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Article ; Online: Hacia una ética del ecosistema híbrido del espacio físico y el ciberespacio

Ángel Gómez de Ágreda / Claudio Feijóo

Revista Diecisiete, Iss 4, Pp 47-

2021 Volume 58

Abstract: Las tecnologías emergentes relacionadas con el entorno cognitivo posibilitan la creación de un ecosistema híbrido entre el espacio físico y el digital en el que crecientemente se desarrolla la actividad humana. Su construcción ética y su posterior ... ...

Abstract	Las tecnologías emergentes relacionadas con el entorno cognitivo posibilitan la creación de un ecosistema híbrido entre el espacio físico y el digital en el que crecientemente se desarrolla la actividad humana. Su construcción ética y su posterior regulación jurídica han de considerar esta realidad híbrida y el uso dual de las tecnologías que sustentan el mundo digital. La elaboración de ambos códigos -ético y legal- puede extraer conclusiones interesantes de los principios que se están diseñando para los casos más extremos como los sistemas de armas autónomos letales, o la neurociencia o la biotecnología con su capacidad de suplantación de los sentidos o de alteración del sistema cognitivo. De estas experiencias, el artículo concluye que se debe mantener el foco en los valores humanos a preservar en este entorno -en especial, la libertad y la dignidad humanas- y no únicamente en las características tecnológicas del sustrato sobre el que se desarrolla la actividad.
Keywords	inteligencia artificial ; uso dual ; sistemas de armas autónomos ; neurociencia ; biotecnología ; influencia ; ética ; autonomía ; percepción ; Social sciences (General) ; H1-99 ; Environmental protection ; TD169-171.8
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Fundación Acción contra el Hambre
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effect of Dietary Supplements with ω-3 Fatty Acids, Ascorbic Acid, and Polyphenolic Antioxidant Flavonoid on Gene Expression, Organ Failure, and Mortality in Endotoxemia-Induced Septic Rats.

Prado, Yolanda / Echeverría, Cesar / Feijóo, Carmen G / Riedel, Claudia A / Cabello-Verrugio, Claudio / Santibanez, Juan F / Simon, Felipe

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 3

Abstract: Sepsis syndrome develops through enhanced secretion of pro-inflammatory cytokines and the generation of reactive oxygen species (ROS). Sepsis syndrome is characterized by vascular hyperpermeability, hypotension, multiple organ dysfunction syndrome (MODS), ...

Abstract	Sepsis syndrome develops through enhanced secretion of pro-inflammatory cytokines and the generation of reactive oxygen species (ROS). Sepsis syndrome is characterized by vascular hyperpermeability, hypotension, multiple organ dysfunction syndrome (MODS), and increased mortality, among others. Endotoxemia-derived sepsis is an important cause of sepsis syndrome. During endotoxemia, circulating endotoxin interacts with endothelial cells (ECs), inducing detrimental effects on endothelium function. The endotoxin induces the conversion of ECs into fibroblasts, which are characterized by a massive change in the endothelial gene-expression pattern. This downregulates the endothelial markers and upregulates fibrotic proteins, mesenchymal transcription factors, and extracellular matrix proteins, producing endothelial fibrosis. Sepsis progression is modulated by the consumption of specific nutrients, including ω-3 fatty acids, ascorbic acid, and polyphenolic antioxidant flavonoids. However, the underlying mechanism is poorly described. The notion that gene expression is modulated during inflammatory conditions by nutrient consumption has been reported. However, it is not known whether nutrient consumption modulates the fibrotic endothelial gene-expression pattern during sepsis as a mechanism to decrease vascular hyperpermeability, hypotension, MODS, and mortality. Therefore, the aim of this study was to investigate the impact of the consumption of dietary ω-3 fatty acids, ascorbic acid, and polyphenolic antioxidant flavonoid supplements on the modulation of fibrotic endothelial gene-expression patterns during sepsis and to determine the effects on sepsis outcomes. Our results indicate that the consumption of supplements based on ω-3 fatty acids and polyphenolic antioxidant flavonoids was effective for improving endotoxemia outcomes through prophylactic ingestion and therapeutic usage. Thus, our findings indicated that specific nutrient consumption improves sepsis outcomes and should be considered in treatment.
Language	English
Publishing date	2023-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12030659
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of Dietary Supplements with ω-3 Fatty Acids, Ascorbic Acid, and Polyphenolic Antioxidant Flavonoid on Gene Expression, Organ Failure, and Mortality in Endotoxemia-Induced Septic Rats

Prado, Yolanda / Echeverría, Cesar / Feijóo, Carmen G. / Riedel, Claudia A. / Cabello-Verrugio, Claudio / Santibanez, Juan F. / Simon, Felipe

