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  1. Article: Tobias Smollett and the Practice of Medicine.

    Harper, P

    The Yale journal of biology and medicine

    2011  Volume 2, Issue 6, Page(s) 408–416

    Language English
    Publishing date 2011-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 200515-3
    ISSN 1551-4056 ; 0044-0086
    ISSN (online) 1551-4056
    ISSN 0044-0086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Book: The clinic and the court

    Harper, Ian / Kelly, Tobias / Khanna, Akshay

    law, medicine and anthropology

    (Cambridge studies in law and society)

    2015  

    Author's details Ian Harper ; Tobias Kelly ; Akshay Khanna
    Series title Cambridge studies in law and society
    Keywords Medical laws and legislation ; Medical jurisprudence ; Applied anthropology
    Subject code 344.041
    Language English
    Size VIII, 305 S. : Ill., 23 cm
    Publisher Cambridge Univ. Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT018665554
    ISBN 978-1-107-07624-2 ; 1-107-07624-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 2152 available for loan (reading room) Lesesaal EG

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  3. Article: Harold Wilson's 'Lavender List' Scandal and the Shifting Moral Economy of Honour.

    Harper, Tobias

    20 century British history

    2018  

    Abstract: Harold Wilson's resignation honours list of 1976 was almost universally condemned by politicians, civil servants, and the press because it contained a number of high honours to individuals who were seen as scandalously lacking in merit. Unknown officials ...

    Abstract Harold Wilson's resignation honours list of 1976 was almost universally condemned by politicians, civil servants, and the press because it contained a number of high honours to individuals who were seen as scandalously lacking in merit. Unknown officials leaked details to the press and used multiple internal mechanisms, including the Political Honours Scrutiny Committee, to try to block the list, but Wilson pushed it through. This article examines the controversy around the list in terms of how the various parties involved used ideas about scandal, honour, and merit to discredit Wilson, his secretary Marcia Falkender and the honours nominees. It shows that the scandal was shaped by three double standards: one of the main grounds for the disqualification of certain appointees was that they had not donated to Labour; in spite of their traditional prioritization of secrecy around honours, the civil service failed to uphold this tradition when it suited them not to; and critics of the list attacked Falkender's influence over the list even as they defended their own traditional place in determining who was selected for honours. The scandal also shows how the British establishment and British society was struggling to deal with broader questions about the value of exactly the kinds of service that Wilson honoured in the list, namely, capitalist entrepreneurship, popular culture, and contributions from traditional outsiders. While the list was universally condemned in 1976, these forms of service were to become more valued in honours lists from the 1990s.
    Language English
    Publishing date 2018-12-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077480-1
    ISSN 1477-4674 ; 0955-2359
    ISSN (online) 1477-4674
    ISSN 0955-2359
    DOI 10.1093/tcbh/hwy048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Closing the accessibility gap to mental health treatment with a personalized self-referral chatbot.

    Habicht, Johanna / Viswanathan, Sruthi / Carrington, Ben / Hauser, Tobias U / Harper, Ross / Rollwage, Max

    Nature medicine

    2024  Volume 30, Issue 2, Page(s) 595–602

    Abstract: Inequality in treatment access is a pressing issue in most healthcare systems across many medical disciplines. In mental healthcare, reduced treatment access for minorities is ubiquitous but remedies are sparse. Here we demonstrate that digital tools can ...

    Abstract Inequality in treatment access is a pressing issue in most healthcare systems across many medical disciplines. In mental healthcare, reduced treatment access for minorities is ubiquitous but remedies are sparse. Here we demonstrate that digital tools can reduce the accessibility gap by addressing several key barriers. In a multisite observational study of 129,400 patients within England's NHS services, we evaluated the impact of a personalized artificial intelligence-enabled self-referral chatbot on patient referral volume and diversity in ethnicity, gender and sexual orientation. We found that services that used this digital solution identified substantially increased referrals (15% increase versus 6% increase in control services). Critically, this increase was particularly pronounced in minorities, such as nonbinary (179% increase) and ethnic minority individuals (29% increase). Using natural language processing to analyze qualitative feedback from 42,332 individuals, we found that the chatbot's human-free nature and the patients' self-realization of their need for treatment were potential drivers for the observed improvement in the diversity of access. This provides strong evidence that digital tools may help overcome the pervasive inequality in mental healthcare.
    MeSH term(s) Humans ; Male ; Female ; Ethnicity/psychology ; Minority Groups/psychology ; Artificial Intelligence ; Mental Health ; Health Services Accessibility ; Referral and Consultation
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-023-02766-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4212: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 39: Show issues

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  5. Article ; Online: Determining the Young's Modulus of the Bacterial Cell Envelope.

