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  1. Article: Clinical practice guidelines for well-being among security personnel.

    Madhusudan, T / Sharma, Neha / Sarkar, Siddharth / Grover, Sandeep

    Indian journal of psychiatry

    2024  Volume 66, Issue Suppl 2, Page(s) S365–S371

    Language English
    Publishing date 2024-01-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 221523-8
    ISSN 0019-5545
    ISSN 0019-5545
    DOI 10.4103/indianjpsychiatry.indianjpsychiatry_917_23
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  2. Article ; Online: Editorial: Faecal microbiota transplantation in IBS-Moving closer or away from success?

    Lesmana, Elvira / Grover, Madhusudan

    Alimentary pharmacology & therapeutics

    2023  Volume 58, Issue 9, Page(s) 950–951

    MeSH term(s) Humans ; Fecal Microbiota Transplantation ; Irritable Bowel Syndrome/therapy ; Feces ; Microbiota
    Language English
    Publishing date 2023-10-13
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17724
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  3. Article ; Online: Inclusive Clinical Trials for Disorders of Gut-Brain Interactions.

    Wieland, Mark L / Grover, Madhusudan

    Gastroenterology

    2022  Volume 163, Issue 3, Page(s) 583–585

    MeSH term(s) Brain ; Gastrointestinal Microbiome ; Humans
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2022.06.077
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  4. Article ; Online: Intestinal proteases.

    Rao, Sameer / Grover, Madhusudan

    Current opinion in gastroenterology

    2023  Volume 39, Issue 6, Page(s) 472–478

    Abstract: Purpose of review: Proteases constitute a group of enzymes that hydrolyze peptide bonds. Intestinal proteases are an integral part of gut homeostasis and digestion. This review discusses the broader classification of proteases, regulation of proteolytic ...

    Abstract Purpose of review: Proteases constitute a group of enzymes that hydrolyze peptide bonds. Intestinal proteases are an integral part of gut homeostasis and digestion. This review discusses the broader classification of proteases, regulation of proteolytic activity (PA) in the intestinal tract, and how dysregulation of intestinal proteases contributes to the pathophysiology of conditions such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and celiac disease. We also discuss recent advancements in therapeutic modulation that directly or indirectly target intestinal proteases and can be utilized to treat these illnesses.
    Recent findings: Host and microbiota derived proteases have been associated with symptoms in subsets of patients with IBS, IBD and celiac disease. Elevated PA mediates barrier dysfunction, visceral hypersensitivity as well as immune activation and inflammation. Recent mechanistic studies have revealed the nature of disease-associated proteases and mechanisms regulating their activity, particularly those driven by the microbiota. Advancements in activity-based probes have allowed novel ways of in vivo imaging of PA. Newer strategies targeting proteases include monoclonal antibodies, engineered microbiota as well as specific protease inhibitors.
    Summary: Significant progresses made in the detection as well as regulation of PA is likely to provide therapeutic advancements for gastrointestinal diseases.
    MeSH term(s) Humans ; Irritable Bowel Syndrome ; Peptide Hydrolases ; Celiac Disease/therapy ; Inflammatory Bowel Diseases/therapy ; Inflammation
    Chemical Substances Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632571-3
    ISSN 1531-7056 ; 0267-1379
    ISSN (online) 1531-7056
    ISSN 0267-1379
    DOI 10.1097/MOG.0000000000000972
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  5. Article ; Online: Editorial: repurposed linaclotide and the quest for abdominal pain management in irritable bowel syndrome.

    Maalouf, Elisia / Grover, Madhusudan

    Alimentary pharmacology & therapeutics

    2022  Volume 57, Issue 2, Page(s) 261–262

    MeSH term(s) Humans ; Irritable Bowel Syndrome/complications ; Irritable Bowel Syndrome/drug therapy ; Pain Management ; Constipation ; Peptides ; Abdominal Pain/drug therapy ; Abdominal Pain/etiology
    Chemical Substances linaclotide (N0TXR0XR5X) ; Peptides
    Language English
    Publishing date 2022-12-23
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17304
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  6. Article ; Online: The COVID-19 Pandemic and Post-Infection Irritable Bowel Syndrome: What Lies Ahead for Gastroenterologists.