Antioxidants. 2023 Mar. 07, v. 12, no. 3

2023

Abstract	Sepsis syndrome develops through enhanced secretion of pro-inflammatory cytokines and the generation of reactive oxygen species (ROS). Sepsis syndrome is characterized by vascular hyperpermeability, hypotension, multiple organ dysfunction syndrome (MODS), and increased mortality, among others. Endotoxemia-derived sepsis is an important cause of sepsis syndrome. During endotoxemia, circulating endotoxin interacts with endothelial cells (ECs), inducing detrimental effects on endothelium function. The endotoxin induces the conversion of ECs into fibroblasts, which are characterized by a massive change in the endothelial gene-expression pattern. This downregulates the endothelial markers and upregulates fibrotic proteins, mesenchymal transcription factors, and extracellular matrix proteins, producing endothelial fibrosis. Sepsis progression is modulated by the consumption of specific nutrients, including ω-3 fatty acids, ascorbic acid, and polyphenolic antioxidant flavonoids. However, the underlying mechanism is poorly described. The notion that gene expression is modulated during inflammatory conditions by nutrient consumption has been reported. However, it is not known whether nutrient consumption modulates the fibrotic endothelial gene-expression pattern during sepsis as a mechanism to decrease vascular hyperpermeability, hypotension, MODS, and mortality. Therefore, the aim of this study was to investigate the impact of the consumption of dietary ω-3 fatty acids, ascorbic acid, and polyphenolic antioxidant flavonoid supplements on the modulation of fibrotic endothelial gene-expression patterns during sepsis and to determine the effects on sepsis outcomes. Our results indicate that the consumption of supplements based on ω-3 fatty acids and polyphenolic antioxidant flavonoids was effective for improving endotoxemia outcomes through prophylactic ingestion and therapeutic usage. Thus, our findings indicated that specific nutrient consumption improves sepsis outcomes and should be considered in treatment.
Keywords	ascorbic acid ; cytokines ; endothelium ; endotoxemia ; endotoxins ; extracellular matrix ; fibroblasts ; fibrosis ; flavonoids ; gene expression ; hypotension ; ingestion ; mortality ; reactive oxygen species ; secretion ; therapeutics
Language	English
Dates of publication	2023-0307
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12030659
Database	NAL-Catalogue (AGRICOLA)

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Article: Sepsis-Induced Coagulopathy Phenotype Induced by Oxidized High-Density Lipoprotein Associated with Increased Mortality in Septic-Shock Patients.

Prado, Yolanda / Tapia, Pablo / Eltit, Felipe / Reyes-Martínez, Cristian / Feijóo, Carmen G / Llancalahuen, Felipe M / Riedel, Claudia A / Cabello-Verrugio, Claudio / Stehberg, Jimmy / Simon, Felipe

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 3

Abstract: Sepsis syndrome is a highly lethal uncontrolled response to an infection, which is characterized by sepsis-induced coagulopathy (SIC). High-density lipoprotein (HDL) exhibits antithrombotic activity, regulating coagulation in vascular endothelial cells. ... ...

Abstract	Sepsis syndrome is a highly lethal uncontrolled response to an infection, which is characterized by sepsis-induced coagulopathy (SIC). High-density lipoprotein (HDL) exhibits antithrombotic activity, regulating coagulation in vascular endothelial cells. Sepsis induces the release of several proinflammatory molecules, including reactive oxygen species, which lead to an increase in oxidative stress in blood vessels. Thus, circulating lipoproteins, such as HDL, are oxidized to oxHDL, which promotes hemostatic dysfunction, acquiring prothrombotic properties linked to the severity of organ failure in septic-shock patients (SSP). However, a rigorous and comprehensive investigation demonstrating that oxHDL is associated with a coagulopathy-associated deleterious outcome of SSP, has not been reported. Thus, we investigated the participation of plasma oxHDL in coagulopathy-associated sepsis pathogenesis and elucidated the underlying molecular mechanism. A prospective study was conducted on 42 patients admitted to intensive care units, (26 SSP and 16 non-SSP) and 39 healthy volunteers. We found that an increased plasma oxHDL level in SSP was associated with a prothrombotic phenotype, increased mortality and elevated risk of death, which predicts mortality in SSP. The underlying mechanism indicates that oxHDL triggers an endothelial protein expression reprogramming of coagulation factors and procoagulant adhesion proteins, to produce a prothrombotic environment, mainly mediated by the endothelial LOX-1 receptor. Our study demonstrates that an increased plasma oxHDL level is associated with coagulopathy in SSP through a mechanism involving the endothelial LOX-1 receptor and endothelial protein expression regulation. Therefore, the plasma oxHDL level plays a role in the molecular mechanism associated with increased mortality in SSP.
Language	English
Publishing date	2023-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12030543
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sepsis-Induced Coagulopathy Phenotype Induced by Oxidized High-Density Lipoprotein Associated with Increased Mortality in Septic-Shock Patients