    Lee, Junsung / Jha, Karan / Harper, Christine E / Zhang, Wenyao / Ramsukh, Malissa / Bouklas, Nikolaos / Dörr, Tobias / Chen, Peng / Hernandez, Christopher J

    ACS biomaterials science & engineering

    2024  

    Abstract: Bacteria experience substantial physical forces in their natural environment, including forces caused by osmotic pressure, growth in constrained spaces, and fluid shear. The cell envelope is the primary load-carrying structure of bacteria, but the ... ...

    Abstract Bacteria experience substantial physical forces in their natural environment, including forces caused by osmotic pressure, growth in constrained spaces, and fluid shear. The cell envelope is the primary load-carrying structure of bacteria, but the mechanical properties of the cell envelope are poorly understood; reports of Young's modulus of the cell envelope of
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.4c00105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Philanthropy and honours in the British empire

    Harper, Tobias

    New global studies Vol. 12, No. 2 , p. 257-276

    2018  Volume 12, Issue 2, Page(s) 257–276

    Author's details Tobias Harper
    Keywords honours system ; British history ; class
    Language English
    Size Online-Ressource
    Publisher De Gruyter
    Publishing place Berlin
    Document type Article ; Online
    ZDB-ID 2401183-6
    ISSN 1940-0004
    DOI 10.1515/ngs-2018-0028
    Database ECONomics Information System

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  7. Article ; Online: Mechanical stimuli activate gene expression via a cell envelope stress sensing pathway.

    Harper, Christine E / Zhang, Wenyao / Lee, Junsung / Shin, Jung-Ho / Keller, Megan R / van Wijngaarden, Ellen / Chou, Emily / Wang, Zhaohong / Dörr, Tobias / Chen, Peng / Hernandez, Christopher J

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 13979

    Abstract: Mechanosensitive mechanisms are often used to sense damage to tissue structure, stimulating matrix synthesis and repair. While this kind of mechanoregulatory process is well recognized in eukaryotic systems, it is not known whether such a process occurs ... ...

    Abstract Mechanosensitive mechanisms are often used to sense damage to tissue structure, stimulating matrix synthesis and repair. While this kind of mechanoregulatory process is well recognized in eukaryotic systems, it is not known whether such a process occurs in bacteria. In Vibrio cholerae, antibiotic-induced damage to the load-bearing cell wall promotes increased signaling by the two-component system VxrAB, which stimulates cell wall synthesis. Here we show that changes in mechanical stress within the cell envelope are sufficient to stimulate VxrAB signaling in the absence of antibiotics. We applied mechanical forces to individual bacteria using three distinct loading modalities: extrusion loading within a microfluidic device, direct compression and hydrostatic pressure. In all cases, VxrAB signaling, as indicated by a fluorescent protein reporter, was increased in cells submitted to greater magnitudes of mechanical loading, hence diverse forms of mechanical stimuli activate VxrAB signaling. Reduction in cell envelope stiffness following removal of the endopeptidase ShyA led to large increases in cell envelope deformation and substantially increased VxrAB response, further supporting the responsiveness of VxrAB. Our findings demonstrate a mechanosensitive gene regulatory system in bacteria and suggest that mechanical signals may contribute to the regulation of cell wall homeostasis.
    MeSH term(s) Cell Membrane ; Cell Wall ; Homeostasis ; Anti-Bacterial Agents ; Gene Expression
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-08-26
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-40897-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: The clinic and the court

    Harper, Ian / Kelly, Tobias / Khanna, Akshay

    law, medicine, and anthropology

    (Cambridge studies in law and society)

    2015  

    Abstract: Law and medicine can be caught in a tight embrace. They both play a central role in the politics of harm, making decisions regarding what counts as injury and what might be the most suitable forms of redress or remedy. But where do law and medicine ... ...

    Author's details edited by Ian Harper, Tobias Kelly, Akshay Khanna
    Series title Cambridge studies in law and society
    Abstract "Law and medicine can be caught in a tight embrace. They both play a central role in the politics of harm, making decisions regarding what counts as injury and what might be the most suitable forms of redress or remedy. But where do law and medicine converge and diverge in their responses to and understandings of harm and suffering? Using empirical case studies from Europe, the Americas and Africa, The Clinic and the Court brings together leading medical and legal anthropologists to explore this question"--
    MeSH term(s) Legislation, Medical ; Compensation and Redress ; Pain ; Bioethical Issues ; Patient Rights
    Language English
    Size viii, 305 pages :, illustrations ;, 24 cm.
    Document type Book
    ISBN 9781107076242 ; 1107076242
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article ; Online: Should patients with complex febrile seizure be admitted for further management?

