Article ; Online: Immune-Pathogenesis of Myeloma.
Hematology/oncology clinics of North America
2024 Volume 38, Issue 2, Page(s) 281–291
Abstract: This research indicates that monoclonal gammopathy of undetermined significance (MGUS) and myeloma may stem from chronic immune activation and inflammation, causing immune dysfunction and spatial immune exclusion. As the conditions progress, a shift ... ...
Abstract | This research indicates that monoclonal gammopathy of undetermined significance (MGUS) and myeloma may stem from chronic immune activation and inflammation, causing immune dysfunction and spatial immune exclusion. As the conditions progress, a shift toward myeloma involves ongoing immune impairment, affecting both innate and adaptive immunity. Intriguingly, even in advanced myeloma stages, susceptibility to immune effector cells persists. This insight highlights the intricate interplay between immune responses and the development of these conditions, paving the way for potential therapeutic interventions targeting immune modulation in the management of MGUS and myeloma. |
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MeSH term(s) | Humans ; Multiple Myeloma/etiology ; Multiple Myeloma/therapy ; Monoclonal Gammopathy of Undetermined Significance/etiology ; Monoclonal Gammopathy of Undetermined Significance/therapy ; Disease Progression |
Language | English |
Publishing date | 2024-01-08 |
Publishing country | United States |
Document type | Journal Article ; Review |
ZDB-ID | 93115-9 |
ISSN | 1558-1977 ; 0889-8588 |
ISSN (online) | 1558-1977 |
ISSN | 0889-8588 |
DOI | 10.1016/j.hoc.2023.12.011 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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