care planning in Germany is unknown. This is a retrospective analysis of all deceased patients of surgical ICUs of a university medical center from March 2020 to July 2021. All included ICUs had established standardized protocols and documentation for EOLD-related aspects of ICU therapy. The frequency of EOLDs and advance directives and the process of EOLDs were analyzed (No. of ethical approval EA2/308/20). A total number of 319 (85.5%) of all deceased patients received an EOLD. Advance directives were possessed by 83 (22.3%) of the patients and a precautionary power of attorney by 92 (24.7%) of the patients. There was no difference in the frequency of EOLDs and patient-sided advance care planning between patients with COVID-19 and non-COVID-19 patients. In addition, no differences in frequencies of do-not-resuscitate orders, withholding or withdrawing of intensive care medicine therapeutic approaches, timing of EOLDs, and participation of senior ICU attendings in EOLDs were noted between patients with COVID-19 and non-COVID-19 patients. Documentation of family conferences occurred more often in deceased patients with COVID-19 compared to non-COVID-19 patients (COVID-19: 80.0% vs. non-COVID-19: 56.8,
MeSH term(s)	Humans ; Pandemics ; Terminal Care ; Retrospective Studies ; Decision Making ; COVID-19/epidemiology ; Intensive Care Units
Language	English
Publishing date	2022-11-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192215015
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Article ; Online: Intraventricular Tension Pneumocephalus After Subarachnoid Hemorrhage and Removal of an External Ventricular Drain.

Samman, Majd A / Wolf, Stefan / Graw, Jan A

World neurosurgery

2020 Volume 146, Page(s) 78–79

Abstract: Pneumocephalus is defined as an accumulation of air or gas in the intracranial space. It is a common complication after skull surgery or craniofacial trauma, sometimes also caused by gas-producing organisms in the context of an infection, and reported ... ...

Abstract	Pneumocephalus is defined as an accumulation of air or gas in the intracranial space. It is a common complication after skull surgery or craniofacial trauma, sometimes also caused by gas-producing organisms in the context of an infection, and reported with cerebrospinal fluid draining procedures. Here we report a case of a large intraventricular tension pneumocephalus after removal of an external ventricular drain in a patient with subarachnoid hemorrhage. The acute management included therapy with normobaric oxygen. Despite the large volume of trapped air and its diffuse distribution inside the skull and spine, therapy with 100% normobaric oxygen appears to be safe and efficient for a rapid improvement of the patient's symptoms and the neuroradiological imaging.
MeSH term(s)	Adult ; Drainage/adverse effects ; Female ; Humans ; Oxygen Inhalation Therapy ; Pneumocephalus/etiology ; Pneumocephalus/therapy ; Postoperative Complications/etiology ; Postoperative Complications/therapy ; Subarachnoid Hemorrhage/surgery
Language	English
Publishing date	2020-11-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2020.10.157
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Zs.A 1159: Show issues

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Article ; Online: Hemolysis in patients with Extracorporeal Membrane Oxygenation therapy for severe Acute Respiratory Distress Syndrome - a systematic review of the literature.

Materne, Lorenz A / Hunsicker, Oliver / Menk, Mario / Graw, Jan A

International journal of medical sciences

2021 Volume 18, Issue 8, Page(s) 1730–1738

Abstract: The Acute Respiratory Distress Syndrome (ARDS) is common in patients on the Intensive Care Unit and associated with significant mortality rates. In situations of severe respiratory insufficiency and failure of all possible conservative therapeutic ... ...

Abstract	The Acute Respiratory Distress Syndrome (ARDS) is common in patients on the Intensive Care Unit and associated with significant mortality rates. In situations of severe respiratory insufficiency and failure of all possible conservative therapeutic approaches, veno-venous extracorporeal membrane oxygenation (VV ECMO) is used as a final option for temporary replacement of pulmonary function. ARDS as well as sepsis and VV ECMO treatment are all associated with intravascular hemolysis. The extent and relevance of intravascular hemolysis in the context of ARDS therapy is unclear. This systematic review aims to summarize the current evidence on the incidence and associated complications of intravascular hemolysis in adult patients with ARDS and treatment with VV ECMO. The databases MEDLINE, EMBASE and Web of Science were systematically searched and 19 publications fulfilled inclusion criteria. The incidence of hemolysis in patients with ARDS and treatment with VV ECMO ranged from 0 to 41% with survivors showing lower incidences and less severe hemolysis. A pump head thrombosis and high blood flows (≥3 l/min) as well as use of dual-lumen cannulas but not different pump models were associated with increased hemolysis. In conclusion, intravascular hemolysis in patients with ARDS and treatment with VV ECMO is a common and relevant complication that appears associated with increased mortality. Apart from ECMO hardware-settings, no additional possible causes for increased red cell breakdown such as disease severity, duration of ECMO therapy, or number and quality of red blood cell transfusions were investigated. Further research is needed to determine the origin and relevance of intravascular hemolysis in patients with ARDS and treatment with VV ECMO.
MeSH term(s)	Extracorporeal Membrane Oxygenation/adverse effects ; Hemolysis ; Humans ; Incidence ; Respiratory Distress Syndrome/blood ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/mortality ; Respiratory Distress Syndrome/therapy ; Severity of Illness Index
Language	English
Publishing date	2021-02-18
Publishing country	Australia
Document type	Journal Article ; Systematic Review
ZDB-ID	2151424-0
ISSN	1449-1907 ; 1449-1907
ISSN (online)	1449-1907
ISSN	1449-1907
DOI	10.7150/ijms.50217
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