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Article ; Online: La melancolía de Francisca Paula de Azúa

Mariana Labarca

Nuevo mundo - Mundos Nuevos (2022)

Rastros de la biografía emocional de la esposa de un hombre privado del uso de la razón. Chile, 1774-1784

2022

Abstract: Francisca Paula de Azúa requested in 1780 the interdiction of her husband Ramón Cortés, claiming he was incapable of administering his patrimony on account of a madness caused by his constant drunkenness. At the same time, she turned to the ... ...

Abstract	Francisca Paula de Azúa requested in 1780 the interdiction of her husband Ramón Cortés, claiming he was incapable of administering his patrimony on account of a madness caused by his constant drunkenness. At the same time, she turned to the ecclesiastical court to request divorce based on the same reasons. Both records constitute the documentation explored by this article to propose a biographical exercise that traces the experience of a woman from the Chilean creole elite society from the late colonial period marked by the melancholy and pain caused by the repeated abuse her husband inflicted on her. Her story is presented as a case of feminine agency in a context particularly adverse, that of cohabitation with a husband whose constant drunkenness and consequent violent conduct was understood by those surrounding him as a mental illness. This article aims at exploring the different layers of Francisca Paula’s story to search for the traces of her emotional biography: it examines what she might have felt, how she and the people surrounding her signified those feelings, and how these emotions were represented and instrumentalized in the judicial procedure. By resorting to the biographical lens, the article intends to rescue her individuality and subjectivity, but also to reflect on the feminine experience in the late colonial period.
Keywords	biography ; emotions ; women ; justice ; madness ; Anthropology ; GN1-890 ; Latin America. Spanish America ; F1201-3799
Subject code	941
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Centre de Recherches sur les Mondes Américains
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The spaces of madness in eighteenth-century Tuscany. Strategies and negotiations to deal with mental afflictions

Mariana Labarca Pinto

Asclepio: Revista de Historia de la Medicina y de la Ciencia, Vol 71, Iss

2019 Volume 1

Abstract: This study explores the different spaces where madness was recorded in the Grand Duchy of Tuscany during the eighteenth century. Drawing from interdiction procedures, criminal records, records of the police and hospital records, it proposes an approach ... ...

Abstract	This study explores the different spaces where madness was recorded in the Grand Duchy of Tuscany during the eighteenth century. Drawing from interdiction procedures, criminal records, records of the police and hospital records, it proposes an approach to the history of madness based on a comprehensive analysis of the connections between the different spaces where people debated about the characteristics and consequences of madness and developed strategies to deal with it. This analytical strategy discloses that the mechanisms for dealing with madness were temporary and flexible responses that functioned as a network that could follow different courses. The study suggests that these itineraries, its agents and languages are essential to fully grasp how mental afflictions were conceived and managed in the eighteenth century. Particularly, it argues that the way they functioned gave origin to a social debate about the indicators and signs of madness that contributed to the systematization of psychiatric knowledge.
Keywords	locura ; interdicción ; historia social de la locura ; pensamiento médico ; instituciones asilares ; History of scholarship and learning. The humanities ; AZ20-999 ; History of medicine. Medical expeditions ; R131-687
Subject code	940
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	Consejo Superior de Investigaciones Científicas
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Los espacios de la locura en la Toscana del siglo XVIII

Mariana Labarca Pinto

Asclepio: Revista de Historia de la Medicina y de la Ciencia, Vol 71, Iss 1, Pp p250-p

Estrategias y negociaciones para enfrentar la enfermedad mental

2019 Volume 250

Abstract: Este trabajo estudia los diferentes espacios en que aparece registrada la locura en el Gran Ducado de Toscana durante el siglo XVIII. A partir de la revisión de expedientes de interdicción por incapacidad mental, archivos de justicia criminal, archivos ... ...

Abstract	Este trabajo estudia los diferentes espacios en que aparece registrada la locura en el Gran Ducado de Toscana durante el siglo XVIII. A partir de la revisión de expedientes de interdicción por incapacidad mental, archivos de justicia criminal, archivos de policía y registros hospitalarios, propone una aproximación a la historia de la locura basada en el análisis comprensivo de las vinculaciones entre las distintas instancias en que se debatió sobre sus características, se evaluaron sus consecuencias y se elaboraron estrategias para hacerle frente. Este enfoque revela que las alternativas existentes para sobrellevar la enfermedad mental funcionaban como respuestas temporales y flexibles que constituían una red de instancias que podían ser recorridas de distintas maneras. Sugiere que el estudio de estos itinerarios, sus actores y lenguajes resulta fundamental para comprender en toda su magnitud la forma en que fueron concebidas y enfrentadas las perturbaciones mentales en el siglo XVIII. En particular, sostiene que su funcionamiento dio pie a un debate social sobre los indicadores y significados de la locura que serviría de insumo para la sistematización del conocimiento psiquiátrico.
Keywords	locura ; interdicción ; historia social de la locura ; pensamiento médico ; instituciones asilares ; History of scholarship and learning. The humanities ; AZ20-999 ; History of medicine. Medical expeditions ; R131-687
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	Consejo Superior de Investigaciones Científicas
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sonic hedgehog is basolaterally sorted from the TGN and transcytosed to the apical domain involving Dispatched-1 at Rab11-ARE

