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  1. Article: Editorial: Interoception and the autonomic nervous system: Investigating affect, decision-making, and mental health.

    Ueno, Daisuke / Ohira, Hideki / Narumoto, Jin

    Frontiers in neuroscience

    2023  Volume 16, Page(s) 1130324

    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2022.1130324
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  2. Article ; Online: The IL-12-STAT4 axis in the pathogenesis of human systemic lupus erythematosus.

    Ueno, Hideki

    European journal of immunology

    2019  Volume 50, Issue 1, Page(s) 10–16

    Abstract: Generation of autoantibodies is a hallmark of systemic lupus erythematosus (SLE). As demonstrated in a number of lupus mouse models, recent evidence suggests that both GC and extrafollicular pathways contribute to the generation of autoantibodies also in ...

    Abstract Generation of autoantibodies is a hallmark of systemic lupus erythematosus (SLE). As demonstrated in a number of lupus mouse models, recent evidence suggests that both GC and extrafollicular pathways contribute to the generation of autoantibodies also in human SLE, and that CD11c
    MeSH term(s) Animals ; Autoantibodies/immunology ; B-Lymphocytes/immunology ; Humans ; Interleukin-12/immunology ; Lupus Erythematosus, Systemic/immunology ; STAT4 Transcription Factor/immunology ; Signal Transduction/immunology ; T-Lymphocytes, Helper-Inducer/immunology
    Chemical Substances Autoantibodies ; STAT4 Transcription Factor ; STAT4 protein, human ; Interleukin-12 (187348-17-0)
    Language English
    Publishing date 2019-12-03
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.201948134
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  3. Article ; Online: Tfh cell response in influenza vaccines in humans: what is visible and what is invisible.

    Ueno, Hideki

    Current opinion in immunology

    2019  Volume 59, Page(s) 9–14

    Abstract: Elucidating the immune mechanism by which seasonal influenza vaccines induce a protective immune response is of great importance to gain insights into the design of next-generation vaccines conferring more effective and long-lasting immune protection. ... ...

    Abstract Elucidating the immune mechanism by which seasonal influenza vaccines induce a protective immune response is of great importance to gain insights into the design of next-generation vaccines conferring more effective and long-lasting immune protection. Recent studies have established that T follicular helper (Tfh) cells play a major role for the generation of antibody response following influenza vaccination. Yet, the evidence is gained largely through the analysis of blood samples, and our knowledge on the role of Tfh cells in influenza vaccination is still largely limited to the generation of antigen-specific plasmablasts. Recently, influenza vaccination was shown to induce the expansion of two types of memory B cells in addition to plasmablasts. It is plausible that activated Tfh cells that remain in the lymph nodes after vaccination, a cell population missed in the analysis of blood samples, might also contribute to the diversification of memory B cell repertoire. However, current evidence shows no increase of somatic hypermutation of the expanded memory B cell clones, suggesting that this mechanism is not efficiently active in current influenza vaccines.
    MeSH term(s) Antibodies, Viral/metabolism ; Antibody Formation ; B-Lymphocytes/immunology ; Germinal Center/immunology ; Humans ; Immunologic Memory ; Influenza Vaccines/immunology ; Influenza, Human/immunology ; Lymphocyte Activation ; Orthomyxoviridae/immunology ; T-Lymphocytes, Helper-Inducer/immunology ; Vaccination
    Chemical Substances Antibodies, Viral ; Influenza Vaccines
    Language English
    Publishing date 2019-03-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2019.02.007
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  4. Article ; Online: Location, Location, Location.

    Ueno, Hideki

    Immunity

    2018  Volume 49, Issue 2, Page(s) 197–199

    Abstract: The B7 receptor PD-1 is highly expressed by T follicular helper (Tfh) cells and represents one of the major markers for Tfh cells localized within the germinal centers (GCs). In this issue of Immunity, Shi et al. (2018) shows that PD-1 is involved in the ...