    Chan, Walter W / Grover, Madhusudan

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2022  Volume 20, Issue 10, Page(s) 2195–2197

    MeSH term(s) COVID-19 ; Gastroenterologists ; Humans ; Irritable Bowel Syndrome/complications ; Irritable Bowel Syndrome/epidemiology ; Pandemics
    Language English
    Publishing date 2022-08-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2022.05.044
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  7. Article ; Online: Gastroparesis and Functional Dyspepsia: Spectrum of Gastroduodenal Neuromuscular Disorders or Unique Entities?

    Sato, Hiroki / Grover, Madhusudan

    Gastro hep advances

    2022  Volume 2, Issue 3, Page(s) 438–448

    Abstract: Gastroparesis is defined by delayed gastric emptying in the absence of mechanical obstruction of the stomach. Patients experience symptoms of nausea, vomiting, abdominal pain, fullness, and early satiety. The recognition of the disorder has progressed ... ...

    Abstract Gastroparesis is defined by delayed gastric emptying in the absence of mechanical obstruction of the stomach. Patients experience symptoms of nausea, vomiting, abdominal pain, fullness, and early satiety. The recognition of the disorder has progressed due to availability of gastric emptying scintigraphy and advancements made in understanding its pathophysiology and treatment options. The clinical presentation and treatment of gastroparesis overlap with a more commonly recognized disorder of gut-brain interaction, functional dyspepsia. Recent studies have reenergized the discussion whether these two are separate entities or perhaps reflect a spectrum of gastroduodenal neuromuscular disorders. The societal guidelines conflict on the utility of gastric emptying scintigraphy in assessment of patients with upper gastrointestinal symptoms. A better appraisal of similarities and differences between gastroparesis and functional dyspepsia will allow targeted treatment for these disorders. This is particularly important as specific pharmacological and endoscopic treatment options are being developed for gastroparesis which are unlikely to be helpful for functional dyspepsia. This review makes the case for considering these disorders in a spectrum where identification of both would most ideally position us toward providing the optimal clinical care.
    Language English
    Publishing date 2022-10-14
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-5723
    ISSN (online) 2772-5723
    DOI 10.1016/j.gastha.2022.10.005
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  8. Article ; Online: Epidemiology of Gastroparesis in the United States.

    Grover, Madhusudan / Parkman, Henry P / Pasricha, Pankaj J

    Gastroenterology

    2021  Volume 162, Issue 7, Page(s) 2136–2137

    MeSH term(s) Gastroparesis/epidemiology ; Hospitalization ; Humans ; United States/epidemiology
    Language English
    Publishing date 2021-10-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.10.030
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  9. Article ; Online: Reply.

    Puthanmadhom Narayanan, Susrutha / Grover, Madhusudan / Bharucha, Adil E

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2021  Volume 20, Issue 10, Page(s) 2413

    Language English
    Publishing date 2021-12-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2021.12.008
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  10. Article ; Online: Sex-Discordant Fecal Microbiota Transplantation for Clostridioides difficile May Increase Risk of Postinfection Irritable Bowel Syndrome.

    Sehgal, Kanika / Yadav, Devvrat / Saha, Srishti / Mara, Kristin / Grover, Madhusudan / Khanna, Sahil

    Gastroenterology

    2023  Volume 166, Issue 4, Page(s) 704–706.e2

    MeSH term(s) Humans ; Fecal Microbiota Transplantation/adverse effects ; Irritable Bowel Syndrome/diagnosis ; Irritable Bowel Syndrome/therapy ; Clostridioides difficile ; Clostridium Infections/diagnosis ; Clostridium Infections/therapy ; Gastrointestinal Microbiome ; Treatment Outcome ; Recurrence
    Language English
    Publishing date 2023-12-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2023.11.295
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