Prado, Yolanda / Tapia, Pablo / Eltit, Felipe / Reyes-Martínez, Cristian / Feijóo, Carmen G. / Llancalahuen, Felipe M. / Riedel, Claudia A. / Cabello-Verrugio, Claudio / Stehberg, Jimmy / Simon, Felipe

Antioxidants. 2023 Feb. 21, v. 12, no. 3

2023

Abstract	Sepsis syndrome is a highly lethal uncontrolled response to an infection, which is characterized by sepsis-induced coagulopathy (SIC). High-density lipoprotein (HDL) exhibits antithrombotic activity, regulating coagulation in vascular endothelial cells. Sepsis induces the release of several proinflammatory molecules, including reactive oxygen species, which lead to an increase in oxidative stress in blood vessels. Thus, circulating lipoproteins, such as HDL, are oxidized to oxHDL, which promotes hemostatic dysfunction, acquiring prothrombotic properties linked to the severity of organ failure in septic-shock patients (SSP). However, a rigorous and comprehensive investigation demonstrating that oxHDL is associated with a coagulopathy-associated deleterious outcome of SSP, has not been reported. Thus, we investigated the participation of plasma oxHDL in coagulopathy-associated sepsis pathogenesis and elucidated the underlying molecular mechanism. A prospective study was conducted on 42 patients admitted to intensive care units, (26 SSP and 16 non-SSP) and 39 healthy volunteers. We found that an increased plasma oxHDL level in SSP was associated with a prothrombotic phenotype, increased mortality and elevated risk of death, which predicts mortality in SSP. The underlying mechanism indicates that oxHDL triggers an endothelial protein expression reprogramming of coagulation factors and procoagulant adhesion proteins, to produce a prothrombotic environment, mainly mediated by the endothelial LOX-1 receptor. Our study demonstrates that an increased plasma oxHDL level is associated with coagulopathy in SSP through a mechanism involving the endothelial LOX-1 receptor and endothelial protein expression regulation. Therefore, the plasma oxHDL level plays a role in the molecular mechanism associated with increased mortality in SSP.
Keywords	adhesion ; blood ; coagulation ; death ; high density lipoprotein ; mortality ; oxidation ; oxidative stress ; pathogenesis ; phenotype ; prospective studies ; protein synthesis ; reactive oxygen species ; risk ; septic shock
Language	English
Dates of publication	2023-0221
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12030543
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Correction: Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis.

Jiménez-Dinamarca, Ivanka / Prado, Yolanda / Tapia, Pablo / Gatica, Sebastian / Alt, Clemens / Lin, Charles P / Reyes-Martínez, Cristian / Feijóo, Carmen G / Aravena, Cristobal / González-Canacer, Alejandra / Correa, Simón / Varela, Diego / Cabello-Verrugio, Claudio / Simon, Felipe

Biological research

2023 Volume 56, Issue 1, Page(s) 24

Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Published Erratum
ZDB-ID	1138990-4
ISSN	0717-6287 ; 0716-9760
ISSN (online)	0717-6287
ISSN	0716-9760
DOI	10.1186/s40659-023-00433-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Author Correction: Ontogenetically distinct neutrophils differ in function and transcriptional profile in zebrafish.

García-López, Juan P / Grimaldi, Alexandre / Chen, Zelin / Meneses, Claudio / Bravo-Tello, Karina / Bresciani, Erica / Banderas, Alvaro / Burgess, Shawn M / Hernández, Pedro P / Feijoo, Carmen G

Nature communications

2023 Volume 14, Issue 1, Page(s) 5292

Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Published Erratum
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-41038-7
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Article ; Online: Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis.

Biological research

2023 Volume 56, Issue 1, Page(s) 8

Abstract: Background: Sepsis is an uncontrolled inflammatory response against a systemic infection that results in elevated mortality, mainly induced by bacterial products known as endotoxins, producing endotoxemia. Disseminated intravascular coagulation (DIC) is ...