Lisette Sandoval / Mariana Labarca / Claudio Retamal / Paula Sánchez / Juan Larraín / Alfonso González

Frontiers in Cell and Developmental Biology, Vol

2022 Volume 10

Abstract: Hedgehog proteins (Hhs) secretion from apical and/or basolateral domains occurs in different epithelial cells impacting development and tissue homeostasis. Palmitoylation and cholesteroylation attach Hhs to membranes, and Dispatched-1 (Disp-1) promotes ... ...

Abstract	Hedgehog proteins (Hhs) secretion from apical and/or basolateral domains occurs in different epithelial cells impacting development and tissue homeostasis. Palmitoylation and cholesteroylation attach Hhs to membranes, and Dispatched-1 (Disp-1) promotes their release. How these lipidated proteins are handled by the complex secretory and endocytic pathways of polarized epithelial cells remains unknown. We show that polarized Madin–Darby canine kidney cells address newly synthesized sonic hedgehog (Shh) from the TGN to the basolateral cell surface and then to the apical domain through a transcytosis pathway that includes Rab11-apical recycling endosomes (Rab11-ARE). Both palmitoylation and cholesteroylation contribute to this sorting behavior, otherwise Shh lacking these lipid modifications is secreted unpolarized. Disp-1 mediates first basolateral secretion from the TGN and then transcytosis from Rab11-ARE. At the steady state, Shh predominates apically and can be basolaterally transcytosed. This Shh trafficking provides several steps for regulation and variation in different epithelia, subordinating the apical to the basolateral secretion.
Keywords	hedgehog ; polarity ; trafficking ; Dispatched ; Rab11-ARE ; transcytosis ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Emociones, locura y familia en el siglo XVIII

Mariana Labarca Pinto

Nuevo mundo - Mundos Nuevos (2015)

apuntes sobre un debate historiográfico en curso

2015

Abstract: This study explores the connexions that can be drawn between emotions, madness and the family through a discussion of relevant historiographical debates, aiming to propose a critical reflection on the possibilities of introducing emotions as a category ... ...

Abstract	This study explores the connexions that can be drawn between emotions, madness and the family through a discussion of relevant historiographical debates, aiming to propose a critical reflection on the possibilities of introducing emotions as a category of historical analysis. It examines the debate that placed the family and the domestic space at the centre of the analysis of the history of madness, a turn that resulted in the introduction of the dimension of experience. Building on this debate, the study suggests an approach to the history of madness that considers the critical role attributed and played by emotions in the interpretation, experience and responses to mental deviance, reflecting on the interconnections between the local and the transnational dimension. To approach the history of madness through the lens of emotions provides a valuable way to grasp the contextual and relational aspects behind the social configuration of the boundaries between sanity and insanity.
Keywords	emotion ; historiography ; interdiction ; circulation of knowledge ; transnational ; Anthropology ; GN1-890 ; Latin America. Spanish America ; F1201-3799
Subject code	900
Language	English
Publishing date	2015-12-01T00:00:00Z
Publisher	Centre de Recherches sur les Mondes Américains
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: D-Propranolol Impairs EGFR Trafficking and Destabilizes Mutant p53 Counteracting AKT Signaling and Tumor Malignancy.

Barra, Jonathan / Cerda-Infante, Javier / Sandoval, Lisette / Gajardo-Meneses, Patricia / Henriquez, Jenny F / Labarca, Mariana / Metz, Claudia / Venegas, Jaime / Retamal, Claudio / Oyanadel, Claudia / Cancino, Jorge / Soza, Andrea / Cuello, Mauricio A / Roa, Juan Carlos / Montecinos, Viviana P / Gonzalez, Alfonso

Cancers

2021 Volume 13, Issue 14

Abstract: Cancer therapy may be improved by the simultaneous interference of two or more oncogenic pathways contributing to tumor progression and aggressiveness, such as EGFR and p53. Tumor cells expressing gain-of-function (GOF) mutants of p53 (mutp53) are ... ...