    Abstract The B7 receptor PD-1 is highly expressed by T follicular helper (Tfh) cells and represents one of the major markers for Tfh cells localized within the germinal centers (GCs). In this issue of Immunity, Shi et al. (2018) shows that PD-1 is involved in the tissue positioning of Tfh cells in lymphoid organs.
    MeSH term(s) Biomarkers ; Germinal Center ; Programmed Cell Death 1 Receptor ; T-Lymphocytes, Helper-Inducer
    Chemical Substances Biomarkers ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2018-08-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2018.08.006
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  5. Article ; Online: Pivotal role of myeloid-derived suppressor cells in infection-related tumor growth.

    Ito, Nozomi / Tsujimoto, Hironori / Miyazaki, Hiromi / Takahata, Risa / Ueno, Hideki

    Cancer medicine

    2024  Volume 13, Issue 4, Page(s) e6917

    Abstract: Background: In this study, we investigated infection-related tumor growth, focusing on myeloid-derived suppressor cells (MDSCs) in clinical and experimental settings.: Patients and methods: In the clinical study, a total 109 patients who underwent ... ...

    Abstract Background: In this study, we investigated infection-related tumor growth, focusing on myeloid-derived suppressor cells (MDSCs) in clinical and experimental settings.
    Patients and methods: In the clinical study, a total 109 patients who underwent gastrectomy or esophagectomy were included. Blood samples were collected from a preoperative time point through 3 months after surgery, and MDSCs were analyzed using flow cytometry. In animal experiments, peritonitis model mice were created by CLP method. We investigated the number of splenic MDSCs in these mice using flow cytometry. Malignant melanoma cells (B16F10) were inoculated on the back of the mice, and tumor growth was monitored. We compared the level of MDSC infiltration around the tumor and the migration ability between CLP and sham-operated mice-derived MDSCs. Finally, we focused on PD-L1
    Results: In patients with postoperative infectious complication, MDSC number was found to remain elevated 3 months after surgery, when the inflammatory responses were normalized. CLP mice showed increased numbers of MDSCs, and following inoculation with B16F10 cells, this higher number of MDSCs was associated with significant tumor growth. CLP-mice-derived MDSCs had higher levels of accumulation around the tumor and had more enhanced migration ability. Finally, CLP mice had increased numbers of PD-L1
    Conclusion: Long-lasting enhanced MDSCs associated with infection may contribute to infection-related tumor progression.
    MeSH term(s) Humans ; Animals ; Mice ; Myeloid-Derived Suppressor Cells ; B7-H1 Antigen ; Neoplasms
    Chemical Substances B7-H1 Antigen
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.6917
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  6. Article ; Online: Circulating T Follicular Helper Subsets in Human Blood.

    Iwamoto, Yayoi / Ueno, Hideki

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2380, Page(s) 29–39

    Abstract: ... ...

    Abstract CXCR5
    MeSH term(s) Autoimmune Diseases ; B-Lymphocytes ; CD4-Positive T-Lymphocytes ; Humans ; Receptors, CXCR5 ; T-Lymphocyte Subsets ; T-Lymphocytes, Helper-Inducer
    Chemical Substances Receptors, CXCR5
    Language English
    Publishing date 2021-11-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1736-6_3
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  7. Article ; Online: Establishment and implementation of Cancer Genomic Medicine in Japan.

    Mukai, Yosuke / Ueno, Hideki

    Cancer science

    2021  Volume 112, Issue 3, Page(s) 970–977

    Abstract: Approximately 1 in 2 Japanese people are estimated to be diagnosed with cancer during their lifetime. Cancer still remains the leading cause of death in Japan, therefore the government of Japan has decided to develop a better cancer control policy and ... ...