    Olson, Heather / Rudloe, Tiffany / Loddenkemper, Tobias / Harper, Marvin B / Kimia, Amir A

    The American journal of emergency medicine

    2017  Volume 36, Issue 8, Page(s) 1386–1390

    Abstract: Background and aims: Children with first complex febrile seizure (CFS) are often admitted for observation. The goals of this study were 1) to assess the risk of seizure recurrence during admission, 2) to determine whether early EEG affects acute ... ...

    Abstract Background and aims: Children with first complex febrile seizure (CFS) are often admitted for observation. The goals of this study were 1) to assess the risk of seizure recurrence during admission, 2) to determine whether early EEG affects acute management.
    Design/methods: We retrospectively reviewed a cohort of children 6-60months of age admitted from a Pediatric Emergency Department for first CFS over a 15year period. We excluded children admitted for supportive care of their febrile illness. Data extraction included age, gender, seizure features, laboratory and imaging studies, EEG, further seizures during admission, and antiepileptic drugs (AEDs) given.
    Results: One hundred eighty three children met inclusion criteria. Seven patients had seizures during the admission (7/183 or 3.8%) Since 38 children were loaded with anti-epileptic medication during their visit, the adjusted rate is 7/145 or 4.8. Increased risk of seizure recurrence during admission was observed in children presenting with multiple seizures (P=0.005). EEG was performed in 104/183 children (57%) and led to change in management in one patient (1%, 95% C.I. 0.05-6%). Six of the 7 children with seizure had an EEG. The study was normal in 3 and findings in the other 2 did not suggest/predict further seizures during the admission.
    Conclusions: Children with first CFSs are at low risk for seizure recurrence during admission. Multiple seizures at presentation are associated with risk of early recurrence and may warrant an admission. EEG had limited effect on acute management and should not be an indication for admission.
    MeSH term(s) Anticonvulsants/therapeutic use ; Boston ; Child, Preschool ; Diagnosis, Computer-Assisted ; Electroencephalography ; Emergency Service, Hospital/statistics & numerical data ; Female ; Hospitalization ; Humans ; Infant ; Male ; Recurrence ; Retrospective Studies ; Risk Factors ; Seizures, Febrile/diagnosis ; Seizures, Febrile/drug therapy ; Severity of Illness Index ; Tertiary Care Centers ; Triage/statistics & numerical data
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2017-12-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2017.12.059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2005: Show issues Location:
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  10. Article ; Online: Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.

    Boland, Sebastian / Swarup, Sharan / Ambaw, Yohannes A / Malia, Pedro C / Richards, Ruth C / Fischer, Alexander W / Singh, Shubham / Aggarwal, Geetika / Spina, Salvatore / Nana, Alissa L / Grinberg, Lea T / Seeley, William W / Surma, Michal A / Klose, Christian / Paulo, Joao A / Nguyen, Andrew D / Harper, J Wade / Walther, Tobias C / Farese, Robert V

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 5924

    Abstract: Haploinsufficiency of GRN causes frontotemporal dementia (FTD). The GRN locus produces progranulin (PGRN), which is cleaved to lysosomal granulin polypeptides. The function of lysosomal granulins and why their absence causes neurodegeneration are unclear. ...

    Abstract Haploinsufficiency of GRN causes frontotemporal dementia (FTD). The GRN locus produces progranulin (PGRN), which is cleaved to lysosomal granulin polypeptides. The function of lysosomal granulins and why their absence causes neurodegeneration are unclear. Here we discover that PGRN-deficient human cells and murine brains, as well as human frontal lobes from GRN-mutation FTD patients have increased levels of gangliosides, glycosphingolipids that contain sialic acid. In these cells and tissues, levels of lysosomal enzymes that catabolize gangliosides were normal, but levels of bis(monoacylglycero)phosphates (BMP), lipids required for ganglioside catabolism, were reduced with PGRN deficiency. Our findings indicate that granulins are required to maintain BMP levels to support ganglioside catabolism, and that PGRN deficiency in lysosomes leads to gangliosidosis. Lysosomal ganglioside accumulation may contribute to neuroinflammation and neurodegeneration susceptibility observed in FTD due to PGRN deficiency and other neurodegenerative diseases.
    MeSH term(s) Animals ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/metabolism ; Gangliosides/metabolism ; Gangliosidoses/metabolism ; Granulins/metabolism ; Humans ; Lysosomes/metabolism ; Mice ; N-Acetylneuraminic Acid/metabolism ; Phosphates/metabolism ; Progranulins/genetics ; Progranulins/metabolism
    Chemical Substances GRN protein, human ; Gangliosides ; Granulins ; Grn protein, mouse ; Phosphates ; Progranulins ; N-Acetylneuraminic Acid (GZP2782OP0)
    Language English
    Publishing date 2022-10-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-33500-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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