Abstract	Cancer therapy may be improved by the simultaneous interference of two or more oncogenic pathways contributing to tumor progression and aggressiveness, such as EGFR and p53. Tumor cells expressing gain-of-function (GOF) mutants of p53 (mutp53) are usually resistant to EGFR inhibitors and display invasive migration and AKT-mediated survival associated with enhanced EGFR recycling. D-Propranolol (D-Prop), the non-beta blocker enantiomer of propranolol, was previously shown to induce EGFR internalization through a PKA inhibitory pathway that blocks the recycling of the receptor. Here, we first show that D-Prop decreases the levels of EGFR at the surface of GOF mutp53 cells, relocating the receptor towards recycling endosomes, both in the absence of ligand and during stimulation with high concentrations of EGF or TGF-α. D-Prop also inactivates AKT signaling and reduces the invasive migration and viability of these mutp53 cells. Unexpectedly, mutp53 protein, which is stabilized by interaction with the chaperone HSP90 and mediates cell oncogenic addiction, becomes destabilized after D-Prop treatment. HSP90 phosphorylation by PKA and its interaction with mutp53 are decreased by D-Prop, releasing mutp53 towards proteasomal degradation. Furthermore, a single daily dose of D-Prop reproduces most of these effects in xenografts of aggressive gallbladder cancerous G-415 cells expressing GOF R282W mutp53, resulting in reduced tumor growth and extended mice survival. D-Prop then emerges as an old drug endowed with a novel therapeutic potential against EGFR- and mutp53-driven tumor traits that are common to a large variety of cancers.
Language	English
Publishing date	2021-07-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13143622
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Harvest and primary culture of the murine aldosterone-sensitive distal nephron.

Labarca, Mariana / Nizar, Jonathan M / Walczak, Elisabeth M / Dong, Wuxing / Pao, Alan C / Bhalla, Vivek

American journal of physiology. Renal physiology

2015 Volume 308, Issue 11, Page(s) F1306–15

Abstract: The aldosterone-sensitive distal nephron (ASDN) exhibits axial heterogeneity in structure and function from the distal convoluted tubule to the medullary collecting duct. Ion and water transport is primarily divided between the cortex and medulla of the ... ...

Abstract	The aldosterone-sensitive distal nephron (ASDN) exhibits axial heterogeneity in structure and function from the distal convoluted tubule to the medullary collecting duct. Ion and water transport is primarily divided between the cortex and medulla of the ASDN, respectively. Transcellular transport in this segment is highly regulated in health and disease and is integrated across different cell types. We currently lack an inexpensive, high-yield, and tractable technique to harvest and culture cells for the study of gene expression and physiological properties of mouse cortical ASDN. To address this need, we harvested tubules bound to Dolichos biflorus agglutinin lectin-coated magnetic beads from the kidney cortex and characterized these cell preparations. We determined that these cells are enriched for markers of distal convoluted tubule, connecting tubule, and cortical collecting duct, including principal and intercalated cells. In primary culture, these cells develop polarized monolayers with high resistance (1,000-1,500 Ω * cm(2)) and maintain expression and activity of key channels. These cells demonstrate an amiloride-sensitive short-circuit current that can be enhanced with aldosterone and maintain measurable potassium and anion secretion. Our method can be easily adopted to study the biology of the ASDN and to investigate phenotypic differences between wild-type and transgenic mouse models.
MeSH term(s)	Aldosterone/metabolism ; Animals ; Cells, Cultured ; Disease Models, Animal ; Kidney Tubules, Collecting/metabolism ; Kidney Tubules, Distal/drug effects ; Kidney Tubules, Distal/metabolism ; Mice, Inbred C57BL ; Nephrons/drug effects ; Nephrons/metabolism ; Potassium/metabolism
Chemical Substances	Aldosterone (4964P6T9RB) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2015-03-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	603837-2
ISSN	1522-1466 ; 0363-6127
ISSN (online)	1522-1466
ISSN	0363-6127
DOI	10.1152/ajprenal.00668.2014
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Article ; Online: Smartphone screen testing, a novel pre-diagnostic method to identify SARS-CoV-2 infectious individuals.

Young, Rodrigo M / Solis, Camila J / Barriga-Fehrman, Andres / Abogabir, Carlos / Thadani, Alvaro R / Labarca, Mariana / Bustamante, Eva / Tapia, Cecilia V / Sarda, Antonia G / Sepulveda, Francisca / Pozas, Nadia / Cerpa, Leslie C / Lavanderos, María A / Varela, Nelson M / Santibañez, Alvaro / Sandino, Ana M / Reyes-Lopez, Felipe / Dixon, Garth / Quiñones, Luis A

eLife

2021 Volume 10

Abstract: The COVID-19 pandemic will likely take years to control globally, and constant epidemic surveillance will be required to limit the spread of SARS-CoV-2, especially considering the emergence of new variants that could hamper the effect of vaccination ... ...