    Abstract Approximately 1 in 2 Japanese people are estimated to be diagnosed with cancer during their lifetime. Cancer still remains the leading cause of death in Japan, therefore the government of Japan has decided to develop a better cancer control policy and launched the Cancer Genomic Medicine (CGM) program. The Ministry of Health, Labour, and Welfare (MHLW) held a consortium at their headquarters with leading academic authorities and the representatives of related organizations to discuss ways to advance CGM in Japan. Based on the report of the consortium, the CGM system under the national health insurance system has gradually been realized. Eleven hospitals were designated in February 2018 as core hospitals for CGM; subsequently, the MHLW built the Center for Cancer Genomics and Advanced Therapeutics (C-CAT) as an institution to aggregate and manage genomic and clinical information on cancer patients, and support appropriate secondary use of the aggregated information to develop research aimed at medical innovation. As the first step in Japan's CGM in routine practice, in June 2019 the MHLW started reimbursement of 2 types of tumor profiling tests for advanced solid cancer patients using the national insurance system. Japan's CGM has swiftly been spreading nationwide with the collaboration of 167 hospitals and patients. The health and research authorities are expected to embody personalized cancer medicine and promote CGM utilizing state-of-the-art technologies.
    MeSH term(s) Clinical Trials as Topic/organization & administration ; Genetic Counseling/economics ; Genetic Counseling/organization & administration ; Genetic Testing/economics ; Genomics/economics ; Genomics/methods ; Genomics/organization & administration ; Health Plan Implementation ; Humans ; Japan ; Medical Oncology/economics ; Medical Oncology/methods ; Medical Oncology/organization & administration ; National Health Programs/economics ; National Health Programs/organization & administration ; Neoplasms/diagnosis ; Neoplasms/economics ; Neoplasms/genetics ; Neoplasms/therapy ; Precision Medicine/economics ; Precision Medicine/methods ; Reimbursement Mechanisms ; Therapies, Investigational/economics
    Language English
    Publishing date 2021-02-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2115647-5
    ISSN 1349-7006 ; 1347-9032
    ISSN (online) 1349-7006
    ISSN 1347-9032
    DOI 10.1111/cas.14754
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  8. Article: Genomic medicine in clinical practice: national genomic medicine program in Japan.

    Ando, Yayoi / Shimoi, Tatsunori / Suzuki, Tatsuya / Ueno, Hideki / Okita, Natsuko / Nakamura, Kenichi

    Cancer biology & medicine

    2023  Volume 21, Issue 1

    MeSH term(s) Humans ; Japan ; Genomic Medicine
    Language English
    Publishing date 2023-10-11
    Publishing country China
    Document type Editorial
    ZDB-ID 2676322-9
    ISSN 2095-3941
    ISSN 2095-3941
    DOI 10.20892/j.issn.2095-3941.2023.0219
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  9. Article: Splenic Infarction Associated With Epstein-Barr Virus in an Adult With an Anatomic Anomaly: A Case Report.

    Kobayashi, Kazuki / Kishi, Yoji / Serizawa, Yusuke / Kimizuka, Yoshifumi / Ueno, Hideki

    Cureus

    2023  Volume 15, Issue 6, Page(s) e40530

    Abstract: Splenic infarction (SI) is often associated with circulatory and hematological diseases and infections. Here, we report a rare case of SI in an adult with infectious mononucleosis (IM) caused by the Epstein-Barr (EB) virus. A 31-year-old male with an ... ...

    Abstract Splenic infarction (SI) is often associated with circulatory and hematological diseases and infections. Here, we report a rare case of SI in an adult with infectious mononucleosis (IM) caused by the Epstein-Barr (EB) virus. A 31-year-old male with an unremarkable medical history presented with abdominal pain and fever. Contrast-enhanced computed tomography revealed focal SI. The splenic artery branching from the superior mesenteric artery was <5 mm in diameter. The diagnosis of EB virus infection was made based on physical examination and blood test results. As no evidence of cardiogenic disease, malignant lymphoma, or other infections were present, a diagnosis of SI associated with IM was made. A symptomatic treatment was administered, and the splenomegaly and SI improved two weeks after discharge. IM was assumed as the cause of the focal SI.
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.40530
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  10. Article ; Online: Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases.

    Yoshitomi, Hiroyuki / Ueno, Hideki

    Cellular & molecular immunology

    2020  Volume 18, Issue 3, Page(s) 523–527

    Abstract: The interactions of ... ...

    Abstract The interactions of CD4
    MeSH term(s) Animals ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Humans ; T Follicular Helper Cells/immunology ; T-Lymphocytes, Helper-Inducer/immunology
    Language English
    Publishing date 2020-08-31
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-020-00529-z
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