Abstract	Background: Sepsis is an uncontrolled inflammatory response against a systemic infection that results in elevated mortality, mainly induced by bacterial products known as endotoxins, producing endotoxemia. Disseminated intravascular coagulation (DIC) is frequently observed in septic patients and is associated with organ failure and death. Sepsis activates endothelial cells (ECs), promoting a prothrombotic phenotype contributing to DIC. Ion channel-mediated calcium permeability participates in coagulation. The transient reception potential melastatin 7 (TRPM7) non-selective divalent cation channel that also contains an α-kinase domain, which is permeable to divalent cations including Ca Results: The results showed that TRPM7 regulated endotoxin-induced platelet and neutrophil adhesion to ECs, dependent on the TRPM7 ion channel activity and by the α-kinase function. Endotoxic animals showed that TRPM7 mediated neutrophil rolling on blood vessels and intravascular coagulation. TRPM7 mediated the increased expression of the adhesion proteins, von Willebrand factor (vWF), intercellular adhesion molecule 1 (ICAM-1), and P-selectin, which were also mediated by the TRPM7 α-kinase function. Notably, endotoxin-induced expression of vWF, ICAM-1 and P-selectin were required for endotoxin-induced platelet and neutrophil adhesion to ECs. Endotoxemic rats showed increased endothelial TRPM7 expression associated with a procoagulant phenotype, liver and kidney dysfunction, increased death events and an increased relative risk of death. Interestingly, circulating ECs (CECs) from septic shock patients (SSPs) showed increased TRPM7 expression associated with increased DIC scores and decreased survival times. Additionally, SSPs with a high expression of TRPM7 in CECs showed increased mortality and relative risk of death. Notably, CECs from SSPs showed significant results from the AUROC analyses for predicting mortality in SSPs that were better than the Acute Physiology and Chronic Health Evaluation II (APACHE II) and the Sequential Organ Failure Assessment (SOFA) scores. Conclusions: Our study demonstrates that sepsis-induced DIC is mediated by TRPM7 in ECs. TRPM7 ion channel activity and α-kinase function are required by DIC-mediated sepsis-induced organ dysfunction and its expression are associated with increased mortality during sepsis. TRPM7 appears as a new prognostic biomarker to predict mortality associated to DIC in SSPs, and as a novel target for drug development against DIC during infectious inflammatory diseases.
MeSH term(s)	Animals ; Rats ; Intercellular Adhesion Molecule-1 ; P-Selectin ; TRPM Cation Channels ; Endothelial Cells ; Endotoxemia ; Calcium ; Disseminated Intravascular Coagulation ; von Willebrand Factor ; Sepsis ; Endotoxins
Chemical Substances	Intercellular Adhesion Molecule-1 (126547-89-5) ; P-Selectin ; TRPM Cation Channels ; Calcium (SY7Q814VUP) ; von Willebrand Factor ; Endotoxins ; Trpm7 protein, rat (EC 2.7.11.1)
Language	English
Publishing date	2023-03-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1138990-4
ISSN	0717-6287 ; 0716-9760
ISSN (online)	0717-6287
ISSN	0716-9760
DOI	10.1186/s40659-023-00419-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction

Ivanka Jiménez-Dinamarca / Yolanda Prado / Pablo Tapia / Sebastian Gatica / Clemens Alt / Charles P. Lin / Cristian Reyes-Martínez / Carmen G. Feijóo / Cristobal Aravena / Alejandra González-Canacer / Simón Correa / Diego Varela / Claudio Cabello-Verrugio / Felipe Simon

Biological Research, Vol 56, Iss 1, Pp 1-

Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis

2023 Volume 3

Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: More than twenty years of European policy for the development of the information society

Claudio Feijóo / José Luis Gómez-Barroso / Edvins Karnitis

Netcom, Iss 21-1/2, Pp 09-

2016 Volume 24

Abstract: La politique adoptée par l'union européenne en matière de société de l’information s’initie avec le "livre blanc de Delors" et le "rapport de Bangemann" au début des années 1990. Durant cette première période et en dépit de quelques orientations sociales, ...

Abstract	La politique adoptée par l'union européenne en matière de société de l’information s’initie avec le "livre blanc de Delors" et le "rapport de Bangemann" au début des années 1990. Durant cette première période et en dépit de quelques orientations sociales, c’est essentiellement la question de la libéralisation des télécommunications qui a été au centre des discussions. La situation a évolué quelque peu avec la mise en place du programme eEurope entre 2000 et 2005 à Lisbonne. L’année 2006 aurait pu annoncer, avec une nouvelle stratégie baptisée i2010, une montée en puissance de l’investissement de la commission européenne en matière de société de l’information. Il n’en est rien. Au contraire, on constate finalement une baisse des ambitions, un retour en arrière, faute de résultats probants de la stratégie de Lisbonne.
Keywords	information society ; European Union ; eEurope ; European policy ; Geography (General) ; G1-922 ; Colonies and colonization. Emigration and immigration. International migration ; JV1-9480
Language	English
Publishing date	2016-12-01T00:00:00Z
Publisher	Netcom Association
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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