Abstract	The COVID-19 pandemic will likely take years to control globally, and constant epidemic surveillance will be required to limit the spread of SARS-CoV-2, especially considering the emergence of new variants that could hamper the effect of vaccination efforts. We developed a simple and robust -
MeSH term(s)	COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/genetics ; COVID-19 Nucleic Acid Testing ; Humans ; Pandemics ; SARS-CoV-2/genetics ; Smartphone
Language	English
Publishing date	2021-06-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.70333
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Article: COVID-19 pneumonia: Perfusion abnormalities shown on subtraction CT angiography in apparently well-ventilated lungs. A prospective cohort study.

Santamarina, Mario G / Lomakin, Felipe Martinez / Beddings, Ignacio / Riscal, Dominique Boisier / Chang Villacís, Jose / Contreras, Roberto / Marambio, Jaime Vidal / Labarca, Eduardo / Torres, Jorge / Volpacchio, Mariano

Heliyon

2023 Volume 9, Issue 7, Page(s) e18085

Abstract: Purpose: To evaluate whether a subtraction CT angiography (sCTA) perfusion score may have prognostic value in patients with COVID-19 pneumonia.: Method: This prospective cohort study included adult patients with RT-PCR-confirmed SARS-CoV-2 infection ... ...

Abstract	Purpose: To evaluate whether a subtraction CT angiography (sCTA) perfusion score may have prognostic value in patients with COVID-19 pneumonia. Method: This prospective cohort study included adult patients with RT-PCR-confirmed SARS-CoV-2 infection admitted to the ED and a sCTA performed within 24 h of admission between June and September 2020. Perfusion abnormalities (PA) in areas of apparently spared lung parenchyma on conventional CT images were assessed with sCTA perfusion score. Airspace disease extension was assessed with CT severity scores, which were then correlated with clinical outcomes (admission to ICU, requirement of IMV, and death). Inter-rater reliability (IRR) was assessed using Cohen's Kappa. Independent predictors of adverse outcomes were evaluated by multivariable logistic regression analyses using the Hosmer and Lemeshow's test. Results: 191 patients were included: 112 males (58%), median age of 60.8 years (SD ± 16.0). The IRR was very high (median Kappa statistic: 0.95). No association was found between perfusion CT scores and D-dimer levels (Kendall's Tau-B coefficient = 0.08, p = 0.16) or between PaO Conclusions: The assessment of pulmonary perfusion abnormalities in areas of apparently spared lung parenchyma on conventional CT images via sCTA perfusion scoring has prognostic value in COVID-19 pneumonia.
Language	English
Publishing date	2023-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e18085
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Article ; Online: Functionalisation of Detonation Nanodiamond for Monodispersed, Soluble DNA-Nanodiamond Conjugates Using Mixed Silane Bead-Assisted Sonication Disintegration.

Edgington, Robert / Spillane, Katelyn M / Papageorgiou, George / Wray, William / Ishiwata, Hitoshi / Labarca, Mariana / Leal-Ortiz, Sergio / Reid, Gordon / Webb, Martin / Foord, John / Melosh, Nicholas / Schaefer, Andreas T

Scientific reports

2018 Volume 8, Issue 1, Page(s) 728

Abstract: Nanodiamonds have many attractive properties that make them suitable for a range of biological applications, but their practical use has been limited because nanodiamond conjugates tend to aggregate in solution during or after functionalisation. Here we ... ...

Abstract	Nanodiamonds have many attractive properties that make them suitable for a range of biological applications, but their practical use has been limited because nanodiamond conjugates tend to aggregate in solution during or after functionalisation. Here we demonstrate the production of DNA-detonation nanodiamond (DNA-DND) conjugates with high dispersion and solubility using an ultrasonic, mixed-silanization chemistry protocol based on the in situ Bead-Assisted Sonication Disintegration (BASD) silanization method. We use two silanes to achieve these properties: (1) 3-(trihydroxysilyl)propyl methylphosphonate (THPMP); a negatively charged silane that imparts high zeta potential and solubility in solution; and (2) (3-aminopropyl)triethoxysilane (APTES); a commonly used functional silane that contributes an amino group for subsequent bioconjugation. We target these amino groups for covalent conjugation to thiolated, single-stranded DNA oligomers using the heterobifunctional crosslinker sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate (Sulfo-SMCC). The resulting DNA-DND conjugates are the smallest reported to date, as determined by Dynamic Light Scattering (DLS) and Atomic Force Microscopy (AFM). The functionalisation method we describe is versatile and can be used to produce a wide variety of soluble DND-biomolecule conjugates.
MeSH term(s)	Chemical Phenomena ; DNA/metabolism ; Dynamic Light Scattering ; Microscopy, Atomic Force ; Nanodiamonds/chemistry ; Silanes/metabolism ; Solubility ; Sonication
Chemical Substances	Nanodiamonds ; Silanes ; DNA (9007-49-2)
Language	English
Publishing date	2018-01-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-017-18601-6
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